U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C5H9NO4.H3N
Molecular Weight 164.1598
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM GLUTAMATE

SMILES

N.N[C@@H](CCC(O)=O)C(O)=O

InChI

InChIKey=PHKGGXPMPXXISP-DFWYDOINSA-N
InChI=1S/C5H9NO4.H3N/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H3/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C5H9NO4
Molecular Weight 147.1293
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions.
2001 Dec
Calcium channels triggering transmitter release in the rat medial superior olive.
2001 Dec
Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
2003
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents.
2003 Nov
Cellular and molecular mechanisms in environmental and occupational inhalation toxicology.
2004
Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats.
2004 Apr 16
RNase-L regulates the stability of mitochondrial DNA-encoded mRNAs in mouse embryo fibroblasts.
2004 Dec 3
Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures.
2004 Jul
Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.
2004 Nov
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2005 Oct 15
Distribution of D2 dopamine receptor in the olfactory glomeruli of the rat olfactory bulb.
2005 Sep
Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations.
2006 May 1
Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.
2006 Nov
The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter.
2007 Apr 20
Comprehensive gene expression analysis in bipolar disorder.
2007 Dec
EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity.
2008 Jan 8
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
2008 Jul
Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
2008 Sep 15
Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model.
2009 Aug
Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.
2009 Aug
Computational structural analysis and kinetic studies of a cytosolic glutamine synthetase from Camellia sinensis (L.) O. Kuntze.
2009 Dec
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
2009 Dec 14
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.
2009 May 22
Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure.
2009 Oct
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.
2009 Sep
Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations.
2009 Sep 8
Hippocampal mossy fiber synaptic transmission and its modulation.
2010
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage.
2010 Dec 1
A biologically plausible model of time-scale invariant interval timing.
2010 Feb
On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases.
2010 Jan 8
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model.
2010 Jul
Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension.
2010 Jul-Aug
Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship.
2010 Mar 3
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:39:24 GMT 2023
Edited
by admin
on Fri Dec 15 18:39:24 GMT 2023
Record UNII
245K560GAW
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMMONIUM GLUTAMATE
Systematic Name English
E 624
Code English
MONOAMMONIUM GLUTAMATE
Systematic Name English
INS-624
Code English
MONOAMMONIUM L-GLUTAMATE [FCC]
Common Name English
MONOAMMONIUM L-GLUTAMATE
FCC  
Systematic Name English
MONOAMMONIUM L-GLUTAMATE MONOHYDRATE
Systematic Name English
INS NO.624
Code English
E-624
Code English
Classification Tree Code System Code
JECFA EVALUATION INS-624
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-624
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID3047714
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
PRIMARY
CAS
7558-63-6
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
PRIMARY
FDA UNII
245K560GAW
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
PRIMARY
CAS
25677-11-6
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
NON-SPECIFIC STOICHIOMETRY
PUBCHEM
23618774
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-447-1
Created by admin on Fri Dec 15 18:39:25 GMT 2023 , Edited by admin on Fri Dec 15 18:39:25 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
SOLVATE->ANHYDROUS