U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C46H56N4O10
Molecular Weight 824.9576
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VINCRISTINE

SMILES

[H][C@@]12N3CC[C@@]14C5=CC(=C(OC)C=C5N(C=O)[C@@]4([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC)[C@]6(C[C@H]7CN(C[C@](O)(CC)C7)CCC8=C6NC9=CC=CC=C89)C(=O)OC

InChI

InChIKey=OGWKCGZFUXNPDA-CFWMRBGOSA-N
InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1

HIDE SMILES / InChI

Molecular Formula C46H56N4O10
Molecular Weight 824.9576
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 8 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/pro/vincristine.html

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific. The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.Vincristine was marketed under the brand name Oncovin, but was discontinued. In 2012 the FDA approved a Liposomal formulation of Vincristine, named MARQIBO KIT.

Originator

Curator's Comment: # Dr. James. Armstrong of Eli Lilly and Company

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P07437
Gene ID: 203068.0
Gene Symbol: TUBB
Target Organism: Homo sapiens (Human)
1.6 µM [IC50]
0.17 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Marqibo

Approved Use

Marqibo® is indicated for the treatment of adult patients with Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse or whose disease has progressed following two or more anti-leukemia therapies.

Launch Date

1.34438401E12
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1220 ng/mL
2.25 mg/m² steady-state, intravenous
dose: 2.25 mg/m²
route of administration: Intravenous
experiment type: STEADY-STATE
co-administered:
VINCRISTINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
14566 ng × h/mL
2.25 mg/m² steady-state, intravenous
dose: 2.25 mg/m²
route of administration: Intravenous
experiment type: STEADY-STATE
co-administered:
VINCRISTINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
25%
VINCRISTINE plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
2.25 mg/m2 1 times / week multiple, intravenous
MTD
Dose: 2.25 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.25 mg/m2, 1 times / week
Co-administed with::
dexamethasone, i.v.(40 mg)
Sources: Page: p.1,6
unhealthy, 19-62
n = 18
Health Status: unhealthy
Condition: Acute lymphoblastic leukemia
Age Group: 19-62
Sex: M+F
Population Size: 18
Sources: Page: p.1,6
2.4 mg/m2 1 times / week multiple, intravenous
Studied dose
Dose: 2.4 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.4 mg/m2, 1 times / week
Co-administed with::
dexamethasone, i.v.(40 mg)
Sources: Page: p.1,6
unhealthy, 19-62
n = 7
Health Status: unhealthy
Condition: Acute lymphoblastic leukemia
Age Group: 19-62
Sex: M+F
Population Size: 7
Sources: Page: p.1,6
DLT: Motor polyneuropathy, Seizure...
Dose limiting toxicities:
Motor polyneuropathy (grade 3, 14.3%)
Seizure (grade 4, 14.3%)
Hepatotoxicity (grade 4, 14.3%)
Sources: Page: p.1,6
2.8 mg/m2 3 times / week multiple, intravenous
Highest studied dose
Dose: 2.8 mg/m2, 3 times / week
Route: intravenous
Route: multiple
Dose: 2.8 mg/m2, 3 times / week
Sources: Page: p.701
unhealthy, 32-83
n = 3
Health Status: unhealthy
Condition: Cancer
Age Group: 32-83
Sex: M+F
Population Size: 3
Sources: Page: p.701
DLT: Neutropenia, Thrombocytopenia...
Dose limiting toxicities:
Neutropenia (grade 4, 33.3%)
Thrombocytopenia (grade 4, 33.3%)
Obstipation
Myalgia (grade 3, 33.3%)
Sources: Page: p.701
2.4 mg/m2 3 times / week multiple, intravenous
MTD
Dose: 2.4 mg/m2, 3 times / week
Route: intravenous
Route: multiple
Dose: 2.4 mg/m2, 3 times / week
Sources: Page: p.704
unhealthy, 32-83
n = 6
Health Status: unhealthy
Condition: Cancer
Age Group: 32-83
Sex: M+F
Population Size: 6
Sources: Page: p.704
2.25 mg/m2 1 times / week multiple, intravenous
Recommended
Dose: 2.25 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.25 mg/m2, 1 times / week
Sources: Page: p.8
unhealthy
n = 83
Health Status: unhealthy
Condition: Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL)
Population Size: 83
Sources: Page: p.8
Disc. AE: Peripheral neuropathy, Tumor lysis syndrome...
AEs leading to
discontinuation/dose reduction:
Peripheral neuropathy (10%)
Tumor lysis syndrome (2%)
Sources: Page: p.8
AEs

AEs

AESignificanceDosePopulation
Motor polyneuropathy grade 3, 14.3%
DLT
2.4 mg/m2 1 times / week multiple, intravenous
Studied dose
Dose: 2.4 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.4 mg/m2, 1 times / week
Co-administed with::
dexamethasone, i.v.(40 mg)
Sources: Page: p.1,6
unhealthy, 19-62
n = 7
Health Status: unhealthy
Condition: Acute lymphoblastic leukemia
Age Group: 19-62
Sex: M+F
Population Size: 7
Sources: Page: p.1,6
Hepatotoxicity grade 4, 14.3%
DLT
2.4 mg/m2 1 times / week multiple, intravenous
Studied dose
Dose: 2.4 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.4 mg/m2, 1 times / week
Co-administed with::
dexamethasone, i.v.(40 mg)
Sources: Page: p.1,6
unhealthy, 19-62
n = 7
Health Status: unhealthy
Condition: Acute lymphoblastic leukemia
Age Group: 19-62
Sex: M+F
Population Size: 7
Sources: Page: p.1,6
Seizure grade 4, 14.3%
DLT
2.4 mg/m2 1 times / week multiple, intravenous
Studied dose
Dose: 2.4 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.4 mg/m2, 1 times / week
Co-administed with::
dexamethasone, i.v.(40 mg)
Sources: Page: p.1,6
unhealthy, 19-62
n = 7
Health Status: unhealthy
Condition: Acute lymphoblastic leukemia
Age Group: 19-62
Sex: M+F
Population Size: 7
Sources: Page: p.1,6
Obstipation DLT
2.8 mg/m2 3 times / week multiple, intravenous
Highest studied dose
Dose: 2.8 mg/m2, 3 times / week
Route: intravenous
Route: multiple
Dose: 2.8 mg/m2, 3 times / week
Sources: Page: p.701
unhealthy, 32-83
n = 3
Health Status: unhealthy
Condition: Cancer
Age Group: 32-83
Sex: M+F
Population Size: 3
Sources: Page: p.701
Myalgia grade 3, 33.3%
DLT
2.8 mg/m2 3 times / week multiple, intravenous
Highest studied dose
Dose: 2.8 mg/m2, 3 times / week
Route: intravenous
Route: multiple
Dose: 2.8 mg/m2, 3 times / week
Sources: Page: p.701
unhealthy, 32-83
n = 3
Health Status: unhealthy
Condition: Cancer
Age Group: 32-83
Sex: M+F
Population Size: 3
Sources: Page: p.701
Neutropenia grade 4, 33.3%
DLT
2.8 mg/m2 3 times / week multiple, intravenous
Highest studied dose
Dose: 2.8 mg/m2, 3 times / week
Route: intravenous
Route: multiple
Dose: 2.8 mg/m2, 3 times / week
Sources: Page: p.701
unhealthy, 32-83
n = 3
Health Status: unhealthy
Condition: Cancer
Age Group: 32-83
Sex: M+F
Population Size: 3
Sources: Page: p.701
Thrombocytopenia grade 4, 33.3%
DLT
2.8 mg/m2 3 times / week multiple, intravenous
Highest studied dose
Dose: 2.8 mg/m2, 3 times / week
Route: intravenous
Route: multiple
Dose: 2.8 mg/m2, 3 times / week
Sources: Page: p.701
unhealthy, 32-83
n = 3
Health Status: unhealthy
Condition: Cancer
Age Group: 32-83
Sex: M+F
Population Size: 3
Sources: Page: p.701
Peripheral neuropathy 10%
Disc. AE
2.25 mg/m2 1 times / week multiple, intravenous
Recommended
Dose: 2.25 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.25 mg/m2, 1 times / week
Sources: Page: p.8
unhealthy
n = 83
Health Status: unhealthy
Condition: Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL)
Population Size: 83
Sources: Page: p.8
Tumor lysis syndrome 2%
Disc. AE
2.25 mg/m2 1 times / week multiple, intravenous
Recommended
Dose: 2.25 mg/m2, 1 times / week
Route: intravenous
Route: multiple
Dose: 2.25 mg/m2, 1 times / week
Sources: Page: p.8
unhealthy
n = 83
Health Status: unhealthy
Condition: Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL)
Population Size: 83
Sources: Page: p.8
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
likely
likely
yes
yes
yes (co-administration study)
Comment: the total area under the plasma concentration-time curve was 43% smaller in patients who were receiving carbamazepine or phenytoin than in the control group; the concomitant use of strong CYP3A inhibitors should be avoided (e.g., ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin). Similarly, the concomitant use of strong CYP3A inducers should be avoided (e.g., dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifapentine, phenobarbital, St. John’s Wort)
Page: 31.0
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
PubMed

PubMed

TitleDatePubMed
Fatal myeloencephalopathy due to intrathecal vincristine administration.
1992
Combined intra-arterial and systemic chemotherapy for recurrent malignant brain tumors.
1992 Feb
Vincristine revisited.
1999 Feb
Charcot-Marie-Tooth disease type I diagnosed in a 5-year-old boy after vincristine neurotoxicity, resulting in maternal diagnosis.
1999 Mar
[Acute vincristine neurotoxicity in a non-Hodgkin's lymphoma patient with Charcot-Marie-Tooth disease].
1999 May
Primary desmoplastic small cell tumor of soft tissues and bone of the hand.
1999 Nov
Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.
1999 Oct
Nerve growth factor prevention of aged-rat sympathetic neuron injury by cisplatin, vincristine and taxol--in vitro explant study.
1999 Oct 22
Clinical and electrophysiological studies in vincristine induced neuropathy.
1999 Sep
Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.
1999 Sep
Mild axonal neuropathy of children during treatment for acute lymphoblastic leukaemia.
2000
[Syndrome of inappropriate secretion of antidiuretic hormone in a patient with myeloid antigen positive acute lymphoblastic leukemia after systemic chemotherapy including vincristine].
2000 Jan
Differential sensitivities of MRP1-overexpressing lung tumor cells to cytotoxic metals.
2000 Jan 3
[Establishment of MRP-overexpression subline of bladder carcinoma and its MDR phenotype].
2000 Jul
Acute deterioration of Charcot-Marie-Tooth disease IA (CMT IA) following 2 mg of vincristine chemotherapy.
2000 Jun
Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy.
2000 Mar
Cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide (CHOPE) for advanced-stage Hodgkin's disease: CALGB 8856.
2001
Treatment of classical type Kaposi's sarcoma with paclitaxel.
2001 Jan-Feb
Evaluating treatment strategies in chronic lymphocytic leukemia: use of quality-adjusted survival analysis.
2001 Jul
Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia.
2001 Mar
Ifosfamide and etoposide are superior to vincristine and melphalan for pediatric metastatic rhabdomyosarcoma when administered with irradiation and combination chemotherapy: a report from the Intergroup Rhabdomyosarcoma Study Group.
2001 May
Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport.
2001 May 11
Delayed functional recovery by vincristine after sciatic nerve crush injury: a mouse model of vincristine neurotoxicity.
2001 May 18
Ischemic heart disease associated with vincristine and doxorubicin chemotherapy.
2001 Nov
Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL.
2001 Sep
Massive cell death of cerebellar granule neurons accompanied with caspase-3-like protease activation and subsequent motor discoordination after intracerebroventricular injection of vincristine in mice.
2002
Effect of thiopental, propofol, and etomidate on vincristine toxicity in PC12 cells.
2002
Different peripheral mechanisms mediate enhanced nociception in metabolic/toxic and traumatic painful peripheral neuropathies in the rat.
2002
Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins.
2002 Apr
Hyponatremia and syndrome of inappropriate anti-diuretic hormone reported with the use of Vincristine: an over-representation of Asians?
2002 Apr-May
Reversible vincristine-related flaccid paralysis in a child with acute lymphoblastic leukemia.
2002 Aug
High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter.
2002 Jun
Functional analysis of MRP1 cloned from bovine.
2002 Jun 19
Primary cardiac lymphoma--a case report.
2002 Mar-Apr
A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical carcinoma: continuous infusion doxorubicin, vincristine, and etoposide with daily mitotane as a P-glycoprotein antagonist.
2002 May 1
Enteropathy-associated T-cell lymphoma of the jejunum complicated with intestinal perforation.
2003 Apr
Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat.
2003 Aug 1
Vincristine neurotoxicity in the presence of hereditary neuropathy.
2003 Jan
Bilateral hearing loss during vincristine therapy: a case report.
2003 Jun
Spinal sensitization mechanism in vincristine-induced hyperalgesia in mice.
2003 Jun 5
Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey.
2003 Mar
Charcot-Marie-Tooth disease and vincristine.
2003 May-Jun
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: For Intravenous Use Only. Fatal if Given by Other Routes.
Marqibo is liposome-encapsulated vincristine. 2.25 mg/m2 intravenously over 1 hour once every 7 days.
Route of Administration: Intravenous
In Vitro Use Guide
Treatment of macrophage monolayers for 24 h with vincristine (10(-5)-10(-7) M) inhibited the antibody dependent cellular cytotoxicity (ADCC) by PMA stimulated rat macrophages.
Substance Class Chemical
Created
by admin
on Fri Dec 15 14:59:52 UTC 2023
Edited
by admin
on Fri Dec 15 14:59:52 UTC 2023
Record UNII
5J49Q6B70F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VINCRISTINE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
(+)-VINCRISTINE
Common Name English
22-OXOVINCALEUKOBLASTINE
Common Name English
VINCALEUKOBLASTINE, 22-OXO-
Common Name English
Vincristine [WHO-DD]
Common Name English
ONCOTCS
Brand Name English
VINCRISTINE [VANDF]
Common Name English
TECNOCRIS
Brand Name English
VINCRISTINE [MI]
Common Name English
VINCRISTINE [HSDB]
Common Name English
VINKRISTIN
Common Name English
VCR
Common Name English
LEUROCRISTINE
Common Name English
LEUCRISTINE
Common Name English
vincristine [INN]
Common Name English
VINCRISTIN
Common Name English
Classification Tree Code System Code
WHO-VATC QL01CA02
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
LIVERTOX 1030
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
NCI_THESAURUS C932
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
WHO-ATC L01CA02
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 8.2
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
NDF-RT N0000007780
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
NDF-RT N0000007780
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
NCI_THESAURUS C67422
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
NDF-RT N0000175612
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
Code System Code Type Description
DRUG BANK
DB00541
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
ChEMBL
CHEMBL90555
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
EVMPD
SUB00059MIG
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
MERCK INDEX
m11453
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID1032278
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PRIMARY
INN
1440
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PRIMARY
DRUG CENTRAL
2825
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-318-1
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
NCI_THESAURUS
C933
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
SMS_ID
100000079089
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
RXCUI
11202
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PRIMARY RxNorm
PUBCHEM
5388993
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
DAILYMED
5J49Q6B70F
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
FDA UNII
5J49Q6B70F
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
CAS
57-22-7
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
WIKIPEDIA
VINCRISTINE
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
MESH
D014750
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
IUPHAR
6785
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
HSDB
3199
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
CHEBI
143658
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
LACTMED
Vincristine
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
CHEBI
28445
Created by admin on Fri Dec 15 14:59:52 UTC 2023 , Edited by admin on Fri Dec 15 14:59:52 UTC 2023
PRIMARY
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