Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C5H7NO4.Na.H |
Molecular Weight | 169.1111 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O
InChI
InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C5H7NO4 |
Molecular Weight | 145.1134 |
Charge | -2 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | H |
Molecular Weight | 1.0079 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.drugbank.ca/drugs/DB00142Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Sources: https://www.drugbank.ca/drugs/DB00142
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10812962 |
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Target ID: CHEMBL2109241 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2552114 |
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Target ID: CHEMBL2096670 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10812962 |
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Target ID: CHEMBL3772 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9131252 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Palliative | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots. | 2001 |
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Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. | 2001 |
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Cooperative helix stabilization by complex Arg-Glu salt bridges. | 2001 Aug 1 |
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Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes. | 2001 Mar 2 |
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Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase. | 2001 Sep |
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Interaction between vanilloid and glutamate receptors in the central modulation of nociception. | 2002 Mar 29 |
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GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents. | 2003 Nov |
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[Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication]. | 2003 Sep-Oct |
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Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination. | 2004 |
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Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit. | 2004 Apr 15 |
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Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough. | 2004 Nov |
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The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli. | 2004 Nov |
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Nonsense-mediated mRNA decay mutation in Aspergillus nidulans. | 2006 Nov |
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Neuro-bioenergetic concepts in cancer prevention and treatment. | 2007 |
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Lidocaine: neurobiological targets and effects on the auditory system. | 2007 |
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Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex. | 2007 Dec |
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Comprehensive gene expression analysis in bipolar disorder. | 2007 Dec |
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(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. | 2008 Aug 15 |
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Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. | 2008 Jul |
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Calculation of the isoelectric point of tryptic peptides in the pH 3.5-4.5 range based on adjacent amino acid effects. | 2008 Jul |
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Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. | 2008 Sep 15 |
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Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. | 2009 |
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Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
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Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. | 2009 Jul |
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Excitatory neurotransmitters in brain regions in interictal migraine patients. | 2009 Jun 30 |
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An evaluation of minimal cellular functions to sustain a bacterial cell. | 2009 Nov 28 |
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Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population. | 2009 Oct |
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Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex. | 2009 Sep |
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Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. | 2010 Dec 1 |
|
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model. | 2010 Jul |
|
Cannabinoids excite circadian clock neurons. | 2010 Jul 28 |
|
Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship. | 2010 Mar 3 |
|
Molecular and cellular mechanisms of excitotoxic neuronal death. | 2010 Nov |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11724641
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2552114
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 23:44:43 UTC 2023
by
admin
on
Wed Jul 05 23:44:43 UTC 2023
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Record UNII |
C3C196L9FG
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Record Status |
Validated (UNII)
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Record Version |
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M7612
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C3C196L9FG
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100000087834
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C45678
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1313974
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C82289
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Related Record | Type | Details | ||
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |