GYKI-52466

CC1=NN=C(C2=CC=C(N)C=C2)C3=C(C1)C=C4OCOC4=C3

InChIKey=LFBZZHVSGAHQPP-UHFFFAOYSA-N

InChI=1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Glutamate receptor ionotropic, AMPA 4 Target ID: CHEMBL2093871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7678966	Negative Allosteric Modulator 43	7.5 µM [IC50]
Glutamate receptor ionotropic, kainate 6 Target ID: CHEMBL2094119 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7678966	Negative Allosteric Modulator 43	11.0 µM [IC50]
Glutamate receptor ionotropic, AMPA 1 9 Target ID: CHEMBL2009 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24738995 \|	Antagonist 2849	145.0 µM [Ki]
Glutamate receptor ionotropic, AMPA 2 6 Target ID: CHEMBL4016 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22059113 \| https://www.ncbi.nlm.nih.gov/pubmed/7678966	Antagonist 2849	61.0 µM [Ki]

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:02:00 GMT 2025` Edited by `admin` on `Mon Mar 31 19:02:00 GMT 2025`
Record UNII	471V8NZ5X3
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

GYKI-52466

Common Name

English

GYKI-2466

Preferred Name

English

BENZENAMINE, 4-(8-METHYL-9H-1,3-DIOXOLO(4,5-H)(2,3)BENZODIAZEPIN-5-YL)-

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

GYKI 52466