U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H24N2O
Molecular Weight 260.3746
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXYMETAZOLINE

SMILES

CC1=CC(=C(O)C(C)=C1CC2=NCCN2)C(C)(C)C

InChI

InChIKey=WYWIFABBXFUGLM-UHFFFAOYSA-N
InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)

HIDE SMILES / InChI

Molecular Formula C16H24N2O
Molecular Weight 260.3746
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/monograph/oxymetazoline-hydrochloride.html

Oxymetazoline is an adrenergic alpha-agonist, direct acting sympathomimetic, used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Oxymetazoline elicits relief of conjunctival hyperemia by causing vasoconstriction of superficial conjunctival blood vessels. The drug's action has been demonstrated in acute allergic conjunctivitis and in chemical (chloride) conjunctivitis. Oxymetazoline is self-medication for temporary relief of nasal congestion associated with the common cold, hay fever, or other upper respiratory allergies. Oxymetazoline is available over-the-counter as a topical decongestant in the form of oxymetazoline hydrochloride in nasal sprays such as Afrin, Operil, Dristan, Dimetapp, oxyspray, Facimin, Nasivin, Nostrilla, Sudafed OM, Vicks Sinex, Zicam, SinuFrin, and Mucinex Full Force. Due to its vasoconstricting properties, oxymetazoline is also used to treat nose bleeds and eye redness.

CNS Activity

Curator's Comment: Oxymetazoline does not cross the blood brain barrier

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Oxymetazoline Hydrochloride

Approved Use

Temporary relief of nasal congestion (due to a cold, hay fever, or other upper respiratory allergies) and sinus congestion/pressure.

Launch Date

6.0721922E11
Primary
OCUCLEAR

Approved Use

Relief of redness of eye due to minor eye irritations

Launch Date

5.17795185E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
60.5 pg/mL
20 mg single, topical
dose: 20 mg
route of administration: Topical
experiment type: SINGLE
co-administered:
OXYMETAZOLINE unknown
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
1.78 ng/mL
0.3 mg single, nasal
dose: 0.3 mg
route of administration: Nasal
experiment type: SINGLE
co-administered: Tetracaine
OXYMETAZOLINE unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
895 pg × h/mL
20 mg single, topical
dose: 20 mg
route of administration: Topical
experiment type: SINGLE
co-administered:
OXYMETAZOLINE unknown
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
4.24 ng × h/mL
0.3 mg single, nasal
dose: 0.3 mg
route of administration: Nasal
experiment type: SINGLE
co-administered: Tetracaine
OXYMETAZOLINE unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
5.23 h
0.3 mg single, nasal
dose: 0.3 mg
route of administration: Nasal
experiment type: SINGLE
co-administered: Tetracaine
OXYMETAZOLINE unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.05 % single, intranasal
Dose: 0.05 %
Route: intranasal
Route: single
Dose: 0.05 %
Sources:
unhealthy, 4 years
n = 1
Health Status: unhealthy
Age Group: 4 years
Sex: M
Population Size: 1
Sources:
Other AEs: Hypertensive crisis...
Other AEs:
Hypertensive crisis (1 patient)
Sources:
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Disc. AE: Application site dermatitis, Application site erythema...
AEs leading to
discontinuation/dose reduction:
Application site dermatitis (1.4%)
Application site erythema (0.5%)
Application site pain (0.5%)
Application site dryness (0.2%)
Hypoesthesia (0.2%)
Paresthesia (0.2%)
Rash (0.2%)
Urticaria (0.2%)
Photosensitivity reaction (0.2%)
Sources:
1.5 % 2 times / day multiple, topical
Highest studied dose
Dose: 1.5 %, 2 times / day
Route: topical
Route: multiple
Dose: 1.5 %, 2 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Condition: Erythema
Age Group: adult
Sources:
AEs

AEs

AESignificanceDosePopulation
Hypertensive crisis 1 patient
0.05 % single, intranasal
Dose: 0.05 %
Route: intranasal
Route: single
Dose: 0.05 %
Sources:
unhealthy, 4 years
n = 1
Health Status: unhealthy
Age Group: 4 years
Sex: M
Population Size: 1
Sources:
Application site dryness 0.2%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Hypoesthesia 0.2%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Paresthesia 0.2%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Photosensitivity reaction 0.2%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Rash 0.2%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Urticaria 0.2%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Application site erythema 0.5%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Application site pain 0.5%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
Application site dermatitis 1.4%
Disc. AE
1 % 1 times / day multiple, topical
Dose: 1 %, 1 times / day
Route: topical
Route: multiple
Dose: 1 %, 1 times / day
Sources:
unhealthy, 53.1 years (range: 19–81 years)
n = 440
Health Status: unhealthy
Condition: Erythema
Age Group: 53.1 years (range: 19–81 years)
Sex: M+F
Population Size: 440
Sources:
OverviewDrug as perpetrator​Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
no
yes
yes
no (co-administration study)
Comment: concomitant oral moderate CYP2C19 inhibitors (e.g., esomeprazole, fluoxetine, and omeprazole): the results did not indicate an increase in oxymetazoline exposure associated with coadministration of oral moderate CYP2C19 inhibitors
Page: 7.0
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha.
2001 Aug
The effect of inferior turbinate hypertrophy on nasal spray distribution to the middle meatus.
2001 Dec
Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha(2)-adrenoceptor activation.
2001 Nov
Vasocontractile effects of alpha 2-adrenergic agonists associated with intracellular calcium release.
2002
The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo.
2002 Feb
Mechanism of vascular relaxation by cholinomimetic drugs with special reference to pilocarpine and arecoline.
2002 Feb
Increased nasal mucosal swelling in subjects with asthma.
2002 Jan
Acute exudative inflammation and nasally exhaled nitric oxide are two independent phenomena.
2002 Jan-Feb
Segmental analysis of nasal cavity compliance by acoustic rhinometry.
2002 Jul
Naphazoline-induced neuroendocrine changes: increases in ANP and cGMP levels, but suppression of NE, 3H-NE, and cAMP levels in rabbit eyes.
2002 Jul
[The relationship between ostial patency and medical treatment in acute maxillary sinusitis: an experimental study].
2002 Jul-Aug
Intracellular sodium modulates the state of protein kinase C phosphorylation of rat proximal tubule Na+,K+-ATPase.
2002 Jun
Effects of oxymetazoline on the ventilation of paranasal sinuses in healthy subjects.
2002 Mar-Apr
Desensitization of alpha(2)-adrenoceptors which regulate noradrenaline synthesis and release after chronic treatment with clorgyline in the rat brain.
2002 May
Topical nasal anesthesia for transnasal fiberoptic laryngoscopy: a prospective, double-blind, cross-over study.
2003 Apr
Alpha(2A)-adrenergic versus imidazoline receptor controversy in rilmenidine's action: alpha(2A)-antagonism in humans versus alpha(2A)-agonism in rabbits.
2003 Dec
Effects of acute, repeated and chronic variable stress on in vivo tyrosine hydroxylase activity and on alpha(2)-adrenoceptor sensitivity in the rat brain.
2003 Dec
Functional characterisation of alpha(1)-adrenoceptors in denervated rat vas deferens.
2003 Jul
Central serous chorioretinopathy associated with administration of sympathomimetic agents.
2003 Jul
Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons.
2003 Mar
[The use of oxymetazoline in nasal endoscopic sinus surgery].
2003 May
[Acute exposure to imidazoline derivatives in children].
2003 Nov-Dec
[Tolerance and effectiveness of oxymetazoline and xylometazoline in treatment of acute rhinitis].
2003 Oct
Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.
2003 Oct 10
Oxymetazoline nasal spray three times daily for four weeks in normal subjects is not associated with rebound congestion or tachyphylaxis.
2003 Sep
Alpha 2-adrenoceptors in the basal ganglia have a role in memory consolidation and reinforcement.
2003 Sep
Sympathomimetic drug allergy: cross-reactivity study by patch test.
2004
Bulk is a determinant of oxymetazoline affinity for the alpha1A-adrenergic receptor.
2004
[Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice.
2004 Aug 30
Safety review of benzalkonium chloride used as a preservative in intranasal solutions: an overview of conflicting data and opinions.
2004 Jan
Human alpha1D-adrenoceptor phosphorylation and desensitization.
2004 May 15
The Janus faces of adrenoceptors: factors controlling the coupling of adrenoceptors to multiple signal transduction pathways.
2004 Nov
Controlling bleeding from superficial wounds by the use of topical alpha adrenoreceptor agonists spray. A randomized, masked, controlled study.
2004 Nov
Allosteric modulation of semicarbazide-sensitive amine oxidase activities in vitro by imidazoline receptor ligands.
2004 Oct
Thunderclap headache and reversible segmental cerebral vasoconstriction associated with use of oxymetazoline nasal spray.
2004 Sep 14
Use of mometasone furoate aqueous nasal spray in the treatment of rhinitis medicamentosa: an experimental study.
2005 Apr
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
2005 Dec 28
Oxymetazoline is equivalent to ciprofloxacin in preventing postoperative otorrhea or tympanostomy tube obstruction.
2005 Feb
Early changes in insulin secretion and action induced by high-fat diet are related to a decreased sympathetic tone.
2005 Jan
An assessment for the presence of bacterial contamination of Venturi principle atomizers in a clinical setting.
2005 Jan-Feb
Is oxymetazoline really safe for middle ear use.
2005 Jul
Otic barotrauma from air travel.
2005 May
[Investigation of the effect of oxymetazoline on the duration of rhinitis].
2005 Oct 13
[Investigation of the effect of oxymetazoline on the duration of rhinitis. results of a placebo-controlled double-blind study in patients with acute rhinitis].
2005 Oct 6
[The observation of the ciliotoxicity of nasal mucosa with nasal decongestant].
2005 Sep
Pharmacological characterization of postjunctional alpha-adrenoceptors in human nasal mucosa.
2005 Sep-Oct
Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites.
2006 Feb
In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form.
2006 Jan
Human breast cell lines exhibit functional alpha2-adrenoceptors.
2006 Jul
Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC.
2006 Mar 18
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Ophthalmic use or intranasal: Intranasal Administration Administer nasal solution intranasally as sprays or nasal pumps. Prior to initial use of metered sprays, prime nasal inhaler by depressing the pump firmly several times. Administer nasal spray or pump into each nostril while head is erect. Ophthalmic Administration Administer ophthalmic solution topically to the conjunctiva.
Pediatric Patients Nasal Congestion Intranasal For self-medication in children ≥6 years of age: 2 or 3 sprays of a 0.05% nasal solution in each nostril every 10–12 hours (usually in the morning and evening), up to 2 times daily. Conjunctival Congestion Ophthalmic For self-medication in children ≥6 years of age: 1 or 2 drops of a 0.025% ophthalmic solution in the affected eye(s) every 6 hours as needed. Adults Nasal Congestion Intranasal For self-medication: 2 or 3 sprays of a 0.05% nasal solution in each nostril every 10–12 hours (usually in the morning and evening), up to 2 times daily. Conjunctival Congestion Ophthalmic For self-medication: 1 or 2 drops of a 0.025% ophthalmic solution in the affected eye(s) every 6 hours as needed.
Route of Administration: Nasal
Oxymetazoline had a concentration-dependent inhibitory effect on cultured human nasal CBF from 0.25 to 2.00 g/L.
Substance Class Chemical
Created
by admin
on Thu Jul 06 22:15:32 UTC 2023
Edited
by admin
on Thu Jul 06 22:15:32 UTC 2023
Record UNII
8VLN5B44ZY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXYMETAZOLINE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
NASACON
Brand Name English
AFRIN
Brand Name English
OPERIL
Brand Name English
OXYMETAZOLINE [VANDF]
Common Name English
Oxymetazoline [WHO-DD]
Common Name English
oxymetazoline [INN]
Common Name English
PHENOL, 3-((4,5-DIHYDRO-1H-IMIDAZOL-2-YL)METHYL)-6-(1,1-DIMETHYLETHYL)-2,4-DIMETHYL-
Systematic Name English
OXYMETAZOLINE [HSDB]
Common Name English
6-TERT-BUTYL-3-(2-IMIDAZOLIN-2-YLMETHYL)-2,4-DIMETHYLPHENOL
Systematic Name English
OXYMETAZOLINE [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QR01AA05
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
WHO-ATC S01GA04
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
WHO-ATC R01AB07
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
NDF-RT N0000192562
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
WHO-VATC QR01AB07
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
NCI_THESAURUS C29709
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
WHO-ATC R01AA05
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
WHO-VATC QS01GA04
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
Code System Code Type Description
ECHA (EC/EINECS)
216-079-1
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
DRUG CENTRAL
2032
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
ChEMBL
CHEMBL762
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
NCI_THESAURUS
C61871
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
HSDB
3143
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
MERCK INDEX
M8335
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY Merck Index
MESH
D010109
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
CHEBI
7862
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
RXCUI
7812
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY RxNorm
DRUG BANK
DB00935
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
SMS_ID
100000083285
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
EPA CompTox
DTXSID3040691
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
EVMPD
SUB09567MIG
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
IUPHAR
124
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
DAILYMED
8VLN5B44ZY
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
NDF-RT
N0000011304
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY Imidazolines [Chemical/Ingredient]
PUBCHEM
4636
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
LACTMED
Oxymetazoline
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
FDA UNII
8VLN5B44ZY
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
NDF-RT
N0000009908
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY Vasoconstriction [PE]
INN
1400
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
CAS
1491-59-4
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
WIKIPEDIA
OXYMETAZOLINE
Created by admin on Thu Jul 06 22:15:34 UTC 2023 , Edited by admin on Thu Jul 06 22:15:34 UTC 2023
PRIMARY
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