CORTICOSTERONE

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H30O4
Molecular Weight	346.4605
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=OMFXVFTZEKFJBZ-HJTSIMOOSA-N

InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H30O4
Molecular Weight	346.4605
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16817814 | https://www.innov-research.com/product/human-corticosterone-elisa-kit/

Corticosterone is an adrenocortical steroid, the major glucocorticoid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. Corticosterone is of minor importance in humans but is known, that it has a profound effect on the structure and function of the hippocampus. Brain corticosterone may involve memory storage and emotional stress might cause increases in plasma corticosterone.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Mineralocorticoid receptor 53 Target ID: CHEMBL1994 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25173821	Activator 1410
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25173821	Activator 1410

Conditions

Condition	Modality	Targets	Highest Phase	Product
Emotional stress 4 Sources: https://www.innov-research.com/product/human-corticosterone-elisa-kit/	Diagnostic		Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Quantitative analysis of the neuroendocrine-immune axis: linear modeling of the effects of exogenous corticosterone and restraint stress on lymphocyte subpopulations in the spleen and thymus in female B6C3F1 mice.	2000 Dec	11120596
[Mineralocorticoids in cervical mucous and female blood serum: levels in the preovulatory phase of the menstrual cycle].	2000 Sep	11082965
Mild prenatal stress enhances learning performance in the non-adopted rat offspring.	2001	11246145
Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis.	2001	11226692
Light and electron microscopy localization of the 11beta-hydroxysteroid dehydrogenase type I enzyme in the rat.	2001 Apr	11250946
Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action.	2001 Apr	11250914
Endomorphins and activation of the hypothalamo-pituitary-adrenal axis.	2001 Apr	11250660
Early growth retardation induced by excessive exposure to glucocorticoids in utero selectively increases cardiac GLUT1 protein expression and Akt/protein kinase B activity in adulthood.	2001 Apr	11250642
Parabrachial nucleus modulates cardiovascular responses to blood loss.	2001 Apr	11247837
Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects.	2001 Apr	11182529
Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine.	2001 Apr 1	11245970
Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strain.	2001 Apr 8	11173082
Bidirectional effects of corticosterone on splenic T-cell activation: critical role of cell density and culture time.	2001 Feb	11244301
Acute changes in the response to peripheral leptin with alteration in the diet composition.	2001 Feb	11208581
Vasopressin pressor receptor-mediated activation of HPA axis by acute ethanol stress in rats.	2001 Feb	11208575
Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum.	2001 Feb	11207816
Role of hypothalamic neuropeptide Y and orexigenic peptides in anorexia associated with experimental colitis in the rat.	2001 Feb	11171292
Glucocorticoids, androgens, testis mass, and the energetics of vocalization in breeding male frogs.	2001 Feb	11161884
Neuroendocrine regulation of sexually dimorphic brain structure and associated sexual behavior in male rats is genetically controlled.	2001 Feb	11159360
Long term modulation of the HPA axis by the hippocampus. Behavioral, biochemical and immunological endpoints in rats exposed to chronic mild stress.	2001 Feb	11087960
Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge.	2001 Feb 1	11137578
Glucocorticoids modulate the NGF mRNA response in the rat hippocampus after traumatic brain injury.	2001 Feb 23	11172788
Central monoamine activity in genetically distinct strains of mice following a psychogenic stressor: effects of predator exposure.	2001 Feb 23	11172776
GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant.	2001 Feb 28	11223190
Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress.	2001 Feb 9	11212944
Interactions between effects of adrenalectomy and diet on insulin secretion in fa/fa Zucker rats.	2001 Jan	11201495
The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages.	2001 Jan	11201289
Bombesin-induced HPA and sympathetic activation requires CRH receptors.	2001 Jan	11179598
Differential effects of dexamethasone treatment on lipopolysaccharide-induced testicular inflammation and reproductive hormone inhibition in adult rats.	2001 Jan	11139783
Manipulation of androgens causes different energetic responses to cold in 60- and 40-day-old male rats.	2001 Jan	11124160
Acute stress rapidly and persistently enhances memory formation in the male rat.	2001 Jan	11124044
Chromaffin-adrenocortical cell interactions: effects of chromaffin cell activation in adrenal cell cocultures.	2001 Jan	11121377
Buffering action of endogenous nitric oxide on the adrenocortical secretagogue effect of endothelins in the rat.	2001 Jan	11115609
Sexual diergism in rat hypothalamic-pituitary-adrenal axis responses to cholinergic stimulation and antagonism.	2001 Jan 1	11226719
Vendor differences in cocaine-induced behavioral activity and hormonal interactions in ovariectomized Fischer rats.	2001 Jan 1	11226708
Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.	2001 Jan 1	11205421
Relationships between IFNgamma, IL-6, corticosterone, and Listeria monocytogenes pathogenesis in BALB/c mice.	2001 Jan 10	11161448
Entrainment of the circadian clock in the liver by feeding.	2001 Jan 19	11161204
The effects of a mild stressor on spontaneous alternation in mice.	2001 Jan 8	11163629
Acetaldehyde, a metabolite of ethanol, activates the hypothalamic-pituitary-adrenal axis in the rat.	2001 Jan-Feb	11139417
Maternal essential fatty acid deficiency depresses serum leptin levels in suckling rat pups.	2001 Mar	11254747
Long-term fasting and re-feeding in penguins.	2001 Mar	11246051
Endocrine regulation of G-protein subunit production in an animal model of type 2 diabetes mellitus.	2001 Mar	11241182
Inhibition of aldosterone production in rat adrenal mitochondria by 18-ethynyl-11-deoxycorticosterone: a simple model for kinetic interpretation of mechanism-based inhibitors.	2001 Mar	11226877
Corticosteroid effects on serotonin responses in granule cells of the rat dentate gyrus.	2001 Mar	11207937
Long-term colony housing in Long Evans rats: immunological, hormonal, and behavioral consequences.	2001 Mar 1	11240023
Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats.	2001 Mar 2	11223006
Stereotaxic delivery of corticosterone to the amygdala modulates colonic sensitivity in rats.	2001 Mar 2	11223001
Alpha-helical-corticotropin-releasing hormone reverses anxiogenic effects of C-type natriuretic peptide in rats.	2001 Mar 2	11222988
Role of corticosterone in ethyl carbamate-induced immunosuppression in female BALB/c mice.	2001 Mar 8	11246170

Patents

Sample Use Guides

In Vivo Use Guide

for rats: effects of chronic exposure to corticosterone in drinking water on corticosterone kinetics, blood chemistry, and concentrations of catecholamines in parts of brain were studied in Long-Evans rats. Rats were randomly grouped into 3 x 2 treatments (n=4), with three treatments of drinking water (tap water, or 2.5% ethanol, or 400 microg/mL of corticosterone in 2.5% ethanol) for 28 days and two treatments of gavage with a single dose of either corn oil or corticosterone 20 mg/kg on day 28. Blood samples were collected at 0, 15, 30, 60, 120, 240, 480, and 720 min after dosing to determine plasma corticosterone concentrations.

Route of Administration: Oral

In Vitro Use Guide

Fibroblast-like synovial cells of rat were stimulated with 10 ng/ml interleukin (IL)-1β for 24 h, and were subsequently, within the next 24 h, treated with or without 10-6 mmol/l corticosterone alone or with 100 nmol/l PF915275. At the end of the second 24 h, PGE2 levels in culture supernatants were assayed. Corticosterone was demonstrated to suppress the mRNA expression levels of inflammatory factors, such as TNF-α and PGE2, induced by IL-1β in vitro. Simultaneously, expression levels of 11β-HSD1 decreased significantly at the mRNA and protein levels (P<0.05).

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:47:17 UTC 2023` Edited by `admin` on `Wed Jul 05 22:47:17 UTC 2023`
Record UNII	W980KJ009P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CORTICOSTERONE

Common Name

English

NSC-9705

Code

English

REICHSTEIN'S SUBSTANCE H

Common Name

English

(11.BETA.)-11,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE

Systematic Name

English

CORTICOSTERONE [MI]

Common Name

English

KENDALL'S COMPOUND B

Common Name

English

4-PREGNENE-11.BETA.,21-DIOL-3,20-DIONE

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 862.1200