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Details

Stereochemistry ACHIRAL
Molecular Formula C12H13N3O2
Molecular Weight 231.2505
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FARAMPATOR

SMILES

O=C(N1CCCCC1)C2=CC3=NON=C3C=C2

InChI

InChIKey=XFVRBYKKGGDPAJ-UHFFFAOYSA-N
InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2

HIDE SMILES / InChI

Molecular Formula C12H13N3O2
Molecular Weight 231.2505
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Farampator (CX 691, ORG 24448 or (1-(benzofurazan-5-ylcarbonyl) piperidine)) is a positive allosteric modulator of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. Farampator exerts antipsychotic and cognitive enhancing properties.

Approval Year

PubMed

PubMed

TitleDatePubMed
Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers.
2007 Jun
Current management of the cognitive dysfunction in Parkinson's disease: how far have we come?
2008 Aug
Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.
2009 Jan
Glutamatergic targets for enhancing extinction learning in drug addiction.
2010 Dec
Patents

Sample Use Guides

Farampator (500 mg) unequivocally improved short-term memory but appeared to impair episodic memory.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Thu Jul 06 00:01:27 UTC 2023
Edited
by admin
on Thu Jul 06 00:01:27 UTC 2023
Record UNII
7X6P5N8K2L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FARAMPATOR
INN   USAN  
INN   USAN  
Official Name English
1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine
Systematic Name English
2,1,3-BENZOXADIAZOL-6-YL-PIPERIDIN-1-YLMETHANONE
Systematic Name English
SCH-900460
Code English
CX-691
Code English
ORG-24448
Code English
ORG 24448
Code English
CX691
Code English
FARAMPATOR [USAN]
Common Name English
PIPERIDINE, 1-(2,1,3-BENZOXADIAZOL-5-YLCARBONYL)-
Systematic Name English
farampator [INN]
Common Name English
CX 691
Code English
Classification Tree Code System Code
NCI_THESAURUS C29710
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
Code System Code Type Description
WIKIPEDIA
FARAMPATOR
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
DRUG BANK
DB15012
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
CAS
211735-76-1
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
ChEMBL
CHEMBL1276138
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
FDA UNII
7X6P5N8K2L
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
SMS_ID
100000174953
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
PUBCHEM
4118151
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
INN
8534
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
EPA CompTox
DTXSID90175413
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
NCI_THESAURUS
C65620
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
USAN
QQ-90
Created by admin on Thu Jul 06 00:01:27 UTC 2023 , Edited by admin on Thu Jul 06 00:01:27 UTC 2023
PRIMARY
Related Record Type Details
TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM)
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Related Record Type Details
ACTIVE MOIETY