ALANINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C3H7NO2
Molecular Weight	89.0932
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

C[C@H](N)C(O)=O

InChI

InChIKey=QNAYBMKLOCPYGJ-REOHCLBHSA-N

InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C3H7NO2
Molecular Weight	89.0932
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Alanine is a non-essential aminoacid encoded by GCU, GCC, GCA, and GCG codons. Besides being a building block of proteins, alanine plays a key role in glucose-alanine cycle. Alanine is medically used as a dietary supplement for conditions such as fructose intolerance, muscle atrophy, low birth weight.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alanine aminotransferase 1 17	Substrate 661

Conditions

Condition	Modality	Highest Phase	Product
Burns 17	Primary	Approved 8,429	FREAMINE III 10%
Fructose intolerance 1	Primary	Natural Metabolite	Unknown
Muscle atrophy 1	Primary	Natural Metabolite	Unknown
Low birth weight 1	Primary	Natural Metabolite	Unknown

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	SLC7A10 1 ASCT2 12

Drug as victim

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Target	Modality	Activity	Metabolite	Clinical evidence
ASCT2 12	substrate 3,367	yes
SLC7A10 1	substrate 3,367	yes

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
ChEBI	CHEBI:16449	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16449
ChemicalBook	CB9143191	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB9143191
MolPort	MolPort-000-871-636	https://www.molport.com/shop/molecule-link/MolPort-000-871-636
MolPort	MolPort-001-573-589	https://www.molport.com/shop/molecule-link/MolPort-001-573-589
eMolecules	476064	https://www.emolecules.com/cgi-bin/more?vid=476064

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PubMed

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Title	Date	PubMed
Structure and function of branched chain aminotransferases.	2001	11642362
Catalysis of peptide formation by inorganic oxides: high efficiency of alumina under mild conditions on the Earth-like planets.	2001	11605636
The genome of Mycobacterium leprae: a minimal mycobacterial gene set.	2001	11532219
Water-soluble L-alanine and related oligopeptide conjugates with poly[(R,S)-3-hydroxybutanoic acid] oligomers, synthesis and structural studies by means of electrospray ionization multistage mass spectrometry.	2001	11484938
Preparation of and tissue response to DNA-lipid films.	2001 Aug	11669492

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Sample Use Guides

In Vivo Use Guide

Alanine is a nutrient, available from animal and vegetarian sources. It could be administered intravenously.

Route of Administration: Other

In Vitro Use Guide

The extent of transamination was measured by measuring the pyruvate concentration after 10 minutes incubation period with the alanine aminotransferase. The Michaelis constant for alanine was shown to be 28 mM for alanine.

Substance Class	Chemical
Record UNII	OF5P57N2ZX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ALANINE

Official Name

English

ALANINE [INCI]

Common Name

English

LYSINE ACETATE IMPURITY C [EP IMPURITY]

Common Name

English

SERINE IMPURITY A [EP IMPURITY]

Common Name

English

ALANINE [MI]

Common Name

English

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Classification Tree

Code System

Code

Bld.dot

LOINC

88018-7

Body fld

LOINC

32222-2

CSF

LOINC

22657-1

Amino Acid

DSLD

256 (Number of products:46)

Urine

LOINC

44291-3

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Code System

Code

Type

Description

DAILYMED

OF5P57N2ZX

PRIMARY

MERCK INDEX

m1467

PRIMARY

Merck Index

CHEBI

16449

PRIMARY

FDA UNII

OF5P57N2ZX

PRIMARY

RS_ITEM_NUM

1012509

PRIMARY

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Related Record

Type

Details


					HG18B9YRS7

VALINE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (TLC)

Qualification:

EP

Amount:

[<0.2] % (limits)


					TTL6G7LIWZ

LYSINE ACETATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (TLC)

Qualification:

EP

Amount:

[<0.5] % (limits)


					91XW058U2C

MALEIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

[<0.05] PERCENT PEAK AREA (limits)


					452VLY9402

SERINE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

[<0.2] PERCENT PEAK AREA (limits)


					817L1N4CKP

Malic acid

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

USP

Amount:

[<0.05] PERCENT PEAK AREA (limits)

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Related Record

Type

Details


					OF5P57N2ZX

ALANINE

ACTIVE MOIETY

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SMILES

InChI

CNS Activity

Originator

Approval Year

Targets

Conditions

Overview

OverviewOther

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides