Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H7NO4.Na.H |
| Molecular Weight | 169.1111 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O
InChI
InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C5H7NO4 |
| Molecular Weight | 145.1134 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H |
| Molecular Weight | 1.0079 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094124 |
|||
Target ID: CHEMBL2109241 |
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Target ID: CHEMBL2096670 |
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Target ID: CHEMBL3772 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
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| Palliative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation. | 2001 Nov 2 |
|
| Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. | 2001 Sep |
|
| FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. | 2003 |
|
| Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells. | 2003 Jul |
|
| Cellular and molecular mechanisms in environmental and occupational inhalation toxicology. | 2004 |
|
| Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit. | 2004 Apr 15 |
|
| The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. | 2004 Apr 23 |
|
| Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough. | 2004 Nov |
|
| Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells. | 2005 Oct 15 |
|
| Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb. | 2005 Sep |
|
| Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations. | 2006 May 1 |
|
| Nonsense-mediated mRNA decay mutation in Aspergillus nidulans. | 2006 Nov |
|
| Lidocaine: neurobiological targets and effects on the auditory system. | 2007 |
|
| Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. | 2007 Apr 6 |
|
| Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. | 2007 Nov |
|
| Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia. | 2007 Oct |
|
| [Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail]. | 2007 Oct |
|
| Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. | 2008 |
|
| Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. | 2008 Dec |
|
| EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity. | 2008 Jan 8 |
|
| Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. | 2008 Jul |
|
| Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins. | 2009 Aug |
|
| Excitatory neurotransmitters in brain regions in interictal migraine patients. | 2009 Jun 30 |
|
| Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure. | 2009 Oct |
|
| Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex. | 2009 Sep |
|
| Fibulin 5 forms a compact dimer in physiological solutions. | 2009 Sep 18 |
|
| Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations. | 2009 Sep 8 |
|
| Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. | 2010 Dec 1 |
|
| Cannabinoids excite circadian clock neurons. | 2010 Jul 28 |
|
| Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship. | 2010 Mar 3 |
|
| Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells. | 2010 May 28 |
Sample Use Guides
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:17:44 GMT 2023
by
admin
on
Fri Dec 15 16:17:44 GMT 2023
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| Record UNII |
C3C196L9FG
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| Record Status |
Validated (UNII)
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m7612
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SUB43582
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C3C196L9FG
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100000087834
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C45678
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1313974
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C82289
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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SOLVATE->ANHYDROUS | |||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |
