PESAMPATOR

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H20N2O4S2
Molecular Weight	392.492
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)S(=O)(=O)N[C@H]1COC[C@H]1OC2=CC=C(C=C2)C3=CC=C(S3)C#N

InChI

InChIKey=TTYKUKSFWHEBLI-DLBZAZTESA-N

InChI=1S/C18H20N2O4S2/c1-12(2)26(21,22)20-16-10-23-11-17(16)24-14-5-3-13(4-6-14)18-8-7-15(9-19)25-18/h3-8,12,16-17,20H,10-11H2,1-2H3/t16-,17+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H20N2O4S2
Molecular Weight	392.492
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28242871 | https://www.ncbi.nlm.nih.gov/pubmed/22886028 | https://www.ncbi.nlm.nih.gov/pubmed/25243609 | https://adisinsight.springer.com/drugs/800032498

PF-04958242 is an AMPA receptor potentiator for the potential treatment of cognitive deficits in schizophrenia. But recent study revealed that there were no pharmacokinetic interactions between PF-04958242 and ketamine. 'High-impact' AMPAR potentiators like PF-04958242 may have a role in the treatment of the cognitive symptoms, but not the positive or negative symptoms, associated with schizophrenia. In addition, a clinical study was underway to evaluate the effects of PF-049582432 in subjects with age-related hearing loss in the US. PF-04958242 has been classified as glycine transporter (GLYT-1) inhibitor in this study. However, this development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Cognitive enhancers (nootropics). Part 1: drugs interacting with receptors.	2012	22886028
Inhibition of glycine transporter 1: The yellow brick road to new schizophrenia therapy?	2015	26205290
Early investigational drugs for hearing loss.	2015 Feb	25243609
The Safety and Efficacy of PF-04958242 in Age-Related Sensorineural Hearing Loss: A Randomized Clinical Trial.	2015 Jul	25997115
The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).	2015 May 28	25905800
Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242.	2017 Nov	28242871
Reverse and Forward Translational Neuropharmacology in Psychiatric Drug Discovery.	2018 Feb	29076553

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 20:51:45 GMT 2025` Edited by `admin` on `Mon Mar 31 20:51:45 GMT 2025`
Record UNII	9G1A824CC2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PF-4958242

Preferred Name

English

PESAMPATOR

Official Name

English

BIIB104

Code

English

N-((3S,4S)-4-(4-(5-CYANOTHIOPHEN-2-YL)PHENOXY)TETRAHYDROFURAN-3-YL)PROPANE-2-SULFONAMIDE

Systematic Name

English

PESAMPATOR [USAN]

Common Name

English

PF-04958242

Code

English

pesampator [INN]

Common Name

English

BIIB-104

Code

English

2-PROPANESULFONAMIDE, N-((3S,4S)-4-(4-(5-CYANO-2-THIENYL)PHENOXY)TETRAHYDRO-3-FURANYL)-

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB11843