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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H9NO4.ClH
Molecular Weight 183.59
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUTAMIC ACID HYDROCHLORIDE

SMILES

Cl.N[C@@H](CCC(O)=O)C(O)=O

InChI

InChIKey=RPAJSBKBKSSMLJ-DFWYDOINSA-N
InChI=1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H9NO4
Molecular Weight 147.1293
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cooperative helix stabilization by complex Arg-Glu salt bridges.
2001 Aug 1
Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.
2001 Dec
Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions.
2001 Dec
Calcium channels triggering transmitter release in the rat medial superior olive.
2001 Dec
Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons.
2002 Jul-Aug
Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion.
2002 Mar
Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit.
2004 Apr 15
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
2004 Mar 31
Shewanella profunda sp. nov., isolated from deep marine sediment of the Nankai Trough.
2004 Nov
Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta).
2005 Aug 15
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2005 Oct 15
Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission.
2005 Sep
Lidocaine: neurobiological targets and effects on the auditory system.
2007
The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter.
2007 Apr 20
Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex.
2007 Dec
Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2.
2007 Nov
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation.
2008
Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glucocorticoids.
2008
Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium.
2008 Aug 18
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.
2008 Dec
[Epileptic seizures in critically ill patients].
2009
Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis.
2009
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
2009 Dec 23
Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population.
2009 Oct
Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure.
2009 Oct
Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations.
2009 Sep 8
Hippocampal mossy fiber synaptic transmission and its modulation.
2010
On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases.
2010 Jan 8
1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model.
2010 Jul
Cannabinoids excite circadian clock neurons.
2010 Jul 28
Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship.
2010 Mar 3
Molecular and cellular mechanisms of excitotoxic neuronal death.
2010 Nov
Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions.
2010 Nov 26
Gabapentin suppresses cortical spreading depression susceptibility.
2010 Sep
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:10:28 GMT 2023
Edited
by admin
on Fri Dec 15 16:10:28 GMT 2023
Record UNII
M0C2SP444T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUTAMIC ACID HYDROCHLORIDE
HSDB   II   MART.   MI   WHO-DD  
Systematic Name English
GLUTAMIC ACID HYDROCHLORIDE [MI]
Common Name English
GLUTAMIC ACID HYDROCHLORIDE [MART.]
Common Name English
L-GLUTAMIC ACID HYDROCHLORIDE
FCC   USP-RS  
Systematic Name English
L-GLUTAMIC ACID HYDROCHLORIDE [USP-RS]
Common Name English
GLUTAMIC ACID HYDROCHLORIDE [HSDB]
Common Name English
Glutamic acid hydrochloride [WHO-DD]
Common Name English
GLUTAMIC ACID HYDROCHLORIDE [II]
Common Name English
NSC-9239
Code English
GLUTAMIC ACID HCL
Common Name English
L-GLUTAMIC ACID HYDROCHLORIDE [FCC]
Common Name English
Classification Tree Code System Code
WHO-ATC A09AB01
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
WHO-VATC QA09AB01
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
CFR 21 CFR 310.540
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
CFR 21 CFR 172.320
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
NCI_THESAURUS C78276
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
Code System Code Type Description
PUBCHEM
2723891
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID6047155
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
MERCK INDEX
m5775
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY Merck Index
FDA UNII
M0C2SP444T
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
RS_ITEM_NUM
1294987
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
NSC
9239
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
SMS_ID
100000078194
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
ChEMBL
CHEMBL1255943
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
RXCUI
91269
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY RxNorm
CAS
138-15-8
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
DAILYMED
M0C2SP444T
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
HSDB
138-15-8
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
NCI_THESAURUS
C28515
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
EVMPD
SUB13989MIG
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
DRUG BANK
DBSALT002484
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-315-9
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY