Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H7NO4.Na.H |
| Molecular Weight | 169.1111 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O
InChI
InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C5H7NO4 |
| Molecular Weight | 145.1134 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H |
| Molecular Weight | 1.0079 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094124 |
|||
Target ID: CHEMBL2109241 |
|||
Target ID: CHEMBL2096670 |
|||
Target ID: CHEMBL3772 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Palliative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots. | 2001 |
|
| Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. | 2001 |
|
| Cooperative helix stabilization by complex Arg-Glu salt bridges. | 2001 Aug 1 |
|
| Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes. | 2001 Mar 2 |
|
| Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase. | 2001 Sep |
|
| Interaction between vanilloid and glutamate receptors in the central modulation of nociception. | 2002 Mar 29 |
|
| GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents. | 2003 Nov |
|
| [Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication]. | 2003 Sep-Oct |
|
| Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination. | 2004 |
|
| Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit. | 2004 Apr 15 |
|
| Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough. | 2004 Nov |
|
| The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli. | 2004 Nov |
|
| Nonsense-mediated mRNA decay mutation in Aspergillus nidulans. | 2006 Nov |
|
| Neuro-bioenergetic concepts in cancer prevention and treatment. | 2007 |
|
| Lidocaine: neurobiological targets and effects on the auditory system. | 2007 |
|
| Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex. | 2007 Dec |
|
| Comprehensive gene expression analysis in bipolar disorder. | 2007 Dec |
|
| (-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. | 2008 Aug 15 |
|
| Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. | 2008 Jul |
|
| Calculation of the isoelectric point of tryptic peptides in the pH 3.5-4.5 range based on adjacent amino acid effects. | 2008 Jul |
|
| Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. | 2008 Sep 15 |
|
| Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. | 2009 |
|
| Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
|
| Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. | 2009 Jul |
|
| Excitatory neurotransmitters in brain regions in interictal migraine patients. | 2009 Jun 30 |
|
| An evaluation of minimal cellular functions to sustain a bacterial cell. | 2009 Nov 28 |
|
| Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population. | 2009 Oct |
|
| Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex. | 2009 Sep |
|
| Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. | 2010 Dec 1 |
|
| 1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model. | 2010 Jul |
|
| Cannabinoids excite circadian clock neurons. | 2010 Jul 28 |
|
| Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship. | 2010 Mar 3 |
|
| Molecular and cellular mechanisms of excitotoxic neuronal death. | 2010 Nov |
Sample Use Guides
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 23:44:43 UTC 2023
by
admin
on
Wed Jul 05 23:44:43 UTC 2023
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| Record UNII |
C3C196L9FG
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| Record Status |
Validated (UNII)
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M7612
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SUB43582
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C3C196L9FG
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100000087834
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C45678
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C82289
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| Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
