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Details

Stereochemistry ACHIRAL
Molecular Formula C5H5N
Molecular Weight 79.1001
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYRIDINE

SMILES

c1ccncc1

InChI

InChIKey=JUJWROOIHBZHMG-UHFFFAOYSA-N
InChI=1S/C5H5N/c1-2-4-6-5-3-1/h1-5H

HIDE SMILES / InChI

Molecular Formula C5H5N
Molecular Weight 79.1001
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pyridine is a basic heterocyclic organic compound used as a solvent in organic synthesis. Since the pyridine ring has three double bonds, six p-electrons exist, which are sufficient for aromatic ring formation without involving the lone pair electrons of the nitrogen atom. Since the lone pair electrons remain free, quaternary salts retain the aromaticity. However, the nitrogen atom has a higher electronegativity than the carbon atoms and shows an electron-withdrawing effect. In oxidation and reduction reactions, the pyridine ring exhibits properties characteristic of pelectron-deficient aromatic rings: resistance to oxidation and facile reduction. Pyridine bases are a constituent of tars. They were isolated from coal tar or coal gas before synthetic manufacturing processes became established. Pyridine is an excellent solvent, especially for dehydrochlorination reactions and extraction of antibiotics. Large amounts of pyridine are used as starting material for pharmaceuticals and agrochemicals: for example, herbicides such as diquat and paraquat, insecticides such as chlorpyrifos, and fungicides such as pyrithione. Pyridine is harmful if inhaled, swallowed or absorbed through the skin. Effects of acute pyridine intoxication include dizziness, headache, lack of coordination, nausea, salivation, and loss of appetite.

