Approval Year
| Substance Class |
Mixture
Created
by
admin
on
Edited
Fri Jun 25 21:40:29 UTC 2021
by
admin
on
Fri Jun 25 21:40:29 UTC 2021
|
| Record UNII |
RU3465V8V1
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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RU3465V8V1
Created by
admin on Fri Jun 25 21:40:29 UTC 2021 , Edited by admin on Fri Jun 25 21:40:29 UTC 2021
|
PRIMARY |
Any of these components may be present:
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET |
OFF-TARGET ACTIVITY: INHIBITING LIGAND BINDING TO THE AGBAA CHLORIDE ION CHANNEL
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INHIBITOR -> TARGET |
OFF-TARGET ACTIVITY: INHIBITING LIGAND BINDING TO GABAA CHLORIDE ION CHANNEL
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AGONIST -> TARGET |
SL651498 is a subtype-selective GABAA agonist, which acts as a full agonist at ?2 and ?3 subtypes, and as a partial agonist at ?1 and ?5 (although its action at ?5 subtypes is much weaker than at the others).
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INHIBITOR->OFF-TARGET |
OFF-TARGET ACTIVITY: INHIBITING LIGAND BINDING TO THE GABAA CHLORIDE ION CHANNEL
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AGONIST -> TARGET | |||
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MODULATOR->TARGET |
ALLOSTERIC ACTIVATOR
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PARTIAL AGONIST->TARGET | |||
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MODULATOR->TARGET | |||
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ACTIVATOR -> TARGET |
ALLOSTERIC ACTIVATOR
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INHIBITOR -> TARGET | |||
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INVERSE AGONIST->TARGET |
Non selective GABAA inverse agonist. Therapeutic potential is limited by severe side effects (anxiogenic, convulsant, and proconvulsant).
ALLOSTERIC
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ACTIVATOR -> TARGET |
MODULATOR
ALLOSTERIC
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AGONIST -> TARGET | |||
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PARTIAL AGONIST->TARGET |
