Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H19N5O4S |
Molecular Weight | 377.418 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C1=CC2=C(C=C1C3=CC=NN3C)C(=O)N(NS(C)(=O)=O)C(=O)N2
InChI
InChIKey=MCECSFFXUPEPDB-UHFFFAOYSA-N
InChI=1S/C16H19N5O4S/c1-9(2)10-8-13-12(7-11(10)14-5-6-17-20(14)3)15(22)21(16(23)18-13)19-26(4,24)25/h5-9,19H,1-4H3,(H,18,23)
Molecular Formula | C16H19N5O4S |
Molecular Weight | 377.418 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Selurampanel (previously known as BGG 492), an orally available, AMPA-type glutamate receptor (AMPAR)/kainate receptor (GluK1; GluR5) antagonist was developed by Novartis. It is known that AMPAR antagonism is under development as a novel mechanism of action for antiepileptic drugs. Selurampanel was studied in phase II clinical trial for the migraine treatment. However, Proof-of-concept criterion was not met. In addition, the drug also participated in phase II clinical trials in therapy-refractory partial seizures for epilepsy surgery and in patients with chronic subjective tinnitus. Development of selurampanel for all these diseases was discontinued as of September 2017.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23963355
BGG492 (SELURAMPANEL) (250 mg), vs placebo and sumatriptan (100 mg), in 75 subjects with acute migraine attacks
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:21:51 UTC 2023
by
admin
on
Fri Dec 15 19:21:51 UTC 2023
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Record UNII |
7WG1MR7DAR
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C264
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45381907
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7WG1MR7DAR
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100000178146
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Selurampanel
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912574-69-7
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C152327
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CHEMBL3545042
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9393
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DB12367
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DTXSID00238467
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ACTIVE MOIETY |