FARAMPATOR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H13N3O2
Molecular Weight	231.2505
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C(N1CCCCC1)C2=CC3=NON=C3C=C2

InChI

InChIKey=XFVRBYKKGGDPAJ-UHFFFAOYSA-N

InChI=1S/C12H13N3O2/c16-12(15-6-2-1-3-7-15)9-4-5-10-11(8-9)14-17-13-10/h4-5,8H,1-3,6-7H2

HIDE SMILES / InChI

Molecular Formula	C12H13N3O2
Molecular Weight	231.2505
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22068461 | https://www.ncbi.nlm.nih.gov/pubmed/18795266 | https://www.ncbi.nlm.nih.gov/pubmed/17119538 | https://adisinsight.springer.com/drugs/800012259

Farampator (CX 691, ORG 24448 or (1-(benzofurazan-5-ylcarbonyl) piperidine)) is a positive allosteric modulator of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. Farampator exerts antipsychotic and cognitive enhancing properties.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate receptor ionotropic, AMPA 3 4 Target ID: CHEMBL3504 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20839777\|https://www.ncbi.nlm.nih.gov/pubmed/11959085\|https://www.ncbi.nlm.nih.gov/pubmed/18795266\|https://www.ncbi.nlm.nih.gov/pubmed/17119538	Positive Allosteric Modulator 179		14.0 µM [EC50]

PubMed

Title	Date	PubMed
Current management of the cognitive dysfunction in Parkinson's disease: how far have we come?	2008 Aug	18535172
Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat.	2009 Jan	18795266
Glutamatergic targets for enhancing extinction learning in drug addiction.	2010 Dec	21629446

Patents

Sample Use Guides

In Vivo Use Guide

Farampator (500 mg) unequivocally improved short-term memory but appeared to impair episodic memory.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:36:07 GMT 2023` Edited by `admin` on `Fri Dec 15 16:36:07 GMT 2023`
Record UNII	7X6P5N8K2L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FARAMPATOR

Official Name

English

1-(2,1,3-Benzoxadiazol-5-ylcarbonyl)piperidine

Systematic Name

English

2,1,3-BENZOXADIAZOL-6-YL-PIPERIDIN-1-YLMETHANONE

Systematic Name

English

SCH-900460

Code

English

CX-691

Code

English

ORG-24448

Code

English

ORG 24448

Code

English

CX691

Code

English

FARAMPATOR [USAN]

Common Name

English

PIPERIDINE, 1-(2,1,3-BENZOXADIAZOL-5-YLCARBONYL)-

Systematic Name

English

farampator [INN]

Common Name

English

CX 691

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29710