U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C5H9NO4.ClH
Molecular Weight 183.59
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUTAMIC ACID HYDROCHLORIDE

SMILES

Cl.N[C@@H](CCC(O)=O)C(O)=O

InChI

InChIKey=RPAJSBKBKSSMLJ-DFWYDOINSA-N
InChI=1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H9NO4
Molecular Weight 147.1293
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Cooperative helix stabilization by complex Arg-Glu salt bridges.
2001 Aug 1
Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions.
2001 Dec
Calcium channels triggering transmitter release in the rat medial superior olive.
2001 Dec
Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation.
2001 Nov 2
Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase.
2001 Sep
Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels.
2001 Sep
Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons.
2002 Jul-Aug
Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion.
2002 Mar
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.
2002 Nov 1
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Cellular and molecular mechanisms in environmental and occupational inhalation toxicology.
2004
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.
2004 Apr
Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission.
2005 Sep
Binding and complementary expression patterns of semaphorin 3E and plexin D1 in the mature neocortices of mice and monkeys.
2006 Nov 10
Neuro-bioenergetic concepts in cancer prevention and treatment.
2007
The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter.
2007 Apr 20
Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia.
2007 Oct
[Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail].
2007 Oct
[Methods of taste sensitivity examination].
2008
Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glucocorticoids.
2008
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells.
2008 Aug 15
Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium.
2008 Aug 18
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.
2008 Dec
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
2008 Jul
Calculation of the isoelectric point of tryptic peptides in the pH 3.5-4.5 range based on adjacent amino acid effects.
2008 Jul
Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation.
2008 Sep 15
[Epileptic seizures in critically ill patients].
2009
Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis.
2009
Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model.
2009 Aug
Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.
2009 Aug
Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death.
2009 Jul
Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.
2009 Jun
Excitatory neurotransmitters in brain regions in interictal migraine patients.
2009 Jun 30
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.
2009 May 22
An evaluation of minimal cellular functions to sustain a bacterial cell.
2009 Nov 28
Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice.
2009 Oct
Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population.
2009 Oct
Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure.
2009 Oct
Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex.
2009 Sep
Fibulin 5 forms a compact dimer in physiological solutions.
2009 Sep 18
Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations.
2009 Sep 8
The functional organisation of glia in the adult brain of Drosophila and other insects.
2010 Apr
A biologically plausible model of time-scale invariant interval timing.
2010 Feb
On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases.
2010 Jan 8
Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension.
2010 Jul-Aug
Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship.
2010 Mar 3
Cholinergic modulation of fast inhibitory and excitatory transmission to pedunculopontine thalamic projecting neurons.
2010 May
Molecular and cellular mechanisms of excitotoxic neuronal death.
2010 Nov
Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions.
2010 Nov 26
Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function.
2010 Oct 1
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:10:28 GMT 2023
Edited
by admin
on Fri Dec 15 16:10:28 GMT 2023
Record UNII
M0C2SP444T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GLUTAMIC ACID HYDROCHLORIDE
HSDB   II   MART.   MI   WHO-DD  
Systematic Name English
GLUTAMIC ACID HYDROCHLORIDE [MI]
Common Name English
GLUTAMIC ACID HYDROCHLORIDE [MART.]
Common Name English
L-GLUTAMIC ACID HYDROCHLORIDE
FCC   USP-RS  
Systematic Name English
L-GLUTAMIC ACID HYDROCHLORIDE [USP-RS]
Common Name English
GLUTAMIC ACID HYDROCHLORIDE [HSDB]
Common Name English
Glutamic acid hydrochloride [WHO-DD]
Common Name English
GLUTAMIC ACID HYDROCHLORIDE [II]
Common Name English
NSC-9239
Code English
GLUTAMIC ACID HCL
Common Name English
L-GLUTAMIC ACID HYDROCHLORIDE [FCC]
Common Name English
Classification Tree Code System Code
WHO-ATC A09AB01
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
WHO-VATC QA09AB01
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
CFR 21 CFR 310.540
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
CFR 21 CFR 172.320
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
NCI_THESAURUS C78276
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
Code System Code Type Description
PUBCHEM
2723891
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID6047155
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
MERCK INDEX
m5775
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY Merck Index
FDA UNII
M0C2SP444T
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
RS_ITEM_NUM
1294987
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
NSC
9239
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
SMS_ID
100000078194
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
ChEMBL
CHEMBL1255943
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
RXCUI
91269
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY RxNorm
CAS
138-15-8
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
DAILYMED
M0C2SP444T
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
HSDB
138-15-8
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
NCI_THESAURUS
C28515
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
EVMPD
SUB13989MIG
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
DRUG BANK
DBSALT002484
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-315-9
Created by admin on Fri Dec 15 16:10:28 GMT 2023 , Edited by admin on Fri Dec 15 16:10:28 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY