MEROPENEM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H25N3O5S.3H2O
Molecular Weight	437.508
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.O.[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O

InChI

InChIKey=CTUAQTBUVLKNDJ-OBZXMJSBSA-N

InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H25N3O5S
Molecular Weight	383.463
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://web.archive.org/web/20161209014344/http://www.ds-pharma.com:80/rd/new_value/meropen.html
Curator's Comment: description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050706s036lbl.pdf |

Meropenem (generic name: meropenem hydrate) is a carbapenem antibiotic for injection showing a strong antibacterial activity to a wide range of bacteria strains from Gram-positive bacteria, Gram-negative bacteria to anaerobic bacteria. It is used as single agent therapy for the treatment of the following infections: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci. This drug also used in case of Intra-abdominal Infections for the treatment complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. In addition is used the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitides. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus. Meropenem has significant stability to hydrolysis by β-lactamases, both penicillinases and cephalosporinases produced by Gram-positive and Gram-negative bacteria. Meropenem should not be used to treat methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-resistant Staphylococcus epidermidis (MRSE). Meropenem product with such superior effectiveness and safety has been approved for marketing by 100 countries or more in the world (as of March 2004) since its first launch in Italy in 1994.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial penicillin-binding protein 232 Target ID: CHEMBL2354204 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050706s036lbl.pdf	Inhibitor 8228

Conditions

Condition	Modality	Highest Phase	Product
Skin structure infections 18 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050706s036lbl.pdf	Curative	Approved 8360	MERREM Approved Use To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection, USP (I.V.) and other antibacterial drugs, Meropenem for injection, USP (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Meropenem for injection, USP (I.V.) is useful as presumptive therapy in the indicated condition (e.g. intra-abdominal infections) prior to the identification of the causative organisms because of its broad spectrum of bactericidal activity. For information regarding use in pediatric patients see Indications and Usage (1.1), (1.2) or (1.3); Dosage and Administration (2.3), Adverse Reactions (6.1), and Clinical Pharmacology (12.3). Meropenem for injection (I.V.) is a penem antibacterial indicated as single agent therapy for the treatment of: Complicated skin and skin structure infections (adult patients and pediatric patients 3 months of age and older only). (1.1) Complicated intra-abdominal infections (adult and pediatric patients). (1.2) Bacterial meningitis (pediatric patients 3 months of age and older only). (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection (I.V.) and other antibacterial drugs, Meropenem for injection (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species. 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis., 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species., 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species., 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis. Launch Date 8.3531517E11
Intra-abdominal infections 47 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050706s036lbl.pdf	Primary	Approved 8360	MERREM Approved Use To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection, USP (I.V.) and other antibacterial drugs, Meropenem for injection, USP (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Meropenem for injection, USP (I.V.) is useful as presumptive therapy in the indicated condition (e.g. intra-abdominal infections) prior to the identification of the causative organisms because of its broad spectrum of bactericidal activity. For information regarding use in pediatric patients see Indications and Usage (1.1), (1.2) or (1.3); Dosage and Administration (2.3), Adverse Reactions (6.1), and Clinical Pharmacology (12.3). Meropenem for injection (I.V.) is a penem antibacterial indicated as single agent therapy for the treatment of: Complicated skin and skin structure infections (adult patients and pediatric patients 3 months of age and older only). (1.1) Complicated intra-abdominal infections (adult and pediatric patients). (1.2) Bacterial meningitis (pediatric patients 3 months of age and older only). (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection (I.V.) and other antibacterial drugs, Meropenem for injection (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species. 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis., 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species., 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species., 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis. Launch Date 8.3531517E11
Bacterial meningitis 3 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050706s036lbl.pdf	Curative	Approved 8360	MERREM Approved Use To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection, USP (I.V.) and other antibacterial drugs, Meropenem for injection, USP (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Meropenem for injection, USP (I.V.) is useful as presumptive therapy in the indicated condition (e.g. intra-abdominal infections) prior to the identification of the causative organisms because of its broad spectrum of bactericidal activity. For information regarding use in pediatric patients see Indications and Usage (1.1), (1.2) or (1.3); Dosage and Administration (2.3), Adverse Reactions (6.1), and Clinical Pharmacology (12.3). Meropenem for injection (I.V.) is a penem antibacterial indicated as single agent therapy for the treatment of: Complicated skin and skin structure infections (adult patients and pediatric patients 3 months of age and older only). (1.1) Complicated intra-abdominal infections (adult and pediatric patients). (1.2) Bacterial meningitis (pediatric patients 3 months of age and older only). (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection (I.V.) and other antibacterial drugs, Meropenem for injection (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species. 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis., 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species., 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species., 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis. Launch Date 8.3531517E11

