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Details

Stereochemistry ACHIRAL
Molecular Formula C5H9N3
Molecular Weight 111.1451
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HISTAMINE

SMILES

NCCC1=CNC=N1

InChI

InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N
InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

HIDE SMILES / InChI
Molecular Formula C5H9N3
Molecular Weight 111.1451
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Histamine is a depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Phosphate salt of jistamine was used as a diagnostic aid for evaluation of gastric acid secretory function. In addition, this compound is used as a positive control in evaluation of allergenic (immediate hypersensitivity or "Type I") skin testing. In addition, histamine is being studied for treatment of multiple sclerosis. It was approved, that histamine physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention. The receptors display molecular heterogeneity and constitutive activity. H1R antagonists are long known antiallergic and sedating drugs, whereas the H2R led to the development of H2R-antagonists that revolutionized stomach ulcer treatment. The H3R is an auto receptor and heteroreceptor providing negative feedback on histaminergic and inhibition on other neurons. The H4R occurs on immuncompetent cells and the development of anti-inflammatory drugs is anticipated.

CNS Activity

Originator

Approval Year

1939
36
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2752
Agonist
2752
Agonist
2752
Agonist
2752
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Not Provided
511
HISTAMINE PHOSPHATE

Approved Use

Indications and Usage Uses temporarily relieves symptoms due to sinus discomforts associated with inflamed sinuses, hay fever or upper respiratory allergies: sinus pain and pressure runny nose sinus headaches sore throat nasal congestion dry mucus membranes sneezing itchy, burning eyes Reference image sinus.jpg

Launch Date

1939
Primary
Basic research
Unknown

Approved Use

Unknown
Diagnostic
Approved
8583
HISTAMINE PHOSPHATE

Approved Use

Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function. Anacidity (achlorhydria) in response to histamine may indicate pernicious anemia, atrophic gastritis, adenomatous polyps of stomach, or gastric carcinoma. Gastric hypersecretion in response to histamine may indicate duodenal ulcer or the Zollinger-Ellison syndrome.

Launch Date

1939
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
39 nM
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/12092744
1 mg single, subcutaneous
dose: 1 mg
route of administration: Subcutaneous
experiment type: SINGLE
co-administered:
HISTAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1877 nM × min
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/12092744
1 mg single, subcutaneous
dose: 1 mg
route of administration: Subcutaneous
experiment type: SINGLE
co-administered:
HISTAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
12 min
EXPERIMENT
https://www.ncbi.nlm.nih.gov/pubmed/12092744
1 mg single, subcutaneous
dose: 1 mg
route of administration: Subcutaneous
experiment type: SINGLE
co-administered:
HISTAMINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
Doses

Doses

DosePopulationAdverse events​
0.03 mg single, intravenous
Highest studied dose
Dose: 0.03 mg
Route: intravenous
Route: single
Dose: 0.03 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/16695374
unhealthy
Health Status: unhealthy
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/16695374
Sources:
https://pubmed.ncbi.nlm.nih.gov/16695374
0.2 mg single, intramuscular
Highest studied dose
Dose: 0.2 mg
Route: intramuscular
Route: single
Dose: 0.2 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/16695374
unhealthy
Health Status: unhealthy
Sex: M
Sources:
https://pubmed.ncbi.nlm.nih.gov/16695374
Sources:
https://pubmed.ncbi.nlm.nih.gov/16695374
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
OCT2
434

OCT3
92
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
OCT2
434
 yes
OCT3
92
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY557484
https://www.001chemical.com/chem/51-45-6
3B Scientific (Wuhan) Corp
3B3-033520
http://www.3bsc.com/index/pro_info.php?id=54784
AA Blocks
AA0037B9
http://www.aablocks.com/goods/Goods/detail?id=AA0037B9
Aaron Chemicals
AR003831
http://www.aaronchem.com/51-45-6
abcr GmbH
AB349089
http://www.abcr.com/shop/en/AB349089
abcr GmbH
AB511890
http://www.abcr.com/shop/en/AB511890
AbMole Bioscience
M5692
http://www.abmole.com/products/histamine.html
Acadechem
ACDS-017396
http://www.acadechemical.com/product/92095
Accela ChemBio Inc
SY041787
http://www.accelachem.com/cn/search.html?keyword=SY041787&attname=GoodsCode
Achemo Scientific Limited
AC-45306
http://www.achemo.com/search/?Keyword=51-45-6
Achemtek
0104-056461
http://www.achemtek.com/51-45-6
Acros Organics
AC411710010
https://www.fishersci.com/shop/products/histamine-97-acros-organics/AC411710010
Acros Organics
AC411710050
https://www.fishersci.com/shop/products/histamine-97-acros-organics/AC411710050
Acros Organics
AC411710250
https://www.fishersci.com/shop/products/histamine-97-acros-organics/AC411710250
AHH Chemical co.,ltd
MB-01356
http://www.ahhchemical.com/product/MB-01356.html
AHH Chemical co.,ltd
MT-52563
http://www.ahhchemical.com/product/MT-52563.html
AK Scientific, Inc. (AKSCI)
Y9749
http://www.aksci.com/item_detail.php?cat=Y9749
Alfa Chemistry
51-45-6
https://www.alfa-chemistry.com/histamine-cas-51-45-6-item-292336.htm
Alfa Chemistry
AP51456-A
https://reagents.alfa-chemistry.com/product/histamine-cas-51-45-6-12315.html
Alfa Chemistry
AP51456-B
https://reagents.alfa-chemistry.com/product/histamine-free-base-cas-51-45-6-cas-51-45-6-12316.html
Alichem
69004288
http://www.alichem.com/en/products/65592-96-3.html
Alinda
ALBB-005968
http://alinda.ru/finechem_en_.html?i=ALBB-005968
Ambeed
A804010
https://www.ambeed.com/products/51-45-6.html
Ambinter
Amb1101977
http://www.ambinter.com/reference/1101977
Angene
AGN-PC-007FY2
http://www.angenechemical.com/productshow/AGN-PC-007FY2.html
Angene
AGN-PC-0TH9T7
http://www.angenechemical.com/productshow/AGN-PC-0TH9T7.html
Anward
ANW-50461
http://www.anward.com/pro_result/36912
Aurora Fine Chemicals LLC
A00.704.248
http://online.aurorafinechemicals.com/info?ID=A00.704.248
Aurora Fine Chemicals LLC
K01.795.228
http://online.aurorafinechemicals.com/info?ID=K01.795.228
Aurum Pharmatech LLC
C-5322
http://www.Aurumpharmatech.com/Product/ProductDetails/C_5322
Avantor Inc
101186-436
https://us.vwr.com/store/catalog/product.jsp?catalog_number=101186-436
BioCrick
BCN2188
http://www.biocrick.com/Histamine-BCN2188.html
BioSynth
J-505349
https://www.biosynth.com/en/products/all-products/products/J-505349.html
BLD Pharm
BD41747
http://www.bldpharm.com/products/51-45-6.html
BLD Pharm
BD61796
http://www.bldpharm.com/products/65592-96-3.html
BOC Sciences
344299-48-5
https://isotope.bocsci.com/product/histamine-d4-dihydrochloride-cas-344299-48-5-110348.html
Boerchem
BC205752
http://www.boerchem.com/?product_34681.html
BroadPharm
BP-11484
http://www.broadpharm.com/products/Amines/BP-11484/
Calbiochem
3779
http://www.emdbiosciences.com/product/3779
Chem Scene
CS-4697
http://www.chemscene.com/51-45-6.html
Chemenu
CM117809
http://www.chemenu.com/products/CM117809
ChemFaces
CFN90029
http://www.chemfaces.com/natural/Histamine-CFN90029.html
ChemMol
30102836
http://www.chemmol.com/chemmol/30102836.html
ChemMol
44002277
http://www.chemmol.com/chemmol/44002277.html
ChemMol
49403308
http://www.chemmol.com/chemmol/49403308.html
ChemMol
49417190
http://www.chemmol.com/chemmol/49417190.html
ChemMol
49425866
http://www.chemmol.com/chemmol/49425866.html
Chemspace
CSSB00000756591
https://chem-space.com/CSSB00000756591
Clearsynth
CS-M-25829
https://www.clearsynth.com/en/CSM25829.html
CSNpharm
CSN16747
https://www.csnpharm.com/products/histamine.html
EMD Millipore
3779
http://www.emdbiosciences.com/product/3779
eNovation Chemicals
D382889
http://www.enovationchem.com/productDetails.asp?productID=D382889
eNovation Chemicals
D914693
https://www.enovationchem.com/ProductDetails.asp?ProductID=D914693
eNovation Chemicals
K66466
https://www.enovationchem.com/ProductDetails.asp?ProductID=K66466
eNovation Chemicals
Y1043716
https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1043716
Finetech
FT-0627839
http://www.finetechnology-ind.com/prod/detail/pub/51-45-6.html
Glentham Life Sciences
GL9196
http://www.glentham.com/products/product/GL9196/
Hairui
HR122599
http://www.hairuichem.com/en/product/51-45-6.html
iChemical
EBD6913
http://www.ichemical.com/products/51-45-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network
LN00011223
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00011223
Matrix Scientific
133714
https://www.matrixscientific.com/133714.html
mcule
MCULE-4970362785
https://mcule.com/MCULE-4970362785/
MedChem Express
HY-B1204
https://www.medchemexpress.com/Histamine.html
Molcore
MC557484
https://www.molcore.com/product/51-45-6
MuseChem
I003852
https://www.musechem.com/product/I003852.html
Oakwood
78943
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=64117&ExtHyperLink=1
OChem
11930
http://www.ocheminc.com/index.php?act=psearch&pid=056H928
OChem
3670
http://www.ocheminc.com/index.php?act=psearch&pid=714I940
Otava
2816948
https://search.otavachemicals.com/#!/search?query=2816948&type=code&base=dbb
Parchem
29572
https://www.parchem.com/chemical-supplier-distributor/Histamine-029572.aspx
Parchem
Histamine
http://www.parchem.com/chemical-supplier-distributor/Histamine-029572.aspx
Renno Tech
RP00535
http://www.rennotech.com/product_show.asp?id=6925
Selleck Chemicals
S3968
http://www.selleckchem.com/products/histamine.html
Sigma-Aldrich
53290_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/53290?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
59964_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/59964?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
H7125_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/h7125?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
V900396_VETEC
https://www.sigmaaldrich.com/catalog/product/vetec/v900396?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
Y0001779_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/y0001779?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech
S001739
http://www.sinfoobiotech.com/product/1005137
Smolecule
S590017
https://www.smolecule.com/products/s590017
THE BioTek
bt-301933
https://www.thebiotek.com/product/others/bt-301933
VladaChem
VL270045-1G
https://www.vladachem.com/product.php?products=51-45-6
Yuhao Chemical
HL1018
http://www.chemyuhao.com/51-45-6.html
PubMed

PubMed

TitleDatePubMed
Diesel exhaust particulates upregulate histamine receptor mRNA and increase histamine-induced IL-8 and GM-CSF production in nasal epithelial cells and endothelial cells.
1999 Jan
Selective substrates for non-neuronal monoamine transporters.
1999 Jul
Involvement of glutamate in transmission of afferent constrictive inputs from the airways to the nucleus tractus solitarius in ferrets.
2000 Apr 12
Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles.
2000 Jun
Assessment and treatment of laboratory animal allergy.
2001
Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids.
2001 Feb
Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial.
2001 Feb
IL-18 might reflect disease activity in mild and moderate asthma exacerbation.
2001 Feb
Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures.
2001 Feb
Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis.
2001 Feb
Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells.
2001 Feb
A human tissue-engineered vascular media: a new model for pharmacological studies of contractile responses.
2001 Feb
IL-13 overexpression predisposes to anaphylaxis following antigen sensitization.
2001 Feb 15
Selective down-regulation of high-affinity IgE receptor (FcepsilonRI) alpha-chain messenger RNA among transcriptome in cord blood-derived versus adult peripheral blood-derived cultured human mast cells.
2001 Feb 15
Involvement of central histaminergic neurons in polypnea induced by hyperthermia in rabbits.
2001 Feb 2
Food-deprived activity stress decreased the activity of the histaminergic neuron system in rats.
2001 Feb 9
Comparison of montelukast and fexofenadine for chronic idiopathic urticaria.
2001 Jan
Preclinical profile of the monodisperse iodinated macromolecular blood pool agent P743.
2001 Jan
The dyspepsia alphabet: DU, GU, GERD, NERD, NUD/FD and UD.
2001 Jan
Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis.
2001 Jan
Combination therapy with anti-mediator drugs in allergic disease.
2001 Jan
Urticaria induced by cetirizine.
2001 Jan
The treatment of rhinovirus infections: progress and potential.
2001 Jan
Effect of acute metabolic acid/base shifts on the human airway calibre.
2001 Jan
Antihistamines.
2001 Jan
Effects of cetirizine and epinastine on the skin response to histamine iontophoresis.
2001 Jan
Management of severe gastroesophageal reflux disease.
2001 Jan
Acidification of formula reduces bacterial translocation and gut colonization in a neonatal rabbit model.
2001 Jan
Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat.
2001 Jan
Expression of humanized Fab fragments that recognize the IgE-binding domain of human Fc(epsilon)RIalpha in COS and CHO cells.
2001 Jan
Identification of rat H3 receptor isoforms with different brain expression and signaling properties.
2001 Jan
Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients.
2001 Jan 1
Approaches to healing and prophylaxis of nonsteroidal anti-inflammatory drug-associated ulcers.
2001 Jan 8
Pharmacological characterization of the rat paw edema induced by Bothrops lanceolatus (Fer de lance) venom.
2001 Jun
Decreased brain histamine-releasing factor protein in patients with Down syndrome and Alzheimer's disease.
2001 Mar 2
Neurohormonal regulation of secretion from isolated rat stomach ECL cells: a critical reappraisal.
2001 Mar 2
Peptide leucine arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens.
2001 Mar 30
Patents

Patents

06084130
4
06518423
6
07517995
4
07678801
7
08022222
6
08299085
6
08519146
4
08691991
8
08754233
4

