Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H17NO3 |
Molecular Weight | 247.2897 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(N1CCCCC1)C2=CC3=C(OCCO3)C=C2
InChI
InChIKey=LJUNPHMOGNFFOS-UHFFFAOYSA-N
InChI=1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
Molecular Formula | C14H17NO3 |
Molecular Weight | 247.2897 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2096670 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11640919 |
PubMed
Title | Date | PubMed |
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Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. | 2001 Nov |
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Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. | 2002 Dec |
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Survival signaling and selective neuroprotection through glutamatergic transmission. | 2002 Mar |
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A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide. | 2002 Nov |
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Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus. | 2005 Apr |
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Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators. | 2005 Feb |
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Effects of agents targeting glutamatergic systems on marble-burying behavior. | 2010 Mar 3 |
|
AMPA receptor mediates mGlu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell. | 2010 Nov |
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:38:18 GMT 2025
by
admin
on
Mon Mar 31 18:38:18 GMT 2025
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Record UNII |
PV6YEC8983
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Record Status |
Validated (UNII)
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Record Version |
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215923-54-9
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CX546
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2890
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DTXSID70175951
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PV6YEC8983
Created by
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C443080
Created by
admin on Mon Mar 31 18:38:18 GMT 2025 , Edited by admin on Mon Mar 31 18:38:18 GMT 2025
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Related Record | Type | Details | ||
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TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM) |
Low-impact AMPAR PAMs decrease AMPAR deactivation (channel closing) alone to augment synaptic currents
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Related Record | Type | Details | ||
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ACTIVE MOIETY |