Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C5H7NO4.2Na |
| Molecular Weight | 191.0931 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C(CC(=O)[O-])[C@@]([H])(C(=O)[O-])N.[Na+].[Na+]
InChI
InChIKey=PXEDJBXQKAGXNJ-QTNFYWBSSA-L
InChI=1S/C5H9NO4.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
| Molecular Formula | C5H7NO4 |
| Molecular Weight | 145.1136 |
| Charge | -2 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment:: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Curator's Comment:: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/11724641
Glutamic acid is a non-essential aminoacid used in biosynthesis of proteins. Besides being a building block of proteins, glutamic acid plays a principal role in neural activation. Glutamate is also responsible for the umami (savory) flavor of certain foods. In medicine, glutamate is used as a metabolic supplemnet in patients undergoing coronary surgery.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2094124 |
|||
Target ID: CHEMBL2109241 |
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Target ID: CHEMBL2096670 |
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Target ID: CHEMBL3772 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Preventing | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
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| Palliative | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. | 2001 Apr 6 |
|
| Cooperative helix stabilization by complex Arg-Glu salt bridges. | 2001 Aug 1 |
|
| Calcium channels triggering transmitter release in the rat medial superior olive. | 2001 Dec |
|
| Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase. | 2001 Sep |
|
| Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels. | 2001 Sep |
|
| Interaction between vanilloid and glutamate receptors in the central modulation of nociception. | 2002 Mar 29 |
|
| Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. | 2002 Nov 1 |
|
| FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. | 2003 |
|
| Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells. | 2003 Jul |
|
| GABAA receptor-expressing astrocytes in the supraoptic nucleus lack glutamate uptake and receptor currents. | 2003 Nov |
|
| Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. | 2004 Apr |
|
| Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit. | 2004 Apr 15 |
|
| Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats. | 2004 Apr 16 |
|
| The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy. | 2004 Apr 23 |
|
| Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina. | 2004 Mar 31 |
|
| Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta). | 2005 Aug 15 |
|
| Protein S100B release from rat brain slices during and after ischemia: comparison with lactate dehydrogenase leakage. | 2005 Dec |
|
| Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations. | 2006 May 1 |
|
| Nonsense-mediated mRNA decay mutation in Aspergillus nidulans. | 2006 Nov |
|
| The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory. | 2006 Nov |
|
| Neuro-bioenergetic concepts in cancer prevention and treatment. | 2007 |
|
| Lidocaine: neurobiological targets and effects on the auditory system. | 2007 |
|
| The glutamate transporter EAAT2 is transiently expressed in developing human cerebral white matter. | 2007 Apr 20 |
|
| Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. | 2008 |
|
| Neurochemical diversity of afferent neurons that transduce sensory signals from dog ventricular myocardium. | 2008 Aug 18 |
|
| EndoS from Streptococcus pyogenes is hydrolyzed by the cysteine proteinase SpeB and requires glutamic acid 235 and tryptophans for IgG glycan-hydrolyzing activity. | 2008 Jan 8 |
|
| Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. | 2008 Jul |
|
| [Epileptic seizures in critically ill patients]. | 2009 |
|
| Receptor architecture of human cingulate cortex: evaluation of the four-region neurobiological model. | 2009 Aug |
|
| Phosphono analogues of 2-oxoglutarate protect cerebellar granule neurons upon glutamate excitotoxicity. | 2009 Aug |
|
| Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase. | 2009 Dec 14 |
|
| Receptors and transduction of umami taste stimuli. | 2009 Jul |
|
| Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. | 2009 Jul |
|
| Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats. | 2009 Jun |
|
| Phenotypic and genotypic characterization of human immunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China. | 2009 May 14 |
|
| A role for Melanin-Concentrating Hormone in learning and memory. | 2009 Nov |
|
| An evaluation of minimal cellular functions to sustain a bacterial cell. | 2009 Nov 28 |
|
| The functional organisation of glia in the adult brain of Drosophila and other insects. | 2010 Apr |
|
| Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage. | 2010 Dec 1 |
|
| On the structure of the proton-binding site in the F(o) rotor of chloroplast ATP synthases. | 2010 Jan 8 |
Sample Use Guides
As a dietary supplement for taste improvement, glutamate is administered orally with food. Glutamate is administered intravenously in patients undergoing coronary artery bypass surgery.
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 05:22:20 UTC 2021
by
admin
on
Sat Jun 26 05:22:20 UTC 2021
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| Record UNII |
H0US799L9M
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| Record Status |
Validated (UNII)
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| Record Version |
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240-733-5
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DISODIUM GLUTAMATE
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167560
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H0US799L9M
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16690-92-9
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
