Details
Stereochemistry | ACHIRAL |
Molecular Formula | C5H5N |
Molecular Weight | 79.0999 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C1=CC=NC=C1
InChI
InChIKey=JUJWROOIHBZHMG-UHFFFAOYSA-N
InChI=1S/C5H5N/c1-2-4-6-5-3-1/h1-5H
Molecular Formula | C5H5N |
Molecular Weight | 79.0999 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Pyridine is a basic heterocyclic organic compound used as a solvent in organic synthesis. Since the pyridine ring has three double bonds, six p-electrons exist, which are sufficient for aromatic ring formation without involving the lone pair electrons of the nitrogen atom. Since the lone pair electrons remain free, quaternary salts retain the aromaticity. However, the nitrogen atom has a higher electronegativity than the carbon atoms and shows an electron-withdrawing effect. In oxidation and reduction reactions, the pyridine ring exhibits properties characteristic of pelectron-deficient aromatic rings: resistance to oxidation and facile reduction. Pyridine bases are a constituent of tars. They were isolated from coal tar or coal gas before synthetic manufacturing processes became established. Pyridine is an excellent solvent, especially for dehydrochlorination reactions and extraction of antibiotics. Large amounts of pyridine are used as starting material for pharmaceuticals and agrochemicals: for example, herbicides such as diquat and paraquat, insecticides such as chlorpyrifos, and fungicides such as pyrithione. Pyridine is harmful if inhaled, swallowed or absorbed through the skin. Effects of acute pyridine intoxication include dizziness, headache, lack of coordination, nausea, salivation, and loss of appetite.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats. | 1999 Aug 15 |
|
Constitutive and induced expression by pyridine and beta-naphthoflavone of rat CYP1A is sexually dimorphic. | 1999 Jun-Jul |
|
Responses of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays. | 2000 Feb |
|
Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. | 2000 Feb-Mar |
|
Metabolic fate of extracellular NAD in human skin fibroblasts. | 2001 |
|
Morphological correlates of functionally defined synaptic vesicle populations. | 2001 Apr |
|
Role of platelet-activating factor in hepatectomy with Pringle's maneuver. | 2001 Apr |
|
Spectrochemical investigations in molecularly organized solvent media: evaluation of pyridinium chloride as a selective fluorescence quenching agent of polycyclic aromatic hydrocarbons in aqueous carboxylate-terminated poly(amido) amine dendrimers and anionic micelles. | 2001 Feb |
|
Separation of basic, acidic and neutral compounds by capillary electrochromatography using uncharged monolithic capillary columns modified with anionic and cationic surfactants. | 2001 Feb |
|
[Ring cleavage of N-arylpyridinium salts by nucleophiles--regioselectivity and stereochemistry of the products. 1]. | 2001 Feb |
|
Symptomatic and urodynamic improvement by oral distigmine bromide in poor voiders after transurethral resection of the prostate. | 2001 Feb |
|
Antiviral and antiproliferative activity in vitro of some new benzimidazole derivatives. | 2001 Feb |
|
Effects of staurosporine on exocytosis and endocytosis at frog motor nerve terminals. | 2001 Feb 1 |
|
Sensitive gas chromatographic--mass spectrometric screening of acetylated benzodiazepines. | 2001 Feb 23 |
|
Fatty acid chain elongation synthesis in eel (Anguilla anguilla) liver mitochondria. | 2001 Jan |
|
Hydrogen peroxide acts as a second messenger for the induction of defense genes in tomato plants in response to wounding, systemin, and methyl jasmonate. | 2001 Jan |
|
The influence of different soil constituents on the reaction kinetics of wet oxidation of the creosote compound quinoline. | 2001 Jan 29 |
|
A rigid linker-scaffold for solid-phase synthesis of dimeric pharmacophores. | 2001 Jan-Feb |
|
Coherent scattering in multi-harmonic light microscopy. | 2001 Mar |
|
Antipsoriatic anthrones with modulated redox properties. 5. Potent inhibition of human keratinocyte growth, induction of keratinocyte differentiation, and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones. | 2001 Mar 1 |
|
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. | 2001 Mar 1 |
|
Highly energetic tetraazidoborate anion and boron triazide adducts. | 2001 Mar 12 |
|
Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors. | 2001 Mar 12 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Thu Jul 06 00:31:19 UTC 2023
by
admin
on
Thu Jul 06 00:31:19 UTC 2023
|
Record UNII |
NH9L3PP67S
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
EPA PESTICIDE CODE |
69202
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
||
|
CFR |
21 CFR 172.515
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
406123
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
C023666
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
NH9L3PP67S
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
203-809-9
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
100000175699
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
110-86-1
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
PYRIDINE
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
1049
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
DTXSID9021924
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
141574
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
118
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
1601747
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
16227
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | |||
|
M9351
Created by
admin on Thu Jul 06 00:31:20 UTC 2023 , Edited by admin on Thu Jul 06 00:31:20 UTC 2023
|
PRIMARY | Merck Index |
Related Record | Type | Details | ||
---|---|---|---|---|
|
TRANSPORTER -> INHIBITOR |
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
||
|
PARENT -> IMPURITY |
Limit of Residual Solvents
CHROMATOGRAPHIC PURITY (GC)
USP
|