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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.Na.H
Molecular Weight 169.1111
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOSODIUM GLUTAMATE ANHYDROUS

SMILES

[H+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O

InChI

InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H7NO4
Molecular Weight 145.1134
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots.
2001
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
2001
Cooperative helix stabilization by complex Arg-Glu salt bridges.
2001 Aug 1
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.
2001 Mar 2
Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase.
2001 Sep
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
2002 Mar 29
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents.
2003 Nov
[Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication].
2003 Sep-Oct
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit.
2004 Apr 15
Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.
2004 Nov
The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli.
2004 Nov
Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.
2006 Nov
Neuro-bioenergetic concepts in cancer prevention and treatment.
2007
Lidocaine: neurobiological targets and effects on the auditory system.
2007
Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex.
2007 Dec
Comprehensive gene expression analysis in bipolar disorder.
2007 Dec
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells.
2008 Aug 15
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
2008 Jul
Calculation of the isoelectric point of tryptic peptides in the pH 3.5-4.5 range based on adjacent amino acid effects.
2008 Jul
Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
2008 Sep 15
Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis.
2009
Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model.
2009 Aug
Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death.
2009 Jul
Excitatory neurotransmitters in brain regions in interictal migraine patients.
2009 Jun 30
An evaluation of minimal cellular functions to sustain a bacterial cell.
2009 Nov 28
Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population.
2009 Oct
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.
2009 Sep
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage.
2010 Dec 1
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model.
2010 Jul
Cannabinoids excite circadian clock neurons.
2010 Jul 28
Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship.
2010 Mar 3
Molecular and cellular mechanisms of excitotoxic neuronal death.
2010 Nov
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:44:43 UTC 2023
Edited
by admin
on Wed Jul 05 23:44:43 UTC 2023
Record UNII
C3C196L9FG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOSODIUM GLUTAMATE ANHYDROUS
Common Name English
MONOSODIUM GLUTAMATE [MI]
Common Name English
GLUTAVENE
Code English
L-GLUTAMIC ACID, SODIUM SALT (1:1)
Common Name English
FEMA NO. 2756
Code English
NSC-135529
Code English
SODIUM L-GLUTAMATE
Systematic Name English
L-GLUTAMIC ACID, MONOSODIUM SALT
Common Name English
Glutamate sodium [WHO-DD]
Common Name English
SODIUM GLUTAMATE [HSDB]
Common Name English
ANCOMA
Brand Name English
MONOSODIUM GLUTAMATE [FHFI]
Common Name English
GLUTAMATE SODIUM
WHO-DD  
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID9020906
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
MERCK INDEX
M7612
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY Merck Index
CHEBI
64243
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
CAS
142-47-2
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
NSC
135529
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
PUBCHEM
23672308
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
EVMPD
SUB43582
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
FDA UNII
C3C196L9FG
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
SMS_ID
100000087834
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
CONCEPT Industrial Aid
DAILYMED
C3C196L9FG
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
RXCUI
1313974
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY RxNorm
NCI_THESAURUS
C82289
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
ChEMBL
CHEMBL2107256
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
ECHA (EC/EINECS)
205-538-1
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
HSDB
580
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
EVMPD
SUB69731
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
EVMPD
SUB20604
Created by admin on Wed Jul 05 23:44:43 UTC 2023 , Edited by admin on Wed Jul 05 23:44:43 UTC 2023
PRIMARY
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY