Cystine-glutamate antiporter system

Substance Class	Protein Created by `admin` on `Sat Dec 16 19:54:58 UTC 2023` Edited by `admin` on `Sat Dec 16 19:54:58 UTC 2023`
Protein Type	TRANSPORTER
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	68ZV6GS9MH
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

Common Name

English

Cystine/glutamate transporter-4F2 cell-surface antigen heavy chain complex

Common Name

English

Code System Code Type Description

UNIPROT

Q9UPY5

Created by admin on Sat Dec 16 19:54:58 UTC 2023 , Edited by admin on Sat Dec 16 19:54:58 UTC 2023

PRIMARY

FDA UNII

68ZV6GS9MH

Created by admin on Sat Dec 16 19:54:58 UTC 2023 , Edited by admin on Sat Dec 16 19:54:58 UTC 2023

PRIMARY

UNIPROT

P08195

Created by admin on Sat Dec 16 19:54:58 UTC 2023 , Edited by admin on Sat Dec 16 19:54:58 UTC 2023

PRIMARY

Glycosylation Type

HUMAN

Related Record Type Details


					3KX376GY7L

SUBSTRATE -> TRANSPORTER

Comments:

Natural substrate transports glutamate out of cell.

Amount:


					E6999JX933

INHIBITOR -> TARGET

Comments:

Reduces the amount of glutathione in cells which leads to ferroptosis. Mechanism assumed to be same as erastin.

Amount:


					3XC8GUZ6CB

INHIBITOR -> TARGET

Amount:


					48TCX9A1VT

CYSTINE

SUBSTRATE -> TRANSPORTER

Comments:

Natural substrate for transporter responsible for enhancing the synthesis of GSH by bringing cystine into cell. Inhibition leads ferroptosis.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL