FARAMPATOR

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H13N3O2
Molecular Weight	231.2505
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(N1CCCCC1)C2=CC3=NON=C3C=C2

InChI

InChIKey=XFVRBYKKGGDPAJ-UHFFFAOYSA-N

InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2

HIDE SMILES / InChI

Molecular Formula	C12H13N3O2
Molecular Weight	231.2505
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22068461 | https://www.ncbi.nlm.nih.gov/pubmed/18795266 | https://www.ncbi.nlm.nih.gov/pubmed/17119538 | https://adisinsight.springer.com/drugs/800012259

Farampator (CX 691, ORG 24448 or (1-(benzofurazan-5-ylcarbonyl) piperidine)) is a positive allosteric modulator of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. Farampator exerts antipsychotic and cognitive enhancing properties.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate receptor ionotropic, AMPA 3 4 Target ID: CHEMBL3504 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20839777\|https://www.ncbi.nlm.nih.gov/pubmed/11959085\|https://www.ncbi.nlm.nih.gov/pubmed/18795266\|https://www.ncbi.nlm.nih.gov/pubmed/17119538	Positive Allosteric Modulator 186		14.0 µM [EC50]

PubMed

Title	Date	PubMed
Glutamatergic targets for enhancing extinction learning in drug addiction.	2010-12	21629446
Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.	2009-01	18795266
Current management of the cognitive dysfunction in Parkinson's disease: how far have we come?	2008-08	18535172
Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers.	2007-06	17119538

Patents

Sample Use Guides

In Vivo Use Guide

Farampator (500 mg) unequivocally improved short-term memory but appeared to impair episodic memory.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:32:20 GMT 2025` Edited by `admin` on `Mon Mar 31 18:32:20 GMT 2025`
Record UNII	7X6P5N8K2L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FARAMPATOR

Official Name

English

CX 691

Preferred Name

English

1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine

Systematic Name

English

2,1,3-BENZOXADIAZOL-6-YL-PIPERIDIN-1-YLMETHANONE

Systematic Name

English

SCH-900460

Code

English

CX-691

Code

English

ORG-24448

Code

English

ORG 24448

Code

English

CX691

Code

English

FARAMPATOR [USAN]

Common Name

English

PIPERIDINE, 1-(2,1,3-BENZOXADIAZOL-5-YLCARBONYL)-

Systematic Name

English

farampator [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710