PACLITAXEL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C47H51NO14
Molecular Weight	853.9061
Optical Activity	UNSPECIFIED
Defined Stereocenters	11 / 11
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](OC(C)=O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C5=CC=CC=C5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7

InChI

InChIKey=RCINICONZNJXQF-MZXODVADSA-N

InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C47H51NO14
Molecular Weight	853.9061
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 11
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.drugbank.ca/drugs/DB01229
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf and https://www.ncbi.nlm.nih.gov/pubmed/18068131

Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a US National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it taxol. Later it was discovered that endophytic fungi in the bark synthesize paclitaxel. When it was developed commercially by Bristol-Myers Squibb (BMS), the generic name was changed to paclitaxel and the BMS compound is sold under the trademark Taxol. In this formulation, paclitaxel is dissolved in Kolliphor EL and ethanol, as a delivery agent. Taxol is marketed for the treatment of Breast cancer; Gastric cancer; Kaposi's sarcoma; Non-small cell lung cancer; Ovarian cancer. A newer formulation, in which paclitaxel is bound to albumin, is sold under the trademark Abraxane. Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast cancer. Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, paclitaxel induces abnormal arrays or "bundles" of microtubules throughout the cell cycle and multiple asters of microtubules during mitosis. Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane® is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer. Paclitaxel interferes with the normal function of microtubule growth. Whereas drugs like colchicine cause the depolymerization of microtubules in vivo, paclitaxel arrests their function by having the opposite effect; it hyper-stabilizes their structure. This destroys the cell's ability to use its cytoskeleton in a flexible manner. Specifically, paclitaxel binds to the β subunit of tubulin. Tubulin is the "building block" of mictotubules, and the binding of paclitaxel locks these building blocks in place. The resulting microtubule/paclitaxel complex does not have the ability to disassemble. This adversely affects cell function because the shortening and lengthening of microtubules (termed dynamic instability) is necessary for their function as a transportation highway for the cell. Chromosomes, for example, rely upon this property of microtubules during mitosis. Further research has indicated that paclitaxel induces programmed cell death (apoptosis) in cancer cells by binding to an apoptosis stopping protein called Bcl-2 (B-cell leukemia 2) and thus arresting its function.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Target ID: HeLa cell growth Sources: https://www.ncbi.nlm.nih.gov/pubmed/27095936	Inhibitor 8146	7.08 µM [IC50]
Target ID: SKOV3 breast cancer cell growth Sources: https://www.ncbi.nlm.nih.gov/pubmed/27599579	Inhibitor 8146	38.7 nM [IC50]
microtubule polymerization 19 Target ID: GO:0046785 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8555181	Activator 1404	23.0 µM [EC50]
Tubulin beta-1 chain 8 Target ID: CHEMBL1915 Sources: http://www.drugbank.ca/drugs/DB01229	Inhibitor 8146
Apoptosis regulator Bcl-2 18 Target ID: CHEMBL4860 Sources: http://www.drugbank.ca/drugs/DB01229	Inhibitor 8146

Conditions

Condition	Modality	Highest Phase	Product
Advanced carcinoma of the ovary 4 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf	Primary	Approved 8307	TAXOL Approved Use TAXOL is indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary. Launch Date 8.9907842E11
Breast cancer 426 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf	Primary	Approved 8307	TAXOL Approved Use TAXOL is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Launch Date 8.9907842E11
Non-small cell lung cancer 197 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf	Primary	Approved 8307	TAXOL Approved Use TAXOL, in combination with cisplatin, is indicated for the first-line treatment of nonsmall cell lung cancer in patients who are not candidates for potentially curative surgery and/or radiation therapy. Launch Date 8.9907842E11

C_max

Value	Dose	Co-administered	Analyte	Population
6.92 μM EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/8664192	250 mg/m² steady-state, intravenous dose: 250 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
0.5 μM EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/7799018	175 mg/m² steady-state, intravenous dose: 175 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
27.07 μM × h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/8664192	250 mg/m² steady-state, intravenous dose: 250 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
14.8 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/7799018	175 mg/m² steady-state, intravenous dose: 175 mg/m² route of administration: Intravenous experiment type: STEADY-STATE co-administered:		PACLITAXEL plasma	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
6.5% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf			PACLITAXEL plasma	Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	Other AEs: Anaphylaxis, Dyspnea... Other AEs: Anaphylaxis (2%) Dyspnea (severe, 2%) Hypotension (severe, 2%) Generalized urticaria (severe, 2%) Angioedema (severe, 2%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf

AEs

AE	Significance	Dose	Population
Anaphylaxis	2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Angioedema	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Dyspnea	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Generalized urticaria	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf
Hypotension	severe, 2%	135 mg/m2 1 times / 3 weeks multiple, intravenous Recommended Dose: 135 mg/m2, 1 times / 3 weeks Route: intravenous Route: multiple Dose: 135 mg/m2, 1 times / 3 weeks Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf	unhealthy, adult Health Status: unhealthy Age Group: adult Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020262s048lbl.pdf

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1670

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
P-gp 1401	CYP2C8 670 P-gp 1491 BCRP 545 MRP2 196 OATP1B3 333 OATP1B1 389 OATP1B2 6

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
P-gp 1588	inhibitor 3185 Sources: https://www.jci.org/articles/view/15451 Page: -	no

Drug as victim

Target	Modality	Activity
CYP2C8 670	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/21660_ABRAXANE_biopharmr.PDF#page=20 Page: 20.0	major
CYP3A4 1670	substrate 3264 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/21660_ABRAXANE_biopharmr.PDF#page=20 Page: 20.0	minor
BCRP 545	substrate 3264 Sources: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.21013 Page: -	no
OATP1B3 333	substrate 3264 Sources: https://www.tandfonline.com/doi/abs/10.4161/cbt.4.8.1867 Page: -	yes [Km 6.79 uM]
MRP2 196	substrate 3264 Sources: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.21013 Page: -	yes
OATP1B1 389	substrate 3264 Sources: https://www.nature.com/articles/tpj201013 Page: -	yes
OATP1B2 6	substrate 3264 Sources: https://www.jci.org/articles/view/96160 Page: -	yes
P-gp 1491	substrate 3264 Sources: https://clincancerres.aacrjournals.org/content/9/7/2849.short Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:45863	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45863
ChemicalBook	CB3273425	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB3273425
MolPort	MolPort-001-742-627	https://www.molport.com/shop/molecule-link/MolPort-001-742-627
ZINC	ZINC000096006020	http://zinc15.docking.org/substances/ZINC000096006020
eMolecules	29541201	https://www.emolecules.com/cgi-bin/more?vid=29541201
eMolecules	36754358	https://www.emolecules.com/cgi-bin/more?vid=36754358
eMolecules	506301	https://www.emolecules.com/cgi-bin/more?vid=506301

PubMed

Title	Date	PubMed
Phase II clinical trials of cisplatin-then-paclitaxel and paclitaxel-then-cisplatin in patients with previously untreated advanced epithelial ovarian cancer.	2000 Dec	11205470
A paclitaxel-containing chemotherapy does not cause central nervous adverse effects: a prospective study in patients with ovarian cancer.	2000 Sep-Oct	11268500
Doxorubicin and paclitaxel in the treatment of advanced breast cancer: efficacy and cardiac considerations.	2001	11296620
The pharmacokinetics and pharmacodynamics of high-dose paclitaxel monotherapy (825 mg/m2 continuous infusion over 24 h) with hematopoietic support in women with metastatic breast cancer.	2001	11221961
Drug approval summaries: arsenic trioxide, tamoxifen citrate, anastrazole, paclitaxel, bexarotene.	2001	11161223
High affinity binding of paclitaxel to human serum albumin.	2001 Apr	11277943
Management of recurrent juvenile granulosa cell tumor of the ovary.	2001 Apr	11277661
Recurrent metastatic fallopian tube carcinoma in pregnancy.	2001 Apr	11277660
HPV16-E6 enhances mitoxantrone sensitivity in a human ovarian cancer line: an isolated instance or a trend?	2001 Apr	11251171
Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts.	2001 Apr	11241350
Connexin 43 (cx43) enhances chemotherapy-induced apoptosis in human glioblastoma cells.	2001 Apr 1	11279616
Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.	2001 Apr 13	11278336
Regional drug delivery with radiation for the treatment of Ewing's sarcoma. In vitro development of a taxol release system.	2001 Apr 2	11274751
Taxol-induced cell cycle arrest and apoptosis: dose-response relationship in lung cancer cells of different wild-type p53 status and under isogenic condition.	2001 Apr 26	11275363
Biweekly gemcitabine, doxorubicin, and paclitaxel as first-line treatment in metastatic breast cancer. Final results from a phase II trial.	2001 Feb	11252890
Gemcitabine, paclitaxel, and trastuzumab in metastatic breast cancer.	2001 Feb	11252888
Gemcitabine plus cisplatin in breast cancer.	2001 Feb	11252886
Phytochemistry and medicinal plants.	2001 Feb	11243450
Membrane macrophage colony-stimulating factor on MADB106 breast cancer cells does not activate cytotoxic macrophages but immunizes rats against breast cancer.	2001 Feb	11237678
Isolation of cortical MTs from tobacco BY-2 cells.	2001 Feb	11230570
Selective drug resistant human osteosarcoma cell lines.	2001 Feb	11210963
Changes in glycosylation during Drosophila development. The influence of ecdysone on hemomucin isoforms.	2001 Feb	11164341
Disruption of microtubular cytoskeleton induced by cryptogein, an elicitor of hypersensitive response in tobacco cells.	2001 Feb	11161014
Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel-induced apoptosis in HL-60 cells.	2001 Feb	11160861
Study of multi-drug resistant mechanisms in a taxol-resistant hepatocellular carcinoma QGY-TR 50 cell line.	2001 Feb 9	11162660
Phase I study of paclitaxel (Taxol) plus vinorelbine (Navelbine) in patients with untreated stage IIIb and IV non-small cell lung cancer.	2001 Feb-Mar	11165410
Cisplatin and vinorelbine as second-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) resistant to taxol plus gemcitabine.	2001 Feb-Mar	11165406
Treatment of non-small-cell lung cancer in North America: the emerging role of irinotecan.	2001 Jan	11221017
Neurotoxicity associated with a regimen of carboplatin (AUC 5-6) and paclitaxel (175 mg/m2 over 3 h) employed in the treatment of gynecologic malignancies.	2001 Jan	11206272
Tumor cell-derived TGF-beta and IL-10 dysregulate paclitaxel-induced macrophage activation.	2001 Jan	11200057
Colchicine and griseofulvin inhibit VCAM-1 expression on human vascular endothelial cells - evidence for the association of VCAM-1 expression with microtubules.	2001 Jan	11154858
Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels.	2001 Jan 15	11212279
Taxane-antibody conjugates afford potent cytotoxicity, enhanced solubility, and tumor target selectivity.	2001 Jan 15	11212270
Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel.	2001 Jan 15	11212244
Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum.	2001 Jan 23	11164964
Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner.	2001 Jan 4	11244509
Enhanced taxol production and release in Taxus chinensis cell suspension cultures with selected organic solvents and sucrose feeding.	2001 Jan-Feb	11170485
The role of actin filaments and microtubules in hepatocyte spheroid self-assembly.	2001 Mar	11223949
Dynamic events are differently mediated by microfilaments, microtubules, and mitogen-activated protein kinase during porcine oocyte maturation and fertilization in vitro.	2001 Mar	11207204
Effects of stathmin inhibition on the mitotic spindle.	2001 Mar	11181174
Phase II trial of paclitaxel and carboplatin in metastatic small-cell lung cancer: a Groupe Français de Pneumo-Cancérologie study.	2001 Mar 1	11230474
Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3.	2001 Mar 1	11222383
Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.	2001 Mar 1	11170102
Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers.	2001 Mar 12	11245908
Paclitaxel restores radiation-induced apoptosis in a bcl-2-expressing, radiation-resistant lymphoma cell line.	2001 Mar 15	11240255
Insulin-like growth factor-I receptor antagonism results in increased cytotoxicity of breast cancer cells to doxorubicin and taxol.	2001 Mar-Apr	11182049
Inhibition of telomerase activity as a measure of tumor cell killing by cisplatin in squamous cell carcinoma cell line.	2001 Mar-Apr	11173816
P-glycoprotein efflux pump expression and activity in Calu-3 cells.	2001 May	11288109
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.	2001 May 11	11279118
Regulation of BRCA1 and BRCA2 transcript in response to cisplatin, adriamycin, taxol and ionising radiation is correlated to p53 functional status in ovarian cancer cell lines.	2001 May-Jun	11295099

Patents

Sample Use Guides

In Vivo Use Guide

For previously untreated patients with carcinoma of the ovary, one of the following recommended regimens may be given every 3 weeks. a.TAXOL (PACLITAXEL) administered intravenously over 3 hours at a dose of 175 mg/m2 followed by cisplatin at a dose of 75 mg/m2; or b.TAXOL (PACLITAXEL) administered intravenously over 24 hours at a dose of 135 mg/m2 followed by cisplatin at a dose of 75 mg/m2 2) In patients previously treated with chemotherapy for carcinoma of the ovary, the recommended regimen is TAXOL (PACLITAXEL) 135 mg/m2 or 175 mg/m2 administered intravenously over 3 hours every 3 weeks.

Route of Administration: Intravenous

In Vitro Use Guide

Paclitaxel inhibited tubulin polymerization in the presence of MAPs in vitro with an IC50 value of 38.19 ± 3.33 uM in living cancer cells (Hela cells and human osteosarcoma U2OS cells).

Substance Class	Chemical Created by `admin` on `Fri Dec 16 16:46:06 UTC 2022` Edited by `admin` on `Fri Dec 16 16:46:06 UTC 2022`
Record UNII	P88XT4IS4D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PACLITAXEL

Official Name

English

ONCOGEL

Common Name

English

PACLITAXEL [MART.]

Common Name

English

EBETAXEL

Common Name

English

PAXENE

Brand Name

English

NSC-125973

Code

English

INTAXEL

Common Name

English

TAXOL

Brand Name

English

PACLITAXEL [USAN]

Common Name

English

MITOTAX

Common Name

English

ABI-007 COMPONENT PACLITAXEL

Code

English

PACLITAXEL [USP-RS]

Common Name

English

BMS-181339-01

Code

English

NAB-PACLITAXEL COMPONENT PACLITAXEL

Common Name

English

ONXAL

Common Name

English

GENETAXYL

Common Name

English

MBT-0206

Code

English

NK-105

Code

English

PACLITAXEL [ORANGE BOOK]

Common Name

English

BENZENEPROPANOIC ACID, .BETA.-(BENZOYLAMINO)-.ALPHA.-HYDROXY-, (2AR,4S,4AS,6R,9S,11S,12S,12AR,12BS)-6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA(3,

Systematic Name

English

DHP-107

Code

English

CAPXOL

Common Name

English

PACLITAXEL [MI]

Common Name

English

ORAXOL COMPONENT PACLITAXEL

Common Name

English

PACLITAXEL [VANDF]

Common Name

English

GENEXOL

Brand Name

English

PACLITAXEL [GREEN BOOK]

Common Name

English

Paclitaxel [WHO-DD]

Common Name

English

EMPAC

Common Name

English

PLAXICEL

Common Name

English

GENEXOL-PM

Common Name

English

ABI 007 COMPONENT PACLITAXEL

Common Name

English

TAXUS

Common Name

English

PACLITAXEL [EP MONOGRAPH]

Common Name

English

PACLIEX

Common Name

English

ENDOTAG 1

Common Name

English

(-)-PACLITAXEL

Common Name

English

PACLITAXEL [USP MONOGRAPH]

Common Name

English

LIPOSOME-ENTRAPPED PACLITAXEL EASY-TO-USE

Common Name

English

TAXOL A

Common Name

English

PACLITAXEL (TAXUS CANADENSIS)

Common Name

English

ABRAXANE COMPONENT PACLITAXEL

Brand Name

English

PACLITAXEL [EMA EPAR]

Common Name

English

paclitaxel [INN]

Common Name

English

GENAXOL

Common Name

English

PACLITAXEL [JAN]

Common Name

English

TAXALBIN

Common Name

English

YEWTAXAN

Brand Name

English

PACLITAXEL [USP IMPURITY]

Common Name

English

CYCLOPAX

Common Name

English

PACLITAXOL

Common Name

English

LEP-ETU

Common Name

English

TAXUS STENT

Common Name

English

ZISU

Brand Name

English

TOCOSOL PACLITAXEL

Common Name

English

QW-8184

Code

English

PACLITAXEL [HSDB]

Common Name

English

ONXOL

Brand Name

English

TAXUS LIBERTE

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

270208