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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.Na.H
Molecular Weight 169.1113
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOSODIUM GLUTAMATE ANHYDROUS

SMILES

C(CC(=O)[O-])[C@@]([H])(C(=O)O)N.[Na+]

InChI

InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H7NO4
Molecular Weight 145.1136
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment:: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots.
2001
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
2001
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.
2001 Dec
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.
2001 Mar 2
Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation.
2001 Nov 2
Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons.
2002 Jul-Aug
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
2002 Mar 29
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.
2002 Nov 1
FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10.
2003
Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
2003
Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells.
2003 Jul
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents.
2003 Nov
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.
2004 Apr
Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit.
2004 Apr 15
Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats.
2004 Apr 16
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
2004 Apr 23
RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts.
2004 Dec 3
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures.
2004 Jul
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
2004 Mar 31
Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.
2004 Nov
The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli.
2004 Nov
Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage.
2005 Dec
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2005 Oct 15
Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission.
2005 Sep
Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb.
2005 Sep
Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations.
2006 May 1
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation.
2008
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.
2008 Dec
[Epileptic seizures in critically ill patients].
2009
Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model.
2009 Aug
Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity.
2009 Aug
Computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from Camellia sinensis (L.) O. Kuntze.
2009 Dec
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
2009 Dec 14
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
2009 Dec 23
Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots.
2009 Jan 5
Receptors and transduction of umami taste stimuli.
2009 Jul
Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.
2009 Jun
Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China.
2009 May 14
A role for Melanin-Concentrating Hormone in learning and memory.
2009 Nov
Fibulin 5 forms a compact dimer in physiological solutions.
2009 Sep 18
Hippocampal mossy fiber synaptic transmission and its modulation.
2010
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage.
2010 Dec 1
Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
2010 Feb 10
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model.
2010 Jul
Cannabinoids excite circadian clock neurons.
2010 Jul 28
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.
2010 Jun 26
Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells.
2010 May 28
Gabapentin suppresses cortical spreading depression susceptibility.
2010 Sep
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Sat Jun 26 08:45:49 UTC 2021
Edited
by admin
on Sat Jun 26 08:45:49 UTC 2021
Record UNII
C3C196L9FG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOSODIUM GLUTAMATE ANHYDROUS
Common Name English
MONOSODIUM GLUTAMATE [MI]
Common Name English
GLUTAVENE
Code English
L-GLUTAMIC ACID, SODIUM SALT (1:1)
Common Name English
FEMA NO. 2756
Code English
NSC-135529
Code English
SODIUM L-GLUTAMATE
Systematic Name English
L-GLUTAMIC ACID, MONOSODIUM SALT
Common Name English
GLUTAMATE SODIUM [WHO-DD]
Common Name English
SODIUM GLUTAMATE [HSDB]
Common Name English
ANCOMA
Brand Name English
MONOSODIUM GLUTAMATE [FHFI]
Common Name English
GLUTAMATE SODIUM
WHO-DD  
Systematic Name English
Code System Code Type Description
EPA CompTox
142-47-2
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
MERCK INDEX
M7612
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY Merck Index
CAS
142-47-2
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
PUBCHEM
23672308
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
EVMPD
SUB43582
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
FDA UNII
C3C196L9FG
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
CONCEPT Industrial Aid
RXCUI
1313974
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C82289
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
ChEMBL
CHEMBL2107256
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
ECHA (EC/EINECS)
205-538-1
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
HSDB
580
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
EVMPD
SUB69731
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
EVMPD
SUB20604
Created by admin on Sat Jun 26 08:45:49 UTC 2021 , Edited by admin on Sat Jun 26 08:45:49 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY