Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C5H9NO4.ClH |
Molecular Weight | 183.59 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.N[C@@H](CCC(O)=O)C(O)=O
InChI
InChIKey=RPAJSBKBKSSMLJ-DFWYDOINSA-N
InChI=1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C5H9NO4 |
Molecular Weight | 147.1293 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.drugbank.ca/drugs/DB00142Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Sources: https://www.drugbank.ca/drugs/DB00142
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2094124 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10812962 |
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Target ID: CHEMBL2109241 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2552114 |
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Target ID: CHEMBL2096670 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10812962 |
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Target ID: CHEMBL3772 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9131252 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Unknown Approved UseUnknown |
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Primary | Unknown Approved UseUnknown |
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Palliative | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Cooperative helix stabilization by complex Arg-Glu salt bridges. | 2001 Aug 1 |
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Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions. | 2001 Dec |
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Calcium channels triggering transmitter release in the rat medial superior olive. | 2001 Dec |
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Role of threonines in the Arabidopsis thaliana somatic embryogenesis receptor kinase 1 activation loop in phosphorylation. | 2001 Nov 2 |
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Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase. | 2001 Sep |
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Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. | 2001 Sep |
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Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons. | 2002 Jul-Aug |
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Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion. | 2002 Mar |
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Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. | 2002 Nov 1 |
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Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination. | 2004 |
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Cellular and molecular mechanisms in environmental and occupational inhalation toxicology. | 2004 |
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Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. | 2004 Apr |
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Anesthetic-induced burst suppression EEG activity requires glutamate-mediated excitatory synaptic transmission. | 2005 Sep |
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Binding and complementary expression patterns of semaphorin 3E and plexin D1 in the mature neocortices of mice and monkeys. | 2006 Nov 10 |
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Neuro-bioenergetic concepts in cancer prevention and treatment. | 2007 |
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The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter. | 2007 Apr 20 |
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Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia. | 2007 Oct |
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[Selective disturbance of associative memory reactivation by serotonin or NMDA glutamate receptor antagonists in snail]. | 2007 Oct |
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[Methods of taste sensitivity examination]. | 2008 |
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Rapid synapse-specific regulation of hypothalamic magnocellular neurons by glucocorticoids. | 2008 |
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(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. | 2008 Aug 15 |
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Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium. | 2008 Aug 18 |
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Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. | 2008 Dec |
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Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. | 2008 Jul |
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Calculation of the isoelectric point of tryptic peptides in the pH 3.5-4.5 range based on adjacent amino acid effects. | 2008 Jul |
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Genetics of Meesmann corneal dystrophy: a novel mutation in the keratin 3 gene in an asymptomatic family suggests genotype-phenotype correlation. | 2008 Sep 15 |
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[Epileptic seizures in critically ill patients]. | 2009 |
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Molecular and functional characterization of a c-type lysozyme from the Asian corn borer, Ostrinia furnacalis. | 2009 |
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Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
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Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins. | 2009 Aug |
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Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. | 2009 Jul |
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Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats. | 2009 Jun |
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Excitatory neurotransmitters in brain regions in interictal migraine patients. | 2009 Jun 30 |
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Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. | 2009 May 22 |
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An evaluation of minimal cellular functions to sustain a bacterial cell. | 2009 Nov 28 |
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Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. | 2009 Oct |
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Association and expression studies of glutamate-cysteine ligase modifier (GCLM) and schizophrenia in the Chinese Han population. | 2009 Oct |
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Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure. | 2009 Oct |
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Differential distribution of aggrecan isoforms in perineuronal nets of the human cerebral cortex. | 2009 Sep |
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Fibulin 5 forms a compact dimer in physiological solutions. | 2009 Sep 18 |
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Muscle differentiation in a colonial ascidian: organisation, gene expression and evolutionary considerations. | 2009 Sep 8 |
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The functional organisation of glia in the adult brain of Drosophila and other insects. | 2010 Apr |
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A biologically plausible model of time-scale invariant interval timing. | 2010 Feb |
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On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases. | 2010 Jan 8 |
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Effect of estrogen on mitochondrial function and intracellular stress markers in rat liver and kidney following trauma-hemorrhagic shock and prolonged hypotension. | 2010 Jul-Aug |
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Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship. | 2010 Mar 3 |
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Cholinergic modulation of fast inhibitory and excitatory transmission to pedunculopontine thalamic projecting neurons. | 2010 May |
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Molecular and cellular mechanisms of excitotoxic neuronal death. | 2010 Nov |
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Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions. | 2010 Nov 26 |
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Metabotropic glutamate receptors 1 and 5 differentially regulate bulbar dopaminergic cell function. | 2010 Oct 1 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11724641
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2552114
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:10:28 GMT 2023
by
admin
on
Fri Dec 15 16:10:28 GMT 2023
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Record UNII |
M0C2SP444T
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Record Status |
Validated (UNII)
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Record Version |
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WHO-ATC |
A09AB01
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WHO-VATC |
QA09AB01
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CFR |
21 CFR 310.540
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CFR |
21 CFR 172.320
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NCI_THESAURUS |
C78276
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2723891
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DTXSID6047155
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m5775
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M0C2SP444T
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1294987
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9239
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100000078194
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CHEMBL1255943
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91269
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138-15-8
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M0C2SP444T
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138-15-8
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C28515
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SUB13989MIG
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DBSALT002484
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205-315-9
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |