U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 19:16:34 GMT 2025
Edited
by admin
on Tue Apr 01 19:16:34 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
P6W5IXV8V9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUA2
Preferred Name English
AMPA-SELECTIVE GLUTAMATE RECEPTOR 2
Common Name English
AMPAR (GLUR-2)4
Common Name English
GLUR-K2
Common Name English
GLUR-B
Common Name English
GLUR2
Common Name English
GLUR-2
Common Name English
GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2
Common Name English
GLUTAMATE RECEPTOR 2
Common Name English
Code System Code Type Description
FDA UNII
P6W5IXV8V9
Created by admin on Tue Apr 01 19:16:34 GMT 2025 , Edited by admin on Tue Apr 01 19:16:34 GMT 2025
PRIMARY
UNIPROT
P42262
Created by admin on Tue Apr 01 19:16:34 GMT 2025 , Edited by admin on Tue Apr 01 19:16:34 GMT 2025
PRIMARY
PHAROS
P42262
Created by admin on Tue Apr 01 19:16:34 GMT 2025 , Edited by admin on Tue Apr 01 19:16:34 GMT 2025
PRIMARY
From To
1_54 1_306
4_54 4_306
2_54 2_306
3_54 3_306
1_715 1_770
4_715 4_770
2_715 2_770
3_715 3_770
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_232
N 1_346
N 1_382
N 1_389
N 2_232
N 2_346
N 2_382
N 2_389
N 3_232
N 3_346
N 3_382
N 3_389
N 4_232
N 4_346
N 4_382
N 4_389
Related Record Type Details
AGONIST -> TARGET
The endogenous agonist
INHIBITOR -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ACTIVATOR -> TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
This action is very weak and its clinical effects may not necessarily be mediated by this action.
AGONIST -> TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
AGONIST -> TARGET
AGONIST -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
INHIBITOR -> TARGET
Endogenous ligand
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
AGONIST -> TARGET
AGONIST -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
ALLOSTERIC ACTIVATOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_836] [1_839] [1_856] DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL