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Details

Stereochemistry ACHIRAL
Molecular Formula C16H10F4N6
Molecular Weight 362.2844
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Zagociguat

SMILES

FC1=CC=CC=C1CC2=NC(=CN3C=CN=C23)C4=NC(=NN4)C(F)(F)F

InChI

InChIKey=GTKNNCQKFKGSHR-UHFFFAOYSA-N
InChI=1S/C16H10F4N6/c17-10-4-2-1-3-9(10)7-11-14-21-5-6-26(14)8-12(22-11)13-23-15(25-24-13)16(18,19)20/h1-6,8H,7H2,(H,23,24,25)

HIDE SMILES / InChI
Molecular Formula C16H10F4N6
Molecular Weight 362.2844
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
139594
Substance Class Chemical
Created
by admin
on Sat Dec 16 14:59:23 GMT 2023
Edited
by admin
on Sat Dec 16 14:59:23 GMT 2023
Record UNII
H7KEN3O8AI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Zagociguat
INN   USAN  
Official Name English
ZAGOCIGUAT [USAN]
Common Name English
zagociguat [INN]
Common Name English
Imidazo[1,2-a]pyrazine, 8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl]-
Systematic Name English
CY6463
Code English
IW-6463
Code English
8-[(2-fluorophenyl)methyl]-6-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl]imidazo[1,2-a]pyrazine
Common Name English
CY-6463
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 931423
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
Code System Code Type Description
PUBCHEM
134304734
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
PRIMARY
CAS
2201048-82-8
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
PRIMARY
INN
11923
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
PRIMARY
SMS_ID
300000000580
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
PRIMARY
NCI_THESAURUS
C188581
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
PRIMARY
USAN
LM-15
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
PRIMARY
FDA UNII
H7KEN3O8AI
Created by admin on Sat Dec 16 14:59:24 GMT 2023 , Edited by admin on Sat Dec 16 14:59:24 GMT 2023
PRIMARY
Related Record Type Details
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
OAT-1
TRANSPORTER -> INHIBITOR
IC50
OAT-3
TRANSPORTER -> INHIBITOR
IC50
GUANYLATE CYCLASE SOLUBLE .ALPHA.1.BETA.1
TARGET -> ACTIVATOR
May activate other SOLUBLE GUANYLATE CYCLASES
ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2
TRANSPORTER -> INHIBITOR
IC50
Related Record Type Details
Structure of Zagociguat
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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National Center for Advancing Translational Sciences (NCATS),
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