Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H9NO4 |
| Molecular Weight | 147.1293 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CCC(O)=O)C(O)=O
InChI
InChIKey=WHUUTDBJXJRKMK-VKHMYHEASA-N
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
| Molecular Formula | C5H9NO4 |
| Molecular Weight | 147.1293 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094124 |
|||
Target ID: CHEMBL2109241 |
|||
Target ID: CHEMBL2096670 |
|||
Target ID: CHEMBL3772 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Palliative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots. | 2001 |
|
| Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. | 2001 |
|
| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. | 2001 Apr 6 |
|
| Mechanisms of neurodegeneration in amyotrophic lateral sclerosis. | 2001 Dec |
|
| Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes. | 2001 Mar 2 |
|
| Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation. | 2001 Nov 2 |
|
| Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons. | 2002 Jul-Aug |
|
| Interaction between vanilloid and glutamate receptors in the central modulation of nociception. | 2002 Mar 29 |
|
| Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. | 2002 Nov 1 |
|
| FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. | 2003 |
|
| Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. | 2003 |
|
| Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells. | 2003 Jul |
|
| GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents. | 2003 Nov |
|
| [Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication]. | 2003 Sep-Oct |
|
| Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination. | 2004 |
|
| Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. | 2004 Apr |
|
| Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats. | 2004 Apr 16 |
|
| The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. | 2004 Apr 23 |
|
| RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts. | 2004 Dec 3 |
|
| Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures. | 2004 Jul |
|
| Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina. | 2004 Mar 31 |
|
| Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough. | 2004 Nov |
|
| Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta). | 2005 Aug 15 |
|
| Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage. | 2005 Dec |
|
| Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells. | 2005 Oct 15 |
|
| Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission. | 2005 Sep |
|
| Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb. | 2005 Sep |
|
| Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations. | 2006 May 1 |
|
| The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter. | 2007 Apr 20 |
|
| Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. | 2008 |
|
| Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. | 2008 Dec |
|
| [Epileptic seizures in critically ill patients]. | 2009 |
|
| Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
|
| Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity. | 2009 Aug |
|
| Computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from Camellia sinensis (L.) O. Kuntze. | 2009 Dec |
|
| Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase. | 2009 Dec 14 |
|
| Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. | 2009 Dec 23 |
|
| Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. | 2009 Jan 5 |
|
| Receptors and transduction of umami taste stimuli. | 2009 Jul |
|
| Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats. | 2009 Jun |
|
| Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China. | 2009 May 14 |
|
| A role for Melanin-Concentrating Hormone in learning and memory. | 2009 Nov |
|
| Fibulin 5 forms a compact dimer in physiological solutions. | 2009 Sep 18 |
|
| Hippocampal mossy fiber synaptic transmission and its modulation. | 2010 |
|
| Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. | 2010 Dec 1 |
|
| Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 Feb 10 |
|
| 1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model. | 2010 Jul |
|
| Cannabinoids excite circadian clock neurons. | 2010 Jul 28 |
|
| Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. | 2010 Jun 26 |
|
| Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells. | 2010 May 28 |
Sample Use Guides
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:00:47 GMT 2023
by
admin
on
Fri Dec 15 15:00:47 GMT 2023
|
| Record UNII |
3KX376GY7L
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
JECFA EVALUATION |
INS-620
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
CODEX ALIMENTARIUS (GSFA) |
INS-620
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
EPA PESTICIDE CODE |
374350
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
NCI_THESAURUS |
C68442
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
CFR |
21 CFR 310.532
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
NCI_THESAURUS |
C29596
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
CFR |
21 CFR 172.320
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
DSLD |
2305 (Number of products:567)
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
WHO-ATC |
A09AB01
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
||
|
FDA ORPHAN DRUG |
806920
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
CHEMBL575060
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
SUB11991MIG
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
490
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
1294976
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
6899-05-4
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
ALTERNATIVE | |||
|
Glutamate (neurotransmitter)
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
DB00142
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
D018698
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
100000092069
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
GLUTAMIC ACID
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
33032
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
1410
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
m5775
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | Merck Index | ||
|
200-293-7
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
29972
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
1310
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
16015
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
C1115
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
SUB35454
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
3KX376GY7L
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
3KX376GY7L
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
143503
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
25916
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | RxNorm | ||
|
56-86-0
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
DTXSID5020659
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
18237
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY | |||
|
66
Created by
admin on Fri Dec 15 15:00:47 GMT 2023 , Edited by admin on Fri Dec 15 15:00:47 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
SALT/SOLVATE -> PARENT | |||
|
TARGET -> AGONIST |
The endogenous agonist
|
||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
INHIBITOR -> TARGET |
INHIBITS GLUTAMATE RELEASE
|
||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT |
|
||
|
|
TRANSPORTER -> SUBSTRATE |
Natural substrate transports glutamate out of cell.
|
||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT | |||
|
|
SALT/SOLVATE -> PARENT |
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (TLC)
EP
|
||
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (TLC)
EP
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
|
