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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H7NO4.2Na
Molecular Weight 191.0931
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DISODIUM GLUTAMATE

SMILES

C(CC(=O)[O-])[C@@]([H])(C(=O)[O-])N.[Na+].[Na+]

InChI

InChIKey=PXEDJBXQKAGXNJ-QTNFYWBSSA-L
InChI=1S/C5H9NO4.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1

HIDE SMILES / InChI

Molecular Formula C5H7NO4
Molecular Weight 145.1136
Charge -2
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11724641

Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.

Originator

Curator's Comment:: Glutamic acid was discovered in 1866 by the German chemist Karl Heinrich Ritthausen who treated wheat gluten (for which it was named) with sulfuric acid.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Palliative
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.
2001 Apr 6
Cooperative helix stabilization by complex Arg-Glu salt bridges.
2001 Aug 1
Calcium channels triggering transmitter release in the rat medial superior olive.
2001 Dec
Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase.
2001 Sep
Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels.
2001 Sep
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
2002 Mar 29
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.
2002 Nov 1
FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10.
2003
Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells.
2003 Jul
GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents.
2003 Nov
Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.
2004 Apr
Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit.
2004 Apr 15
Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats.
2004 Apr 16
The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy.
2004 Apr 23
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
2004 Mar 31
Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta).
2005 Aug 15
Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage.
2005 Dec
Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations.
2006 May 1
Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.
2006 Nov
The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory.
2006 Nov
Neuro-bioenergetic concepts in cancer prevention and treatment.
2007
Lidocaine: neurobiological targets and effects on the auditory system.
2007
The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter.
2007 Apr 20
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation.
2008
Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium.
2008 Aug 18
EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity.
2008 Jan 8
Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior.
2008 Jul
[Epileptic seizures in critically ill patients].
2009
Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model.
2009 Aug
Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity.
2009 Aug
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase.
2009 Dec 14
Receptors and transduction of umami taste stimuli.
2009 Jul
Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death.
2009 Jul
Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.
2009 Jun
Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China.
2009 May 14
A role for Melanin-Concentrating Hormone in learning and memory.
2009 Nov
An evaluation of minimal cellular functions to sustain a bacterial cell.
2009 Nov 28
The functional organisation of glia in the adult brain of Drosophila and other insects.
2010 Apr
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage.
2010 Dec 1
On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases.
2010 Jan 8
Patents

Sample Use Guides

As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration: Other
In Vitro Use Guide
To study binding of glutamate to AMPA and Kainate ion channels, [3H]APMA and [3H]kainic acid were used as a radioligands.
Substance Class Chemical
Created
by admin
on Sat Jun 26 05:22:20 UTC 2021
Edited
by admin
on Sat Jun 26 05:22:20 UTC 2021
Record UNII
H0US799L9M
Record Status Validated (UNII)
Record Version
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Name Type Language
DISODIUM GLUTAMATE
Systematic Name English
GLUTAMIC ACID DISODIUM SALT
Common Name English
L-GLUTAMIC ACID, SODIUM SALT (1:2)
Common Name English
L(+)-GLUTAMIC ACID DISODIUM SALT
Common Name English
GLUTAMIC ACID, DISODIUM SALT, L-
Common Name English
DISODIUM S-GLUTAMATE
Common Name English
DISODIUM GLUTAMATE, L-
Common Name English
DISODIUM L-GLUTAMATE
Systematic Name English
L-GLUTAMIC ACID, DISODIUM SALT
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
240-733-5
Created by admin on Sat Jun 26 05:22:20 UTC 2021 , Edited by admin on Sat Jun 26 05:22:20 UTC 2021
PRIMARY
WIKIPEDIA
DISODIUM GLUTAMATE
Created by admin on Sat Jun 26 05:22:20 UTC 2021 , Edited by admin on Sat Jun 26 05:22:20 UTC 2021
PRIMARY
PUBCHEM
167560
Created by admin on Sat Jun 26 05:22:20 UTC 2021 , Edited by admin on Sat Jun 26 05:22:20 UTC 2021
PRIMARY
FDA UNII
H0US799L9M
Created by admin on Sat Jun 26 05:22:20 UTC 2021 , Edited by admin on Sat Jun 26 05:22:20 UTC 2021
PRIMARY
CAS
16690-92-9
Created by admin on Sat Jun 26 05:22:20 UTC 2021 , Edited by admin on Sat Jun 26 05:22:20 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE