Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H17NO3 |
| Molecular Weight | 247.2897 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(N1CCCCC1)C2=CC3=C(OCCO3)C=C2
InChI
InChIKey=LJUNPHMOGNFFOS-UHFFFAOYSA-N
InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
| Molecular Formula | C14H17NO3 |
| Molecular Weight | 247.2897 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion. | 2003 |
|
| Identification of a site in GluR1 and GluR2 that is important for modulation of deactivation and desensitization. | 2003 Jul |
|
| Ampakines alleviate respiratory depression in rats. | 2006 Dec 15 |
|
| Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats. | 2007 Dec 1 |
|
| Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome. | 2007 Oct 3 |
|
| Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations. | 2009 Dec |
|
| Memory and the NMDA receptors. | 2009 Jul 16 |
|
| Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats. | 2010 Feb 11 |
|
| Effects of agents targeting glutamatergic systems on marble-burying behavior. | 2010 Mar 3 |
|
| AMPA receptor mediates mGlu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell. | 2010 Nov |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:56:28 GMT 2023
by
admin
on
Fri Dec 15 16:56:28 GMT 2023
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| Record UNII |
PV6YEC8983
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| Record Status |
Validated (UNII)
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| Record Version |
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215923-54-9
Created by
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CX546
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2890
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DTXSID70175951
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PV6YEC8983
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C443080
Created by
admin on Fri Dec 15 16:56:28 GMT 2023 , Edited by admin on Fri Dec 15 16:56:28 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM) |
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
