U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H10N2O
Molecular Weight 174.1992
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EDARAVONE

SMILES

CC1=NN(C(=O)C1)C2=CC=CC=C2

InChI

InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N
InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

HIDE SMILES / InChI

Molecular Formula C10H10N2O
Molecular Weight 174.1992
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Edaravone is a free radical scavenger developed for the treatment of amyotrophic lateral sclerosis.

CNS Activity

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
RADICUT
Primary
RADICUT
PubMed

PubMed

TitleDatePubMed
[Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion].
2009 Aug
Protective effect of edaravone against PrP106-126-induced PC12 cell death.
2010 Jul-Aug
Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation.
2010 Mar
Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury.
2010 Mar 25
[Effects of edaravone on the expression of GRP78, Caspase-12, and neuron apoptosis in juvenile rat hippocampus after status convulsive].
2011 Jan
Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat?
2011 Jan
Edaravone inhibits hypoxia-induced trophoblast-soluble Fms-like tyrosine kinase 1 expression: a possible therapeutic approach to preeclampsia.
2014 Jul
Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice.
2014 Oct
A novel pyrazolone-based derivative induces apoptosis in human esophageal cells via reactive oxygen species (ROS) generation and caspase-dependent mitochondria-mediated pathway.
2015 Apr 25
Change in soluble epoxide hydrolase (sEH) during cisplatin-induced acute renal failure in mice.
2015 Aug
Ginsenoside Rd attenuates Aβ25-35-induced oxidative stress and apoptosis in primary cultured hippocampal neurons.
2015 Sep 5
Patents

Sample Use Guides

In Vivo Use Guide
30 mg of edaravone diluted with an appropriate volume of physiological saline, intravenously over 30 minutes twice a day in the morning and the evening (stroke); 60 mg of edaravone diluted with an appropriate volume of physiological saline, intravenously over 60 minutes once a day (amyotrophic lateral sclerosis).
Route of Administration: Intravenous
In Vitro Use Guide
1 uM or more of edaravone inhibited cultured vascular endothelial cell injury in vitro caused by 15-HPETE (hydroperoxyeicosatetraenoic acid).
Substance Class Chemical
Created
by admin
on Tue Mar 06 10:57:25 UTC 2018
Edited
by admin
on Tue Mar 06 10:57:25 UTC 2018
Record UNII
S798V6YJRP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EDARAVONE
HSDB   INN   JAN   MART.   USAN   WHO-DD  
USAN   INN  
Official Name English
3H-PYRAZOL-3-ONE, 2,4-DIHYDRO-5-METHYL-2-PHENYL-
Systematic Name English
COLOREX PMP
Brand Name English
ANTIPYRINE RELATED COMPOUND A
USP-RS  
Common Name English
NORPHENAZONE [MI]
Common Name English
NSC-12
Code English
NSC-2629
Code English
C.I. DEVELOPER 1
Common Name English
NORPHENAZONE
MI  
Common Name English
DEVELOPER Z
Common Name English
RADICUT
Brand Name English
EDARAVONE [USAN]
Common Name English
EDARAVONE [HSDB]
Common Name English
EDARAVONE [WHO-DD]
Common Name English
MCI-186
Code English
1-PHENYL-3-METHYL-5-PYRAZOLONE
Systematic Name English
RADICAVA
Brand Name English
NSC-26139
Code English
JAROCOL PMP
Brand Name English
3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE
Systematic Name English
PHENYL METHYL PYRAZOLONE
INCI  
INCI  
Official Name English
ANTIPYRINE RELATED COMPOUND A [USP-RS]
Common Name English
EDARAVONE [MART.]
Common Name English
EDARAVONE [JAN]
Common Name English
PHENYLMETHYLPYRAZOLONE
Systematic Name English
PHENYL METHYL PYRAZOLONE [INCI]
Common Name English
EDARAVONE [INN]
Common Name English
Code System Code Type Description
JAPANESE REVIEW
RADICUT
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY APPROVED JUNE 2015
RXCUI
1921877
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
CAS
89-25-8
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
MESH
C005435
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
ChEMBL
CHEMBL290916
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
PUBCHEM
4021
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY SWITZERF
CAS
942-32-5
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
ALTERNATIVE
HSDB
89-25-8
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
WIKIPEDIA
EDARAVONE
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
ECHA (EC/EINECS)
201-891-0
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
INN
7362
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
EVMPD
SUB06453MIG
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
MERCK INDEX
M8072
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY Merck Index
ECHA (EC/EINECS)
213-390-4
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
ALTERNATIVE
NCI_THESAURUS
C74323
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
EPA CompTox
942-32-5
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
Related Record Type Details
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
IN-VITRO
Km
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
IN-VITRO
Km
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
METABOLIC ENZYME -> SUBSTRATE
IN-VITRO
Km
Related Record Type Details
METABOLITE INACTIVE -> PARENT
METABOLITE INACTIVE -> PARENT
Related Record Type Details
ACTIVE MOIETY