Sourcing

Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B2-0044	http://www.3bsc.com/index/pro_info.php?id=19400
3B Scientific (Wuhan) Corp	3B1-01460	http://www.3bsc.com/index/pro_info.php?id=21672
3B Scientific (Wuhan) Corp	3B2-1156	http://www.3bsc.com/index/pro_info.php?id=54872
AEchem Scientific Corp., USA	AE1-006420	http://www.aechemsc.com/info_products/AE1-006420.php
AHH Chemical co.,ltd	API-1041	http://www.ahhchemical.com/product/API-1041.html
AHH Chemical co.,ltd	MT-53511	http://www.ahhchemical.com/product/MT-53511.html
AK Scientific, Inc. (AKSCI)	J10087	http://www.aksci.com/item_detail.php?cat=J10087
Aaron Chemicals	AR00397K	http://www.aaronchem.com/96036-03-2
Achemo Scientific Limited	AC-13275	http://www.achemo.com/search/?Keyword= 96036-03-2
Achemtek	0101-001564	http://www.achemtek.com/96036-03-2
Acorn PharmaTech	ACN-048182	http://www.acornpharmatech.com/
Adooq BioScience	A10569	https://www.adooq.com/meropenem.html
Ambeed	A647306	https://www.ambeed.com/products/96036-03-2.html
ApexBio Technology	A5124	http://www.apexbt.com/meropenem-22012.html
AstaTech, Inc.	45000	http://www.astatechinc.com/CPSResult.php?CRNO=1382
Aurum Pharmatech LLC	S-3680	http://www.Aurumpharmatech.com/Product/ProductDetails/S_3680
AvaChem Scientific	1716	http://www.avachem.com/productSearch.asp?1716
BLD Pharm	BD23263	http://www.bldpharm.com/products/96036-03-2.html
BioSynth	M-2780	https://www.biosynth.com/products/biochemistry/culture-media-additives/products/M-2780.html
CSNpharm	CSN13108	https://www.csnpharm.com/products/meropenem.html
Capot Chemical	17275	http://www.capotchem.com/en/17275.htm
Capot Chemical	PubChem17275	http://www.capotchem.com/en/17275.htm
Chem Scene	CS-1865	http://www.chemscene.com/96036-03-2.html
ChemMol	2100052	http://www.chemmol.com/chemmol/2100052.html
ChemMol	97602823	http://www.chemmol.com/chemmol/97602823.html
Chemspace	CSSB00020615435	https://chem-space.com/CSSB00020615435
Chiralblock Biosciences	CB11530	http://www.chiralblock.com/products/96036-03-2.html
Clearsynth	CS-M-58087	http://www.clearsynth.com/en/CSM58087.html
DC Chemicals	DCAPI1395	http://www.dcchemicals.com//product_show-Meropenem.html
Glentham Life Sciences	GP7412	http://www.glentham.com/products/product/GP7412/
Hairui	HR124915	http://www.hairuichem.com/en/product/119478-56-7.html
Hairui	HR127380	http://www.hairuichem.com/en/product/96036-03-2.html
Lab Network	LN00174071	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00174071
Matrix Scientific	75811	https://www.matrixscientific.com/075811.html
MedChem Express	HY-13678	https://www.medchemexpress.com/meropenem.html
MuseChem	A000590	https://www.musechem.com/product/A000590.html
OChem	7522	http://www.ocheminc.com/index.php?act=psearch&pid=036M032
Oakwood	M05727	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=130064&ExtHyperLink=1
Oakwood	36531	http://www.oakwoodchemical.com/p-31256-036531.aspx
Sinfoo Biotech	S061047	http://www.sinfoobiotech.com/product/1064450
Smolecule	S535012	http://www.smolecule.com/products/s535012
Smolecule	S795550	https://www.smolecule.com/products/s795550
TCI (Tokyo Chemical Industry)	M2279	http://www.tcichemicals.com/eshop/en/us/commodity/M2279/index.html
THE BioTek	bt-274921	https://www.thebiotek.com/product/inhibitors/bt-274921
THE BioTek	bt-289487	https://www.thebiotek.com/product/others/bt-289487
eNovation Chemicals	D518319	https://www.enovationchem.com/ProductDetails.asp?ProductID=D518319

PubMed

Title	Date	PubMed
Safety profile of meropenem: a review of nearly 5,000 patients treated with meropenem.	1999	10381210
Investigation of synergism of meropenem and ciprofloxacin against Pseudomonas aeruginosa and Acinetobacter strains isolated from intensive care unit infections.	2001	11760161
Streptococcal toxic shock syndrome revealed by a peritonitis. Case report and review of the literature.	2001	11234313
[Antimicrobial activities of meropenem against clinically isolated strains in 1999].	2001 Apr	11436501
Antimicrobial susceptibility of potentially pathogenic halophilic vibrios isolated from seafood.	2001 Aug	11516936
Meropenem and continuous renal replacement.	2001 Aug	11505159
Antimicrobial susceptibility of respiratory isolates of Enterobacteriaceae and Staphylococcus aureus in Italy: incidence and trends over the period 1997-1999.	2001 Dec	11837636
Empirical monotherapy with meropenem in serious bacterial infections in children.	2001 Dec	11825008
Survey of antibiotic resistance in Pseudomonas aeruginosa by The Tokyo Johoku Association of Pseudomonas Studies.	2001 Dec	11810595
MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) conference. Hamburg, Germany, 10 May 2001.	2001 Dec	11777654
In-vitro activities of various antibiotics, alone and in combination with amikacin against Pseudomonas aeruginosa.	2001 Dec	11738346
[Microbiological monitoring of the microbic strain stability to antibacterial preparations in surgical in-patient clinics].	2001 Feb	11482029
Carbapenem-resistant Serratia marcescens isolates producing Bush group 2f beta-lactamase (SME-1) in the United States: results from the MYSTIC Programme.	2001 Feb	11248526
Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia.	2001 Feb	11233804
Guidelines and critical pathways for severe hospital-acquired pneumonia.	2001 Feb	11171778
Nosocomial pneumonia. Diagnostic and therapeutic considerations.	2001 Jan	11190353
Convalescent phase outpatient parenteral antiinfective therapy for children with complicated appendicitis.	2001 Jan	11176562
Ertapenem: a new carbapenem.	2001 Jun	11772242
Treatment of nosocomial pneumonia: an experience with meropenem.	2001 Jun	11506775
Pharmacokinetics of meropenem in preterm neonates.	2001 Jun	11360025
Antifungal antibiotics and breakthrough bacteremias.	2001 Jun 1	11340523
Continuous beta-lactam antibiotic therapy in a double-lung transplanted patient with a multidrug-resistant Pseudomonas aeruginosa infection.	2001 Mar 27	11330535
Adult Enterobacter meningitis: a high incidence of coinfection with other pathogens and frequent association with neurosurgical procedures.	2001 Mar-Apr	11339479
Melioidosis: an emerging infection in Taiwan?	2001 May-Jun	11384520
Pharmacokinetics of high-dose meropenem in adult cystic fibrosis patients.	2001 May-Jun	11306783
[Comparative antibacterial activity of carbapenems against P. aeruginosa (1)].	2001 Nov	11828603
In vitro and in vivo activities of meropenem and comparable antimicrobial agents against Haemophilus influenzae, including beta-lactamase-negative ampicillin-resistant strains.	2001 Nov	11679563
Influence of in-vivo endotoxin liberation on anti-anaerobic antimicrobial efficacy.	2001 Oct	11760215
Failure of cefotaxime and meropenem to eradicate meningitis caused by an intermediately susceptible Streptococcus pneumoniae strain.	2001 Oct	11757981
[Antimicrobial activities of carbapenems and fourth generation cephems against clinically isolated strains].	2001 Sep	11729712
Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits.	2001 Sep	11683247
Isolation and culture of airway epithelial cells from chronically infected human lungs.	2001 Sep	11669281
Synthesis and biological properties of new 1beta-methylcarbapenems containing heteroaromatic thioether moiety.	2001 Sep 3	11527740
Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase.	2001 Sep 7	11443136
Comparative in vitro activity of isepamicin and other antibiotics against gram-negative bacilli from intensive care units (ICU) in Belgium.	2001 Sep-Oct	11774843
Antibiotic persistence: the role of spontaneous DNA repair response.	2001 Winter	11822773
Use of Etests with carbapenems for Gram-negative rods producing beta-lactamases.	2002 Feb	11850170

Patents

Sample Use Guides

In Vivo Use Guide

Adult Patients: The recommended dose of MERREM I.V. is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intra-abdominal infections. When treating complicated skin and skin structure infections caused by P.aeruginosa, a dose of 1 gram every 8 hours is recommended. Pediatric Patients 3 Months of Age and Older: For pediatric patients 3 months of age and older, the MERREM I.V. dose is 10 mg/kg, 20 mg/kg or 40 mg/kg every 8 hours (maximum dose is 2 grams every 8 hours), depending on the type of infection (complicated skin and skin structure, intra-abdominal or meningitis). Pediatric patients weighing over 50 kg should be administered MERREM I.V. at a dose of 500 mg every 8 hours for complicated skin and skin structure infections, 1 gram every 8 hours for intra-abdominal infections and 2 grams every 8 hours for meningitis. MERREM I.V. should be given as intravenous infusion over approximately 15 minutes to 30 minutes or as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes. There is limited safety data available to support the administration of a 40 mg/kg (up to a maximum of 2 grams) bolus dose.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:43:08 UTC 2023` Edited by `admin` on `Wed Jul 05 23:43:08 UTC 2023`
Record UNII	FV9J3JU8B1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEROPENEM

Official Name

English

ICI 194,660

Code

English

MERREM I.V.

Brand Name

English

MERONEM

Brand Name

English

MEROPENEM [USAN]

Common Name

English

MEROPENEM TRIHYDRATE

Common Name

English

NSC-759621

Code

English

Meropenem trihydrate [WHO-DD]

Common Name

English

MEROPENEM HYDRATE [JAN]

Common Name

English

MEROPENEM [VANDF]

Common Name

English

(4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, trihydrate

Common Name

English

MEROPENEM HYDRATE

Common Name

English

MEROPENEM [USP-RS]

Common Name

English

MEROPENEM (AS TRIHYDRATE)

Common Name

English

MEROPENEM [USP MONOGRAPH]

Common Name

English

MEROPENEM TRIHYDRATE [MI]

Common Name

English

MEROPENEM [MART.]

Common Name

English

SM-7338

Code

English

MERREM

Brand Name

English

MEROPENEM TRIHYDRATE [EP MONOGRAPH]

Common Name

English

MEROPENEM [ORANGE BOOK]

Common Name

English

VABOMERE COMPONENT MEROPENEM

Brand Name

English

MEROPENEM COMPONENT OF CARBAVANCE

Brand Name

English

1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID, 3-((5-((DIMETHYLAMINO)CARBONYL)-3-PYRROLIDINYL)THIO)-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-, TRIHYDRATE, (4R-(3(3S*,5S*),4.ALPHA.,5.BETA.,6.BETA.(R*)))-

Common Name

English

ICI-194660

Code

English

MEROPENEM [USP IMPURITY]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QJ01DH02