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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.2Na
Molecular Weight 191.0929
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DISODIUM GLUTAMATE

SMILES

[Na+].[Na+].N[C@@H](CCC([O-])=O)C([O-])=O

InChI

InChIKey=PXEDJBXQKAGXNJ-QTNFYWBSSA-L
InChI=1S/C5H9NO4.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H7NO4
Molecular Weight 145.1134
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Alterations of amino acids and monoamine metabolism in male Fmr1 knockout mice: a putative animal model of the human fragile X mental retardation syndrome.
2001
Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase.
2001 Sep
FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10.
2003
Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells.
2003 Jul
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents.
2003 Nov
Model-independent fluxome profiling from 2H and 13C experiments for metabolic variant discrimination.
2004
Cellular and molecular mechanisms in environmental and occupational inhalation toxicology.
2004
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
2004 Mar 31
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.
2007 Apr 6
Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex.
2007 Dec
[Methods of taste sensitivity examination].
2008
EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity.
2008 Jan 8
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
2009 Dec 14
Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression.
2009 Dec 23
Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.
2009 Jun
Cannabinoids excite circadian clock neurons.
2010 Jul 28
Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression.
2010 Jun 26
Entamoeba histolytica Phosphoserine aminotransferase (EhPSAT): insights into the structure-function relationship.
2010 Mar 3
Cholinergic modulation of fast inhibitory and excitatory transmission to pedunculopontine thalamic projecting neurons.
2010 May
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:38:13 GMT 2023
Edited
by admin
on Fri Dec 15 19:38:13 GMT 2023
Record UNII
H0US799L9M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DISODIUM GLUTAMATE
Systematic Name English
GLUTAMIC ACID DISODIUM SALT
Common Name English
L-GLUTAMIC ACID, SODIUM SALT (1:2)
Common Name English
L(+)-GLUTAMIC ACID DISODIUM SALT
Common Name English
GLUTAMIC ACID, DISODIUM SALT, L-
Common Name English
DISODIUM S-GLUTAMATE
Common Name English
DISODIUM GLUTAMATE, L-
Common Name English
DISODIUM L-GLUTAMATE
Systematic Name English
L-GLUTAMIC ACID, DISODIUM SALT
Common Name English
Code System Code Type Description
RXCUI
2601595
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
ECHA (EC/EINECS)
240-733-5
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
WIKIPEDIA
DISODIUM GLUTAMATE
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
PUBCHEM
167560
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
FDA UNII
H0US799L9M
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
EPA CompTox
DTXSID00894749
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
DAILYMED
H0US799L9M
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
CAS
16690-92-9
Created by admin on Fri Dec 15 19:38:13 GMT 2023 , Edited by admin on Fri Dec 15 19:38:13 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE