Details
Stereochemistry | UNKNOWN |
Molecular Formula | C14H16ClN3O4S2 |
Molecular Weight | 389.8802 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C1=CC2CC1CC2C3Nc4cc(c(cc4S(=O)(=O)N3)S(=O)(=O)N)Cl
InChI
InChIKey=BOCUKUHCLICSIY-UHFFFAOYSA-N
InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)
Molecular Formula | C14H16ClN3O4S2 |
Molecular Weight | 389.8802 |
Charge | 0 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/10653443Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14534329
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10653443
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/14534329
Cyclothiazide was presumably developed by Eli Lilly for the treatment of hypertension. It is believed that the drug, which belongs to the class of thiazide diuretics, exerts its action by inhibitin sodium reabsorption in the renal tubules. In 1993 it was discovered that cyclothiazide stimulates AMPA receptors thus inducing seizure behavior.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:0070294 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10653443 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | ANHYDRON Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Antihypertensive, saluretic and hypokalaemic effects of cyclothiazide in comparison with hydrochlorthiazide with amiloride supplement. | 1982 |
|
Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents. | 1993 Sep |
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Similar increases in extracellular lactic acid in the limbic system during epileptic and/or olfactory stimulation. | 2000 |
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Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro. | 2001 Jun |
|
Cyclothiazide potently inhibits gamma-aminobutyric acid type A receptors in addition to enhancing glutamate responses. | 2003 Oct 28 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3912112
2.5 mg daily.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7751964
Cyclothiazide was added at concentration of 100 uM to rat medullary slices to test its effect on AMPA receptor channel desensitization.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Jun 25 22:10:10 UTC 2021
by
admin
on
Fri Jun 25 22:10:10 UTC 2021
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Record UNII |
P71U09G5BW
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Record Status |
Validated (UNII)
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Record Version |
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C03AA09
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QC03AB09
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NCI_THESAURUS |
C49185
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CYCLOTHIAZIDE
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