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Details

Stereochemistry RACEMIC
Molecular Formula C11H12Cl2N2O
Molecular Weight 259.132
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LOFEXIDINE

SMILES

CC(OC1=C(Cl)C=CC=C1Cl)C2=NCCN2

InChI

InChIKey=KSMAGQUYOIHWFS-UHFFFAOYSA-N
InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)

HIDE SMILES / InChI

Molecular Formula C11H12Cl2N2O
Molecular Weight 259.132
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

PubMed

PubMed

TitleDatePubMed
Animal experiments on the safety pharmacology of lofexidine.
1982
Alcohol withdrawal syndromes: clinical management with lofexidine.
1985 Mar-Apr
Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal.
1997 Nov 25
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
1998 May 1
Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking.
2000 Aug
Evidence-based addiction medicine: the use of lofexidine for opioid detoxification.
2004 Nov
Lofexidine for opioid detoxification.
2005 Jan
Opioid dependence.
2009 Jul 24
A case report of inpatient detoxification after kratom (Mitragyna speciosa) dependence.
2010
The pharmacological treatment of opioid addiction--a clinical perspective.
2010 Jun
Clonidine in adults as a sedative agent in the intensive care unit.
2010 Oct
Substance Class Chemical
Created
by admin
on Tue Mar 06 11:35:12 UTC 2018
Edited
by admin
on Tue Mar 06 11:35:12 UTC 2018
Record UNII
UI82K0T627
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LOFEXIDINE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
LOFEXIDINE [VANDF]
Common Name English
LOFEXIDINE [WHO-DD]
Common Name English
LOFEXIDINE [MI]
Common Name English
1H-IMIDAZOLE, 2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-4,5-DIHYDRO-
Systematic Name English
2-(1-(2,6-DICHLOROPHENOXY)ETHYL)-2-IMIDAZOLINE
Systematic Name English
LOFEXIDINE [INN]
Common Name English
Classification Tree Code System Code
WHO-ATC N07BC04
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
WHO-VATC QN07BC04
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
Code System Code Type Description
MERCK INDEX
M6885
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY Merck Index
EPA CompTox
31036-80-3
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
NCI_THESAURUS
C87578
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
MESH
C025655
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
ChEMBL
CHEMBL17860
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
EVMPD
SUB08558MIG
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
DRUG BANK
DB04948
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
CAS
31036-80-3
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
PUBCHEM
30668
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY SWITZERF
INN
3766
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY
RXCUI
28863
Created by admin on Tue Mar 06 11:35:12 UTC 2018 , Edited by admin on Tue Mar 06 11:35:12 UTC 2018
PRIMARY RxNorm
Related Record Type Details
TARGET -> AGONIST
Related Record Type Details
ACTIVE MOIETY