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Details

Stereochemistry ACHIRAL
Molecular Formula C25H27N2O5S.Na
Molecular Weight 490.5491
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EVATANEPAG SODIUM

SMILES

CC(C)(C)c1ccc(cc1)CN(Cc2cccc(c2)OCC(=O)[O-])S(=O)(=O)c3cccnc3.[Na+]

InChI

InChIKey=SVNBMCJEDANCKY-UHFFFAOYSA-M
InChI=1S/C25H28N2O5S.Na/c1-25(2,3)21-11-9-19(10-12-21)16-27(33(30,31)23-8-5-13-26-15-23)17-20-6-4-7-22(14-20)32-18-24(28)29;/h4-15H,16-18H2,1-3H3,(H,28,29);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula C25H27N2O5S
Molecular Weight 467.5593
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Evatanepag (CP-533,536) is a prostaglandin E2 EP2 receptor agonist. It stimulates new bone formation on trabecular, endocortical, and periosteal surfaces and enhances fracture healing. Evatanepag was under development with Pfizer as a bone formation stimulant for therapeutic use in the healing of fractures.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
5 nM [EC50]
PubMed

PubMed

TitleDatePubMed
In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP(4) receptor antagonist.
2008 Jan 16
CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
2008 Oct
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
2009 Apr 1
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 03:00:11 UTC 2021
Edited
by admin
on Sat Jun 26 03:00:11 UTC 2021
Record UNII
U6GMO13KCQ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EVATANEPAG SODIUM
USAN  
USAN  
Official Name English
CP-533,536-02
Code English
SODIUM 2-(3-((((4-(1,1-DIMETHYLETHYL)PHENYL)METHYL)(PYRIDIN-3-YLSULFONYL)AMINO)METHYL)PHENOXY)ACETATE
Systematic Name English
C-533536-02
Code English
CP-533536-02
Code English
EVATANEPAG SODIUM [USAN]
Common Name English
ACETIC ACID, 2-(3-((((4-(1,1-DIMETHYLETHYL)PHENYL)METHYL)(3-PYRIDINYLSULFONYL)AMINO)METHYL)PHENOXY)-, SODIUM SALT (1:1)
Systematic Name English
C-533,536-02
Code English
C-53353602
Code English
Classification Tree Code System Code
NCI_THESAURUS C78568
Created by admin on Sat Jun 26 03:00:11 UTC 2021 , Edited by admin on Sat Jun 26 03:00:11 UTC 2021
Code System Code Type Description
CAS
223490-49-1
Created by admin on Sat Jun 26 03:00:11 UTC 2021 , Edited by admin on Sat Jun 26 03:00:11 UTC 2021
PRIMARY
DRUG BANK
DBSALT002124
Created by admin on Sat Jun 26 03:00:11 UTC 2021 , Edited by admin on Sat Jun 26 03:00:11 UTC 2021
PRIMARY
PUBCHEM
23674101
Created by admin on Sat Jun 26 03:00:11 UTC 2021 , Edited by admin on Sat Jun 26 03:00:11 UTC 2021
PRIMARY
NCI_THESAURUS
C83708
Created by admin on Sat Jun 26 03:00:11 UTC 2021 , Edited by admin on Sat Jun 26 03:00:11 UTC 2021
PRIMARY
ChEMBL
CHEMBL563646
Created by admin on Sat Jun 26 03:00:11 UTC 2021 , Edited by admin on Sat Jun 26 03:00:11 UTC 2021
PRIMARY
FDA UNII
U6GMO13KCQ
Created by admin on Sat Jun 26 03:00:11 UTC 2021 , Edited by admin on Sat Jun 26 03:00:11 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY