U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 19:54:58 GMT 2023
Edited
by admin
on Sat Dec 16 19:54:58 GMT 2023
Protein Type TRANSPORTER
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
68ZV6GS9MH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Cystine-glutamate antiporter system
Common Name English
Cystine/glutamate transporter-4F2 cell-surface antigen heavy chain complex
Common Name English
Code System Code Type Description
UNIPROT
Q9UPY5
Created by admin on Sat Dec 16 19:54:58 GMT 2023 , Edited by admin on Sat Dec 16 19:54:58 GMT 2023
PRIMARY
FDA UNII
68ZV6GS9MH
Created by admin on Sat Dec 16 19:54:58 GMT 2023 , Edited by admin on Sat Dec 16 19:54:58 GMT 2023
PRIMARY
UNIPROT
P08195
Created by admin on Sat Dec 16 19:54:58 GMT 2023 , Edited by admin on Sat Dec 16 19:54:58 GMT 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_365
N 1_381
N 1_424
N 1_506
N 2_314
Related Record Type Details
SUBSTRATE -> TRANSPORTER
Natural substrate transports glutamate out of cell.
INHIBITOR -> TARGET
Reduces the amount of glutathione in cells which leads to ferroptosis. Mechanism assumed to be same as erastin.
INHIBITOR -> TARGET
SUBSTRATE -> TRANSPORTER
Natural substrate for transporter responsible for enhancing the synthesis of GSH by bringing cystine into cell. Inhibition leads ferroptosis.
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL