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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.Na.H.H2O
Molecular Weight 187.1264
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOSODIUM GLUTAMATE

SMILES

[H+].O.[Na+].N[C@@H](CCC([O-])=O)C([O-])=O

InChI

InChIKey=GJBHGUUFMNITCI-QTNFYWBSSA-M
InChI=1S/C5H9NO4.Na.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H7NO4
Molecular Weight 145.1134
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots.
2001
Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation.
2001 Nov 2
Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase.
2001 Sep
Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion.
2002 Mar
Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells.
2003 Jul
[Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication].
2003 Sep-Oct
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures.
2004 Jul
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
2004 Mar 31
Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta).
2005 Aug 15
Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage.
2005 Dec
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2005 Oct 15
Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb.
2005 Sep
Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations.
2006 May 1
Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.
2006 Nov
The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory.
2006 Nov
Binding and complementary expression patterns of semaphorin 3E and plexin D1 in the mature neocortices of mice and monkeys.
2006 Nov 10
Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus.
2006 Sep 21
Neuro-bioenergetic concepts in cancer prevention and treatment.
2007
Lidocaine: neurobiological targets and effects on the auditory system.
2007
The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter.
2007 Apr 20
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.
2007 Apr 6
Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex.
2007 Dec
Comprehensive gene expression analysis in bipolar disorder.
2007 Dec
Alanine aminotransferase catalyses the breakdown of alanine after hypoxia in Arabidopsis thaliana.
2007 Mar
Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2.
2007 Nov
Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia.
2007 Oct
[Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail].
2007 Oct
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation.
2008
[Methods of taste sensitivity examination].
2008
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells.
2008 Aug 15
Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium.
2008 Aug 18
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.
2008 Dec
EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity.
2008 Jan 8
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
2008 Jul
Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
2008 Sep 15
Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis.
2009
Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.
2009 Aug
Computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from Camellia sinensis (L.) O. Kuntze.
2009 Dec
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
2009 Dec 23
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.
2009 May 22
A role for Melanin-Concentrating Hormone in learning and memory.
2009 Nov
Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population.
2009 Oct
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.
2009 Sep
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage.
2010 Dec 1
A biologically plausible model of time-scale invariant interval timing.
2010 Feb
Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.
2010 Feb 10
Cannabinoids excite circadian clock neurons.
2010 Jul 28
Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship.
2010 Mar 3
Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.
2010 Oct 1
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Wed Jul 05 23:08:13 UTC 2023
Edited
by admin
on Wed Jul 05 23:08:13 UTC 2023
Record UNII
W81N5U6R6U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOSODIUM GLUTAMATE
USP-RS   VANDF  
Systematic Name English
MONOSODIUM L-GLUTAMATE
FCC  
Systematic Name English
INS-621
Code English
SODIUM GLUTAMATE [INCI]
Common Name English
INS NO.621
Code English
CHINESE SEASONING
Common Name English
SODIUM GLUTAMATE
INCI  
INCI  
Official Name English
RL-50
Code English
MSG
Common Name English
SODIUM L-GLUTAMATE HYDRATE
JAN  
Systematic Name English
MONOSODIUM GLUTAMATE [USP-RS]
Common Name English
SODIUM L-GLUTAMATE HYDRATE [JAN]
Common Name English
MONOSODIUM GLUTAMATE MONOHYDRATE
Systematic Name English
MONOSODIUM L-GLUTAMATE [FCC]
Common Name English
E-621
Code English
B1652 [LANGUAL]
Code English
MONOSODIUM GLUTAMATE [VANDF]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-621
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
DSLD 2181 (Number of products:2)
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
CODEX ALIMENTARIUS (GSFA) INS-621
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
Code System Code Type Description
CHEBI
64243
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
MESH
D012970
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
PUBCHEM
23666328
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
NCI_THESAURUS
C82288
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
DAILYMED
W81N5U6R6U
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
CAS
6106-04-3
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
CHEBI
64220
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
EVMPD
SUB21151
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
EVMPD
SUB21636
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
EVMPD
SUB20604
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
RS_ITEM_NUM
1446600
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
ChEMBL
CHEMBL2106738
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
CONCEPT Industrial Aid
WIKIPEDIA
MONOSODIUM GLUTAMATE
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
JECFA MONOGRAPH
INS-621
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY CAS# 142-47-2 given in JECFA is for anhydrous form, not for mono hydrate form as called for in JECFA code.
EVMPD
SUB49895
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
EPA CompTox
DTXSID0047240
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
FDA UNII
W81N5U6R6U
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
RXCUI
1311588
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY RxNorm
SMS_ID
100000130222
Created by admin on Wed Jul 05 23:08:13 UTC 2023 , Edited by admin on Wed Jul 05 23:08:13 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE
Related Record Type Details
PARENT -> IMPURITY
USP
Related Record Type Details
ACTIVE MOIETY