OAT-2

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 08:51:54 UTC 2023` Edited by `admin` on `Sat Dec 16 08:51:54 UTC 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	5840721PJZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

OAT-2

Common Name

English

OAT2

Common Name

English

ORGANIC ANION TRANSPORTER 2

Common Name

English

MGC45202

Common Name

English

MGC24091

Common Name

English

SLC22A7

Common Name

English

NLT

Common Name

English

NOVEL LIVER TRANSPORTER

Common Name

English

Classification Tree Code System Code

UCSF-FDA TRANSPORTAL

SLC22A7

Created by admin on Sat Dec 16 08:51:56 UTC 2023 , Edited by admin on Sat Dec 16 08:51:56 UTC 2023

Code System Code Type Description

FDA UNII

5840721PJZ

Created by admin on Sat Dec 16 08:51:56 UTC 2023 , Edited by admin on Sat Dec 16 08:51:56 UTC 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_91

Related Record Type Details


					BKJ8M8G5HI

IMATINIB

SUBSTRATE -> TRANSPORTER

Amount:


					YL5FZ2Y5U1

METHOTREXATE

SUBSTRATE -> TRANSPORTER

Amount:


					AYI8EX34EU

CREATININE

SUBSTRATE -> TRANSPORTER

Amount:


					PO572Z7917

PROBENECID

INHIBITOR -> TRANSPORTER

Amount:


					OH2O403D1G

MEZLOCILLIN

INHIBITOR -> TRANSPORTER

Comments:

Showed high in vivo inhibition potential due to the high unbound plasma concentrations attained at clinically relevant doses.

Amount:


					M5DP350VZV

ETHACRYNIC ACID

INHIBITOR -> TRANSPORTER

Amount:


					4B9XT59T7S

ZIDOVUDINE

SUBSTRATE -> TRANSPORTER

Amount:


					P88XT4IS4D

PACLITAXEL

SUBSTRATE -> TRANSPORTER

Amount:


					367589PJ2C

MEFENAMIC ACID

INHIBITOR -> TRANSPORTER

Amount:


					F8VB5M810T

TETRACYCLINE

SUBSTRATE -> TRANSPORTER

Amount:


					184SNS8VUH

SULINDAC

INHIBITOR -> TRANSPORTER

Amount:


					57Y76R9ATQ

NAPROXEN

INHIBITOR -> TRANSPORTER

Amount:


					0Y2S3XUQ5H

BUMETANIDE

INHIBITOR -> TRANSPORTER

Amount:


					77W477J15H

CHLOROTHIAZIDE

INHIBITOR -> TRANSPORTER

Amount:


					Q58C92TUN0

TRICHLORMETHIAZIDE

INHIBITOR -> TRANSPORTER

Amount:


					7U75I1278D

CEFOPERAZONE

INHIBITOR -> TRANSPORTER

Amount:


					13T4O6VMAM

PIROXICAM

INHIBITOR -> TRANSPORTER

Amount:


					V99T50803M

SUNITINIB

SUBSTRATE -> TRANSPORTER

Amount:


					ER0CTH01H9

PHENACETIN

INHIBITOR -> TRANSPORTER

Amount:


					4975G9NM6T

ENTACAPONE

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					2Z2A7OKI0A

HUMAN KIDNEY

TISSUE EXPRESSION->TRANSPORTER

Comments:

Considerable role along with organic cation transporter 2 (OCT2), in the tubular secretion and thus renal clearance of creatinine.

Amount:


					H2D2X058MU

CYCLIC GMP

SUBSTRATE -> TRANSPORTER

Amount:


					0J48LPH2TH

HYDROCHLOROTHIAZIDE

INHIBITOR -> TRANSPORTER

Amount:


					4B9XT59T7S

ZIDOVUDINE

SUBSTRATE -> TRANSPORTER

Amount:


					0I55128JYK

THEOPHYLLINE ANHYDROUS

INHIBITOR -> TRANSPORTER

Comments:

Showed high in vivo inhibition potential due to the high unbound plasma concentrations attained at clinically relevant doses.

Amount:


					359HUE8FJC

PENCICLOVIR

SUBSTRATE -> TRANSPORTER

Amount:


					P9G3CKZ4P5

GANCICLOVIR

SUBSTRATE -> TRANSPORTER

Amount:


					J4T82NDH7E

ERLOTINIB

SUBSTRATE -> TRANSPORTER

Amount:


					5CKP8C2LLI

CEFAMANDOLE

INHIBITOR -> TRANSPORTER

Amount:


					90Y4QC304K

KETOPROFEN

INHIBITOR -> TRANSPORTER

Amount:


					VS58MO4P47

BMS-986299

SUBSTRATE -> TRANSPORTER

Amount:


					EXL67I47IK

NIFEDIPINE PYRIMIDINE

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					JFENOMOVE6

HUMAN LIVER

TISSUE EXPRESSION->TRANSPORTER

Interaction Type:

INFLUX

Amount:


					9F388J00UK

TROVAFLOXACIN

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					9ZOQ3TZI87

SORAFENIB

SUBSTRATE -> TRANSPORTER

Amount:


					LW2E03M5PG

COBICISTAT

NON-INHIBITOR -> TRANSPORTER

Amount:


					XXE1CET956

INDOMETHACIN

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					P71U09G5BW

CYCLOTHIAZIDE

INHIBITOR -> TRANSPORTER

Amount:


					4T36H88UA7

APALUTAMIDE

INHIBITOR -> TRANSPORTER

Amount:


					144O8QL0L1

DICLOFENAC

INHIBITOR -> TRANSPORTER

Amount:


					LVZ1VC61HB

CEPHALORIDINE

INHIBITOR -> TRANSPORTER

Amount:


					76LB1G2X6V

MK-571

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					7LXU5N7ZO5

FUROSEMIDE

INHIBITOR -> TRANSPORTER

Amount:


					N2GI8B1GK7

CEFOTAXIME

INHIBITOR -> TRANSPORTER

Amount:


					R72LW146E6

CEPHALOTHIN

INHIBITOR -> TRANSPORTER

Amount:


					U3P01618RT

FLUOROURACIL

SUBSTRATE -> TRANSPORTER

Amount:


					WK2XYI10QM

IBUPROFEN

INHIBITOR -> TRANSPORTER

Amount:


					63CZ7GJN5I

ALLOPURINOL

SUBSTRATE -> TRANSPORTER

Amount:


					X4HES1O11F

ACYCLOVIR

SUBSTRATE -> TRANSPORTER

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL