U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C18H22ClNO
Molecular Weight 303.827
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENOXYBENZAMINE

SMILES

CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

InChIKey=QZVCTJOXCFMACW-UHFFFAOYSA-N
InChI=1S/C18H22ClNO/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3

HIDE SMILES / InChI

Molecular Formula C18H22ClNO
Molecular Weight 303.827
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment:: https://www.ncbi.nlm.nih.gov/pubmed/11395517

Phenoxybenzamin (marketed under the trade name Dibenzyline) is an alpha-adrenergic antagonist with long duration of action. It is indicated in the treatment of pheochromocytoma, to control episodes of hypertension and sweating. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. Phenoxybenzamine hydrochloride can produce and maintain “chemical sympathectomy” by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Twenty to percent of orally administered phenoxybenzamine appears to be absorbed in the active form. The half-life of orally administered phenoxybenzamine hydrochloride is not known; however, the half-life of intravenously administered drug is approximately 24 hours. Demonstrable effects with intravenous administration persist for at least 3 to 4 days, and the effects of daily administration are cumulative for nearly a week. The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency: Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, and miosis. These so-called “side effects” are actually evidence of adrenergic blockade and vary according to the degree of blockade. Miscellaneous: Gastrointestinal irritation, drowsiness, fatigue.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
DIBENZYLINE

Approved Use

INDICATION AND USAGE Phenoxybenzamine hydrochloride is indicated in the treatment of pheochromocytoma, to control episodes of hypertension and sweating. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly.

Launch Date

-534297600000
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
3332.3 pg/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENOXYBENZAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
3746.5 pg × h/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENOXYBENZAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
1.54 h
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
PHENOXYBENZAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
40 mg 3 times / day multiple, oral
Recommended
Dose: 40 mg, 3 times / day
Route: oral
Route: multiple
Dose: 40 mg, 3 times / day
Sources:
unhealthy
Other AEs: Hypotension, Tachycardia...
AEs

AEs

AESignificanceDosePopulation
Hypotension
40 mg 3 times / day multiple, oral
Recommended
Dose: 40 mg, 3 times / day
Route: oral
Route: multiple
Dose: 40 mg, 3 times / day
Sources:
unhealthy
Tachycardia
40 mg 3 times / day multiple, oral
Recommended
Dose: 40 mg, 3 times / day
Route: oral
Route: multiple
Dose: 40 mg, 3 times / day
Sources:
unhealthy
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
no [IC50 >100 uM]
yes [Activation 28.1838 uM]
yes [IC50 2.72 uM]
yes [IC50 4.9 uM]
yes [IC50 6.13 uM]
yes
yes
yes
yes
yes
yes
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
[Effects of 2-(4-benzyl-piperidino)-1-(4-hydroxyphenyl)-1-propanol (ifenprodil) on the cardiovascular system in vivo].
1975 Sep
[Comparison of selective alpha-1 blockades for alpha-receptors in human hypertrophied prostatic adenomas].
1992 Mar
Neurotransmitter-mediated open-field behavioral action of CGRP.
1999
[Prevention and release of epidural-morphine-induced urinary retention with phenoxybenzamine and neostigmine].
2000 Dec
Clinical management of malignant adrenal tumors.
2001
Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery.
2001 Apr
Pheochromocytoma in a pregnant woman with multiple endocrine neoplasia type 2a.
2001 Dec
Potency, affinity constants and receptor reserves for noradrenaline and adrenaline on aortae from aged normo- and hypertensive rats.
2001 Feb
Novel dual 'small' vesicle model of ATP- and noradrenaline-mediated sympathetic neuromuscular transmission.
2001 Feb 20
Doxazosin inhibits monocyte chemotactic protein 1-directed migration of human monocytes.
2001 May
Responsiveness, affinity constants and receptor reserves for serotonin on aortae of aged normotensive and hypertensive rats.
2001 Oct
Rapid preparation of a patient with pheochromocytoma with labetolol and magnesium sulfate.
2001 Oct
Modulation of ET(B) receptor-induced arginine-vasopressin secretion by N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid (GABA)-dependent mechanisms in hypothalamo-neurohypophysial explants.
2002 Aug
Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.
2002 Feb
alpha(1A)-adrenoceptors mediate sympathetically evoked pupillary dilation in rats.
2002 Feb
Cerebrovascular effects of intravenous dopamine infusions in fetal sheep.
2002 Feb
Alpha blockade in preoperative preparation of patients with pheochromocytomas.
2002 Jul-Sep
Structure--activity relationships among novel phenoxybenzamine-related beta-chloroethylamines.
2002 May
Atrial supersensitivity to noradrenaline in stressed female rats.
2002 Nov 8
The role of alpha1D-adrenoceptors in prostatic contraction examined using protection studies.
2002 Oct-Dec
Neurotransmitter release in an arterial preparation and the action of alpha-adrenoceptor antagonists.
2002 Oct-Dec
Pheochromocytoma: an approach to antihypertensive management.
2002 Sep
[Haematemesis and dysphagia in a 20-year-old woman with congenital spine malformation and situs inversus partialis].
2003 Apr
Characterization of adrenoceptor involvement in skeletal and cardiac myotoxicity Induced by sympathomimetic agents: toward a new bioassay for beta-blockers.
2003 Apr
Phaeochromocytoma--views on current management.
2003 Aug
Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors.
2003 Dec
Urethral pressure profile and hemodynamic effects of phenoxybenzamine and prazosin in non-sedated male beagle dogs.
2003 Jan
Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves.
2003 Jan
Functional characterisation of alpha(1)-adrenoceptors in denervated rat vas deferens.
2003 Jul
Elevation of the nasal mucosal surface temperature after warming of the feet occurs via a neural reflex.
2003 Jun
Studies of alpha-adrenoceptor antagonists on sympathetic mydriasis in rabbits.
2003 Jun
Mechanisms involved in the pressor response to noradrenaline injection into the cingulate cortex of unanesthetized rats.
2003 May
Involvement of different receptors in pituitary adenylate cyclase activating polypeptide induced open field activity in rats.
2004 Feb
Release and functional role of neuropeptide Y as a sympathetic modulator in human saphenous vein biopsies.
2004 Jan
Increased reactivity of murine mesenteric veins to adrenergic agonists: functional evidence supporting increased alpha1-adrenoceptor reserve in veins compared with arteries.
2004 Jan
Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense.
2004 Mar
Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure.
2004 Mar
Patents

Sample Use Guides

Initially, 10 mg twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:29:07 UTC 2021
Edited
by admin
on Sat Jun 26 04:29:07 UTC 2021
Record UNII
0TTZ664R7Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENOXYBENZAMINE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
PHENOXYBENZAMINE [INN]
Common Name English
BENSYLYT
Common Name English
BENZYLYT
Common Name English
(+/-)-PHENOXYBENZAMINE
Common Name English
DIBENYLIN
Common Name English
N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)BENZENEMETHANAMINE
Systematic Name English
BENZENEMETHANAMINE, N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)-
Systematic Name English
DIBENZYLINE
Brand Name English
PHENOXYBENZAMINE [HSDB]
Common Name English
BENZYLAMINE, N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)-
Systematic Name English
DIBENYLINE
Common Name English
PHENOXYBENZAMINE [VANDF]
Common Name English
N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)BENZYLAMINE
Systematic Name English
PHENOXYBENZAMINE [MI]
Common Name English
N-PHENOXYISOPROPYL-N-BENZYL-.BETA.-CHLOROETHYLAMINE
Systematic Name English
PHENOXYBENZAMINE [WHO-DD]
Common Name English
688A
Common Name English
Classification Tree Code System Code
NDF-RT N0000000099
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
WHO-ATC C04AX02
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
NDF-RT N0000175553
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
WHO-VATC QC04AX02
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
NCI_THESAURUS C29713
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
NCI_THESAURUS C45178
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
Code System Code Type Description
RXCUI
8149
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY RxNorm
INN
608
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
PUBCHEM
4768
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
CAS
102737-84-8
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
SUPERSEDED
MESH
D010643
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
HSDB
4005
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
ChEMBL
CHEMBL753
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-446-8
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
EVMPD
SUB09778MIG
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
WIKIPEDIA
PHENOXYBENZAMINE
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
DRUG BANK
DB00925
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
MERCK INDEX
M8638
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY Merck Index
DRUG CENTRAL
2136
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
IUPHAR
7268
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
NCI_THESAURUS
C62065
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
CAS
59-96-1
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
EPA CompTox
59-96-1
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
FDA UNII
0TTZ664R7Z
Created by admin on Sat Jun 26 04:29:07 UTC 2021 , Edited by admin on Sat Jun 26 04:29:07 UTC 2021
PRIMARY
Related Record Type Details
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
TRANSPORTER -> INHIBITOR
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC