ALPHA-1A ADRENERGIC RECEPTOR

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Thu Jul 06 17:45:25 UTC 2023` Edited by `admin` on `Thu Jul 06 17:45:25 UTC 2023`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	3T7136LE8K
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ALPHA-1A ADRENERGIC RECEPTOR

Common Name

English

ADRA1C

Common Name

English

ALPHA-1A ADRENOCEPTOR

Common Name

English

ALPHA-1A ADRENORECEPTOR

Common Name

English

Code System Code Type Description

FDA UNII

3T7136LE8K

Created by admin on Thu Jul 06 17:45:27 UTC 2023 , Edited by admin on Thu Jul 06 17:45:27 UTC 2023

PRIMARY

PHAROS

P35348

Created by admin on Thu Jul 06 17:45:27 UTC 2023 , Edited by admin on Thu Jul 06 17:45:27 UTC 2023

PRIMARY

UNIPROT

P35348

Created by admin on Thu Jul 06 17:45:27 UTC 2023 , Edited by admin on Thu Jul 06 17:45:27 UTC 2023

PRIMARY

WIKIPEDIA

ALPHA-1_ADRENERGIC_RECEPTOR

Created by admin on Thu Jul 06 17:45:27 UTC 2023 , Edited by admin on Thu Jul 06 17:45:27 UTC 2023

PRIMARY

From	To
1_99	1_176

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_7
N	1_13
N	1_22

Related Record Type Details


					R5H8897N95

LABETALOL

AGONIST -> TARGET


					R9PHW59SFN

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					2L5SGH4CVS

RS-97078 FREE BASE

INHIBITOR -> TARGET


					0M3S43XK27

AGONIST -> TARGET


					CUZ39LUY82

SILODOSIN

INHIBITOR -> TARGET

Comments:

Selectivity of silodosin determined in cloned human α1-adrenergic receptor (α1-AR) subtypes in cultured Chinese hamster ovary cells.Silodosin has greater affinity for the α1A-adrenergic receptor than for the α1B-adrenergic receptor (by a factor of 583), minimizing the propensity for blood pressure-related adverse effects mediated by α1B blockade.

Qualification:

Ki

Amount:


					WPY40FTH8K

AGONIST -> TARGET


					7CUC9DDI9F

PSEUDOEPHEDRINE

AGONIST -> TARGET


					8L5014XET7

TERAZOSIN

INHIBITOR -> TARGET


					PEG5DP7434

OXEDRINE

AGONIST -> TARGET


					J7A92W69L7

DROXIDOPA

AGONIST -> TARGET


					PW8QYA7KI0

AGONIST -> TARGET


					843CEN85DI

AGONIST -> TARGET


					394E3P3B99

AGONIST -> TARGET


					6YE7PBM15H

MIDODRINE

AGONIST -> TARGET


					Z468598HBV

AGONIST -> TARGET


					3AK2RKG763

RS-100975

INHIBITOR -> TARGET


					U42B7VYA4P

INHIBITOR -> TARGET


					R2H3YN6E3L

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					ZB6F8MY53V

AGONIST -> TARGET


					XM03YJ541D

PRAZOSIN

INHIBITOR -> TARGET


					J4CZH8D9EN

AGONIST -> TARGET

Amount:


					L76T0ZCA8K

AGONIST -> TARGET


					838F01T721

INHIBITOR -> TARGET

Interaction Type:

INHIBITOR

Qualification:

Ki

Amount:


					S9U025Y077

TETRAHYDROZOLINE

AGONIST -> TARGET


					W9O92HYT6I

FIDUXOSIN

INHIBITOR -> TARGET

Amount:


					1WS297W6MV

AGONIST -> TARGET


					EQ8YV2D86Y

INHIBITOR -> TARGET

Amount:


					M7IAS8PR23

RWJ-38063

INHIBITOR -> TARGET


					QK318GVY3Y

AGONIST -> TARGET


					0Z802HMY7H

INDORAMIN

AGONIST -> TARGET


					H231GF11BV

AGONIST -> TARGET


					R5H8897N95

LABETALOL

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					CHH9H12AQ3

AGONIST -> TARGET


					195V08O55G

AGONIST -> TARGET


					OVB8F8P39Q

4-MA

AGONIST -> TARGET

Amount:


					YKH834O4BH

AGONIST -> TARGET


					4P31I0M3BF

INHIBITOR -> TARGET

Amount:


					B6CJY5K2ST

ADIMOLOL

INHIBITOR -> TARGET


					90347YTW5F

ALFUZOSIN

INHIBITOR -> TARGET


					HUQ1KC1YLI

AGONIST -> TARGET


					5RNZ8GJO7K

INHIBITOR -> TARGET


					1PJ59Z2KLT

SHI-437 FREE BASE

INHIBITOR -> TARGET


					X4W3ENH1CV

AGONIST -> TARGET


					LGX4GZ74WO

AGONIST -> TARGET

Amount:


					AB2794W8KV

PHENDIMETRAZINE

AGONIST -> TARGET


					31L760807H

AGONIST -> TARGET


					214IZI85K3

TRIFLUOPERAZINE

INHIBITOR -> TARGET


					TXG28R7G4Y

UPIDOSIN

INHIBITOR -> TARGET

Amount:


					8VLN5B44ZY

AGONIST -> TARGET


					2G7CCY4TFN

RADIOLIGAND->TARGET

Comments:

REPRESENTIVE ALPHA-1 ADRENERGIC RECEPTOR

Qualification:

Ki

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL