U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C17H25N3O5S.3H2O
Molecular Weight 437.508
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEROPENEM

SMILES

O.O.O.[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O

InChI

InChIKey=CTUAQTBUVLKNDJ-OBZXMJSBSA-N
InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C17H25N3O5S
Molecular Weight 383.463
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 6 / 6
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/050706s036lbl.pdf |

Meropenem (generic name: meropenem hydrate) is a carbapenem antibiotic for injection showing a strong antibacterial activity to a wide range of bacteria strains from Gram-positive bacteria, Gram-negative bacteria to anaerobic bacteria. It is used as single agent therapy for the treatment of the following infections: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci. This drug also used in case of Intra-abdominal Infections for the treatment complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. In addition is used the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitides. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus. Meropenem has significant stability to hydrolysis by β-lactamases, both penicillinases and cephalosporinases produced by Gram-positive and Gram-negative bacteria. Meropenem should not be used to treat methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-resistant Staphylococcus epidermidis (MRSE). Meropenem product with such superior effectiveness and safety has been approved for marketing by 100 countries or more in the world (as of March 2004) since its first launch in Italy in 1994.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
MERREM

Approved Use

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection, USP (I.V.) and other antibacterial drugs, Meropenem for injection, USP (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Meropenem for injection, USP (I.V.) is useful as presumptive therapy in the indicated condition (e.g. intra-abdominal infections) prior to the identification of the causative organisms because of its broad spectrum of bactericidal activity. For information regarding use in pediatric patients see Indications and Usage (1.1), (1.2) or (1.3); Dosage and Administration (2.3), Adverse Reactions (6.1), and Clinical Pharmacology (12.3). Meropenem for injection (I.V.) is a penem antibacterial indicated as single agent therapy for the treatment of: Complicated skin and skin structure infections (adult patients and pediatric patients 3 months of age and older only). (1.1) Complicated intra-abdominal infections (adult and pediatric patients). (1.2) Bacterial meningitis (pediatric patients 3 months of age and older only). (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection (I.V.) and other antibacterial drugs, Meropenem for injection (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species. 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis., 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species., 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species., 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis.

Launch Date

8.3531517E11
Primary
MERREM

Approved Use

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection, USP (I.V.) and other antibacterial drugs, Meropenem for injection, USP (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Meropenem for injection, USP (I.V.) is useful as presumptive therapy in the indicated condition (e.g. intra-abdominal infections) prior to the identification of the causative organisms because of its broad spectrum of bactericidal activity. For information regarding use in pediatric patients see Indications and Usage (1.1), (1.2) or (1.3); Dosage and Administration (2.3), Adverse Reactions (6.1), and Clinical Pharmacology (12.3). Meropenem for injection (I.V.) is a penem antibacterial indicated as single agent therapy for the treatment of: Complicated skin and skin structure infections (adult patients and pediatric patients 3 months of age and older only). (1.1) Complicated intra-abdominal infections (adult and pediatric patients). (1.2) Bacterial meningitis (pediatric patients 3 months of age and older only). (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection (I.V.) and other antibacterial drugs, Meropenem for injection (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species. 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis., 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species., 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species., 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis.

Launch Date

8.3531517E11
Curative
MERREM

Approved Use

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection, USP (I.V.) and other antibacterial drugs, Meropenem for injection, USP (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Meropenem for injection, USP (I.V.) is useful as presumptive therapy in the indicated condition (e.g. intra-abdominal infections) prior to the identification of the causative organisms because of its broad spectrum of bactericidal activity. For information regarding use in pediatric patients see Indications and Usage (1.1), (1.2) or (1.3); Dosage and Administration (2.3), Adverse Reactions (6.1), and Clinical Pharmacology (12.3). Meropenem for injection (I.V.) is a penem antibacterial indicated as single agent therapy for the treatment of: Complicated skin and skin structure infections (adult patients and pediatric patients 3 months of age and older only). (1.1) Complicated intra-abdominal infections (adult and pediatric patients). (1.2) Bacterial meningitis (pediatric patients 3 months of age and older only). (1.3) To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for injection (I.V.) and other antibacterial drugs, Meropenem for injection (I.V.) should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species. 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis., 1.1 Skin and Skin Structure Infections (Adult Patients and Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species., 1.2 Intra-abdominal Infections (Adult and Pediatric Patients) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species., 1.3 Bacterial Meningitis (Pediatric Patients 3 Months of age and older only) Meropenem for injection, USP (I.V.) is indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae ‡, Haemophilus influenzae, and Neisseria meningitidis. ‡ The efficacy of meropenem as monotherapy in the treatment of meningitis caused by penicillin nonsusceptible isolates of Streptococcus pneumoniae has not been established. Meropenem for injection, USP (I.V.) has been found to be effective in eliminating concurrent bacteremia in association with bacterial meningitis.

Launch Date

8.3531517E11
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Safety profile of meropenem: a review of nearly 5,000 patients treated with meropenem.
1999
Investigation of synergism of meropenem and ciprofloxacin against Pseudomonas aeruginosa and Acinetobacter strains isolated from intensive care unit infections.
2001
Streptococcal toxic shock syndrome revealed by a peritonitis. Case report and review of the literature.
2001
[Antimicrobial activities of meropenem against clinically isolated strains in 1999].
2001 Apr
Antimicrobial susceptibility of potentially pathogenic halophilic vibrios isolated from seafood.
2001 Aug
Meropenem and continuous renal replacement.
2001 Aug
Antimicrobial susceptibility of respiratory isolates of Enterobacteriaceae and Staphylococcus aureus in Italy: incidence and trends over the period 1997-1999.
2001 Dec
Empirical monotherapy with meropenem in serious bacterial infections in children.
2001 Dec
Survey of antibiotic resistance in Pseudomonas aeruginosa by The Tokyo Johoku Association of Pseudomonas Studies.
2001 Dec
MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) conference. Hamburg, Germany, 10 May 2001.
2001 Dec
In-vitro activities of various antibiotics, alone and in combination with amikacin against Pseudomonas aeruginosa.
2001 Dec
[Microbiological monitoring of the microbic strain stability to antibacterial preparations in surgical in-patient clinics].
2001 Feb
Carbapenem-resistant Serratia marcescens isolates producing Bush group 2f beta-lactamase (SME-1) in the United States: results from the MYSTIC Programme.
2001 Feb
Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia.
2001 Feb
Guidelines and critical pathways for severe hospital-acquired pneumonia.
2001 Feb
Nosocomial pneumonia. Diagnostic and therapeutic considerations.
2001 Jan
Convalescent phase outpatient parenteral antiinfective therapy for children with complicated appendicitis.
2001 Jan
Ertapenem: a new carbapenem.
2001 Jun
Treatment of nosocomial pneumonia: an experience with meropenem.
2001 Jun
Pharmacokinetics of meropenem in preterm neonates.
2001 Jun
Antifungal antibiotics and breakthrough bacteremias.
2001 Jun 1
Continuous beta-lactam antibiotic therapy in a double-lung transplanted patient with a multidrug-resistant Pseudomonas aeruginosa infection.
2001 Mar 27
Adult Enterobacter meningitis: a high incidence of coinfection with other pathogens and frequent association with neurosurgical procedures.
2001 Mar-Apr
Melioidosis: an emerging infection in Taiwan?
2001 May-Jun
Pharmacokinetics of high-dose meropenem in adult cystic fibrosis patients.
2001 May-Jun
[Comparative antibacterial activity of carbapenems against P. aeruginosa (1)].
2001 Nov
In vitro and in vivo activities of meropenem and comparable antimicrobial agents against Haemophilus influenzae, including beta-lactamase-negative ampicillin-resistant strains.
2001 Nov
Influence of in-vivo endotoxin liberation on anti-anaerobic antimicrobial efficacy.
2001 Oct
Failure of cefotaxime and meropenem to eradicate meningitis caused by an intermediately susceptible Streptococcus pneumoniae strain.
2001 Oct
[Antimicrobial activities of carbapenems and fourth generation cephems against clinically isolated strains].
2001 Sep
Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits.
2001 Sep
Isolation and culture of airway epithelial cells from chronically infected human lungs.
2001 Sep
Synthesis and biological properties of new 1beta-methylcarbapenems containing heteroaromatic thioether moiety.
2001 Sep 3
Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase.
2001 Sep 7
Comparative in vitro activity of isepamicin and other antibiotics against gram-negative bacilli from intensive care units (ICU) in Belgium.
2001 Sep-Oct
Antibiotic persistence: the role of spontaneous DNA repair response.
2001 Winter
Use of Etests with carbapenems for Gram-negative rods producing beta-lactamases.
2002 Feb
Patents

Sample Use Guides

Adult Patients: The recommended dose of MERREM I.V. is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intra-abdominal infections. When treating complicated skin and skin structure infections caused by P.aeruginosa, a dose of 1 gram every 8 hours is recommended. Pediatric Patients 3 Months of Age and Older: For pediatric patients 3 months of age and older, the MERREM I.V. dose is 10 mg/kg, 20 mg/kg or 40 mg/kg every 8 hours (maximum dose is 2 grams every 8 hours), depending on the type of infection (complicated skin and skin structure, intra-abdominal or meningitis). Pediatric patients weighing over 50 kg should be administered MERREM I.V. at a dose of 500 mg every 8 hours for complicated skin and skin structure infections, 1 gram every 8 hours for intra-abdominal infections and 2 grams every 8 hours for meningitis. MERREM I.V. should be given as intravenous infusion over approximately 15 minutes to 30 minutes or as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes. There is limited safety data available to support the administration of a 40 mg/kg (up to a maximum of 2 grams) bolus dose.
Route of Administration: Intravenous
In Vitro Use Guide
Curator's Comment: Meropenem was 4-64 times more active than imipenem against gram-negatives, including Enterobacteriaceae organisms, Pseudomonas aeruginosa, Burkholderia cepacia, Neisseria meningiditis, and Haemophilus influenzae. Imipenem was up to 2-4 times more active than meropenem against some gram-positive cocci, including Enterococcus faecalis. Meropenem, unlike imipenem or ceftazidime, was bactericidal for all strains of Enterobacteriaceae, P. aeruginosa, and gram-positive cocci tested at < or = 8 times the MIC.
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:43:08 UTC 2023
Edited
by admin
on Wed Jul 05 23:43:08 UTC 2023
Record UNII
FV9J3JU8B1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEROPENEM
MART.   ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
ICI 194,660
Code English
MERREM I.V.
Brand Name English
MERONEM
Brand Name English
MEROPENEM [USAN]
Common Name English
MEROPENEM TRIHYDRATE
EP   MI   WHO-DD  
Common Name English
NSC-759621
Code English
Meropenem trihydrate [WHO-DD]
Common Name English
MEROPENEM HYDRATE [JAN]
Common Name English
MEROPENEM [VANDF]
Common Name English
(4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, trihydrate
Common Name English
MEROPENEM HYDRATE
JAN  
Common Name English
MEROPENEM [USP-RS]
Common Name English
MEROPENEM (AS TRIHYDRATE)
Common Name English
MEROPENEM [USP MONOGRAPH]
Common Name English
MEROPENEM TRIHYDRATE [MI]
Common Name English
MEROPENEM [MART.]
Common Name English
SM-7338
Code English
MERREM
Brand Name English
MEROPENEM TRIHYDRATE [EP MONOGRAPH]
Common Name English
MEROPENEM [ORANGE BOOK]
Common Name English
VABOMERE COMPONENT MEROPENEM
Brand Name English
MEROPENEM COMPONENT OF CARBAVANCE
Brand Name English
1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID, 3-((5-((DIMETHYLAMINO)CARBONYL)-3-PYRROLIDINYL)THIO)-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-, TRIHYDRATE, (4R-(3(3S*,5S*),4.ALPHA.,5.BETA.,6.BETA.(R*)))-
Common Name English
ICI-194660
Code English
MEROPENEM [USP IMPURITY]
Common Name English
Classification Tree Code System Code
WHO-VATC QJ01DH02
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
NCI_THESAURUS C260
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
NDF-RT N0000175496
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
WHO-ATC J01DH02
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
WHO-ATC J01DH52
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
FDA ORPHAN DRUG 130799
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
LIVERTOX NBK547861
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
Code System Code Type Description
PUBCHEM
441129
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
DRUG BANK
DB00760
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
WIKIPEDIA
MEROPENEM
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
LACTMED
Meropenem
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
ChEMBL
CHEMBL127
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
USAN
BB-52
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
FDA UNII
FV9J3JU8B1
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
RS_ITEM_NUM
1392454
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
MERCK INDEX
M7240
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY Merck Index
EVMPD
SUB21617
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
EPA CompTox
DTXSID10274179
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
MESH
C059500
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
DAILYMED
FV9J3JU8B1
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
NSC
759621
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
CHEBI
6770
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
DRUG CENTRAL
1709
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
SMS_ID
100000085626
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
RXCUI
29561
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY RxNorm
CHEBI
43968
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
NCI_THESAURUS
C1160
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
CAS
119478-56-7
Created by admin on Wed Jul 05 23:43:08 UTC 2023 , Edited by admin on Wed Jul 05 23:43:08 UTC 2023
PRIMARY
Related Record Type Details
BINDER->LIGAND
BINDING
TRANSPORTER -> SUBSTRATE
ANHYDROUS->SOLVATE
EXCRETED UNCHANGED
Meropenem: approximately 40–60% of dose was excreted unchanged within 24 to 48 hours with a further 28% recovered as the microbiologically inactive hydrolysis product; fecal elimination accounts for ~2% of dose.
PARENT -> SALT/SOLVATE
TRANSPORTER -> SUBSTRATE
Related Record Type Details
IMPURITY -> PARENT
correction factor: for the calculation of content, multiply the peak area of impurity A by 1.6
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC