Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H7NO4.Na.H.H2O |
| Molecular Weight | 187.1264 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].O.[Na+].N[C@@H](CCC([O-])=O)C([O-])=O
InChI
InChIKey=GJBHGUUFMNITCI-QTNFYWBSSA-M
InChI=1S/C5H9NO4.Na.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C5H7NO4 |
| Molecular Weight | 145.1134 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | H |
| Molecular Weight | 1.0079 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094124 |
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Target ID: CHEMBL2109241 |
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Target ID: CHEMBL2096670 |
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Target ID: CHEMBL3772 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
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| Palliative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. | 2001 Apr 6 |
|
| Mechanisms of neurodegeneration in amyotrophic lateral sclerosis. | 2001 Dec |
|
| Interaction between vanilloid and glutamate receptors in the central modulation of nociception. | 2002 Mar 29 |
|
| Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. | 2002 Nov 1 |
|
| FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. | 2003 |
|
| Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. | 2003 |
|
| Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells. | 2003 Jul |
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| GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents. | 2003 Nov |
|
| Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination. | 2004 |
|
| Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit. | 2004 Apr 15 |
|
| Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats. | 2004 Apr 16 |
|
| The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. | 2004 Apr 23 |
|
| Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina. | 2004 Mar 31 |
|
| Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough. | 2004 Nov |
|
| The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli. | 2004 Nov |
|
| Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage. | 2005 Dec |
|
| Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells. | 2005 Oct 15 |
|
| Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission. | 2005 Sep |
|
| Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb. | 2005 Sep |
|
| Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations. | 2006 May 1 |
|
| The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory. | 2006 Nov |
|
| Lidocaine: neurobiological targets and effects on the auditory system. | 2007 |
|
| Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. | 2007 Apr 6 |
|
| Comprehensive gene expression analysis in bipolar disorder. | 2007 Dec |
|
| Alanine aminotransferase catalyses the breakdown of alanine after hypoxia in Arabidopsis thaliana. | 2007 Mar |
|
| Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia. | 2007 Oct |
|
| [Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail]. | 2007 Oct |
|
| Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. | 2008 |
|
| [Methods of taste sensitivity examination]. | 2008 |
|
| Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glucocorticoids. | 2008 |
|
| (-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. | 2008 Aug 15 |
|
| Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium. | 2008 Aug 18 |
|
| Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. | 2008 Dec |
|
| EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity. | 2008 Jan 8 |
|
| Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. | 2008 Jul |
|
| Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. | 2008 Sep 15 |
|
| [Epileptic seizures in critically ill patients]. | 2009 |
|
| Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
|
| Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. | 2009 Dec 23 |
|
| Transcript and proteomic analysis of developing white lupin (Lupinus albus L.) roots. | 2009 Jan 5 |
|
| Receptors and transduction of umami taste stimuli. | 2009 Jul |
|
| Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats. | 2009 Jun |
|
| Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China. | 2009 May 14 |
|
| Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. | 2009 May 22 |
|
| A role for Melanin-Concentrating Hormone in learning and memory. | 2009 Nov |
|
| Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex. | 2009 Sep |
|
| Fibulin 5 forms a compact dimer in physiological solutions. | 2009 Sep 18 |
|
| Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists. | 2010 Feb 10 |
|
| Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. | 2010 Jun 26 |
|
| Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells. | 2010 May 28 |
Sample Use Guides
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:39:02 GMT 2023
by
admin
on
Fri Dec 15 15:39:02 GMT 2023
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| Record UNII |
W81N5U6R6U
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| Record Status |
Validated (UNII)
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| Record Version |
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JECFA EVALUATION |
INS-621
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DSLD |
2181 (Number of products:2)
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CODEX ALIMENTARIUS (GSFA) |
INS-621
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64243
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D012970
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23666328
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C82288
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W81N5U6R6U
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6106-04-3
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64220
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SUB21151
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SUB21636
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SUB20604
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1446600
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CHEMBL2106738
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C45678
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CONCEPT | Industrial Aid | ||
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MONOSODIUM GLUTAMATE
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SUB49895
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DTXSID0047240
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W81N5U6R6U
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1311588
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100000130222
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE | |||
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ANHYDROUS->SOLVATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> IMPURITY |
USP
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |