DASOLAMPANEL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H20ClN5O3
Molecular Weight	377.825
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@@H](C[C@]1([H])C[C@H](NC2)C(O)=O)OC3=C(C4=NN=NN4)C(Cl)=CC=C3

InChI

InChIKey=LAKQPSQCICNZII-NOHGZBONSA-N

InChI=1S/C17H20ClN5O3/c18-12-2-1-3-14(15(12)16-20-22-23-21-16)26-11-5-4-9-8-19-13(17(24)25)7-10(9)6-11/h1-3,9-11,13,19H,4-8H2,(H,24,25)(H,20,21,22,23)/t9-,10+,11-,13-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C17H20ClN5O3
Molecular Weight	377.825
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24631589 | https://www.ncbi.nlm.nih.gov/pubmed/23110368 | https://www.ncbi.nlm.nih.gov/pubmed/24140446

Dasolampanel (NGX-426) is an orally available competitive antagonist of the AMPA and kainate receptors. The dug originated at Eli Lilly and Horizon Pharma and was developed for the treatment of migraine and neuropathic pain. Dasalompanel was reduced capsaicin-induced pain and hyperalgesia in human volunteers but failed to achieve positive results in phase 2 clinical trials in patients with pain due to osteoarthritis of the knee and diabetic peripheral neuropathic pain.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:15:00 GMT 2023` Edited by `admin` on `Fri Dec 15 20:15:00 GMT 2023`
Record UNII	1P85D6BE9K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DASOLAMPANEL

Official Name

English

dasolampanel [INN]

Common Name

English

3-ISOQUINOLINECARBOXYLIC ACID, 6-(3-CHLORO-2-(2H-TETRAZOL-5-YL)PHENOXY)DECAHYDRO-, (3S,4AS,6S,8AR)-

Common Name

English

(3S,4AS,6S,8AR)-6-(3-CHLORO-2-(1H-TETRAZOL-5-YL)PHENOXY)-DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID

Common Name

English

DASOLAMPANEL [USAN]

Common Name

English

Code System Code Type Description

WIKIPEDIA

DASOLAMPANEL