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Details

Stereochemistry ABSOLUTE
Molecular Formula C3H7NO2
Molecular Weight 89.0932
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALANINE

SMILES

C[C@H](N)C(O)=O

InChI

InChIKey=QNAYBMKLOCPYGJ-REOHCLBHSA-N
InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

HIDE SMILES / InChI

Molecular Formula C3H7NO2
Molecular Weight 89.0932
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Alanine is a non-essential aminoacid encoded by GCU, GCC, GCA, and GCG codons. Besides being a building block of proteins, alanine plays a key role in glucose-alanine cycle. Alanine is medically used as a dietary supplement for conditions such as fructose intolerance, muscle atrophy, low birth weight.

CNS Activity

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Structure and function of branched chain aminotransferases.
2001
Catalysis of peptide formation by inorganic oxides: high efficiency of alumina under mild conditions on the Earth-like planets.
2001
Water-soluble L-alanine and related oligopeptide conjugates with poly[(R,S)-3-hydroxybutanoic acid] oligomers, synthesis and structural studies by means of electrospray ionization multistage mass spectrometry.
2001
Preparation of and tissue response to DNA-lipid films.
2001 Aug
Comparison of the omega-transaminases from different microorganisms and application to production of chiral amines.
2001 Aug
Analysis of the role of bacterial endospore cortex structure in resistance properties and demonstration of its conservation amongst species.
2001 Aug
Depolarization of the liver cell membrane by metformin.
2001 Aug 6
Enantioseparation of chiral amino acids as the N(O,S)-ethoxycarbonylated diastereomeric esters by achiral dual-capillary column gas chromatography.
2001 Dec
Isolation of Bacillus subtilis (chungkookjang), a poly-gamma-glutamate producer with high genetic competence.
2001 Dec
Antifungal alkyl amino alcohols from the tropical marine sponge Haliclona n. sp.
2001 Dec
Potential energy surfaces for the gas-phase interaction between alpha-alanine and alkali metal Ions (Li+, Na+, K+). A density functional study.
2001 Dec 3
Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus.
2001 Jul
Comparison of monomeric and polymeric amino acid based surfactants for chiral separations.
2001 Jul 13
Safinamide (Newron Pharmaceuticals).
2001 Jun
Oxygen K-edge X-ray absorption near edge structures (XANES) of sublimated films of amino acids.
2001 Mar 1
Relationship between hepatitis C virus infection and schistosomal liver disease: not simply an additive effect.
2001 Nov
Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans.
2001 Nov
pH and kinetic isotope effects in d-amino acid oxidase catalysis.
2001 Nov
Na+ transport by the neural glutamine transporter ATA1.
2001 Oct
Lactoferrin-induced reduction of vanB vancomycin resistance in enterococci.
2001 Oct
Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy.
2001 Oct
Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.
2001 Oct 1
Glutamate 47 in 1-aminocyclopropane-1-carboxylate synthase is a major specificity determinant.
2001 Oct 16
Spider silk fibre extrusion: combined wide- and small-angle X-ray microdiffraction experiments.
2001 Oct 22
Biochemical characterization of a phosphinate inhibitor of Escherichia coli MurC.
2001 Oct 9
Sequential treatment with lamivudine and interferon monotherapies in patients with chronic hepatitis B not responding to interferon alone: results of a pilot study.
2001 Sep
Degradation signals in ErbB-2 dictate proteasomal processing and immunogenicity and resist protection by cis glycine-alanine repeat.
2001 Sep 15
Possible involvement of amino acid transporters on S-nitroso-cysteine-induced inhibition of arachidonic acid release in PC12 cells.
2001 Sep 28
Physiological roles of free D- and L-alanine in the crayfish Procambarus clarkii with special reference to osmotic and anoxic stress responses.
2002 Apr
Dye-linked D-proline dehydrogenase from hyperthermophilic archaeon Pyrobaculum islandicum is a novel FAD-dependent amino acid dehydrogenase.
2002 Apr 12
Antitumour and toxic effects on Wistar rats of two new platinum complexes.
2002 Feb
Preparation of optically active allothreonine via optical resolution by replacing crystallization.
2002 Feb
EPR dosimetric properties of 2-methylalanine: EPR, ENDOR and FT-EPR investigations.
2002 Feb
Analysis of the E. coli NifS CsdB protein at 2.0 A reveals the structural basis for perselenide and persulfide intermediate formation.
2002 Feb 1
Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon.
2002 Feb 22
Mutations in the carboxyl-terminal domain of phospholipase C-beta 1 delineate the dimer interface and a potential Galphaq interaction site.
2002 Feb 8
Glycine and alanine dehydrogenase activities are catalyzed by the same protein in Mycobacterium smegmatis: upregulation of both activities under microaerophilic adaptation.
2002 Jan
Formation of D-alanyl-lipoteichoic acid is required for adhesion and virulence of Listeria monocytogenes.
2002 Jan
Highly selective molecularly imprinted overoxidized polypyrrole colloids: one-step preparation technique.
2002 Jan
The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice.
2002 Jan
Oligomeric beta(beta)(alpha) miniprotein motifs: pivotal role of single hinge residue in determining the oligomeric state.
2002 Jan 23
The unique ribbon morphology of the major ampullate silk of spiders from the genus Loxosceles (recluse spiders).
2002 Jan-Feb
In vitro hepatotoxicity of alachlor and its by-products.
2002 Jan-Feb
Nepenthes insignis uses a C2-portion of the carbon skeleton of L-alanine acquired via its carnivorous organs, to build up the allelochemical plumbagin.
2002 Mar
Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein.
2002 Mar 1
A Y2 receptor mimetic aptamer directed against neuropeptide Y.
2002 Mar 29
Mechanisms of the protective effect of L-alanine to D-galactosamine-induced hepatocellular injury: comparative studies of L-alanine and pyruvate.
2002 Mar 8
Structural characterization of the M* partly folded intermediate of wild type and P138A aspartate aminotransferase from Escherichia coli.
2002 May 17
Reaction mechanism of alanine racemase from Bacillus stearothermophilus: x-ray crystallographic studies of the enzyme bound with N-(5'-phosphopyridoxyl)alanine.
2002 May 24
3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti.
2002 May 3
Patents

