U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H17NO3
Molecular Weight 247.2897
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CX-546

SMILES

O=C(N1CCCCC1)C2=CC3=C(OCCO3)C=C2

InChI

InChIKey=LJUNPHMOGNFFOS-UHFFFAOYSA-N
InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2

HIDE SMILES / InChI

Molecular Formula C14H17NO3
Molecular Weight 247.2897
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
PubMed

PubMed

TitleDatePubMed
Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.
2002 Dec
Survival signaling and selective neuroprotection through glutamatergic transmission.
2002 Mar
A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide.
2002 Nov
Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus.
2005 Apr
Ampakines alleviate respiratory depression in rats.
2006 Dec 15
Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations.
2009 Dec
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.
2009 Feb 24
Memory and the NMDA receptors.
2009 Jul 16
Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats.
2010 Feb 11
Effects of agents targeting glutamatergic systems on marble-burying behavior.
2010 Mar 3
AMPA receptor mediates mGlu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell.
2010 Nov
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:56:28 UTC 2023
Edited
by admin
on Fri Dec 15 16:56:28 UTC 2023
Record UNII
PV6YEC8983
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CX-546
Common Name English
BDP-17
Code English
2,3-DIHYDRO-1,4-BENZODIOXIN-7-YL-(1-PIPERIDYL)METHANONE
Systematic Name English
GR-87
Code English
BDP 17
Code English
GR 87
Code English
METHANONE, (2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-1-PIPERIDINYL-
Systematic Name English
CX 546
Code English
CX546
Common Name English
PIPERIDINE, 1-((2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL)-
Systematic Name English
Code System Code Type Description
CAS
215923-54-9
Created by admin on Fri Dec 15 16:56:28 UTC 2023 , Edited by admin on Fri Dec 15 16:56:28 UTC 2023
PRIMARY
WIKIPEDIA
CX546
Created by admin on Fri Dec 15 16:56:28 UTC 2023 , Edited by admin on Fri Dec 15 16:56:28 UTC 2023
PRIMARY
PUBCHEM
2890
Created by admin on Fri Dec 15 16:56:28 UTC 2023 , Edited by admin on Fri Dec 15 16:56:28 UTC 2023
PRIMARY
EPA CompTox
DTXSID70175951
Created by admin on Fri Dec 15 16:56:28 UTC 2023 , Edited by admin on Fri Dec 15 16:56:28 UTC 2023
PRIMARY
FDA UNII
PV6YEC8983
Created by admin on Fri Dec 15 16:56:28 UTC 2023 , Edited by admin on Fri Dec 15 16:56:28 UTC 2023
PRIMARY
MESH
C443080
Created by admin on Fri Dec 15 16:56:28 UTC 2023 , Edited by admin on Fri Dec 15 16:56:28 UTC 2023
PRIMARY
Related Record Type Details
TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM)
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
Related Record Type Details
ACTIVE MOIETY