U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C47H64N4O12
Molecular Weight 877.0307
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of RIFAPENTINE

SMILES

CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C2=O)C4=C(O)C(\C=N\N5CCN(CC5)C6CCCC6)=C(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C(O)=C4C(O)=C3C

InChI

InChIKey=WDZCUPBHRAEYDL-GZAUEHORSA-N
InChI=1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1

HIDE SMILES / InChI
Molecular Formula C47H64N4O12
Molecular Weight 877.0307
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 9 / 9
E/Z Centers 1
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including: http://www.accessdata.fda.gov/drugsatfda_docs/label/1998/21024lbl.pdf http://www.drugbank.ca/drugs/DB01201

PRIFTIN® (rifapentine) is indicated in adults and children 12 years and older for the treatment of active pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis. PRIFTIN must always be used in combination with one or more antituberculosis (anti-TB) drugs to which the isolate is susceptible. Rifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. And it acts via the inhibition of DNA-dependent RNA polymerase, leading to a suppression of RNA synthesis and cell death. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency. Rifapentine has shown higher bacteriostatic and bactericidal activities especially against intracellular bacteria growing in human monocyte-derived macrophages.

Approval Year

1998
113
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8228
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8360
PRIFTIN

Approved Use

is indicated in adults and children 12 years and older for the treatment of active pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis. PRIFTIN must always be used in combination with one or more antituberculosis (anti-TB) drugs to which the isolate is susceptible

Launch Date

9.3934079E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
25.8 μg/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021024s017s018lbl.pdf
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ISONIAZID
ISONIAZID
 RIFAPENTINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
15.05 μg/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021024s017s018lbl.pdf
600 mg 1 times / 3 days steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
RIFAPENTINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
817 μg × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021024s017s018lbl.pdf
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ISONIAZID
ISONIAZID
 RIFAPENTINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
319.54 μg × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021024s017s018lbl.pdf
600 mg 1 times / 3 days steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
RIFAPENTINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
16.6 h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021024s017s018lbl.pdf
900 mg single, oral
dose: 900 mg
route of administration: Oral
experiment type: SINGLE
co-administered: ISONIAZID
ISONIAZID
 RIFAPENTINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: FED
13.19 h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021024s017s018lbl.pdf
600 mg 1 times / 3 days steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
RIFAPENTINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
2.3%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021024s017s018lbl.pdf
600 mg 1 times / 3 days steady-state, oral
dose: 600 mg
route of administration: Oral
experiment type: STEADY-STATE
co-administered:
RIFAPENTINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
20 mg/kg 1 times / day multiple, oral
MTD
Dose: 20 mg/kg, 1 times / day
Route: oral
Route: multiple
Dose: 20 mg/kg, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/22472995
Page: p.2, p.4
healthy
n = 6
Health Status: healthy
Sex: M+F
Population Size: 6
Sources:
https://pubmed.ncbi.nlm.nih.gov/22472995
Page: p.2, p.4
Sources:
https://pubmed.ncbi.nlm.nih.gov/22472995
Page: p.2, p.4
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
Disc. AE: Hepatotoxicity...
Other AEs: Hyperbilirubinemia, Discoloration urine...
AEs leading to
discontinuation/dose reduction:
Hepatotoxicity
Other AEs:
Hyperbilirubinemia
Discoloration urine
Clostridium difficile colitis
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Co-administed with::
isoniazid, po(q.d.)
pyrazinamide, po(q.d.)
ethambutol, po(q.d.)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
unhealthy
n = 361
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Population Size: 361
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
Disc. AE: Hepatitis, ALT increased...
AEs leading to
discontinuation/dose reduction:
Hepatitis (0.28%)
ALT increased (0.28%)
AST increased (0.28%)
LDH increased (0.28%)
Bilirubin increased (0.28%)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
AEs

AEs

AESignificanceDosePopulation
Clostridium difficile colitis
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
Discoloration urine
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
Hyperbilirubinemia
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
Hepatotoxicity Disc. AE
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.1
ALT increased 0.28%
Disc. AE
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Co-administed with::
isoniazid, po(q.d.)
pyrazinamide, po(q.d.)
ethambutol, po(q.d.)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
unhealthy
n = 361
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Population Size: 361
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
AST increased 0.28%
Disc. AE
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Co-administed with::
isoniazid, po(q.d.)
pyrazinamide, po(q.d.)
ethambutol, po(q.d.)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
unhealthy
n = 361
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Population Size: 361
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
Bilirubin increased 0.28%
Disc. AE
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Co-administed with::
isoniazid, po(q.d.)
pyrazinamide, po(q.d.)
ethambutol, po(q.d.)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
unhealthy
n = 361
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Population Size: 361
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
Hepatitis 0.28%
Disc. AE
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Co-administed with::
isoniazid, po(q.d.)
pyrazinamide, po(q.d.)
ethambutol, po(q.d.)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
unhealthy
n = 361
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Population Size: 361
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
LDH increased 0.28%
Disc. AE
600 mg 2 times / week multiple, oral
Recommended
Dose: 600 mg, 2 times / week
Route: oral
Route: multiple
Dose: 600 mg, 2 times / week
Co-administed with::
isoniazid, po(q.d.)
pyrazinamide, po(q.d.)
ethambutol, po(q.d.)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
unhealthy
n = 361
Health Status: unhealthy
Condition: Pulmonary tuberculosis caused by Mycobacterium tuberculosis
Population Size: 361
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021024s009lbl.pdf
Page: p.6
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inducer
768
inhibitor
1752

inducer
383
inhibitor
1837

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP2C19
1463

CYP2E1
876

UGT1A1
204

UGT1A4
77

UGT1A6
108

UGT1A9
116

UGT2B7
146

UGT2B15
64

CYP3A
211

CYP2B6
799

CYP2C8
901

CYP1A2
1509
CYP2C8
168

OATP1B1
26

OATP1B3
6

MRP1
48

MRP2
111
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP1A2
1673
 no
CYP2B6
985
 no
CYP2C19
1537
 no
CYP2C8
955
 no
CYP2C9
1803
 no
CYP2D6
1875
 no
CYP2E1
964
 no
CYP3A
295
 no
UGT1A6
141
 no
UGT1A9
121
 no
UGT2B15
64
 no
UGT1A4
80
 yes [IC50 230 uM]
UGT2B7
157
 yes [IC50 357 uM]
UGT1A1
254
 yes [IC50 70 uM]
CYP2C8
955
 yes
CYP2C9
1803
 yes
CYP3A4
1909
 yes
MRP1
172
 yes
MRP2
459
 yes
OATP1B1
796
 yes
OATP1B3
709
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
ChEBI
CHEBI:45304
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45304
ChemicalBook
CB7482119
https://www.chemicalbook.com/ChemicalProductProperty_EN_CB7482119
MolPort
MolPort-006-132-325
https://www.molport.com/shop/molecule-link/MolPort-006-132-325
MolPort
MolPort-035-395-832
https://www.molport.com/shop/molecule-link/MolPort-035-395-832
Selleck Chemicals
Rifapentine(Priftin)
http://www.selleckchem.com/products/Rifapentine(Priftin).html
ZINC
ZINC000169621228
http://zinc15.docking.org/substances/ZINC000169621228
eMolecules
30100394
https://www.emolecules.com/cgi-bin/more?vid=30100394
PubMed

PubMed

TitleDatePubMed
Antibacterial activity of DL 473, a new semisynthetic rifamycin derivative.
1981 Aug
Comparison of the sensitivity of mycobacteria to the cyclopentyl rifamycin DL473 and rifampicin.
1982 Aug
Comparative in vitro activities of MDL 473, rifampin, and ansamycin against Mycobacterium intracellulare.
1985 Sep
In vitro activity of new rifamycins against rifampicin-resistant M. tuberculosis and MAIS-complex mycobacteria.
1987 Sep
New antibacterial drugs for the treatment of mycobacterial disease in man.
1988 Jul
Activity in vitro of rifabutin, FCE 22807, rifapentine, and rifampin against Mycobacterium microti and M. tuberculosis and their penetration into mouse peritoneal macrophages.
1992 Jan
Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model.
1994 Nov
Effectiveness of rifabutin alone or in combination with isoniazid in preventive therapy of mouse tuberculosis.
1994 Oct
Mutation position and type of substitution in the beta-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis.
1995 Feb
How effective is KRM-1648 in treatment of disseminated Mycobacterium avium complex infections in beige mice?
1996 Feb
Rifapentine is active in vitro and in vivo against Toxoplasma gondii.
1996 Jun
Comparative antimycobacterial activities of rifampin, rifapentine, and KRM-1648 against a collection of rifampin-resistant Mycobacterium tuberculosis isolates with known rpoB mutations.
1996 Nov
Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis.
1998 Jul
Development of rifapentine susceptibility tests for Mycobacterium tuberculosis.
1999 Jan
Evaluation of rifapentine in long-term treatment regimens for tuberculosis in mice.
1999 Oct
Analysis of rifapentine for preventive therapy in the Cornell mouse model of latent tuberculosis.
1999 Sep
In vitro susceptibilities of rapidly growing mycobacteria to telithromycin (HMR 3647) and seven other antimicrobials.
2000 Jan
Effectiveness of once-weekly rifapentine and moxifloxacin regimens against Mycobacterium tuberculosis in mice.
2001 Dec
Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.
2006 Oct
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
2008 Jul
Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia.
2010 Apr 23
Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine.
2011 Dec 1
Short-course chemotherapy with TMC207 and rifapentine in a murine model of latent tuberculosis infection.
2011 Sep 15
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
2013 Nov
Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.
2015 Jun
Patents

Patents

US 5306715 A
2

Sample Use Guides

In Vivo Use Guide
Curator's Comment: PRIFTIN should be administered at a dose of 600 mg twice weekly for two months as directly observed therapy (DOT), with an interval of no less than 3 consecutive days (72 hours) between doses, in combination with other anti- tuberculosis drugs as part of an appropriate regimen which includes daily companion drugs such as isoniazid (INH), ethambutol (EMB) and pyrazinamide (PZA).
600 mg twice weekly for two months
Route of Administration: Oral
In Vitro Use Guide
In a comparison of in vitro properties of rifapentine (RIF), the minimal inhibitory concentration of RIF against Mycobacterium tuberculosis in Tween-albumin liquid medium was usually 0.02 micrograms/ml; the bactericidal activity against a log phase culture was slightly less than that of RMP and the recovery after pulsed exposures to 1 microgram/ml of RIF lasting 6, 24 and 96 h was identical for the two rifamycins.
Substance Class Chemical
Created
by admin
on Thu Jul 06 22:54:36 UTC 2023
Edited
by admin
on Thu Jul 06 22:54:36 UTC 2023
Record UNII
XJM390A33U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RIFAPENTINE
INN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INN  
Official Name English
KTC-1
Code English
RIFAPENTINE [VANDF]
Common Name English
R-773
Code English
DL-473
Code English
R-77-3
Code English
rifapentine [INN]
Common Name English
Rifapentine [WHO-DD]
Common Name English
RIFAPENTINE [MART.]
Common Name English
RIFAMYCIN AF/ACPP
Common Name English
MDL 473
Code English
RIFAPENTINE [MI]
Common Name English
3-((4-CYCLOPENTYL-1-PIPERAZINYL)IMINO)METHYL)RIFAMYCIN
Common Name English
RIFAMYCIN, 3-(((4-CYCLOPENTYL-1-PIPERAZINYL)IMINO)METHYL)-
Common Name English
3-(((4-CYCLOPENTYL-1-PIPERAZINYL)IMINO)METHYL)RIFAMYCIN
Common Name English
RIFAPENTIN
Common Name English
RIFAPENTINE [ORANGE BOOK]
Common Name English
PRIFITIN
Brand Name English
PRIFTIN
Brand Name English
ANTIBIOTIC DL-473IT
Code English
RIFAPENTINE [USAN]
Common Name English
MDL-473
Code English
3-[N-(4-Cyclopentyl-1-piperazinyl)formimidoyl]rifamycin
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C280
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
NDF-RT N0000007911
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
FDA ORPHAN DRUG 89495
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
NDF-RT N0000007911
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
NDF-RT N0000007911
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
WHO-VATC QJ04AB05
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
NDF-RT N0000175501
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
FDA ORPHAN DRUG 89695
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
LIVERTOX NBK548547
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
EU-Orphan Drug EU/3/10/750
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
FDA ORPHAN DRUG 89595
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
WHO-ATC J04AB05
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
NDF-RT N0000007911
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
Code System Code Type Description
EVMPD
SUB10311MIG
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
SMS_ID
100000080562
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
MERCK INDEX
M9614
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C66516
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
WIKIPEDIA
Rifapentine
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
FDA UNII
XJM390A33U
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
DRUG BANK
DB01201
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
DAILYMED
XJM390A33U
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
INN
4765
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY
LACTMED
Rifapentine
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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CHEBI
45304
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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EPA CompTox
DTXSID8041115
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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RXCUI
35617
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
PRIMARY RxNorm
USAN
X-15
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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CAS
61379-65-5
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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ECHA (EC/EINECS)
262-743-9
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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DRUG CENTRAL
2378
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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PUBCHEM
135403821
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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ChEMBL
CHEMBL1660
Created by admin on Thu Jul 06 22:54:38 UTC 2023 , Edited by admin on Thu Jul 06 22:54:38 UTC 2023
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Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
The bound concentration increased slightly (,2%) as the concentration of 14C-rifapentine increased from 0.5 to 10 mg/ml. At concentrations above 10 mg/ml, protein binding did not appear to vary with increasing concentration.
BINDING
Structure of RIFAPENTINE
EXCRETED UNCHANGED
FECAL
Structure of RIFAPENTINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
CYTOCHROME P450 3A4
METABOLIC ENZYME -> INDUCER
CYTOCHROME P450 3A5
METABOLIC ENZYME -> INDUCER
Structure of RIFAPENTINE
EXCRETED UNCHANGED
URINE
Related Record Type Details
Structure of 25-DESACETYLRIFAPENTINE
METABOLITE -> PARENT
URINE
Structure of 3-FORMYLRIFAMYCIN
METABOLITE -> PARENT
FECAL
Structure of 3-FORMYL-25-DESACETYLRIFAMYCIN
METABOLITE -> PARENT
FECAL
Structure of 25-DESACETYLRIFAPENTINE
METABOLITE -> PARENT
FECAL
Related Record Type Details
Structure of RIFAPENTINE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC ORAL ADMINISTRATION

Tmax PHARMACOKINETIC ORAL ADMINISTRATION

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