BSEP

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 09:17:48 UTC 2023` Edited by `admin` on `Sat Dec 16 09:17:48 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	WCI46BYD7T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BSEP

Common Name

English

BILE SALT EXPORT PUMP

Common Name

English

ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 11

Common Name

English

SPGP

Common Name

English

PFIC2

Common Name

English

ABCB11

Common Name

English

ABC16

Common Name

English

PFIC-2

Common Name

English

BRIC2

Common Name

English

PGY4

Common Name

English

Classification Tree Code System Code

UCSF-FDA TRANSPORTAL

ABCB11

Created by admin on Sat Dec 16 09:17:49 UTC 2023 , Edited by admin on Sat Dec 16 09:17:49 UTC 2023

Code System Code Type Description

FDA UNII

WCI46BYD7T

Created by admin on Sat Dec 16 09:17:49 UTC 2023 , Edited by admin on Sat Dec 16 09:17:49 UTC 2023

PRIMARY

UNIPROT

O95342

Created by admin on Sat Dec 16 09:17:49 UTC 2023 , Edited by admin on Sat Dec 16 09:17:49 UTC 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_109
N	1_116
N	1_122
N	1_125

Related Record Type Details


					NI7FZ38DO2

1-(((4-((7-METHOXY-6-(SULFOOXY)-4-QUINOLINYL)OXY)PHENYL)AMINO)CARBONYL)CYCLOPROPANECARBOXYLIC ACID

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					VJT6J7R4TR

RIFAMPIN

INHIBITOR -> TRANSPORTER


					X4OV71U42S

PIOGLITAZONE

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					83HN0GTJ6D

CYCLOSPORINE

INHIBITOR -> TRANSPORTER


					P88XT4IS4D

PACLITAXEL

SUBSTRATE -> TRANSPORTER


					N561YS75MN

VALINOMYCIN

INHIBITOR -> TRANSPORTER


					8YE81R1X1J

GRAZOPREVIR ANHYDROUS

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					A0JWA85V8F

ATORVASTATIN

INHIBITOR -> TRANSPORTER


					JFENOMOVE6

HUMAN LIVER

TISSUE EXPRESSION->TRANSPORTER


					I66ZZ0ZN0E

TROGLITAZONE

INHIBITOR -> TRANSPORTER


					1WPE73O1WV

PRALSETINIB

INHIBITOR -> TRANSPORTER


					D959AE5USF

CLOFAZIMINE

INHIBITOR -> TRANSPORTER


					KCU0C7RS7Z

VELPATASVIR

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					8B1QWR724A

RESERPINE

INHIBITOR -> TRANSPORTER


					1H09Y5WO1F

LETERMOVIR

INHIBITOR -> TRANSPORTER

Amount:


					5V9KLZ54CY

VINBLASTINE

SUBSTRATE -> TRANSPORTER


					7LBRZUYSHU

BRANEBRUTINIB

INHIBITOR -> TRANSPORTER


					SX6K58TVWC

GLYBURIDE

INHIBITOR -> TRANSPORTER


					0J0U795MFZ

BT-070

INHIBITOR -> TRANSPORTER


					P88XT4IS4D

PACLITAXEL

SUBSTRATE -> TRANSPORTER


					AM91H2KS67

CERIVASTATIN

INHIBITOR -> TRANSPORTER

0570F37359

VOXILAPREVIR

SUBSTRATE -> TRANSPORTER

Qualification:

IC50

Amount:


					610V23S0JI

DUVELISIB

INHIBITOR -> TRANSPORTER


					45TPJ4MBQ1

ELUXADOLINE

SUBSTRATE -> TRANSPORTER

Comments:

Based on in-vitro studies, eluxadoline appears to be a substrate for OAT3, OATP1B1, BSEP, and MRP2

Amount:


					KXO2KT9N0G

PRAVASTATIN

SUBSTRATE -> TRANSPORTER

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL