U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C37H67NO13
Molecular Weight 733.9282
Optical Activity UNSPECIFIED
Defined Stereocenters 18 / 18
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ERYTHROMYCIN

SMILES

CC[C@]1([H])[C@](C)([C@@]([H])([C@@]([H])(C)C(=O)[C@]([H])(C)C[C@](C)([C@@]([H])([C@@]([H])(C)[C@@]([H])([C@@]([H])(C)C(=O)O1)O[C@@]2([H])C[C@](C)([C@]([H])([C@]([H])(C)O2)O)OC)O[C@@]3([H])[C@@]([H])([C@]([H])(C[C@@]([H])(C)O3)N(C)C)O)O)O)O

InChI

InChIKey=ULGZDMOVFRHVEP-RWJQBGPGSA-N
InChI=1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

HIDE SMILES / InChI
Molecular Formula C37H67NO13
Molecular Weight 733.9282
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 18 / 18
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/mesh/68015643

Erythromycin ethylsuccinate (E.E.S.®, ERY-PED®) is an ester of erythromycin base and succinic acid. It is suitable for oral administration. Erythromycin is a macrolide antibiotic, produced by Saccharopolyspora erythraea (formerly Streptomyces erythraeus). It acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin does not affect nucleic acid synthesis.

CNS Activity

CNS Penetrant
2344
Curator's Comment:: Information about erythromycin ethylsuccinate is unavailable.

Originator

Eli Lilly
226
Curator's Comment:: Information about erythromycin ethylsuccinate is unavailable.

Approval Year

1952
105
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
996
 14.0 nM [Kd]
Inhibitor
7728
Binding Agent
996
 14.0 nM [Kd]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8043
Erythromycin

Approved Use

Erythromycin is indicated in the treatment of respiratory tract infections due to Mycoplasma pneumoniae; skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus; listeriosis caused by Listeria monocytogenes; diphtheria due to Corynebacterium diphtheriae infection, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers; erythrasma due to Corynebacterium minutissimum infection.

Launch Date

7.9660802E10
Curative
Approved
8043
Erythromycin

Approved Use

Erythromycin is indicated in the treatment of respiratory tract infections due to Mycoplasma pneumoniae; skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus; listeriosis caused by Listeria monocytogenes; diphtheria due to Corynebacterium diphtheriae infection, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers; erythrasma due to Corynebacterium minutissimum infection.

Launch Date

7.9660802E10
Curative
Approved
8043
Erythromycin

Approved Use

Erythromycin is indicated in the treatment of respiratory tract infections due to Mycoplasma pneumoniae; skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus; listeriosis caused by Listeria monocytogenes; diphtheria due to Corynebacterium diphtheriae infection, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers; erythrasma due to Corynebacterium minutissimum infection.

Launch Date

7.9660802E10
Curative
Approved
8043
Erythromycin

Approved Use

Erythromycin is indicated in the treatment of respiratory tract infections due to Mycoplasma pneumoniae; skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus; listeriosis caused by Listeria monocytogenes; diphtheria due to Corynebacterium diphtheriae infection, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers; erythrasma due to Corynebacterium minutissimum infection.

Launch Date

7.9660802E10
Curative
Approved
8043
Erythromycin

Approved Use

Erythromycin is indicated in the treatment of respiratory tract infections due to Mycoplasma pneumoniae; skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus; listeriosis caused by Listeria monocytogenes; diphtheria due to Corynebacterium diphtheriae infection, as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers; erythrasma due to Corynebacterium minutissimum infection.

Launch Date

7.9660802E10
Curative
Approved
8043
Davercin

Approved Use

For the topical treatment of acne vulgaris
Curative
Approved
8043
Davercin

Approved Use

For the topical treatment of pneumonia
Curative
Approved
8043
Davercin

Approved Use

Indicated for the treatment of bacterial endocarditis
Curative
Approved
8043
Davercin

Approved Use

Unknown
Curative
Approved
8043
E.E.S.

Approved Use

E.E.S. is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes, Streptococcus pneumoniae, or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H.influenzae are not susceptible to the erythromycin concentrations ordinarily achieved). Lower-respiratory tract infections of mild to moderate severity caused by Streptococcus pneumonia or Streptococcus pyogenes. Listeriosis caused by Listeria monocytogenes. Pertussis (whooping cough) caused by Bordetella pertussis. Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals. Respiratory tract infections due to Mycoplasma pneumoniae. Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment). Diphtheria: Infections due to Corynebacterium diphtheria , as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers. Erythrasma: In the treatment of infections due to Corynebacterium minutissimum. Intestinal amebiasis caused by Entamoeba histolytica (oral erythromycins only). Extraenteric amebiasis requires treatment with other agents. Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: As an alternative drug in treatment of acute pelvic inflammatory disease caused by N.gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving erythromycin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months. Syphilis caused by Treponema pallidum: Erythromycin is an alternate choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid examinations should be done before treatment and as part of follow-up after therapy. Erythromycins are indicated for the treatment of the following infections caused by Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum. Legionnaires' Disease caused by Legionella pneumophila . Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that erythromycin may be effective in treating Legionnaires' Disease.

Launch Date

-1.49990408E11
Curative
Approved
8043
E.E.S.

Approved Use

E.E.S. is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes, Streptococcus pneumoniae, or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H.influenzae are not susceptible to the erythromycin concentrations ordinarily achieved). Lower-respiratory tract infections of mild to moderate severity caused by Streptococcus pneumonia or Streptococcus pyogenes. Listeriosis caused by Listeria monocytogenes. Pertussis (whooping cough) caused by Bordetella pertussis. Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals. Respiratory tract infections due to Mycoplasma pneumoniae. Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment). Diphtheria: Infections due to Corynebacterium diphtheria , as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers. Erythrasma: In the treatment of infections due to Corynebacterium minutissimum. Intestinal amebiasis caused by Entamoeba histolytica (oral erythromycins only). Extraenteric amebiasis requires treatment with other agents. Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: As an alternative drug in treatment of acute pelvic inflammatory disease caused by N.gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving erythromycin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months. Syphilis caused by Treponema pallidum: Erythromycin is an alternate choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid examinations should be done before treatment and as part of follow-up after therapy. Erythromycins are indicated for the treatment of the following infections caused by Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum. Legionnaires' Disease caused by Legionella pneumophila . Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that erythromycin may be effective in treating Legionnaires' Disease.

Launch Date

-1.49990408E11
Curative
Approved
8043
E.E.S

Approved Use

E.E.S. is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes, Streptococcus pneumoniae, or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H.influenzae are not susceptible to the erythromycin concentrations ordinarily achieved). Lower-respiratory tract infections of mild to moderate severity caused by Streptococcus pneumonia or Streptococcus pyogenes. Listeriosis caused by Listeria monocytogenes. Pertussis (whooping cough) caused by Bordetella pertussis. Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals. Respiratory tract infections due to Mycoplasma pneumoniae. Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment). Diphtheria: Infections due to Corynebacterium diphtheria , as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers. Erythrasma: In the treatment of infections due to Corynebacterium minutissimum. Intestinal amebiasis caused by Entamoeba histolytica (oral erythromycins only). Extraenteric amebiasis requires treatment with other agents. Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: As an alternative drug in treatment of acute pelvic inflammatory disease caused by N.gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving erythromycin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months. Syphilis caused by Treponema pallidum: Erythromycin is an alternate choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid examinations should be done before treatment and as part of follow-up after therapy. Erythromycins are indicated for the treatment of the following infections caused by Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum. Legionnaires' Disease caused by Legionella pneumophila . Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that erythromycin may be effective in treating Legionnaires' Disease.

Launch Date

-1.49990408E11
Curative
Approved
8043
E.E.S.

Approved Use

E.E.S. is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes, Streptococcus pneumoniae, or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H.influenzae are not susceptible to the erythromycin concentrations ordinarily achieved). Lower-respiratory tract infections of mild to moderate severity caused by Streptococcus pneumonia or Streptococcus pyogenes. Listeriosis caused by Listeria monocytogenes. Pertussis (whooping cough) caused by Bordetella pertussis. Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals. Respiratory tract infections due to Mycoplasma pneumoniae. Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment). Diphtheria: Infections due to Corynebacterium diphtheria , as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers. Erythrasma: In the treatment of infections due to Corynebacterium minutissimum. Intestinal amebiasis caused by Entamoeba histolytica (oral erythromycins only). Extraenteric amebiasis requires treatment with other agents. Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: As an alternative drug in treatment of acute pelvic inflammatory disease caused by N.gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving erythromycin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months. Syphilis caused by Treponema pallidum: Erythromycin is an alternate choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid examinations should be done before treatment and as part of follow-up after therapy. Erythromycins are indicated for the treatment of the following infections caused by Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum. Legionnaires' Disease caused by Legionella pneumophila . Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that erythromycin may be effective in treating Legionnaires' Disease.

Launch Date

-1.50076801E11
Curative
Approved
8043
E.E.S.

Approved Use

E.E.S. is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes, Streptococcus pneumoniae, or Haemophilus influenzae (when used concomitantly with adequate doses of sulfonamides, since many strains of H.influenzae are not susceptible to the erythromycin concentrations ordinarily achieved). Lower-respiratory tract infections of mild to moderate severity caused by Streptococcus pneumonia or Streptococcus pyogenes. Listeriosis caused by Listeria monocytogenes. Pertussis (whooping cough) caused by Bordetella pertussis. Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals. Respiratory tract infections due to Mycoplasma pneumoniae. Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment). Diphtheria: Infections due to Corynebacterium diphtheria , as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers. Erythrasma: In the treatment of infections due to Corynebacterium minutissimum. Intestinal amebiasis caused by Entamoeba histolytica (oral erythromycins only). Extraenteric amebiasis requires treatment with other agents. Acute pelvic inflammatory disease caused by Neisseria gonorrhoeae: As an alternative drug in treatment of acute pelvic inflammatory disease caused by N.gonorrhoeae in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving erythromycin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months. Syphilis caused by Treponema pallidum: Erythromycin is an alternate choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid examinations should be done before treatment and as part of follow-up after therapy. Erythromycins are indicated for the treatment of the following infections caused by Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to Chlamydia trachomatis. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of nongonococcal urethritis caused by Ureaplasma urealyticum. Legionnaires' Disease caused by Legionella pneumophila . Although no controlled clinical efficacy studies have been conducted, in vitro and limited preliminary clinical data suggest that erythromycin may be effective in treating Legionnaires' Disease.

Launch Date

-1.50076801E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
1.18 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/6628511/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2.44 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/6628511/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.62 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/6628511/
250 mg 4 times / day multiple, oral
dose: 250 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ERYTHROMYCIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1.99 μg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/6628511/
250 mg 4 times / day multiple, oral
dose: 250 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
ERYTHROMYCIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
1161.5 ng/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/062055Orig1s034.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
1386.1 ng/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/062055Orig1s034.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
3.1 μg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/6628511/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
6.1 μg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/6628511/
500 mg single, oral
dose: 500 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
3544.7 ng × h/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/062055Orig1s034.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
4096.7 ng × h/mL
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/062055Orig1s034.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4.48 h
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/062055Orig1s034.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
5.31 h
OTHER GOV
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/062055Orig1s034.pdf
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
ERYTHROMYCIN unknown
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
5 g 1 times / day single, oral
Studied dose
Dose: 5 g, 1 times / day
Route: oral
Route: single
Dose: 5 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/1408521/
healthy, 12 years
n = 1
Health Status: healthy
Age Group: 12 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/1408521/
Other AEs: Pancreatitis...
Other AEs:
Pancreatitis
Sources:
https://pubmed.ncbi.nlm.nih.gov/1408521/
5.3 g 1 times / day single, oral
Studied dose
Dose: 5.3 g, 1 times / day
Route: oral
Route: single
Dose: 5.3 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/16215473/
healthy, 15 years
n = 1
Health Status: healthy
Age Group: 15 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/16215473/
Other AEs: Pancreatitis...
Other AEs:
Pancreatitis
Sources:
https://pubmed.ncbi.nlm.nih.gov/16215473/
500 mg 2 times / day multiple, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: multiple
Dose: 500 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
unhealthy, mean age 30 years
n = 35
Health Status: unhealthy
Condition: maxillary sinusitis
Age Group: mean age 30 years
Sex: M+F
Population Size: 35
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
Disc. AE: Vomiting...
AEs leading to
discontinuation/dose reduction:
Vomiting (2.8%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
500 mg 3 times / day multiple, oral
Recommended
Dose: 500 mg, 3 times / day
Route: oral
Route: multiple
Dose: 500 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
unhealthy, mean age 30 years
n = 41
Health Status: unhealthy
Condition: maxillary sinusitis
Age Group: mean age 30 years
Sex: M+F
Population Size: 41
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
Disc. AE: Nausea, Abdominal pain...
AEs leading to
discontinuation/dose reduction:
Nausea (14.6%)
Abdominal pain (4.9%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
500 mg 2 times / day multiple, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: multiple
Dose: 500 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
unhealthy, mean age 44 years
n = 120
Health Status: unhealthy
Condition: streptococcal pharyngitis
Age Group: mean age 44 years
Sex: M+F
Population Size: 120
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
Disc. AE: Epigastralgia, Nausea...
AEs leading to
discontinuation/dose reduction:
Epigastralgia (grade 2-3, 2.5%)
Nausea (grade 3, 3.3%)
Vomiting (grade 2, 0.8%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
100 mg single, intravenous
Dose: 100 mg
Route: intravenous
Route: single
Dose: 100 mg
Sources:
https://clinicaltrials.gov/ct2/show/NCT02005029
unhealthy
n = 9
Health Status: unhealthy
Condition: Parkinson's Disease
Population Size: 9
Sources:
https://clinicaltrials.gov/ct2/show/NCT02005029
Other AEs: Akathisia, Diarrhea...
Other AEs:
Akathisia (below serious, 1 patient)
Diarrhea (below serious, 1 patient)
Sources:
https://clinicaltrials.gov/ct2/show/NCT02005029
AEs

AEs

AESignificanceDosePopulation
Pancreatitis
5 g 1 times / day single, oral
Studied dose
Dose: 5 g, 1 times / day
Route: oral
Route: single
Dose: 5 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/1408521/
healthy, 12 years
n = 1
Health Status: healthy
Age Group: 12 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/1408521/
Pancreatitis
5.3 g 1 times / day single, oral
Studied dose
Dose: 5.3 g, 1 times / day
Route: oral
Route: single
Dose: 5.3 g, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/16215473/
healthy, 15 years
n = 1
Health Status: healthy
Age Group: 15 years
Sex: F
Population Size: 1
Sources:
https://pubmed.ncbi.nlm.nih.gov/16215473/
Vomiting 2.8%
Disc. AE
500 mg 2 times / day multiple, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: multiple
Dose: 500 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
unhealthy, mean age 30 years
n = 35
Health Status: unhealthy
Condition: maxillary sinusitis
Age Group: mean age 30 years
Sex: M+F
Population Size: 35
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
Nausea 14.6%
Disc. AE
500 mg 3 times / day multiple, oral
Recommended
Dose: 500 mg, 3 times / day
Route: oral
Route: multiple
Dose: 500 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
unhealthy, mean age 30 years
n = 41
Health Status: unhealthy
Condition: maxillary sinusitis
Age Group: mean age 30 years
Sex: M+F
Population Size: 41
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
Abdominal pain 4.9%
Disc. AE
500 mg 3 times / day multiple, oral
Recommended
Dose: 500 mg, 3 times / day
Route: oral
Route: multiple
Dose: 500 mg, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
unhealthy, mean age 30 years
n = 41
Health Status: unhealthy
Condition: maxillary sinusitis
Age Group: mean age 30 years
Sex: M+F
Population Size: 41
Sources:
https://pubmed.ncbi.nlm.nih.gov/241119/
Vomiting grade 2, 0.8%
Disc. AE
500 mg 2 times / day multiple, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: multiple
Dose: 500 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
unhealthy, mean age 44 years
n = 120
Health Status: unhealthy
Condition: streptococcal pharyngitis
Age Group: mean age 44 years
Sex: M+F
Population Size: 120
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
Epigastralgia grade 2-3, 2.5%
Disc. AE
500 mg 2 times / day multiple, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: multiple
Dose: 500 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
unhealthy, mean age 44 years
n = 120
Health Status: unhealthy
Condition: streptococcal pharyngitis
Age Group: mean age 44 years
Sex: M+F
Population Size: 120
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
Nausea grade 3, 3.3%
Disc. AE
500 mg 2 times / day multiple, oral
Recommended
Dose: 500 mg, 2 times / day
Route: oral
Route: multiple
Dose: 500 mg, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
unhealthy, mean age 44 years
n = 120
Health Status: unhealthy
Condition: streptococcal pharyngitis
Age Group: mean age 44 years
Sex: M+F
Population Size: 120
Sources:
https://pubmed.ncbi.nlm.nih.gov/2140547/
Akathisia below serious, 1 patient
100 mg single, intravenous
Dose: 100 mg
Route: intravenous
Route: single
Dose: 100 mg
Sources:
https://clinicaltrials.gov/ct2/show/NCT02005029
unhealthy
n = 9
Health Status: unhealthy
Condition: Parkinson's Disease
Population Size: 9
Sources:
https://clinicaltrials.gov/ct2/show/NCT02005029
Diarrhea below serious, 1 patient
100 mg single, intravenous
Dose: 100 mg
Route: intravenous
Route: single
Dose: 100 mg
Sources:
https://clinicaltrials.gov/ct2/show/NCT02005029
unhealthy
n = 9
Health Status: unhealthy
Condition: Parkinson's Disease
Population Size: 9
Sources:
https://clinicaltrials.gov/ct2/show/NCT02005029
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1467
inhibitor
1475

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1383

P-gp
1330

OATP1B1
733

OATP1B3
657
CYP3A
172

OAT2
109
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP1A2
1532
 likely
CYP3A4
1772
 moderate [IC50 9.9 uM]
yes (co-administration study)
Comment: Erythromycin increased mean Cmax value of simvastatin 3.4 fold and AUC0-24 value 6.2 fold; coadministered erythromycin has been reported to increase AUCs of simvastatin, triazolam, and midazolam 6.2-, 3.6-, and 3.8-fold, respectively; A significant increase in colchicine plasma concentration is anticipated when co-administered with moderate CYP3A4 inhibitors such as erythromycin;
Page: 10.0
OATP1B1
748
 yes [IC50 217 uM]
P-gp
1514
 yes [IC50 22.7 uM]
OATP1B3
666
 yes [IC50 34 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
OAT2
109
 yes
CYP3A
172
 yes
likely (co-administration study)
Comment: Coadministration of erythromycin and a drug primarily metabolized by CYP3A may be associated with elevations in drug concentrations that could increase or prolong both the therapeutic and adverse effects of the concomitant drug
Page: 9.0
Tox targets

Tox targets

TargetModalityActivityMetaboliteClinical evidence
hERG
1507
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B2-0126
http://www.3bsc.com/index/pro_info.php?id=19482
AEchem Scientific Corp., USA
AE061269
https://www.aechemsc.com/info_products/AE061269.php
AHH Chemical co.,ltd
API-1112
http://www.ahhchemical.com/product/API-1112.html
Aaron Chemicals
AR0039Z1
http://www.aaronchem.com/114-07-8
Achemtek
0104-008056
http://www.achemtek.com/114-07-8
Acorn PharmaTech
ACN-048190
http://www.acornpharmatech.com/
Acros Organics
AC227330050
https://www.fishersci.com/shop/products/erythromycin-98-acros-organics/AC227330050
Acros Organics
AC227330250
https://www.fishersci.com/shop/products/erythromycin-98-acros-organics/AC227330250
Acros Organics
AC227331000
https://www.fishersci.com/shop/products/erythromycin-98-acros-organics/AC227331000
Acros Organics
AC343880250
https://www.fishersci.com/shop/products/erythromycin-eur-ph-acros-organics-1/AC343880250
Acros Organics
AC343880050
https://www.fishersci.com/shop/products/erythromycin-eur-ph-acros-organics/AC343880050
Alfa Chemistry
AP114078
https://reagents.alfa-chemistry.com/product/erythromycin-cas-114-07-8-1997.html
Alfa Chemistry
AP114078-B
https://reagents.alfa-chemistry.com/product/erythromycin-cas-114-07-8-1999.html
Alfa Chemistry
AP114078-A
https://reagents.alfa-chemistry.com/product/erythromycin-standard-solution-cas-114-07-8-1998.html
Alfa Chemistry
114-07-8
https://www.alfa-chemistry.com/erythromycin-cas-114-07-8-item-289674.htm
ApexBio Technology
B1939
http://www.apexbt.com/erythromycin.html
Aurora Fine Chemicals LLC
A13.139.732
http://online.aurorafinechemicals.com/info?ID=A13.139.732
Avantor Inc
97061-220
https://us.vwr.com/store/catalog/product.jsp?catalog_number=97061-220
Avantor Inc
200006-440
https://us.vwr.com/store/product/18600820/erythromycin
BLD Pharm
BD17733
http://www.bldpharm.com/products/114-07-8.html
BioCrick
BCC4778
http://www.biocrick.com/Erythromycin-BCC4778.html
BioSynth
E-3250
https://www.biosynth.com/products/biochemistry/culture-media-additives/products/E-3250.html
Boerchem
BC205124
http://www.boerchem.com/?product_34527.html
CSNpharm
CSN12503
https://www.csnpharm.com/products/erythromycin.html
Chem Scene
CS-2168
http://www.chemscene.com/114-07-8.html
ChemMol
30102455
http://www.chemmol.com/chemmol/30102455.html
ChemMol
30102582
http://www.chemmol.com/chemmol/30102582.html
Chemchart
cc-erythromycin
http://chemchart.com/erythromycin-detail.html
Chemspace
CSSB00000053730
https://chem-space.com/CSSB00000053730
DC Chemicals
DC7409
http://www.dcchemicals.com/product_show-E_Mycin.html
Glentham Life Sciences
GA1145
http://www.glentham.com/products/product/GA1145/
Hairui
HR130758
http://www.hairuichem.com/en/product/114-07-8.html
LGC Standards
DRE-A13203490AL-100
https://www.lgcstandards.com/US/en/p/DRE-A13203490AL-100
LGC Standards
DRE-C13203490
https://www.lgcstandards.com/US/en/p/DRE-C13203490
Lab Network
LN00237041
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00237041
MedChem Express
HY-B0220
https://www.medchemexpress.com/Erythromycin.html
MuseChem
A000680
https://www.musechem.com/product/A000680.html
MuseChem
R007004
https://www.musechem.com/product/R007004.html
OChem
657
http://www.ocheminc.com/index.php?act=psearch&pid=114E078
Oakwood
94643
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=79817&ExtHyperLink=1
Parchem
16967
http://www.parchem.com/chemical-supplier-distributor/Erythromycin-006967.aspx
Parchem
10930
http://www.parchem.com/chemical-supplier-distributor/Erythromycines-000930.aspx
Shanghai Tauto Biotech Co., Ltd
E-0288
http://www.tautobiotech.com/BRM/eProductShow.asp?ArticleID=370
Sigma-Aldrich
45674_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/45674?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
BP794_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/bp794?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
E0774_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/e0774?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
45703_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/45703?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
1242000_USP
https://www.sigmaaldrich.com/catalog/product/usp/1242000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S527402
http://www.smolecule.com/products/s527402
TCI (Tokyo Chemical Industry)
E0751
http://www.tcichemicals.com/eshop/en/us/commodity/E0751/index.html
THE BioTek
bt-267660
https://www.thebiotek.com/product/inhibitors/bt-267660
VladaChem
VL272699-25G
https://www.vladachem.com/product.php?products=114-07-8
Yuhao Chemical
HL1432
http://www.chemyuhao.com/114-07-8.html
abcr GmbH
AB251852
http://www.abcr.com/shop/en/AB251852
eNovation Chemicals
D565961
https://enovationchem.com/ProductDetails.asp?ProductID=D565961
eNovation Chemicals
D488558
https://www.enovationchem.com/ProductDetails.asp?ProductID=D488558
eNovation Chemicals
D916215
https://www.enovationchem.com/ProductDetails.asp?ProductID=D916215
iChemical
EBD28902
http://www.ichemical.com/products/114-07-8.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule
MCULE-4566208867
https://mcule.com/MCULE-4566208867/
PubMed

PubMed

TitleDatePubMed
The in-vitro activity of two new quinolones: rufloxacin and MF 961.
1992 Jun
[Bacteriostatic activity and killing curves of eight antibiotics against seven strains of penicillin G-resistant pneumococci].
1992 May
[In vitro activity of sparfloxacin against mycoplasmas].
1992 May
Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs.
1992 Sep
Receptor for motilin identified in the human gastrointestinal system.
1999 Jun 25
Clinical efficacy of intravenous followed by oral azithromycin monotherapy in hospitalized patients with community-acquired pneumonia. The Azithromycin Intravenous Clinical Trials Group.
2000 Jul
Bone marrow engraftment: histopathology of hematopoietic reconstitution following allogeneic transplantation in CML patients.
2001 Jan
Insertion of H2C=CHX (X = F, Cl, Br, O(i)Pr) into (tBu3SiO)3TaH2 and beta-X-Elimination from (tBu3SiO)3HTaCH2CH2X (X = OR): relevance to Ziegler-Natta copolymerizations.
2001 May 23
Early and delayed effects of carboplatin on the blood system.
2001 Nov
Stereochemistry of aldols: configuration and conformation of aldols derived from cycloalkanones and aldehydes.
2001 Sep 19
Stereodivergent approach to beta-hydroxy alpha-amino acids from C(2)-symmetrical alk-2-yne-1,4-diols.
2002 Dec 12
L-erythrulose production by oxidative fermentation is catalyzed by PQQ-containing membrane-bound dehydrogenase.
2002 Feb
Stereoselective binding of 2-(4-biphenylyl)-3-substituted-3-hydroxypropionic acids on an immobilised human serum albumin chiral stationary phase.
2002 Feb 25
[Hormone level and metabolism of xenobiotics in rats with various phenotype of resistance to hypoxia].
2002 Jan-Feb
Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice.
2002 Jul
Dynamics of CD34+ progenitor cells following allogeneic bone marrow transplantation in Ph1+CML--an immunohistochemical study on 113 patients with sequential trephine biopsies.
2002 Jun
Erythro- and threo-2-hydroxynonyl substituted 2-phenyladenines and 2-phenyl-8-azaadenines: ligands for A1 adenosine receptors and adenosine deaminase.
2002 Mar
A density-functional study of the mechanism for the diastereoselective epoxidation of chiral allylic alcohols by the titanium peroxy complexes.
2002 Mar 8
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
2002 Nov 1
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
2002 Oct
Clinical evaluation of Double Strength Isotrexin versus Benzamycin in the topical treatment of mild to moderate acne vulgaris.
2002 Sep
QT prolongation and torsades de pointes associated with concurrent use of cisapride and erythromycin.
2002 Sep-Oct
Massive venlafaxine overdose resulted in a false positive Abbott AxSYM urine immunoassay for phencyclidine.
2003
Mixed chimerism of erythro- and megakaryopoiesis following allogeneic bone marrow transplantation.
2003
Gamma-fluorinated analogues of glutamic acid and glutamine.
2003 Apr
[Postoperative ileus: part II (Clinical therapy)].
2003 Apr
Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients.
2003 Feb 1
A randomized, double-blind, multicenter, parallel group study to compare relative efficacies of the topical gels 3% erythromycin/5% benzoyl peroxide and 0.025% tretinoin/erythromycin 4% in the treatment of moderate acne vulgaris of the face.
2003 Jan-Feb
A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning.
2003 Jul
Stereoselective biosynthesis of chloroarylpropane diols by the basidiomycete Bjerkandera adusta.
2003 Jul
Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produce antagonists with increased affinity.
2003 Jun 5
Systematic synthesis of Bis-THF ring cores in annonaceous acetogenins.
2003 May 1
The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids.
2003 Sep 1
erythro-1-Naphthyl-1-(2-piperidyl)methanol: synthesis, resolution, NMR relative configuration, and VCD absolute configuration.
2003 Sep 19
Bitterness evaluation of medicines for pediatric use by a taste sensor.
2004 Aug
Delayed Gastric Emptying in Functional Dyspepsia.
2004 Aug
Evidence of significant contribution from CYP3A5 to hepatic drug metabolism.
2004 Dec
Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis.
2004 Feb
[3 + 2] Cycloreversion of bicyclo[m.3.0]alkan-3-on-2-yl-1-oxonium ylides to alkenyloxyketenes. Stereospecific aspect.
2004 Feb 20
Cytochrome P450/NADPH-dependent formation of trans epoxides from trans-arachidonic acids.
2004 Feb 23
Conformational study of a guaiacyl beta-O-4 lignin model compound by NMR. Examination of intramolecular hydrogen bonding interactions and conformational flexibility in solution.
2004 Mar
Mechanism of beta-silyl diacyl peroxide decomposition: a mild and stereoselective synthesis of beta-silyl esters.
2004 May 28
Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats.
2004 Sep
Initial (latent) polycythemia vera with thrombocytosis mimicking essential thrombocythemia.
2005
Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne.
2005 Jan
High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line.
2005 Jan
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Cytotoxicity of neolignans identified in Saururus chinensis towards human cancer cell lines.
2005 May
Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]).
2005 May
The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine.
2005 May
Patents

Patents

03963579
26
06794372
28
EP0119431 A1
26
JP2000229993A
26
JP2000516450A
29
JP2001521945A
45
JP2002121197A
26
JP2002241392A
26
JP2002511777A
379
JP2002520071A
27
JP2002521468A
35
JP2004323414A
26
JP2006137765A
26
JP2006514917A
59
JP2007505906A
44
JP2009137975A
26
JP2009513190A
32
JP2011508747A
59
JP2011526302A
65
JPH06189748A
26
JPH06199887A
26
JPH07247299A
26
JPH07278177A
26
JPH1072457A
26
JPH11322777A
26
JPS05785319A
26
JPS56125382A
26
JPS56147798A
26
JPS58159500A
26
JPS61291516A
32
JPS62115299A
26
JPS62294623A
35
JPS6287599A
26
JPS6423A
26
JPS6466122A
26
US20140128583
26
US2653899
26
US4219641
26
US5118799
26

Sample Use Guides

In Vivo Use Guide
The usual dosage of erythromycin tablets is one 250 mg tablet four times daily in equally spaced doses or one 500 mg tablet every 12 hours. Dosage may be increased up to 4 g per day according to the severity of the infection. However, twice-a-day dosing is not recommended when doses larger than 1 g daily are administered.
Route of Administration: Oral
In Vitro Use Guide
The MIC values for erythromycin were: 0.25-1 ug/ml (Staphylococcus aureus ATCC 29213), 1-4 ug/ml (Enterococcus faecalis ATCC 29212), 0.03-0.12 ug/ml (Streptococcus pneumoniae ATCC 49619).
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:58:28 UTC 2021
Edited
by admin
on Fri Jun 25 20:58:28 UTC 2021
Record UNII
63937KV33D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ERYTHROMYCIN
EP   GREEN BOOK   HSDB   INN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
ERYTHROMYCIN [MART.]
Common Name English
TORLAMICINA
Common Name English
ROBIMYCIN
Brand Name English
A/T/S
Brand Name English
ERYTHROMYCINUM [WHO-IP LATIN]
Common Name English
ERYTHROMYCIN [ORANGE BOOK]
Common Name English
ERYGEL
Brand Name English
E-SOLVE 2
Brand Name English
ERYTHROMYCIN [HSDB]
Common Name English
ERYCETTE
Brand Name English
ERYTHROMYCIN COMPONENT OF BENZAMYCIN
Common Name English
E-GLADES
Brand Name English
NSC-55929
Code English
ERYTHRA-DERM
Brand Name English
ERYTHROMYCIN-A
Common Name English
E-BASE
Brand Name English
ERYTHROMYCIN A
Common Name English
ERYTHROMYCIN [EP MONOGRAPH]
Common Name English
PCE (ERYTHROMYCIN)
Brand Name English
ERYTHRO-STATIN
Brand Name English
ERY-TAB
Brand Name English
PANTOMICINA
Common Name English
ERYTHROMYCIN [WHO-IP]
Common Name English
R-P MYCIN
Brand Name English
ILOTYCIN
Brand Name English
ERYTHROMYCIN [GREEN BOOK]
Common Name English
ERYTHROMYCIN [INN]
Common Name English
T-STAT
Brand Name English
ERYTHROMYCIN [WHO-DD]
Common Name English
STATICIN
Brand Name English
ERYTHROMYCIN ESTOLATE IMPURITY, FREE ERYTHROMYCIN- [USP]
Common Name English
J01FA01
Code English
ERYDERM
Brand Name English
SANSAC
Brand Name English
EMGEL
Brand Name English
AKNE-MYCIN
Brand Name English
BENZAMYCIN COMPONENT ERYTHROMYCIN
Common Name English
ERYTHROMYCIN [VANDF]
Common Name English
ERYMAX
Brand Name English
ERYTHROMYCIN [MI]
Common Name English
ERYTHROMYCIN ESTOLATE SPECIFIED IMPURITY, FREE ERYTHROMYCIN [EP]
Common Name English
ERYTHROMYCIN [USP MONOGRAPH]
Common Name English
E-MYCIN
Brand Name English
ERYC
Brand Name English
ERYTHROMYCIN [USP-RS]
Common Name English
C-SOLVE-2
Brand Name English
Classification Tree Code System Code
NDF-RT N0000007529
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-ATC S01AA17
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-ATC D10AF52
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
LIVERTOX 367
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-ATC D10AF02
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
NDF-RT N0000175877
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-VATC QJ51RF02
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-ESSENTIAL MEDICINES LIST 6.2.2
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
CFR 21 CFR 520.823
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-VATC QD10AF02
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-VATC QS01AA17
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
NDF-RT N0000007529
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
NDF-RT N0000009982
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
NCI_THESAURUS C261
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-VATC QJ01FA01
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-VATC QJ51FA01
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
NDF-RT N0000175935
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
WHO-ATC J01FA01
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
CFR 21 CFR 522.820
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
CFR 21 CFR 526.820
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
CFR 21 CFR 556.230
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
CFR 21 CFR 558.248
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
NDF-RT N0000007529
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
Code System Code Type Description
ChEMBL
CHEMBL2110577
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
ChEMBL
CHEMBL532
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
PUBCHEM
12560
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
LACTMED
Erythromycin
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
IUPHAR
1456
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
EVMPD
SUB06605MIG
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
HSDB
3074
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
FDA UNII
63937KV33D
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
DRUG CENTRAL
1048
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
INN
39
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
DRUG BANK
DB00199
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
RXCUI
4053
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY RxNorm
WHO INTERNATIONAL PHARMACOPEIA
ERYTHROMYCIN
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY Description: White or slightly yellow crystals or powder; odourless or almost odourless.Solubility: Soluble in 1000 parts of water but less soluble in hot water; freely soluble in ethanol (~750 g/l) TS and ether R.Category: Antibacterial drug.Storage: Erythromycin should be kept in a tightly closed container, protected from light.Additional information: Erythromycin is slightly hygroscopic.Definition: Erythromycin is a mixture of substances produced by the growth of certain strains of Streptomyces erythreus. The main component of the mixture is erythromycin A with lesser amounts of erythromycins B and C.
EPA CompTox
114-07-8
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
WIKIPEDIA
ERYTHROMYCIN
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
MERCK INDEX
M5009
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY Merck Index
NCI_THESAURUS
C476
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
CAS
114-07-8
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
USP_CATALOG
1242000
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY USP-RS
MESH
D004917
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
ECHA (EC/EINECS)
204-040-1
Created by admin on Fri Jun 25 20:58:28 UTC 2021 , Edited by admin on Fri Jun 25 20:58:28 UTC 2021
PRIMARY
Related Record Type Details
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> INHIBITOR
Structure of ERYTHROMYCIN HYDRIODIDE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of ERYTHROMYCIN OXALATE DIHYDRATE
SALT/SOLVATE -> PARENT
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
Structure of ERYTHROMYCIN C-13
LABELED -> NON-LABELED
CYTOCHROME P450 3A12 (CANINE)
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 3A5
METABOLIC ENZYME -> SUBSTRATE
Structure of ERYTHROMYCIN ESTOLATE
SUBSTANCE->BASIS OF STRENGTH
ALDEHYDE OXIDASE
METABOLIC ENZYME -> INHIBITOR
IC50
Structure of ERYTHROMYCIN N-METHYL C-14
LABELED -> NON-LABELED
CYTOCHROME P450 1A2 (CANINE)
METABOLIC ENZYME -> SUBSTRATE
Related Record Type Details
Structure of ERYTHROMYCIN
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC POPULATION: ADULTS

MIC BIOLOGICAL SUSCEPTIBILITY: S. PNEUMONIAE, S. PYOGENES

MIC BIOLOGICAL SUSCEPTIBILITY: S. PNEUMONIAE, S. PYOGENES

Tmax PHARMACOKINETIC COMBINATION FORM: ERYTHROMYCIN ETHYLSUCCINATE

FOOD EFFECT: DELAYED Tmax

Biological Half-life PHARMACOKINETIC POPULATION: END-STAGE RENAL DISEASE

Volume of Distribution PHARMACOKINETIC
MIC BIOLOGICAL SUSCEPTIBILITY: S. AUREUS

MIC BIOLOGICAL SUSCEPTIBILITY: S. AUREUS

Tmax PHARMACOKINETIC FOOD EFFECT: DELAYED Tmax

COMBINATION FORM: ERYTHROMYCIN STEARATE

Tmax PHARMACOKINETIC FOOD EFFECT: BASE

COMBINATION FORM: ERYTHROMYCIN BASE

MIC BIOLOGICAL SUSCEPTIBILITY: S. PNEUMONIAE, S. PYOGENES

Biological Half-life PHARMACOKINETIC POPULATION: NEONATES (LESS THAN OR EQUAL TO 15 DAYS OF AGE)

MIC BIOLOGICAL SUSCEPTIBILITY: S. AUREUS

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