U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Mon Oct 21 21:25:39 UTC 2019
Edited
by admin
on Mon Oct 21 21:25:39 UTC 2019
Protein Sub Type
Sequence Type COMPLETE
Record UNII
WCI46BYD7T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BSEP
Common Name English
BILE SALT EXPORT PUMP
Common Name English
ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 11
Common Name English
SPGP
Common Name English
PFIC2
Common Name English
ABCB11
Common Name English
ABC16
Common Name English
PFIC-2
Common Name English
BRIC2
Common Name English
PGY4
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL ABCB11
Created by admin on Mon Oct 21 21:25:39 UTC 2019 , Edited by admin on Mon Oct 21 21:25:39 UTC 2019
Code System Code Type Description
UNIPROT
O95342
Created by admin on Mon Oct 21 21:25:39 UTC 2019 , Edited by admin on Mon Oct 21 21:25:39 UTC 2019
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_109
N 1_116
N 1_122
N 1_125
Related Record Type Details
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
IC50
INHIBITOR -> TRANSPORTER
SUBSTRATE -> TRANSPORTER
Based on in-vitro studies, eluxadoline appears to be a substrate for OAT3, OATP1B1, BSEP, and MRP2
SUBSTRATE -> TRANSPORTER
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL