MK-8777

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NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C11H12N2O2
Molecular Weight	204.2252
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MK-8777

Structure Search

SMILES

O=C1N2CCC[C@H]2COC3=NC=CC=C13

InChI

InChIKey=FIKUEZUFASUKAH-QMMMGPOBSA-N

InChI=1S/C11H12N2O2/c14-11-9-4-1-5-12-10(9)15-7-8-3-2-6-13(8)11/h1,4-5,8H,2-3,6-7H2/t8-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C11H12N2O2
Molecular Weight	204.2252
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate receptor ionotropic AMPA 42 Target ID: CHEMBL2096670 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22954616 \| https://www.ncbi.nlm.nih.gov/pubmed/15993447	Positive Allosteric Modulator 186

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:02:36 GMT 2025` Edited by `admin` on `Mon Mar 31 23:02:36 GMT 2025`
Record UNII	0H1IDR8Z4F
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MK-8777

Code

English

ORG-26576

Preferred Name

English

5H,7H-PYRIDO(3,2-F)PYRROLO(2,1-C)(1,4)OXAZEPIN-5-ONE, 8,9,9A,10-TETRAHYDRO-, (9AS)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

13584912

Created by admin on Mon Mar 31 23:02:36 GMT 2025 , Edited by admin on Mon Mar 31 23:02:36 GMT 2025

PRIMARY

FDA UNII

0H1IDR8Z4F

Created by admin on Mon Mar 31 23:02:36 GMT 2025 , Edited by admin on Mon Mar 31 23:02:36 GMT 2025

PRIMARY

SMS_ID

300000047855

Created by admin on Mon Mar 31 23:02:36 GMT 2025 , Edited by admin on Mon Mar 31 23:02:36 GMT 2025

PRIMARY

WIKIPEDIA

ORG-26576

Created by admin on Mon Mar 31 23:02:36 GMT 2025 , Edited by admin on Mon Mar 31 23:02:36 GMT 2025

PRIMARY

CAS

1026791-61-6

Created by admin on Mon Mar 31 23:02:36 GMT 2025 , Edited by admin on Mon Mar 31 23:02:36 GMT 2025

PRIMARY

EPA CompTox

DTXSID001336129

Created by admin on Mon Mar 31 23:02:36 GMT 2025 , Edited by admin on Mon Mar 31 23:02:36 GMT 2025

PRIMARY

Related Record Type Details


					P6W5IXV8V9

AMPA-SELECTIVE GLUTAMATE RECEPTOR 2

TARGET->POSITIVE ALLOSTERIC MODULATOR (PAM)

Amount:

Related Record Type Details


					0H1IDR8Z4F

MK-8777

ACTIVE MOIETY

Amount: