Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H28N2O5S |
Molecular Weight | 468.5673 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)(C)c1ccc(cc1)CN(Cc2cccc(c2)OCC(=O)O)S(=O)(=O)c3cccnc3
InChI
InChIKey=WOHRHWDYFNWPNG-UHFFFAOYSA-N
InChI=1S/C25H28N2O5S/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29/h4-15H,16-18H2,1-3H3,(H,28,29)
Molecular Formula | C25H28N2O5S |
Molecular Weight | 468.5673 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Evatanepag (CP-533,536) is a prostaglandin E2 EP2 receptor agonist. It stimulates new bone formation on trabecular, endocortical, and periosteal surfaces and enhances fracture healing. Evatanepag was under development with Pfizer as a bone formation stimulant for therapeutic use in the healing of fractures.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1881 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24279689 |
5.0 nM [EC50] |
PubMed
Title | Date | PubMed |
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CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance. | 2008 Oct |
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Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. | 2009 Apr 1 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 00:44:23 UTC 2021
by
admin
on
Sat Jun 26 00:44:23 UTC 2021
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Record UNII |
L266R6E31E
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C78568
Created by
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223488-57-1
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DB12022
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C83707
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9151
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9890801
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L266R6E31E
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admin on Sat Jun 26 00:44:23 UTC 2021 , Edited by admin on Sat Jun 26 00:44:23 UTC 2021
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CHEMBL563646
Created by
admin on Sat Jun 26 00:44:23 UTC 2021 , Edited by admin on Sat Jun 26 00:44:23 UTC 2021
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