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Details

Stereochemistry ABSOLUTE
Molecular Formula C6H14N4O2.C5H9NO4
Molecular Weight 321.3302
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ARGININE GLUTAMATE

SMILES

N[C@@H](CCC(O)=O)C(O)=O.N[C@@H](CCCNC(N)=N)C(O)=O

InChI

InChIKey=RVEWUBJVAHOGKA-WOYAITHZSA-N
InChI=1S/C6H14N4O2.C5H9NO4/c7-4(5(11)12)2-1-3-10-6(8)9;6-3(5(9)10)1-2-4(7)8/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);3H,1-2,6H2,(H,7,8)(H,9,10)/t4-;3-/m00/s1

HIDE SMILES / InChI

Molecular Formula C6H14N4O2
Molecular Weight 174.201
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula C5H9NO4
Molecular Weight 147.1293
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

L-arginine is a nonessential amino acid that may play an important role in the treatment of cardiovascular disease due to its antiatherogenic, anti-ischemic, antiplatelet, and antithrombotic properties. It has been promoted as a growth stimulant and as a treatment for erectile dysfunction in men. L-arginine is a nonessential amino acid that may play an important role in the treatment of heart disease due to its block arterial plaque buildup, blood clots, platelet clumping, and to increase blood flow through the coronary artery. L-arginine is commonly sold as a health supplement claiming to improve vascular health and treat erectile dysfunction in men. L-arginine, which is promoted as a human growth stimulant, has also been used in bodybuilding. In the 1800s, it was first isolated from animal horn.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
44.1 µM [EC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
R-GENE 10
Diagnostic
R-GENE 10
Diagnostic
R-GENE 10
Diagnostic
R-GENE 10
Preventing
Unknown
Preventing
Unknown
Primary
Unknown

Cmax

ValueDoseCo-administeredAnalytePopulation
310 μM
6 g single, oral
ARGININE plasma
Homo sapiens
6219 μM
30 g single, intravenous
ARGININE plasma
Homo sapiens
882 μM
6 g single, intravenous
ARGININE plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
24788 M × min
6 g single, oral
ARGININE plasma
Homo sapiens
265435 M × min
30 g single, intravenous
ARGININE plasma
Homo sapiens
38223 M × min
6 g single, intravenous
ARGININE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
77.5 min
6 g single, oral
ARGININE plasma
Homo sapiens
41.6 min
30 g single, intravenous
ARGININE plasma
Homo sapiens
59.6 min
6 g single, intravenous
ARGININE plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
100%
ARGININE plasma
Homo sapiens

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
L-arginine has been studied at oral doses of 6 to 30 g/day for a variety of conditions. Many formulations have been used.
Route of Administration: Oral
In Vitro Use Guide
A strong inward current in X. laevis oocytes expressing 5.24 (C terminus of the homologous goldfish 5.24 receptor) when L-Arg (L-arginine) was applied at 10 uM. When testing chimera h6A/5.24 (h6A/5.24, containing the ligand binding amino-terminal domain (ATD) of hGPRC6A with the signal transducing transmembrane and C terminus of the homologous goldfish 5.24 receptor) in this system, the responses were obtained with L-Arg at 100 uM.
Substance Class Chemical
Record UNII
TU1X77K34Q
Record Status Validated (UNII)
Record Version