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US Approved Rx

2

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Primary Target

CCRF-CEM

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Tubulin beta chain

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microtubule polymerization

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transformed cell apoptotic process

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Highest Phase

Approved

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Approval Year

1963

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Condition

Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse

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Treatment Modality

Primary

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CNS Activity

CNS Non-penetrant

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Originator

Eli Lilly

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Chemical

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CAS

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CHEBI

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ChEMBL

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DAILYMED

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DRUG BANK

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ATC Level 1

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

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ANTINEOPLASTIC AGENTS

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PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS

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ATC Level 4

Vinca alkaloids and analogues

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Principal Form

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Salts, Hydrates, Esters, etc.

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VINCRISTINE

5J49Q6B70F

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Status:

US Approved Rx (1988)

First approved in 1963

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Tubulin beta chain

microtubule polymerization

transformed cell apoptotic process

Conditions:

Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 mu...

ltiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific. The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.Vincristine was marketed under the brand name Oncovin, but was discontinued. In 2012 the FDA approved a Liposomal formulation of Vincristine, named MARQIBO KIT.

VINCRISTINE SULFATE

T5IRO3534A

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Status:

US Approved Rx (1988)

First approved in 1963

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Tubulin beta chain

microtubule polymerization

transformed cell apoptotic process

Conditions:

Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL) in second or greater relapse

Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 mu...

ltiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vincristine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vincristine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific. The antitumor activity of Vincristine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, Vincristine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin-dependent Ca2+-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis.Vincristine was marketed under the brand name Oncovin, but was discontinued. In 2012 the FDA approved a Liposomal formulation of Vincristine, named MARQIBO KIT.

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