Approval Year

PubMed

PubMed

TitleDatePubMed
Fluorescent and electroactive cyclic assemblies from perylene tetracarboxylic acid bisimide ligands and metal phosphane triflates.
2001
Morphological correlates of functionally defined synaptic vesicle populations.
2001 Apr
Characterization of the flavoprotein domain of gp91phox which has NADPH diaphorase activity.
2001 Apr
Imaging stochastic spatial variability of active channel clusters during excitation of single neurons.
2001 Apr
Role of platelet-activating factor in hepatectomy with Pringle's maneuver.
2001 Apr
Presynaptic function is altered in snake K+-depolarized motor nerve terminals containing compromised mitochondria.
2001 Apr 1
Determination of the disulfide structure of sillucin, a highly knotted, cysteine-rich peptide, by cyanylation/cleavage mass mapping.
2001 Apr 17
Two new elastin cross-links having pyridine skeleton. Implication of ammonia in elastin cross-linking in vivo.
2001 Apr 20
Photoreaction of 2-halo-N-pyridinylbenzamide: intramolecular cyclization mechanism of phenyl radical assisted with n-complexation of chlorine radical.
2001 Apr 6
New halogenated [11C]WAY analogues, [11C]6FPWAY and [11C]6BPWAY--radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey.
2001 Feb
Cytoplasmic Ca2+ at low submicromolar concentration stimulates mitochondrial metabolism in rat luteal cells.
2001 Feb
Spectrochemical investigations in molecularly organized solvent media: evaluation of pyridinium chloride as a selective fluorescence quenching agent of polycyclic aromatic hydrocarbons in aqueous carboxylate-terminated poly(amido) amine dendrimers and anionic micelles.
2001 Feb
Structural determinants for AMPA agonist activity of aryl or heteroaryl substituted AMPA analogues. Synthesis and pharmacology.
2001 Feb
Separation of basic, acidic and neutral compounds by capillary electrochromatography using uncharged monolithic capillary columns modified with anionic and cationic surfactants.
2001 Feb
Synthesis and chain length-anti-HIV activity relationship of fully N- and O-sulfated homooligomers of tyrosine.
2001 Feb
[Ring cleavage of N-arylpyridinium salts by nucleophiles--regioselectivity and stereochemistry of the products. 1].
2001 Feb
High-performance liquid chromatographic assays for a second-generation novel oral iron chelator (APCP363) and their application to pharmacokinetic studies in rats.
2001 Feb 10
Molecular and crystal structures of N-(beta-D-galactopyranosyl)pyridinium bromide and its per-O-acetylated derivative.
2001 Feb 15
Optimization of separation and migration behavior of chloropyridines in micellar electrokinetic chromatography.
2001 Feb 23
Sensitive gas chromatographic--mass spectrometric screening of acetylated benzodiazepines.
2001 Feb 23
Improvement of graft function without donor pretreatment in liver transplantation from non-heart-beating donors.
2001 Feb-Mar
Potential 166Ho radiopharmaceuticals for endovascular radionuclide therapy. II. Preparation and evaluation of 166Ho-DTPA.
2001 Jan
Acid-base chemistry of a carbenium ion in a zeolite under equilibrium conditions: verification of a theoretical explanation of carbenium ion stability.
2001 Jan 10
New eudesmane sesquiterpenes from the root of Lindera strychnifolia.
2001 Mar
Monooxygenases involved in GA12 and GA14 synthesis in Gibberella fujikuroi.
2001 Mar
The 1:1 adduct of 2,5-dihydroxy-1,4-benzoquinone with 4,4'-bipyridine.
2001 Mar
Allergic contact dermatitis from a pyridine derivative in polyvinyl chloride leather.
2001 Mar
Metabolism of the beta-oxidized intermediates of N-nitrosodi-n-propylamine: N-nitroso-beta-hydroxypropylpropylamine and N-nitroso-beta-oxopropylpropylamine.
2001 Mar
Cytochrome p450-dependent metabolism of trichloroethylene in rat kidney.
2001 Mar
Coherent scattering in multi-harmonic light microscopy.
2001 Mar
Optimization of force constants with an Urey-Bradley force field avoiding normal mode crossings.
2001 Mar 1
Fragment mode analysis and its application to the vibrational normal modes of boron trichloride-ammonia and boron trichloride-pyridine complexes.
2001 Mar 1
Scanning tunneling microscopy with chemically modified tips: discrimination of porphyrin centers based on metal coordination and hydrogen bond interactions.
2001 Mar 1
Antipsoriatic anthrones with modulated redox properties. 5. Potent inhibition of human keratinocyte growth, induction of keratinocyte differentiation, and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones.
2001 Mar 1
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.
2001 Mar 1
Excited-state properties of Rh(2)(O(2)CCH(3))(4)(L)(2) (L = CH(3)OH, THF, PPh(3), py).
2001 Mar 12
Highly energetic tetraazidoborate anion and boron triazide adducts.
2001 Mar 12
Crystal structure analysis and chiral recognition study of Delta-[Ru(bpy)2(py)2][(+)-O,O'-dibenzoylD-tartrate].12H2O and Lambda-[Ru(bpy)2(py)2][(-)-O,O'-dibenzoyl-L-tartrate].12H2O.
2001 Mar 12
Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3.
2001 Mar 12
Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.
2001 Mar 12
Symmetry, stereotypy, and topography of odorant representations in mouse olfactory bulbs.
2001 Mar 15
Probing the influence of local coordination environment on the properties of Fe-type nitrile hydratase model complexes.
2001 Mar 26
A synthetic, structural, magnetic, and spectral study of several [Fe[tris(pyrazolyl)methane]2](BF4)2 complexes: observation of an unusual spin-state crossover.
2001 Mar 26
Vesicle-associated proteins and transmitter release from sympathetic ganglionic boutons.
2001 Mar 5
Inhibition of Shiga toxin-induced tumor necrosis factor-alpha production and gene expression in human monocytic cells by CV6209.
2001 Mar 9
Determination of thiodyglycol in groundwater using solid-phase extraction followed by gas chromatography with mass spectrometric detection in the selected-ion mode.
2001 Mar 9
NAD/NADH models with axial/central chiralities: superiority of the quinoline ring system.
2001 Mar 9
Mapping action potentials and calcium transients simultaneously from the intact heart.
2001 May
Deformation-induced lipid trafficking in alveolar epithelial cells.
2001 May
Inhibition of ATP-induced surfactant exocytosis by dihydropyridine (DHP) derivatives: a non-stereospecific, photoactivated effect and independent of L-type Ca2+ channels.
2001 May 1
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 10:06:42 UTC 2021
Edited
by admin
on Sat Jun 26 10:06:42 UTC 2021
Record UNII
NH9L3PP67S
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PYRIDINE
FHFI   HSDB   MI  
Systematic Name English
AZABENZENE
Systematic Name English
PYRIDINE [FHFI]
Common Name English
PYRIDINE [USP-RS]
Common Name English
CEFTAZIDIME IMPURITY F [EP]
Common Name English
NSC-406123
Code English
PYRIDINE [IARC]
Common Name English
FEMA NO. 2966
Code English
CEFTAZIDIME SPECIFIED IMPURITY F [EP]
Common Name English
PYRIDINE [HSDB]
Common Name English
CEFTAZIDIME PENTAHYDRATE IMPURITY F [EP]
Common Name English
NSC-141574
Code English
PYRIDINE [MI]
Common Name English
AZINE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 69202
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
CFR 21 CFR 172.515
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
Code System Code Type Description
USP_CATALOG
1601747
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY USP-RS
MESH
C023666
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
FDA UNII
NH9L3PP67S
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
ECHA (EC/EINECS)
203-809-9
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
CAS
110-86-1
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
WIKIPEDIA
PYRIDINE
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
PUBCHEM
1049
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
EPA CompTox
110-86-1
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
HSDB
118
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY
MERCK INDEX
M9351
Created by admin on Sat Jun 26 10:06:43 UTC 2021 , Edited by admin on Sat Jun 26 10:06:43 UTC 2021
PRIMARY Merck Index
Related Record Type Details
TRANSPORTER -> INHIBITOR
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
Limit of Residual Solvents
CHROMATOGRAPHIC PURITY (GC)
USP