U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 12:27:15 GMT 2023
Edited
by admin
on Sat Dec 16 12:27:15 GMT 2023
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
P6W5IXV8V9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMPA-SELECTIVE GLUTAMATE RECEPTOR 2
Common Name English
AMPAR (GLUR-2)4
Common Name English
GLUR-K2
Common Name English
GLUR-B
Common Name English
GLUA2
Common Name English
GLUR2
Common Name English
GLUR-2
Common Name English
GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2
Common Name English
GLUTAMATE RECEPTOR 2
Common Name English
Code System Code Type Description
FDA UNII
P6W5IXV8V9
Created by admin on Sat Dec 16 12:27:19 GMT 2023 , Edited by admin on Sat Dec 16 12:27:19 GMT 2023
PRIMARY
UNIPROT
P42262
Created by admin on Sat Dec 16 12:27:19 GMT 2023 , Edited by admin on Sat Dec 16 12:27:19 GMT 2023
PRIMARY
PHAROS
P42262
Created by admin on Sat Dec 16 12:27:19 GMT 2023 , Edited by admin on Sat Dec 16 12:27:19 GMT 2023
PRIMARY
From To
1_54 1_306
4_54 4_306
2_54 2_306
3_54 3_306
1_715 1_770
4_715 4_770
2_715 2_770
3_715 3_770
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_232
N 1_346
N 1_382
N 1_389
N 2_232
N 2_346
N 2_382
N 2_389
N 3_232
N 3_346
N 3_382
N 3_389
N 4_232
N 4_346
N 4_382
N 4_389
Related Record Type Details
AGONIST -> TARGET
The endogenous agonist
INHIBITOR -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
INHIBITOR -> TARGET
RADIOLIGAND->TARGET
INHIBITOR -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ACTIVATOR -> TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
This action is very weak and its clinical effects may not necessarily be mediated by this action.
AGONIST -> TARGET
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
AGONIST -> TARGET
AGONIST -> TARGET
NEGATIVE ALLOSTERIC MODULATOR (NAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
INHIBITOR -> TARGET
Endogenous ligand
INHIBITOR -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
High-impact AMPAR PAM decreases both deactivation and desensitization together to enhance and prolong synaptic currents.
AGONIST -> TARGET
AGONIST -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents.
ALLOSTERIC ACTIVATOR
POSITIVE ALLOSTERIC MODULATOR (PAM)->TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL