Cystine-glutamate antiporter system

Approval Year

Substance Class	Protein
Protein Type	TRANSPORTER
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	68ZV6GS9MH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Cystine-glutamate antiporter system

Common Name

English

Cystine/glutamate transporter-4F2 cell-surface antigen heavy chain complex

Common Name

English

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Code System

Code

Type

Description

UNIPROT

Q9UPY5

PRIMARY

FDA UNII

68ZV6GS9MH

PRIMARY

UNIPROT

P08195

PRIMARY

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Subunit 0

Subunit 1

Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_365
N	1_381
N	1_424
N	1_506
N	2_314

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Related Record

Type

Details


					3KX376GY7L

GLUTAMIC ACID

SUBSTRATE -> TRANSPORTER

Comments:

Natural substrate transports glutamate out of cell.

Amount:


					E6999JX933

PRLX-93936

INHIBITOR -> TARGET

Comments:

Reduces the amount of glutathione in cells which leads to ferroptosis. Mechanism assumed to be same as erastin.

Amount:


					3XC8GUZ6CB

SULFASALAZINE

INHIBITOR -> TARGET

Amount:


					48TCX9A1VT

CYSTINE

SUBSTRATE -> TRANSPORTER

Comments:

Natural substrate for transporter responsible for enhancing the synthesis of GSH by bringing cystine into cell. Inhibition leads ferroptosis.

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C5621H8829N1440O1603S36
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 123417.364 Da (average)

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