Sample Use Guides

In Vivo Use Guide
The skin in the test area should be cleansed with alcohol and air dried. The histamine control skin test solution should be placed at the same site with the other skin test antigens, either on the patient's back or on the volar surface of the forearm. The patient should be placed in a comfortable position before the testing is begun. For the prick test, a sharp needle is used to puncture the skin, but not to draw blood. If the scratch test is used, carefully break or scratch the skin with a sterile scarifier. Do not draw blood. Each scratch should be about 2 mm - 4 mm in length. A small drop of the histamine base 1 mg/mL (Histamine Phosphate 2.75 mg/mL) is placed on the abraded skin site no closer than 4 or 5 cm from an adjacent test site. Some physicians prefer to place the solution on the test area and then prick through the drop with a sharp needle.
Route of Administration: Parenteral
In Vitro Use Guide
Histamine prevented monocytic apoptosis induced by serum deprivation, CD95/Fas ligation, or dexamethasone in a dose- and time-dependent fashion. The inhibitory effects of histamine on monocytic apoptosis were blocked by an H2R antagonist, and mimicked by an H2R agonist. Histamine also up-regulated the expression of Bcl-2 and Mcl-1, and inhibited the activation of caspase-3. The culture supernatants from histamine-treated monocytes inhibited monocytic apoptosis, which was partly reversed by the removal of IL-10. Monocytes cultured with anti-IL-10 mAb and histamine did not exhibit an inhibitory effect on apoptosis. The histamine-induced anti-apoptotic effect was attenuated when monocytes were cultured in the presence of a cAMP inhibitor.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:49:15 GMT 2025
Edited
by admin
on Mon Mar 31 17:49:15 GMT 2025
Record UNII
820484N8I3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NSC-33792
Preferred Name English
HISTAMINE
HSDB   MART.   MI   VANDF   WHO-DD  
Systematic Name English
ERGOTIDINE
Common Name English
ERGAMINE
Common Name English
Histamine [WHO-DD]
Common Name English
HISTAMINE [MI]
Common Name English
5-IMIDAZOLEETHYLAMINE
Systematic Name English
HISTAMINE [MART.]
Common Name English
1H-IMIDAZOLE-4-ETHANAMINE
Systematic Name English
HISTAMINE [VANDF]
Common Name English
.BETA.-AMINOETHYLGLYOXALINE
Common Name English
4-IMIDAZOLEETHYLAMINE
Systematic Name English
.BETA.-AMINOETHYLIMIDAZOLE
Systematic Name English
2-(4-IMIDAZOLYL)ETHYLAMINE
Systematic Name English
HISTAMINE [HSDB]
Common Name English
Classification Tree Code System Code
LOINC 34316-0
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 33290-8
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 25439-1
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 2417-4
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 34317-8
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
NCI_THESAURUS C687
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
FDA ORPHAN DRUG 127199
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 2416-6
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
FDA ORPHAN DRUG 127399
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 13755-4
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 13756-2
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 9410-2
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 2415-8
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 25925-9
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
WHO-ATC L03AX14
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
NCI_THESAURUS C2139
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 35260-9
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
LOINC 43577-6
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LOINC 44371-3
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C73238
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
NSC
33792
Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025
PRIMARY
FDA UNII
820484N8I3
Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025
PRIMARY
DRUG BANK
DB05381
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-100-6
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
CAS
51-45-6
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
WIKIPEDIA
HISTAMINE
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
MESH
D006632
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
DRUG CENTRAL
1375
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
MERCK INDEX
m6026
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY Merck Index
PUBCHEM
774
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
CHEBI
18295
Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025
PRIMARY
CHEBI
58432
Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025
PRIMARY
EPA CompTox
DTXSID4023125
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
HSDB
3338
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
SMS_ID
100000089506
Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025
PRIMARY
DAILYMED
820484N8I3
Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025
PRIMARY
RXCUI
5333
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY RxNorm
EVMPD
SUB14107MIG
Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025
PRIMARY
Related Record Type Details
HISTAMINE H1 RECEPTOR
TARGET -> AGONIST
IC50
Structure of HISTAMINE DIHYDROCHLORIDE
SALT/SOLVATE -> PARENT
OCT-1
TRANSPORTER -> SUBSTRATE
Structure of HISTAMINE PHOSPHATE
SALT/SOLVATE -> PARENT
Histamine N-methyltransferase
METABOLIC ENZYME -> SUBSTRATE
OCT-3
TRANSPORTER -> INHIBITOR
HISTAMINE H1 RECEPTOR
TARGET -> AGONIST
CHO-H1 cells, histamine stimulation resulted in a concentration-dependent increase in [Ca2+]i with an EC50 of 170±30 nM.
EC50
Structure of HISTAMINE MONOHYDROCHLORIDE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of N-METHYLIMIDAZOLEACETIC ACID
METABOLITE INACTIVE -> PARENT
MAJOR
Structure of 1-METHYLHISTAMINE
METABOLITE INACTIVE -> PARENT
Structure of Imidazole acetylaldehyde
METABOLITE INACTIVE -> PARENT
Structure of IMIDAZOLEACETIC ACID
METABOLITE INACTIVE -> PARENT
MAJOR
Related Record Type Details
Structure of HISTAMINE
ACTIVE MOIETY
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NCATS
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