Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H4N4O6 |
| Molecular Weight | 252.1406 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[O-][N+](=O)C1=CC2=C(NC(=O)C(=O)N2)C=C1[N+]([O-])=O
InChI
InChIKey=RWVIMCIPOAXUDG-UHFFFAOYSA-N
InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
| Molecular Formula | C8H4N4O6 |
| Molecular Weight | 252.1406 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
FG-9041 (6,7-Dinitroquinoxaline-2,3-dion or DNQX) is an antagonist of non-NMDA glutamate (AMPA and kainate) receptor. FG-9041 is used in molecular biology to identify the properties of different types of channels. In addition, experiments in rats have shown that DNQX reduces electroconvulsive shock-induced impairment of learning-memory.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Nuclear factor kappaB activation is mediated by NMDA and non-NMDA receptor and L-type voltage-gated Ca(2+) channel following severe global ischemia in rat hippocampus. | 2002 Apr 12 |
|
| Contribution of ionotropic glutamate receptors to acute amphetamine-stimulated preproenkephalin mRNA expression in the rat striatum in vivo. | 2003 Jul 31 |
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| Antioxidant NAC and AMPA/KA receptor antagonist DNQX inhibited JNK3 activation following global ischemia in rat hippocampus. | 2003 Jun |
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| Antioxidant N-acetylcysteine and AMPA/KA receptor antagonist DNQX inhibited mixed lineage kinase-3 activation following cerebral ischemia in rat hippocampus. | 2003 Sep |
|
| The putative glutamate receptor 1.1 (AtGLR1.1) in Arabidopsis thaliana regulates abscisic acid biosynthesis and signaling to control development and water loss. | 2004 Oct |
|
| Activation of c-Jun NH2-terminal kinase 3 is mediated by the GluR6.PSD-95.MLK3 signaling module following cerebral ischemia in rat hippocampus. | 2005 Nov 2 |
|
| Methotrexate induces seizure and decreases glutamate uptake in brain slices: prevention by ionotropic glutamate receptors antagonists and adenosine. | 2006 Dec 3 |
|
| NMDA receptor/L-VGCC-dependent expression and AMPA/KA receptor-dependent activation of c-Jun induced by cerebral ischemia in rat hippocampus. | 2006 May 8 |
|
| AMPA and NMDA receptor regulation of firing activity in 5-HT neurons of the dorsal and median raphe nuclei. | 2007 May |
|
| Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex. | 2008 Apr 2 |
|
| Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats. | 2012 Feb |
Patents
Sample Use Guides
Forty-eight adult Wistar-Kyoto (WKY) rats (an animal model for depressive behavior): DNQX (FG9041) (iv 2 mL 5 mg/kg DNQX through the tail veins of WKY rats )
Route of Administration:
Intravenous
It was tested the effects of the quinoxaline derivative DNQX (FG9041) on the membrane potential of thalamic reticular nucleus (TRN) and ventrobasal (VB) neurons. DNQX (20 μM) produced a slow-onset, long-duration depolarization in all TRN neurons tested with average amplitude of 3.3 ± 1.1 mV. In contrast, DNQX (20 μM) did not alter the membrane potential (0.2 ± 0.5 mV, n = 6) or input resistance of VB neurons. Accordingly, in voltage-clamp recordings, DNQX (20 μM) evoked an inward current that averaged −14.3 ± 5.6 pA but not in VB neurons (1.3 ± 2.3 pA, n = 5, P > 0.1). At a lower concentration, DNQX (4 μM) produced a negligible depolarization (0.3 ± 0.3 mV, n = 5) in TRN neurons, but at higher concentrations, DNQX (100 μM) produced a larger depolarization that averaged 3.7 ± 1.6 mV.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:08:27 GMT 2023
by
admin
on
Sat Dec 16 10:08:27 GMT 2023
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| Record UNII |
62T278S1MX
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| Record Status |
Validated (UNII)
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| Record Version |
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3899541
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62T278S1MX
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2379-57-9
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DTXSID60178476
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DB03759
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DNQX
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