Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C16H24N2O6 |
Molecular Weight | 340.3716 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)[C@H]1CCCN1C(=O)CCCCC(=O)N2CCC[C@@H]2C(O)=O
InChI
InChIKey=HZLAWYIBLZNRFZ-VXGBXAGGSA-N
InChI=1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)/t11-,12-/m1/s1
Molecular Formula | C16H24N2O6 |
Molecular Weight | 340.3716 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
RO-638695 (also known as Miridesap, CPHPC and GSK-2315698) is an antineoplastic and a serum amyloid P component inhibitor. RO-638695 almost completely depletes circulating serum amyloid P component (SAP), but a small amount of SAP is left for recognition by subsequently administered therapeutic IgG anti-SAP antibodies. SAP is a blood protein that is the target of a novel immunotherapy approach. RO-638695 has therefore been evaluated in phase I and II clinical trials for its safety and potential in treatment of diseases like Alzheimer’s disease, HIV infection and other diseases with systemic amyloid deposition.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4929 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14998318 |
900.0 nM [IC50] |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:32:51 GMT 2023
by
admin
on
Sat Dec 16 05:32:51 GMT 2023
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Record UNII |
WO97N24A47
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Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C78275
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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FDA ORPHAN DRUG |
462614
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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Code System | Code | Type | Description | ||
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DB13087
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY | |||
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DTXSID00176996
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY | |||
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10363
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY | |||
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100000174642
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY | |||
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C153209
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY | |||
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WO97N24A47
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY | |||
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224624-80-0
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY | |||
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CPHPC
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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125516
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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FG-82
Created by
admin on Sat Dec 16 05:32:51 GMT 2023 , Edited by admin on Sat Dec 16 05:32:51 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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ACTIVE MOIETY |