U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.Na.H.H2O
Molecular Weight 187.1264
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOSODIUM GLUTAMATE

SMILES

[H+].O.[Na+].N[C@@H](CCC([O-])=O)C([O-])=O

InChI

InChIKey=GJBHGUUFMNITCI-QTNFYWBSSA-M
InChI=1S/C5H9NO4.Na.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H7NO4
Molecular Weight 145.1134
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H
Molecular Weight 1.0079
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cycling treatment of anaerobic and aerobic incubation increases the content of gamma-aminobutyric acid in tea shoots.
2001
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
2001
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.
2001 Dec
Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions.
2001 Dec
Calcium channels triggering transmitter release in the rat medial superior olive.
2001 Dec
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.
2001 Mar 2
Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation.
2001 Nov 2
Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons.
2002 Jul-Aug
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
2002 Mar 29
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.
2002 Nov 1
[Assessment of energy-dependent Ca2+ transport in myocardial mitochondria in the ventricular fibrillation: potential diagnostic implication].
2003 Sep-Oct
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Cellular and molecular mechanisms in environmental and occupational inhalation toxicology.
2004
RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts.
2004 Dec 3
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures.
2004 Jul
Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.
2004 Nov
Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta).
2005 Aug 15
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2005 Oct 15
Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission.
2005 Sep
The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory.
2006 Nov
Binding and complementary expression patterns of semaphorin 3E and plexin D1 in the mature neocortices of mice and monkeys.
2006 Nov 10
Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus.
2006 Sep 21
Neuro-bioenergetic concepts in cancer prevention and treatment.
2007
Lidocaine: neurobiological targets and effects on the auditory system.
2007
The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter.
2007 Apr 20
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.
2007 Apr 6
Alanine aminotransferase catalyses the breakdown of alanine after hypoxia in Arabidopsis thaliana.
2007 Mar
Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia.
2007 Oct
[Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail].
2007 Oct
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation.
2008
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells.
2008 Aug 15
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.
2008 Dec
Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.
2009 Aug
Computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from Camellia sinensis (L.) O. Kuntze.
2009 Dec
An evaluation of minimal cellular functions to sustain a bacterial cell.
2009 Nov 28
Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure.
2009 Oct
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.
2009 Sep
Fibulin 5 forms a compact dimer in physiological solutions.
2009 Sep 18
Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations.
2009 Sep 8
The functional organisation of glia in the adult brain of Drosophila and other insects.
2010 Apr
A biologically plausible model of time-scale invariant interval timing.
2010 Feb
On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases.
2010 Jan 8
Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells.
2010 May 28
Molecular and cellular mechanisms of excitotoxic neuronal death.
2010 Nov
Gabapentin suppresses cortical spreading depression susceptibility.
2010 Sep
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:39:02 GMT 2023
Edited
by admin
on Fri Dec 15 15:39:02 GMT 2023
Record UNII
W81N5U6R6U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOSODIUM GLUTAMATE
USP-RS   VANDF  
Systematic Name English
MONOSODIUM L-GLUTAMATE
FCC  
Systematic Name English
INS-621
Code English
SODIUM GLUTAMATE [INCI]
Common Name English
INS NO.621
Code English
CHINESE SEASONING
Common Name English
SODIUM GLUTAMATE
INCI  
INCI  
Official Name English
RL-50
Code English
MSG
Common Name English
SODIUM L-GLUTAMATE HYDRATE
JAN  
Systematic Name English
MONOSODIUM GLUTAMATE [USP-RS]
Common Name English
SODIUM L-GLUTAMATE HYDRATE [JAN]
Common Name English
MONOSODIUM GLUTAMATE MONOHYDRATE
Systematic Name English
MONOSODIUM L-GLUTAMATE [FCC]
Common Name English
E-621
Code English
B1652 [LANGUAL]
Code English
MONOSODIUM GLUTAMATE [VANDF]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-621
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
DSLD 2181 (Number of products:2)
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-621
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
Code System Code Type Description
CHEBI
64243
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
MESH
D012970
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
PUBCHEM
23666328
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
NCI_THESAURUS
C82288
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
DAILYMED
W81N5U6R6U
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
CAS
6106-04-3
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
CHEBI
64220
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
EVMPD
SUB21151
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
EVMPD
SUB21636
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
EVMPD
SUB20604
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
RS_ITEM_NUM
1446600
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106738
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
CONCEPT Industrial Aid
WIKIPEDIA
MONOSODIUM GLUTAMATE
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
EVMPD
SUB49895
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID0047240
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
FDA UNII
W81N5U6R6U
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
RXCUI
1311588
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY RxNorm
SMS_ID
100000130222
Created by admin on Fri Dec 15 15:39:02 GMT 2023 , Edited by admin on Fri Dec 15 15:39:02 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE
Related Record Type Details
PARENT -> IMPURITY
USP
Related Record Type Details
ACTIVE MOIETY