Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H15ClN4S |
Molecular Weight | 342.846 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=CC2=C(S1)N3C(C)=NN=C3CN=C2C4=C(Cl)C=CC=C4
InChI
InChIKey=VMZUTJCNQWMAGF-UHFFFAOYSA-N
InChI=1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3
Molecular Formula | C17H15ClN4S |
Molecular Weight | 342.846 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including, www.ncbi.nlm.nih.gov/pubmed/25538342
Curator's Comment: description was created based on several sources, including, www.ncbi.nlm.nih.gov/pubmed/25538342
Etizolam is an analogue of benzodiazepine that contains thienotriazolodiazepine group. The drug was developed and approved in Japan and now is used in Japan, Italy and India for the treatment of anxiety disorders. Etizolam exerts its action through activation of GABA A receptors, moreover, the agonistic behavior was shown on isolated neurons. There are several cases when etizolam dependence was reported. In many countries the drug is recognized as a psychoactive substance and its distribution is illegal there.
Approval Year
PubMed
Title | Date | PubMed |
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Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography. | 2002 Feb |
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Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism. | 2004 Aug |
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Effects of concomitant fluvoxamine on the plasma concentration of etizolam in Japanese psychiatric patients: wide interindividual variation in the drug interaction. | 2004 Dec |
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Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. | 2005 Sep |
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Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates. | 2005 Sep 5 |
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Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. | 2006 Apr |
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Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. | 2007 Aug |
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Accidental etizolam ingestion in a child. | 2007 Jul |
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Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam. | 2007 May |
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Absence status associated with focal activity and polydipsia-induced hyponatremia. | 2008 Apr |
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Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats. | 2008 Nov 12 |
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Case report: Etizolam and its major metabolites in two unnatural death cases. | 2008 Nov 20 |
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Benzodiazepine metabolism: an analytical perspective. | 2008 Oct |
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[A case of serotonin syndrome following minimum doses of sertraline]. | 2009 |
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Effects of treatment with etizolam 0.5 mg BID on cognitive performance: a 3-week, multicenter, randomized, double-blind, placebo-controlled, two-treatment, three-period, noninferiority crossover study in patients with anxiety disorder. | 2009 Dec |
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Fluvoxamine monotherapy for psychotic depression: the potential role of sigma-1 receptors. | 2009 Dec 21 |
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Inclusion of thienodiazepines in prescription rate of anxiolytics. | 2009 Jun |
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Benzodiazepine prescription and length of hospital stay at a Japanese university hospital. | 2009 Oct 9 |
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Fluvoxamine for blonanserin-associated akathisia in patients with schizophrenia: report of five cases. | 2010 Apr 24 |
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Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. | 2010 Dec |
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Medication use as a risk factor for inpatient falls in an acute care hospital: a case-crossover study. | 2010 May |
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/16107249
Exposure of rat hippocampal neurons in culture to 10 microM etizolam for 5 days reduced the amounts of alpha5 and gamma2S receptor subunit mRNAs.
Substance Class |
Chemical
Created
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admin
on
Edited
Fri Dec 15 16:27:23 UTC 2023
by
admin
on
Fri Dec 15 16:27:23 UTC 2023
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Record UNII |
A76XI0HL37
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C1012
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WIKIPEDIA |
Designer-drugs-Etizolam
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WHO-ATC |
N05BA19
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WHO-VATC |
QN05BA19
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ETIZOLAM
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SUB07313MIG
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CHEMBL1289779
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100000082100
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C044610
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40054-69-1
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DTXSID0023030
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m5189
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A76XI0HL37
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1102
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4563
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3307
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C65583
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DB09166
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Related Record | Type | Details | ||
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TARGET -> AGONIST |
Etizolam acts as a full agonist at the benzodiazepine/GABAa receptor to produce its range of therapeutic and adverse effects.
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Related Record | Type | Details | ||
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METABOLITE -> PARENT |
MAJOR
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Related Record | Type | Details | ||
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ACTIVE MOIETY |