PF-06650833

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H20FN3O4
Molecular Weight	361.3682
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of PF-06650833

Structure Search

SMILES

CC[C@@]1([H])[C@@]([H])(COc2c3cc(c(cc3ccn2)C(=N)O)OC)N=C([C@@]1([H])F)O

InChI

InChIKey=JKDGKIBAOAFRPJ-ZBINZKHDSA-N

InChI=1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H20FN3O4
Molecular Weight	361.3682
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Interleukin-1 receptor-associated kinase 4 2 Target ID: Q9NWZ3 Gene ID: 51135.0 Gene Symbol: IRAK4 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28498658	Inhibitor 7728		0.2 nM [IC50]

Substance Class	Chemical Created by `admin` on `Sat Jun 26 10:23:15 UTC 2021` Edited by `admin` on `Sat Jun 26 10:23:15 UTC 2021`
Record UNII	S3F315JJXI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PF-06650833

Common Name

English

6-ISOQUINOLINECARBOXAMIDE, 1-(((2S,3S,4S)-3-ETHYL-4-FLUORO-5-OXO-2-PYRROLIDINYL)METHOXY)-7-METHOXY-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB15143

Created by admin on Sat Jun 26 10:23:15 UTC 2021 , Edited by admin on Sat Jun 26 10:23:15 UTC 2021

PRIMARY

FDA UNII

S3F315JJXI

Created by admin on Sat Jun 26 10:23:15 UTC 2021 , Edited by admin on Sat Jun 26 10:23:15 UTC 2021

PRIMARY

PUBCHEM

118414016

Created by admin on Sat Jun 26 10:23:15 UTC 2021 , Edited by admin on Sat Jun 26 10:23:15 UTC 2021

PRIMARY

CAS

1817626-54-2

Created by admin on Sat Jun 26 10:23:15 UTC 2021 , Edited by admin on Sat Jun 26 10:23:15 UTC 2021

PRIMARY

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