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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.Na.H
Molecular Weight 169.1111
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOSODIUM GLUTAMATE ANHYDROUS

SMILES

[H+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O

InChI

InChIKey=LPUQAYUQRXPFSQ-DFWYDOINSA-M
InChI=1S/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H7NO4
Molecular Weight 145.1134
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.
2001 Dec
Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation.
2001 Nov 2
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
2002 Mar 29
Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
2003
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents.
2003 Nov
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats.
2004 Apr 16
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
2004 Apr 23
RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts.
2004 Dec 3
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures.
2004 Jul
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
2004 Mar 31
Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.
2004 Nov
The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli.
2004 Nov
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2005 Oct 15
Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb.
2005 Sep
Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations.
2006 May 1
Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.
2006 Nov
Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus.
2006 Sep 21
Neuro-bioenergetic concepts in cancer prevention and treatment.
2007
The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter.
2007 Apr 20
Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex.
2007 Dec
Comprehensive gene expression analysis in bipolar disorder.
2007 Dec
Alanine aminotransferase catalyses the breakdown of alanine after hypoxia in Arabidopsis thaliana.
2007 Mar
[Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail].
2007 Oct
[Methods of taste sensitivity examination].
2008
Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glucocorticoids.
2008
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells.
2008 Aug 15
Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium.
2008 Aug 18
EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity.
2008 Jan 8
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
2008 Jul
Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
2008 Sep 15
Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis.
2009
Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model.
2009 Aug
Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity.
2009 Aug
Computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from Camellia sinensis (L.) O. Kuntze.
2009 Dec
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
2009 Dec 14
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
2009 Dec 23
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.
2009 May 22
A role for Melanin-Concentrating Hormone in learning and memory.
2009 Nov
Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population.
2009 Oct
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.
2009 Sep
Hippocampal mossy fiber synaptic transmission and its modulation.
2010
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage.
2010 Dec 1
Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
2010 Feb 10
On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases.
2010 Jan 8
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model.
2010 Jul
Cannabinoids excite circadian clock neurons.
2010 Jul 28
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.
2010 Jun 26
Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells.
2010 May 28
Gabapentin suppresses cortical spreading depression susceptibility.
2010 Sep
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:17:44 GMT 2023
Edited
by admin
on Fri Dec 15 16:17:44 GMT 2023
Record UNII
C3C196L9FG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOSODIUM GLUTAMATE ANHYDROUS
Common Name English
MONOSODIUM GLUTAMATE [MI]
Common Name English
GLUTAVENE
Code English
L-GLUTAMIC ACID, SODIUM SALT (1:1)
Common Name English
FEMA NO. 2756
Code English
NSC-135529
Code English
SODIUM L-GLUTAMATE
Systematic Name English
L-GLUTAMIC ACID, MONOSODIUM SALT
Common Name English
Glutamate sodium [WHO-DD]
Common Name English
SODIUM GLUTAMATE [HSDB]
Common Name English
ANCOMA
Brand Name English
MONOSODIUM GLUTAMATE [FHFI]
Common Name English
GLUTAMATE SODIUM
WHO-DD  
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID9020906
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
MERCK INDEX
m7612
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY Merck Index
CHEBI
64243
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
CAS
142-47-2
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
NSC
135529
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
PUBCHEM
23672308
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
EVMPD
SUB43582
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
FDA UNII
C3C196L9FG
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
SMS_ID
100000087834
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
CONCEPT Industrial Aid
DAILYMED
C3C196L9FG
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
RXCUI
1313974
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY RxNorm
NCI_THESAURUS
C82289
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107256
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-538-1
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
HSDB
580
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
EVMPD
SUB69731
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
EVMPD
SUB20604
Created by admin on Fri Dec 15 16:17:44 GMT 2023 , Edited by admin on Fri Dec 15 16:17:44 GMT 2023
PRIMARY
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY