Cystine-glutamate antiporter system

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:42:44 GMT 2025` Edited by `admin` on `Wed Apr 02 17:42:44 GMT 2025`
Protein Type	TRANSPORTER
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	68ZV6GS9MH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Cystine-glutamate antiporter system

Common Name

English

Cystine/glutamate transporter-4F2 cell-surface antigen heavy chain complex

Preferred Name

English

Code System Code Type Description

UNIPROT

Q9UPY5

Created by admin on Wed Apr 02 17:42:44 GMT 2025 , Edited by admin on Wed Apr 02 17:42:44 GMT 2025

PRIMARY

FDA UNII

68ZV6GS9MH

Created by admin on Wed Apr 02 17:42:44 GMT 2025 , Edited by admin on Wed Apr 02 17:42:44 GMT 2025

PRIMARY

UNIPROT

P08195

Created by admin on Wed Apr 02 17:42:44 GMT 2025 , Edited by admin on Wed Apr 02 17:42:44 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_365
N	1_381
N	1_424
N	1_506
N	2_314

Related Record Type Details


					3KX376GY7L

Glutamic Acid

SUBSTRATE -> TRANSPORTER

Comments:

Natural substrate transports glutamate out of cell.

Amount:


					E6999JX933

PRLX-93936

INHIBITOR -> TARGET

Comments:

Reduces the amount of glutathione in cells which leads to ferroptosis. Mechanism assumed to be same as erastin.

Amount:


					3XC8GUZ6CB

Sulfasalazine

INHIBITOR -> TARGET

Amount:


					48TCX9A1VT

CYSTINE

SUBSTRATE -> TRANSPORTER

Comments:

Natural substrate for transporter responsible for enhancing the synthesis of GSH by bringing cystine into cell. Inhibition leads ferroptosis.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1]				N-ACETYLMETHIONINE	9J12WX5B6A

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL