RIVOGLITAZONE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H19N3O4S.ClH
Molecular Weight	433.908
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of RIVOGLITAZONE HYDROCHLORIDE

Structure Search

SMILES

Cl.COC1=CC2=C(C=C1)N=C(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)N2C

InChI

InChIKey=LKKAMJRUPIIUTC-UHFFFAOYSA-N

InChI=1S/C20H19N3O4S.ClH/c1-23-16-10-14(26-2)7-8-15(16)21-18(23)11-27-13-5-3-12(4-6-13)9-17-19(24)22-20(25)28-17;/h3-8,10,17H,9,11H2,1-2H3,(H,22,24,25);1H

HIDE SMILES / InChI

Molecular Formula	C20H19N3O4S
Molecular Weight	397.448
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.jstage.jst.go.jp/article/jphs/advpub/0/advpub_09084FP/_pdf/-char/en | https://clinicaltrials.gov/ct2/show/NCT00571519 | https://clinicaltrials.gov/ct2/show/NCT00143520 | https://patents.google.com/patent/US8017633B2/en

Rivoglitazone hydrochloride (CS-011) is a thiazolidinedione-derivative peroxisome proliferator–activated receptor (PPAR)-γ agonist. It has been developed as potential treatment in type 2 diabetes mellitus and was shown to decrease plasma glucose and triglyceride levels in a dose-dependent manner in animals. Phase II and III clinical studies have assessed the efficacy and safety of rivoglitazone hydrochloride in patients with type 2 diabetes mellitus.

Approval Year

PubMed

Title	Date	PubMed
Drug evaluation: rivoglitazone, a new oral therapy for the treatment of type 2 diabetes.	2007 Apr	17458185
A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes.	2011 Sep	21492364

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:50:31 GMT 2023` Edited by `admin` on `Sat Dec 16 01:50:31 GMT 2023`
Record UNII	60HQU68H8A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RIVOGLITAZONE HYDROCHLORIDE

Common Name

English

CS-011 HYDROCHLORIDE

Code

English

Rivoglitazone hydrochloride [WHO-DD]

Common Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-((6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YL)METHOXY)PHENYL)METHYL)-, HYDROCHLORIDE

Systematic Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-((6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YL)METHOXY)PHENYL)METHYL)-, MONOHYDROCHLORIDE

Common Name

English

RIVOGLITAZONE HCL

Common Name

English

2,4-THIAZOLIDINEDIONE, 5-((4-((6-METHOXY-1-METHYL-1H-BENZIMIDAZOL-2-YL)METHOXY)PHENYL)METHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

CAS

299176-11-7