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Approval Year

Substance Class Mixture
Created
by admin
on Fri Jun 25 21:40:29 UTC 2021
Edited
by admin
on Fri Jun 25 21:40:29 UTC 2021
Record UNII
RU3465V8V1
Record Status Validated (UNII)
Record Version
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Name Type Language
GABAA RECEPTOR
Common Name English
GABAAR
Common Name English
GAMMA-AMINOBUTYRIC ACID A RECEPTOR
Common Name English
.GAMMA.-AMINOBUTYRIC ACID A RECEPTOR
Common Name English
Code System Code Type Description
FDA UNII
RU3465V8V1
Created by admin on Fri Jun 25 21:40:29 UTC 2021 , Edited by admin on Fri Jun 25 21:40:29 UTC 2021
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
OFF-TARGET ACTIVITY: INHIBITING LIGAND BINDING TO THE AGBAA CHLORIDE ION CHANNEL
INHIBITOR -> TARGET
OFF-TARGET ACTIVITY: INHIBITING LIGAND BINDING TO GABAA CHLORIDE ION CHANNEL
AGONIST -> TARGET
SL651498 is a subtype-selective GABAA agonist, which acts as a full agonist at ?2 and ?3 subtypes, and as a partial agonist at ?1 and ?5 (although its action at ?5 subtypes is much weaker than at the others).
INHIBITOR->OFF-TARGET
OFF-TARGET ACTIVITY: INHIBITING LIGAND BINDING TO THE GABAA CHLORIDE ION CHANNEL
AGONIST -> TARGET
MODULATOR->TARGET
ALLOSTERIC ACTIVATOR
PARTIAL AGONIST->TARGET
MODULATOR->TARGET
ACTIVATOR -> TARGET
ALLOSTERIC ACTIVATOR
INHIBITOR -> TARGET
INVERSE AGONIST->TARGET
Non selective GABAA inverse agonist. Therapeutic potential is limited by severe side effects (anxiogenic, convulsant, and proconvulsant).
ALLOSTERIC
ACTIVATOR -> TARGET
MODULATOR
ALLOSTERIC
AGONIST -> TARGET
PARTIAL AGONIST->TARGET
Definition References