Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H7NO4.Na.H |
| Molecular Weight | 169.1111 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O
InChI
InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C5H7NO4 |
| Molecular Weight | 145.1134 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H |
| Molecular Weight | 1.0079 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094124 |
|||
Target ID: CHEMBL2109241 |
|||
Target ID: CHEMBL2096670 |
|||
Target ID: CHEMBL3772 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Palliative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots. | 2001 |
|
| Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome. | 2001 |
|
| Mechanisms of neurodegeneration in amyotrophic lateral sclerosis. | 2001 Dec |
|
| Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons. | 2002 Jul-Aug |
|
| Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. | 2002 Nov 1 |
|
| Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells. | 2003 Jul |
|
| [Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication]. | 2003 Sep-Oct |
|
| Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination. | 2004 |
|
| Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. | 2004 Apr |
|
| Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit. | 2004 Apr 15 |
|
| Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats. | 2004 Apr 16 |
|
| The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. | 2004 Apr 23 |
|
| Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures. | 2004 Jul |
|
| Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina. | 2004 Mar 31 |
|
| Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough. | 2004 Nov |
|
| Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta). | 2005 Aug 15 |
|
| Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage. | 2005 Dec |
|
| Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells. | 2005 Oct 15 |
|
| Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb. | 2005 Sep |
|
| Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations. | 2006 May 1 |
|
| The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory. | 2006 Nov |
|
| Neuro-bioenergetic concepts in cancer prevention and treatment. | 2007 |
|
| The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter. | 2007 Apr 20 |
|
| Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. | 2007 Apr 6 |
|
| [Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail]. | 2007 Oct |
|
| Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. | 2008 |
|
| [Methods of taste sensitivity examination]. | 2008 |
|
| Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. | 2008 Dec |
|
| EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity. | 2008 Jan 8 |
|
| Calculation of the isoelectric point of tryptic peptides in the pH 3.5-4.5 range based on adjacent amino acid effects. | 2008 Jul |
|
| Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. | 2008 Sep 15 |
|
| [Epileptic seizures in critically ill patients]. | 2009 |
|
| Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. | 2009 |
|
| Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
|
| Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. | 2009 Dec 23 |
|
| Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. | 2009 Jan 5 |
|
| Receptors and transduction of umami taste stimuli. | 2009 Jul |
|
| Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China. | 2009 May 14 |
|
| Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. | 2009 May 22 |
|
| A role for Melanin-Concentrating Hormone in learning and memory. | 2009 Nov |
|
| An evaluation of minimal cellular functions to sustain a bacterial cell. | 2009 Nov 28 |
|
| Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. | 2009 Oct |
|
| Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population. | 2009 Oct |
|
| Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure. | 2009 Oct |
|
| Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex. | 2009 Sep |
|
| Fibulin 5 forms a compact dimer in physiological solutions. | 2009 Sep 18 |
|
| Hippocampal mossy fiber synaptic transmission and its modulation. | 2010 |
|
| On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases. | 2010 Jan 8 |
|
| Cannabinoids excite circadian clock neurons. | 2010 Jul 28 |
|
| Gabapentin suppresses cortical spreading depression susceptibility. | 2010 Sep |
Sample Use Guides
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:17:44 UTC 2023
by
admin
on
Fri Dec 15 16:17:44 UTC 2023
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| Record UNII |
C3C196L9FG
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID9020906
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m7612
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64243
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SUB43582
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C3C196L9FG
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100000087834
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C45678
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C3C196L9FG
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1313974
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C82289
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CHEMBL2107256
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
