U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H21N3O
Molecular Weight 307.3895
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZOLPIDEM

SMILES

CN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C3=CC=C(C)C=C3

InChI

InChIKey=ZAFYATHCZYHLPB-UHFFFAOYSA-N
InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C19H21N3O
Molecular Weight 307.3895
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Zolpidem is usually used for the treatment of insomnia as a hypnotic drug. It was also suggested to be effective in the treatment of dystonia in some studies. Zolpidem can be one of useful alternative pharmacological treatments for blepharospasm. Zolpidem interacts with a GABA-BZ receptor complex and shares some of the pharmacological properties of the benzodiazepines. In contrast to the benzodiazepines, which non-selectively bind to and activate all BZ receptor subtypes, zolpidem in vitro binds the BZ1 receptor preferentially with a high affinity ratio of the α1/α5 subunits. This selective binding of zolpidem on the BZ1 receptor is not absolute, but it may explain the relative absence of myorelaxant and anticonvulsant effects in animal studies as well as the preservation of deep sleep in human studies of zolpidem tartrate at hypnotic doses.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
AMBIEN

Approved Use

Ambien (zolpidem tartrate) is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation. Ambien has been shown to decrease sleep latency for up to 35 days in controlled clinical studies [see Clinical Studies (14)

Launch Date

7.2446398E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
121 ng/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZOLPIDEM unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
59 ng/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZOLPIDEM unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2.5 h
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZOLPIDEM unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
26 h
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZOLPIDEM unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
7.5%
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZOLPIDEM unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
7.5%
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ZOLPIDEM unknown
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.5 mg/kg single, oral
Highest studied dose
Dose: 0.5 mg/kg
Route: oral
Route: single
Dose: 0.5 mg/kg
Sources:
unhealthy, 2 - 12 years
n = 65
Health Status: unhealthy
Condition: sleep disturbances
Age Group: 2 - 12 years
Sex: M+F
Population Size: 65
Sources:
Other AEs: Psychiatric symptom, Gastrointestinal disorder (NOS)...
Other AEs:
Psychiatric symptom (6 patients)
Gastrointestinal disorder (NOS) (6 patients)
Nervous system disorder NOS (5 patients)
Sources:
300 mg single, oral
Overdose
Dose: 300 mg
Route: oral
Route: single
Dose: 300 mg
Sources:
unhealthy, 68 years
n = 1
Health Status: unhealthy
Condition: sleep disturbances
Age Group: 68 years
Sex: F
Population Size: 1
Sources:
Disc. AE: Death...
AEs leading to
discontinuation/dose reduction:
Death (grade 5, 1 patient)
Sources:
50 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, adult
n = 1959
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1959
Sources:
Disc. AE: Drowsiness, Vertigo...
AEs leading to
discontinuation/dose reduction:
Drowsiness (1.1%)
Vertigo (0.8%)
Amnesia (0.5%)
Nausea (0.5%)
Headache (0.4%)
Fall (0.4%)
Sources:
90 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 90 mg, 1 times / day
Route: oral
Route: steady
Dose: 90 mg, 1 times / day
Sources:
unhealthy, adult
n = 1701
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1701
Sources:
Disc. AE: Drowsiness, Dizziness...
AEs leading to
discontinuation/dose reduction:
Drowsiness (0.5%)
Dizziness (0.4%)
Headache (0.5%)
Nausea (0.6%)
Vomiting (0.5%)
Sources:
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, adult
n = 344
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 344
Sources:
Disc. AE: Death...
AEs leading to
discontinuation/dose reduction:
Death (grade 5, 10 patients)
Sources:
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, adult
n = 54
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 54
Sources:
Disc. AE: Somnolence, Coma...
AEs leading to
discontinuation/dose reduction:
Somnolence (100%)
Coma (1 patient)
Sources:
AEs

AEs

AESignificanceDosePopulation
Nervous system disorder NOS 5 patients
0.5 mg/kg single, oral
Highest studied dose
Dose: 0.5 mg/kg
Route: oral
Route: single
Dose: 0.5 mg/kg
Sources:
unhealthy, 2 - 12 years
n = 65
Health Status: unhealthy
Condition: sleep disturbances
Age Group: 2 - 12 years
Sex: M+F
Population Size: 65
Sources:
Gastrointestinal disorder (NOS) 6 patients
0.5 mg/kg single, oral
Highest studied dose
Dose: 0.5 mg/kg
Route: oral
Route: single
Dose: 0.5 mg/kg
Sources:
unhealthy, 2 - 12 years
n = 65
Health Status: unhealthy
Condition: sleep disturbances
Age Group: 2 - 12 years
Sex: M+F
Population Size: 65
Sources:
Psychiatric symptom 6 patients
0.5 mg/kg single, oral
Highest studied dose
Dose: 0.5 mg/kg
Route: oral
Route: single
Dose: 0.5 mg/kg
Sources:
unhealthy, 2 - 12 years
n = 65
Health Status: unhealthy
Condition: sleep disturbances
Age Group: 2 - 12 years
Sex: M+F
Population Size: 65
Sources:
Death grade 5, 1 patient
Disc. AE
300 mg single, oral
Overdose
Dose: 300 mg
Route: oral
Route: single
Dose: 300 mg
Sources:
unhealthy, 68 years
n = 1
Health Status: unhealthy
Condition: sleep disturbances
Age Group: 68 years
Sex: F
Population Size: 1
Sources:
Fall 0.4%
Disc. AE
50 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, adult
n = 1959
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1959
Sources:
Headache 0.4%
Disc. AE
50 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, adult
n = 1959
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1959
Sources:
Amnesia 0.5%
Disc. AE
50 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, adult
n = 1959
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1959
Sources:
Nausea 0.5%
Disc. AE
50 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, adult
n = 1959
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1959
Sources:
Vertigo 0.8%
Disc. AE
50 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, adult
n = 1959
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1959
Sources:
Drowsiness 1.1%
Disc. AE
50 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, adult
n = 1959
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1959
Sources:
Dizziness 0.4%
Disc. AE
90 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 90 mg, 1 times / day
Route: oral
Route: steady
Dose: 90 mg, 1 times / day
Sources:
unhealthy, adult
n = 1701
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1701
Sources:
Drowsiness 0.5%
Disc. AE
90 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 90 mg, 1 times / day
Route: oral
Route: steady
Dose: 90 mg, 1 times / day
Sources:
unhealthy, adult
n = 1701
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1701
Sources:
Headache 0.5%
Disc. AE
90 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 90 mg, 1 times / day
Route: oral
Route: steady
Dose: 90 mg, 1 times / day
Sources:
unhealthy, adult
n = 1701
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1701
Sources:
Vomiting 0.5%
Disc. AE
90 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 90 mg, 1 times / day
Route: oral
Route: steady
Dose: 90 mg, 1 times / day
Sources:
unhealthy, adult
n = 1701
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1701
Sources:
Nausea 0.6%
Disc. AE
90 mg 1 times / day steady, oral (max)
Highest studied dose
Dose: 90 mg, 1 times / day
Route: oral
Route: steady
Dose: 90 mg, 1 times / day
Sources:
unhealthy, adult
n = 1701
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 1701
Sources:
Death grade 5, 10 patients
Disc. AE
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, adult
n = 344
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 344
Sources:
Coma 1 patient
Disc. AE
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, adult
n = 54
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 54
Sources:
Somnolence 100%
Disc. AE
600 mg single, oral
Overdose
Dose: 600 mg
Route: oral
Route: single
Dose: 600 mg
Sources:
unhealthy, adult
n = 54
Health Status: unhealthy
Condition: sleep disturbances
Age Group: adult
Sex: unknown
Population Size: 54
Sources:
Overview

OverviewOther

Other InhibitorOther SubstrateOther Inducer







Drug as perpetrator​Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
yes
yes
yes
yes
yes (co-administration study)
Comment: A single-dose interaction study with zolpidem tartrate 10 mg and rifampin (CYP3A4 inducer) 600 mg at steady-state levels in female subjects showed significant reductions of the AUC (-73%), Cmax (-58%), and T1/2 (-36 %) of zolpidem together
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
[Development of drug withdrawal delirium after dependence on zolpidem and zoplicone].
1999 Nov
Acute zolpidem overdose--report of two cases.
1999 Oct
Extraordinary arousal from semi-comatose state on zolpidem. A case report.
2000 Jan
[Zolpidem (ivadal) treatment of sleep disorders].
2001
Measurement of cerebral perfusion after zolpidem administration in the baboon model.
2001
[Comparative study of effects of ivadal and rodedorm in insomnia in structure of borderline mental diseases].
2001
The acute effects of zolpidem compared to diazepam and lorazepam using radiotelemetry.
2001 Apr
Zolpidem for antipsychotic-induced parkinsonism.
2001 Apr
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
2001 Apr
Alternative medicine. Achieving balance between herbal remedies and medical therapy.
2001 Aug
Zolpidem abuse.
2001 Aug
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
2001 Dec 1
Triazolam discrimination in squirrel monkeys distinguishes high-efficacy agonists from other benzodiazepines and non-benzodiazepine drugs.
2001 Feb
Hormonal responses to exercise after partial sleep deprivation and after a hypnotic drug-induced sleep.
2001 Feb
Acute zolpidem overdose leading to coma and respiratory failure.
2001 Jul
Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux.
2001 May
Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone.
2001 May
Arousal from a semi-comatose state on zolpidem.
2001 Oct
Tolerability of hypnosedatives in older patients.
2002
Hallucinations and Zolpidem.
2002 Aug
Zolpidem improves dystonia in "Lubag" or X-linked dystonia-parkinsonism syndrome.
2002 Feb 26
Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia.
2002 Jan
[Abuse, tolerance and dependence of zolpidem: three case reports].
2002 Jul-Aug
Early cerebral activities of the environmental estrogen bisphenol A appear to act via the somatostatin receptor subtype sst(2).
2002 Jun
The effect of zolpidem on operant behavior and its relation to pharmacokinetics after intravenous and subcutaneous administration: concentration-effect relations.
2002 Mar
Soyka M, Bottlender R, Möller H-J; Epidemiological evidence for a low abuse potential of zolpidem; Pharmacopsychiatry 2000, 33: 138 - 141.
2002 Mar
Selective actions on sleep or anxiety by exploiting GABA-A/benzodiazepine receptor subtypes.
2002 Mar
Sleep disorders and daytime sleepiness in state police shiftworkers.
2002 Mar-Apr
Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats.
2002 May
Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys.
2002 May
Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells.
2002 May
Long term benzodiazepine use for insomnia in patients over the age of 60: discordance of patient and physician perceptions.
2002 May 8
Patents