Sample Use Guides

In Vivo Use Guide
Alanine is a nutrient, available from animal and vegetarian sources. It could be administered intravenously.
Route of Administration: oral; intravenous
In Vitro Use Guide
The extent of transamination was measured by measuring the pyruvate concentration after 10 minutes incubation period with the alanine aminotransferase. The Michaelis constant for alanine was shown to be 28 mM for alanine.
Substance Class Chemical
Created
by admin
on Tue Oct 22 00:21:10 UTC 2019
Edited
by admin
on Tue Oct 22 00:21:10 UTC 2019
Record UNII
OF5P57N2ZX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALANINE
EP   HSDB   II   INCI   INN   MI   USAN   USP   VANDF   WHO-DD  
USAN   INCI   INN  
Official Name English
ALANINE [INCI]
Common Name English
ALANINE [MI]
Common Name English
ALANINE [VANDF]
Common Name English
ALANINE [USAN]
Common Name English
ALANINE [USP]
Common Name English
NSC-206315
Code English
L-ALANINE [USP-RS]
Common Name English
ALANINE [WHO-DD]
Common Name English
ALANINE [INN]
Common Name English
(2S)-2-AMINOPROPANOIC ACID
Common Name English
ALANINE [HSDB]
Common Name English
L-ALANINE
FCC   JAN   USP-RS  
Systematic Name English
ALANINE [EP]
Common Name English
ALANINE [II]
Common Name English
L-ALANINE [JAN]
Common Name English
ALANINE, L-
Systematic Name English
SERINE IMPURITY A [EP]
Common Name English
L-ALANINE [FCC]
Common Name English
L-2-AMINOPROPANOIC ACID
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 342911
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
CFR 21 CFR 172.320
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
CFR 21 CFR 310.532
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
NDF-RT N0000175780
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
Code System Code Type Description
MERCK INDEX
M1467
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY Merck Index
HSDB
56-41-7
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
ECHA (EC/EINECS)
200-273-8
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
CAS
56-41-7
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
DRUG BANK
DB00160
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
MESH
D000409
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
NCI_THESAURUS
C29605
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
ChEMBL
CHEMBL12198
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
WIKIPEDIA
ALANINE
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
INN
6161
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
EVMPD
SUB41388
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
EVMPD
SUB05290MIG
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY
RXCUI
426
Created by admin on Tue Oct 22 00:21:10 UTC 2019 , Edited by admin on Tue Oct 22 00:21:10 UTC 2019
PRIMARY RxNorm
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