PF-06650833

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H20FN3O4
Molecular Weight	361.3682
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@@]1([H])[C@@]([H])(COc2c3cc(c(cc3ccn2)C(=N)O)OC)N=C([C@@]1([H])F)O

InChI

InChIKey=JKDGKIBAOAFRPJ-ZBINZKHDSA-N

InChI=1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H20FN3O4
Molecular Weight	361.3682
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Interleukin-1 receptor-associated kinase 4 2 Target ID: Q9NWZ3 Gene ID: 51135 Gene Symbol: IRAK4 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28498658	Inhibitor 7701		0.200000000000000011 nM [IC50]

Substance Class	Chemical Created by `admin` on `Sat Jun 26 10:23:15 UTC 2021` Edited by `admin` on `Sat Jun 26 10:23:15 UTC 2021`
Record UNII	S3F315JJXI
Record Status	`Validated (UNII)`
Record Version