Patents

Sample Use Guides

Dosage in Adults: the recommended initial dose is 5 mg for women and either 5 or 10 mg for men, taken only once per night immediately before bedtime with at least 7-8 hours remaining before the planned time of awakening. If the 5 mg dose is not effective, the dose can be increased to 10 mg. In some patients, the higher morning blood levels following use of the 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness. The total dose of AMBIEN (zolpidem tartrate) should not exceed 10 mg once daily immediately before bedtime. Ambien should be taken as a single dose and should not be readministered during the same night.
Route of Administration: Oral
Human embryonic kidney (HEK) 293 cells stably expressing recombinant α1β2γ2s GABA(A) receptors were exposed to zolpidem (1 and 10 μmol/L) for short-term (2 h daily for 1, 2, or 3 consecutive days) or long-term (continuously for 48 h). Radioligand binding studies were used to determine the parameters of [(3)H]flunitrazepam binding sites. A single (2 h) or repeated (2 h daily for 2 or 3 d) short-term exposure to zolpidem affected neither the maximum number of [(3)H]flunitrazepam binding sites nor the affinity. In both control and short-term zolpidem treated groups, addition of GABA (1 nmol/L-1 mmol/L) enhanced [(3)H]flunitrazepam binding in a concentration-dependent manner. The maximum enhancement of [(3)H]flunitrazepam binding in short-term zolpidem treated group was not significantly different from that in the control group. In contrast, long-term exposure to zolpidem resulted in significantly increase in the maximum number of [(3)H]flunitrazepam binding sites without changing the affinity. Furthermore, long-term exposure to zolpidem significantly decreased the ability of GABA to stimulate [(3)H]flunitrazepam binding.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:45:30 UTC 2023
Edited
by admin
on Fri Dec 15 15:45:30 UTC 2023
Record UNII
7K383OQI23
Record Status Validated (UNII)
Record Version
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Name Type Language
ZOLPIDEM
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
zolpidem [INN]
Common Name English
ZOLPIDEM CIV
USP-RS  
Common Name English
SANVAL
Brand Name English
Zolpidem [WHO-DD]
Common Name English
ZOLPIDEM [MI]
Common Name English
N,N,6-TRIMETHYL-2-P-TOLYL-IMIDAZO(1,2-A)PYRIDINE-3-ACETAMIDE
Common Name English
ZOLPIDEM [VANDF]
Common Name English
IMIDAZO(1,2-A)PYRIDINE-3-ACETAMIDE, N,N,6-TRIMETHYL-2-(4-METHYLPHENYL)-
Systematic Name English
ZOLPIDEM CIV [USP-RS]
Common Name English
Classification Tree Code System Code
WHO-VATC QN05CF02
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
NDF-RT N0000175759
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
DEA NO. 2783
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
WHO-ATC N05CF02
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
NCI_THESAURUS C29756
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
LIVERTOX NBK547962
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
Code System Code Type Description
SMS_ID
100000078817
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
PUBCHEM
5732
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
WIKIPEDIA
ZOLPIDEM
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
MERCK INDEX
m11661
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY Merck Index
CAS
82626-48-0
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
INN
5741
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
ChEMBL
CHEMBL911
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
RS_ITEM_NUM
1724893
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
FDA UNII
7K383OQI23
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
DRUG BANK
DB00425
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
DRUG CENTRAL
2870
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
LACTMED
Zolpidem
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
CHEBI
10125
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
DAILYMED
7K383OQI23
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
EPA CompTox
DTXSID7045946
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
EVMPD
SUB00183MIG
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
MESH
C049109
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
IUPHAR
4348
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
RXCUI
39993
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY RxNorm
NDF-RT
N0000007570
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY Pyridines [Chemical/Ingredient]
NCI_THESAURUS
C62000
Created by admin on Fri Dec 15 15:45:30 UTC 2023 , Edited by admin on Fri Dec 15 15:45:30 UTC 2023
PRIMARY
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ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Route of Elimination PHARMACOKINETIC
MAXIMUM TOLERATED DOSE TOXICITY ORAL SPRAY, SL TABLET

EXTENDED-RELEASE TABLET

Route of Elimination PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC SPECIAL POPULATIONS
PHARMACOKINETIC
SPECIAL POPULATIONS
PHARMACOKINETIC
SPECIAL POPULATIONS
PHARMACOKINETIC
SPECIAL POPULATIONS
PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC SPECIAL POPULATIONS
PHARMACOKINETIC
SPECIAL POPULATIONS
PHARMACOKINETIC
SPECIAL POPULATIONS
PHARMACOKINETIC