U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ACHIRAL
Molecular Formula C14H17NO3
Molecular Weight 247.2897
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CX-546

SMILES

O=C(N1CCCCC1)C2=CC3=C(OCCO3)C=C2

InChI

InChIKey=LJUNPHMOGNFFOS-UHFFFAOYSA-N
InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2

HIDE SMILES / InChI

Molecular Formula C14H17NO3
Molecular Weight 247.2897
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.
2001 Nov
Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.
2002 Dec
Survival signaling and selective neuroprotection through glutamatergic transmission.
2002 Mar
A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide.
2002 Nov
Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus.
2005 Apr
Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators.
2005 Feb
Effects of agents targeting glutamatergic systems on marble-burying behavior.
2010 Mar 3
AMPA receptor mediates mGlu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell.
2010 Nov
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:38:18 GMT 2025
Edited
by admin
on Mon Mar 31 18:38:18 GMT 2025
Record UNII
PV6YEC8983
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CX-546
Common Name English
BDP 17
Preferred Name English
BDP-17
Code English
2,3-DIHYDRO-1,4-BENZODIOXIN-7-YL-(1-PIPERIDYL)METHANONE
Systematic Name English
GR-87
Code English
GR 87
Code English
METHANONE, (2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-1-PIPERIDINYL-
Systematic Name English
CX 546
Code English
CX546
Common Name English
PIPERIDINE, 1-((2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL)-
Systematic Name English
Code System Code Type Description
CAS
215923-54-9
Created by admin on Mon Mar 31 18:38:18 GMT 2025 , Edited by admin on Mon Mar 31 18:38:18 GMT 2025
PRIMARY
WIKIPEDIA
CX546
Created by admin on Mon Mar 31 18:38:18 GMT 2025 , Edited by admin on Mon Mar 31 18:38:18 GMT 2025
PRIMARY
PUBCHEM
2890
Created by admin on Mon Mar 31 18:38:18 GMT 2025 , Edited by admin on Mon Mar 31 18:38:18 GMT 2025
PRIMARY
EPA CompTox
DTXSID70175951
Created by admin on Mon Mar 31 18:38:18 GMT 2025 , Edited by admin on Mon Mar 31 18:38:18 GMT 2025
PRIMARY
FDA UNII
PV6YEC8983
Created by admin on Mon Mar 31 18:38:18 GMT 2025 , Edited by admin on Mon Mar 31 18:38:18 GMT 2025
PRIMARY
MESH
C443080
Created by admin on Mon Mar 31 18:38:18 GMT 2025 , Edited by admin on Mon Mar 31 18:38:18 GMT 2025
PRIMARY
Related Record Type Details
TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM)
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Related Record Type Details
ACTIVE MOIETY