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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.Na.H
Molecular Weight 169.1111
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOSODIUM GLUTAMATE ANHYDROUS

SMILES

[H+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O

InChI

InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H8NO4
Molecular Weight 146.1213
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots.
2001
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
2001
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.
2001 Mar 2
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
2002 Mar 29
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.
2002 Nov 1
FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10.
2003
Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells.
2003 Jul
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents.
2003 Nov
[Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication].
2003 Sep-Oct
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.
2004 Apr
Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit.
2004 Apr 15
Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats.
2004 Apr 16
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
2004 Apr 23
RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts.
2004 Dec 3
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures.
2004 Jul
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
2004 Mar 31
Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.
2004 Nov
The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli.
2004 Nov
Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage.
2005 Dec
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2005 Oct 15
Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission.
2005 Sep
Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb.
2005 Sep
Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations.
2006 May 1
Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.
2006 Nov
The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory.
2006 Nov
Binding and complementary expression patterns of semaphorin 3E and plexin D1 in the mature neocortices of mice and monkeys.
2006 Nov 10
Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus.
2006 Sep 21
Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2.
2007 Nov
[Methods of taste sensitivity examination].
2008
Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium.
2008 Aug 18
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.
2008 Dec
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
2008 Jul
Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
2008 Sep 15
Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model.
2009 Aug
Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity.
2009 Aug
Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.
2009 Aug
Computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from Camellia sinensis (L.) O. Kuntze.
2009 Dec
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
2009 Dec 23
Receptors and transduction of umami taste stimuli.
2009 Jul
Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.
2009 Jun
An evaluation of minimal cellular functions to sustain a bacterial cell.
2009 Nov 28
Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population.
2009 Oct
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.
2009 Sep
On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases.
2010 Jan 8
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model.
2010 Jul
Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension.
2010 Jul-Aug
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.
2010 Jun 26
Molecular and cellular mechanisms of excitotoxic neuronal death.
2010 Nov
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:24:20 GMT 2025
Edited
by admin
on Mon Mar 31 18:24:20 GMT 2025
Record UNII
C3C196L9FG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOSODIUM GLUTAMATE ANHYDROUS
Common Name English
GLUTAMATE SODIUM
WHO-DD  
Preferred Name English
MONOSODIUM GLUTAMATE [MI]
Common Name English
GLUTAVENE
Code English
L-GLUTAMIC ACID, SODIUM SALT (1:1)
Common Name English
FEMA NO. 2756
Code English
NSC-135529
Code English
SODIUM L-GLUTAMATE
Systematic Name English
L-GLUTAMIC ACID, MONOSODIUM SALT
Common Name English
Glutamate sodium [WHO-DD]
Common Name English
SODIUM GLUTAMATE [HSDB]
Common Name English
ANCOMA
Brand Name English
MONOSODIUM GLUTAMATE [FHFI]
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID9020906
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
MERCK INDEX
m7612
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY Merck Index
CHEBI
64243
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
CAS
142-47-2
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
NSC
135529
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
PUBCHEM
23672308
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
EVMPD
SUB43582
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
FDA UNII
C3C196L9FG
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
SMS_ID
100000087834
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
CONCEPT Industrial Aid
DAILYMED
C3C196L9FG
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
RXCUI
1313974
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY RxNorm
NCI_THESAURUS
C82289
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
ChEMBL
CHEMBL2107256
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
ECHA (EC/EINECS)
205-538-1
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
HSDB
580
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
EVMPD
SUB69731
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
EVMPD
SUB20604
Created by admin on Mon Mar 31 18:24:20 GMT 2025 , Edited by admin on Mon Mar 31 18:24:20 GMT 2025
PRIMARY
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY