Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H5N |
Molecular Weight | 79.0999 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C1=CC=NC=C1
InChI
InChIKey=JUJWROOIHBZHMG-UHFFFAOYSA-N
InChI=1S/C5H5N/c1-2-4-6-5-3-1/h1-5H
Molecular Formula | C5H5N |
Molecular Weight | 79.0999 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Pyridine is a basic heterocyclic organic compound used as a solvent in organic synthesis. Since the pyridine ring has three double bonds, six p-electrons exist, which are sufficient for aromatic ring formation without involving the lone pair electrons of the nitrogen atom. Since the lone pair electrons remain free, quaternary salts retain the aromaticity. However, the nitrogen atom has a higher electronegativity than the carbon atoms and shows an electron-withdrawing effect. In oxidation and reduction reactions, the pyridine ring exhibits properties characteristic of pelectron-deficient aromatic rings: resistance to oxidation and facile reduction. Pyridine bases are a constituent of tars. They were isolated from coal tar or coal gas before synthetic manufacturing processes became established. Pyridine is an excellent solvent, especially for dehydrochlorination reactions and extraction of antibiotics. Large amounts of pyridine are used as starting material for pharmaceuticals and agrochemicals: for example, herbicides such as diquat and paraquat, insecticides such as chlorpyrifos, and fungicides such as pyrithione. Pyridine is harmful if inhaled, swallowed or absorbed through the skin. Effects of acute pyridine intoxication include dizziness, headache, lack of coordination, nausea, salivation, and loss of appetite.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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Imaging stochastic spatial variability of active channel clusters during excitation of single neurons. | 2001 Apr |
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Role of platelet-activating factor in hepatectomy with Pringle's maneuver. | 2001 Apr |
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Separation of basic, acidic and neutral compounds by capillary electrochromatography using uncharged monolithic capillary columns modified with anionic and cationic surfactants. | 2001 Feb |
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Symptomatic and urodynamic improvement by oral distigmine bromide in poor voiders after transurethral resection of the prostate. | 2001 Feb |
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Antiviral and antiproliferative activity in vitro of some new benzimidazole derivatives. | 2001 Feb |
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Effects of staurosporine on exocytosis and endocytosis at frog motor nerve terminals. | 2001 Feb 1 |
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High-performance liquid chromatographic assays for a second-generation novel oral iron chelator (APCP363) and their application to pharmacokinetic studies in rats. | 2001 Feb 10 |
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Optimization of separation and migration behavior of chloropyridines in micellar electrokinetic chromatography. | 2001 Feb 23 |
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Potential 166Ho radiopharmaceuticals for endovascular radionuclide therapy. II. Preparation and evaluation of 166Ho-DTPA. | 2001 Jan |
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Absorbance data of hypericin and pseudohypericin used as reference compounds for medicinal plant analysis. | 2001 Jan |
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Experimental and ab initio MO studies on the IR spectra and structure of pyridinium dicyanomethylide and trimethylammonium dicyanomethylide. | 2001 Jan |
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NBD-labeled phosphatidylcholine and phosphatidylethanolamine are internalized by transbilayer transport across the yeast plasma membrane. | 2001 Jan |
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N-(8-Quinolyl)pyridine-2-carboxamide. | 2001 Jan |
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Hydrogen peroxide acts as a second messenger for the induction of defense genes in tomato plants in response to wounding, systemin, and methyl jasmonate. | 2001 Jan |
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Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6. | 2001 Jan |
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Functional plasticity triggers formation and pruning of dendritic spines in cultured hippocampal networks. | 2001 Jan 1 |
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A covalent vanadium(III) 2-dimensional network and vanadyl chains linked by aryldioxides. | 2001 Jan 15 |
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Mono- and dinuclear zinc complexes derived from unsymmetric binucleating ligands: synthesis, characterization, and formation of tetranuclear arrays. | 2001 Jan 15 |
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Dinuclear alkyldiamine platinum antitumor compounds: a structure-activity relationship study. | 2001 Jan 18 |
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Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases. | 2001 Jan 22 |
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Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease. | 2001 Jan 26 |
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Reactions of some 2- and 4-O-triflylglycopyranosides with MeLi, t-BuOK, and pyridine. | 2001 Jan 30 |
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Capillary zone electrophoresis of basic analytes in methanol as non-aqueous solvent mobility and ionisation constant. | 2001 Jan 5 |
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A rigid linker-scaffold for solid-phase synthesis of dimeric pharmacophores. | 2001 Jan-Feb |
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Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney. | 2001 Mar |
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Coherent scattering in multi-harmonic light microscopy. | 2001 Mar |
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Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment. | 2001 Mar |
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Fragment mode analysis and its application to the vibrational normal modes of boron trichloride-ammonia and boron trichloride-pyridine complexes. | 2001 Mar 1 |
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Antipsoriatic anthrones with modulated redox properties. 5. Potent inhibition of human keratinocyte growth, induction of keratinocyte differentiation, and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones. | 2001 Mar 1 |
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Excited-state properties of Rh(2)(O(2)CCH(3))(4)(L)(2) (L = CH(3)OH, THF, PPh(3), py). | 2001 Mar 12 |
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Highly energetic tetraazidoborate anion and boron triazide adducts. | 2001 Mar 12 |
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Crystal structure analysis and chiral recognition study of Delta-[Ru(bpy)2(py)2][(+)-O,O'-dibenzoylD-tartrate].12H2O and Lambda-[Ru(bpy)2(py)2][(-)-O,O'-dibenzoyl-L-tartrate].12H2O. | 2001 Mar 12 |
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On the enzymatic activation of NADH. | 2001 Mar 23 |
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Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons. | 2001 Mar 5 |
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NAD/NADH models with axial/central chiralities: superiority of the quinoline ring system. | 2001 Mar 9 |
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Mapping action potentials and calcium transients simultaneously from the intact heart. | 2001 May |
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Inhibition of ATP-induced surfactant exocytosis by dihydropyridine (DHP) derivatives: a non-stereospecific, photoactivated effect and independent of L-type Ca2+ channels. | 2001 May 1 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:40:52 GMT 2025
by
admin
on
Mon Mar 31 18:40:52 GMT 2025
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Record UNII |
NH9L3PP67S
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Record Status |
Validated (UNII)
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Record Version |
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EPA PESTICIDE CODE |
69202
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CFR |
21 CFR 172.515
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406123
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C023666
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NH9L3PP67S
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100000175699
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110-86-1
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PYRIDINE
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m9351
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PRIMARY | Merck Index |
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PARENT -> IMPURITY | |||
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PARENT -> IMPURITY |
Limit of Residual Solvents
CHROMATOGRAPHIC PURITY (GC)
USP
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