Details
Stereochemistry | RACEMIC |
Molecular Formula | C17H26ClN |
Molecular Weight | 279.848 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CC(N(C)C)C1(CCC1)C2=CC=C(Cl)C=C2
InChI
InChIKey=UNAANXDKBXWMLN-UHFFFAOYSA-N
InChI=1S/C17H26ClN/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14/h6-9,13,16H,5,10-12H2,1-4H3
Molecular Formula | C17H26ClN |
Molecular Weight | 279.848 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionCurator's Comment: description was created based on several sources, including http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm228830.htm
Curator's Comment: description was created based on several sources, including http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm228830.htm
Subitramine is a potent inhibitor of monoamines (serotonin, dopamine, noradrenaline) reuptake that was approved by FDA for the treatmen of obesity. Sibutramine is metabolized to metabolites M1 and M2 which are more active toward the monoamine transporters.The drug was withdrawn from the market because of clinical trial data indicating an increased risk of heart attack and stroke. It was sold under a variety of brand names including Reductil, Meridia and Sibutrex.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P31645 Gene ID: 6532.0 Gene Symbol: SLC6A4 Target Organism: Homo sapiens (Human) |
298.0 nM [Ki] | ||
Target ID: Q01959 Gene ID: 6531.0 Gene Symbol: SLC6A3 Target Organism: Homo sapiens (Human) |
943.0 nM [Ki] | ||
Target ID: P23975 Gene ID: 6530.0 Gene Symbol: SLC6A2 Target Organism: Homo sapiens (Human) |
5451.0 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | MERIDIA Approved UseMERIDIA is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced calorie diet. Launch Date1997 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
7.12 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
8.09 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
4368.5 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
SIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
4067.7 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
6579.8 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
4 ng/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
6.4 ng/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
133.03 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
205.86 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
23296.9 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
SIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
100736.1 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
194500.9 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
25.5 ng × h/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
92.1 ng × h/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
22.31 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
23.07 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
3.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
SIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
25.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
23.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
17.2 h |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
6% |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
6% |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
20 mg 1 times / day multiple, oral Recommended Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, adult Health Status: unhealthy Age Group: adult Sex: unknown Sources: |
Disc. AE: Hypertension, Tachycardia... AEs leading to discontinuation/dose reduction: Hypertension (0.4%) Sources: Tachycardia (0.4%) |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Disc. AE: Palpitations... Other AEs: Palpitations... AEs leading to discontinuation/dose reduction: Palpitations (1 patient) Other AEs:Palpitations (2 patients) Sources: |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Other AEs: Palpitations, Paresthesia... Other AEs: Palpitations (1 patient) Sources: Paresthesia (1 patient) Anxiety (1 patient) Insomnia (1 patient) Fatigue (1 patient) |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<1.4%) Other AEs:Tachycardia (<3%) Dry mouth (32.2%) Sources: Anorexia (32.2%) Insomnia (10.3%) Increased appetite (11.6%) Nausea (8.2%) Dyspepsia (5.5%) Nervousness (12.3%) Asthenia (8.9%) Dizziness (12.3%) Constipation (12.3%) Rash (4.1%) Palpitation (4.1%) Vasodilation (4.8%) Dyspnea (1.4%) Taste perversion (4.1%) Hypertension (1.4%) Sweating (4.1%) Tachycardia (6.8%) Ecchymosis (1.4%) Paresthesia (3.4%) |
10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<2%) Other AEs:Tachycardia (<3%) Dry mouth (16.7%) Sources: Anorexia (18.7%) Insomnia (9.4%) Increased appetite (16.7%) Nausea (3.4%) Dyspepsia (4.4%) Nervousness (6.4%) Asthenia (7.9%) Dizziness (7.9%) Constipation (10.8%) Rash (4.9%) Palpitation (4.9%) Vasodilation (2%) Dyspnea (1.5%) Taste perversion (2%) Hypertension (4.9%) Sweating (1%) Tachycardia (4.4%) Ecchymosis (0.5%) Paresthesia (3.9%) |
30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (2%) Other AEs:Tachycardia (3%) Dry mouth (31.8%) Sources: Anorexia (31.8%) Insomnia (24.5%) Increased appetite (21.2%) Nausea (12.6%) Dyspepsia (12.6%) Nervousness (11.3%) Asthenia (10.6%) Dizziness (7.9%) Constipation (7.9%) Rash (7.3%) Palpitation (6%) Vasodilation (5.3%) Dyspnea (4.6%) Taste perversion (4.6%) Hypertension (3.3%) Sweating (2.6%) Tachycardia (2.6%) Ecchymosis (2%) Paresthesia (1.3%) |
5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<1.2%) Other AEs:Tachycardia (<1.8%) Dry mouth (11.8%) Sources: Anorexia (18.9%) Insomnia (8.3%) Increased appetite (16.6%) Nausea (4.1%) Dyspepsia (4.1%) Nervousness (5.3%) Asthenia (7.1%) Dizziness (8.9%) Constipation (13%) Rash (4.1%) Vasodilation (2.4%) Dyspnea (0.6%) Taste perversion (1.2%) Hypertension (1.2%) Sweating (1.2%) Tachycardia (1.8%) Ecchymosis (1.2%) Paresthesia (2.4%) |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<2%) Other AEs:Tachycardia (<3%) Dry mouth (25.5%) Sources: Anorexia (21.4%) Insomnia (10.2%) Increased appetite (14.3%) Nausea (5.1%) Dyspepsia (8.2%) Nervousness (7.7%) Asthenia (6.1%) Dizziness (8.2%) Constipation (11.7%) Rash (7.1%) Palpitation (2.6%) Vasodilation (2%) Dyspnea (1%) Taste perversion (2.6%) Hypertension (5.1%) Sweating (2.6%) Tachycardia (7.7%) Ecchymosis (3.1%) Paresthesia (2%) |
1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<2%) Other AEs:Tachycardia (<0.7%) Dry mouth (6%) Sources: Anorexia (20.1%) Insomnia (12.1%) Increased appetite (11.4%) Nausea (3.4%) Dyspepsia (4%) Nervousness (4.7%) Asthenia (2.7%) Dizziness (4.7%) Constipation (6.7%) Rash (5.4%) Palpitations (2%) Vasodilation (1.3%) Dyspnea (1.3%) Taste perversion (0.7%) Hypertension (2%) Tachycardia (0.7%) Paresthesia (2%) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Hypertension | 0.4% Disc. AE |
20 mg 1 times / day multiple, oral Recommended Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, adult Health Status: unhealthy Age Group: adult Sex: unknown Sources: |
Tachycardia | 0.4% Disc. AE |
20 mg 1 times / day multiple, oral Recommended Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, adult Health Status: unhealthy Age Group: adult Sex: unknown Sources: |
Palpitations | 1 patient Disc. AE |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Palpitations | 2 patients | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Anxiety | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Fatigue | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Insomnia | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Palpitations | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Paresthesia | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years Health Status: unhealthy Age Group: mean 32 years Sex: M+F Sources: |
Dyspnea | 1.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Ecchymosis | 1.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Hypertension | 1.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Insomnia | 10.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Increased appetite | 11.6% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Constipation | 12.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Dizziness | 12.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Nervousness | 12.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Paresthesia | 3.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Anorexia | 32.2% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Dry mouth | 32.2% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Palpitation | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Rash | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Sweating | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Taste perversion | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Vasodilation | 4.8% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Dyspepsia | 5.5% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Tachycardia | 6.8% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Nausea | 8.2% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Asthenia | 8.9% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Hypertension | <1.4% Disc. AE |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Tachycardia | <3% Disc. AE |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years Health Status: unhealthy Age Group: mean 42.9 years Sex: M+F Sources: |
Ecchymosis | 0.5% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Sweating | 1% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Dyspnea | 1.5% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Constipation | 10.8% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Dry mouth | 16.7% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Increased appetite | 16.7% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Anorexia | 18.7% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Taste perversion | 2% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Vasodilation | 2% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Nausea | 3.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Paresthesia | 3.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Dyspepsia | 4.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Tachycardia | 4.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Hypertension | 4.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Palpitation | 4.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Rash | 4.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Nervousness | 6.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Asthenia | 7.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Dizziness | 7.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Insomnia | 9.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Hypertension | <2% Disc. AE |
10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Tachycardia | <3% Disc. AE |
10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years Health Status: unhealthy Age Group: mean 43.3 years Sex: M+F Sources: |
Paresthesia | 1.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Asthenia | 10.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Nervousness | 11.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dyspepsia | 12.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Nausea | 12.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Ecchymosis | 2% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Hypertension | 2% Disc. AE |
30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Sweating | 2.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Tachycardia | 2.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Increased appetite | 21.2% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Insomnia | 24.5% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Tachycardia | 3% Disc. AE |
30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Hypertension | 3.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Anorexia | 31.8% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dry mouth | 31.8% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dyspnea | 4.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Taste perversion | 4.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Vasodilation | 5.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Palpitation | 6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Rash | 7.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Constipation | 7.9% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dizziness | 7.9% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dyspnea | 0.6% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Ecchymosis | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Hypertension | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Sweating | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Taste perversion | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Tachycardia | 1.8% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dry mouth | 11.8% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Constipation | 13% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Increased appetite | 16.6% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Anorexia | 18.9% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Paresthesia | 2.4% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Vasodilation | 2.4% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dyspepsia | 4.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Nausea | 4.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Rash | 4.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Nervousness | 5.3% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Asthenia | 7.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Insomnia | 8.3% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dizziness | 8.9% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Hypertension | <1.2% Disc. AE |
5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Tachycardia | <1.8% Disc. AE |
5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years Health Status: unhealthy Age Group: mean 43.4 years Sex: M+F Sources: |
Dyspnea | 1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Insomnia | 10.2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Constipation | 11.7% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Increased appetite | 14.3% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Paresthesia | 2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Vasodilation | 2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Palpitation | 2.6% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Sweating | 2.6% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Taste perversion | 2.6% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Anorexia | 21.4% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Dry mouth | 25.5% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Ecchymosis | 3.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Hypertension | 5.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Nausea | 5.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Asthenia | 6.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Rash | 7.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Nervousness | 7.7% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Tachycardia | 7.7% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Dizziness | 8.2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Dyspepsia | 8.2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Hypertension | <2% Disc. AE |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Tachycardia | <3% Disc. AE |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years Health Status: unhealthy Age Group: mean 44.2 years Sex: M+F Sources: |
Tachycardia | 0.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Taste perversion | 0.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Dyspnea | 1.3% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Vasodilation | 1.3% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Increased appetite | 11.4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Insomnia | 12.1% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Hypertension | 2% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Palpitations | 2% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Paresthesia | 2% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Asthenia | 2.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Anorexia | 20.1% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Nausea | 3.4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Dyspepsia | 4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Dizziness | 4.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Nervousness | 4.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Rash | 5.4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Dry mouth | 6% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Constipation | 6.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Tachycardia | <0.7% Disc. AE |
1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Hypertension | <2% Disc. AE |
1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years Health Status: unhealthy Age Group: mean 44.5 years Sex: M+F Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 0.829 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 15.6 uM] | |||
yes [IC50 29 uM] | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
yes | |||
Page: 3.0 |
yes | yes (co-administration study) Comment: Ketoconazole: resulted in moderate increases in AUC and Cmax of 58% and 36% for M1 and of 20% and 19% for M2, respectively; Erythromycin: resulted in small increases in the AUC (less than 14%) for M1 and M2. A small reduction in Cmax for M1 (11%) and a slight increase in Cmax for M2 (10%) were observed. Other tested drugs that are substrates and/or inhibitors of CYP 450 isozymes were tested. Cimetidine: resulted insmall increases in combined (M1 and M2) plasma Cmax (3.4%) and AUC (7.3%); Simvastatin: no significant effect on plasma Cmax and AUC of M2 or M1 and M2 combined. The Cmax (16%) and AUC (12%) of M1 were slightly decreased. Simvastatin slightly decreased sibutramine Cmax (14%) and AUC (21%); Omeprazole: slightly increased plasma Cmax and AUC of M1 and M2 combined (approximately 15%). M2 Cmax and AUC were not significantly affected whereas M1 Cmax (30%) and AUC (40%) were modestly increased. Plasma Cmax (57%) and AUC (67%) of unchanged sibutramine were moderately increased; Olanzapine: Olanzapine had no significant effect on plasma Cmax and AUC of M2 and M1 and M2 combined, or the AUC of M1; Lorazepam: Lorazepam had no significant effect on the pharmacokinetics of sibutramine metabolites M1 and M2. Page: 3.0 |
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
PubMed
Title | Date | PubMed |
---|---|---|
Sibutramine: a review of the pharmacology of a novel anti-obesity agent. | 1997 Mar |
|
Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine. | 1998 Aug |
|
Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity. | 1999 Sep |
|
[Obesity: principles of drug therapy]. | 2000 Aug |
|
Sibutramine in overweight/obese hypertensive patients. | 2001 Dec |
|
Organic hypomania secondary to sibutramine-citalopram interaction. | 2002 Feb |
|
Efficacy and safety of sibutramine for weight loss in obese patients with hypertension well controlled by beta-adrenergic blocking agents: a placebo-controlled, double-blind, randomised trial. | 2002 Jan |
|
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. | 2007 Apr 17 |
|
[Pharmacological therapy of obesity]. | 2008 Apr |
|
Pharmacotherapy for obesity. | 2009 Dec |
|
Long-term effects of weight-reducing drugs in hypertensive patients. | 2009 Jul 8 |
|
Multiple effects of sibutramine on ejaculation and on vas deferens and seminal vesicle contractility. | 2009 Sep 15 |
|
Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. | 2010 Apr 15 |
|
Diabesity: therapeutic options. | 2010 Jun |
|
[32-year-old patient with acute myocardial infarction possibly induced by the appetite suppressant sibutramine]. | 2010 May |
|
The role of adiponectin in the pathogenesis and treatment of non-alcoholic fatty liver disease. | 2010 May |
|
Elevation of QT dispersion after obesity drug sibutramine. | 2010 Nov |
|
Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes. | 2013 Sep 5 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 09:30:15 GMT 2025
by
admin
on
Wed Apr 02 09:30:15 GMT 2025
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Record UNII |
WV5EC51866
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NDF-RT |
N0000175372
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NDF-RT |
N0000175372
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WHO-ATC |
A08AA10
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NDF-RT |
N0000175424
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DEA NO. |
1675
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WHO-VATC |
QA08AA10
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NDF-RT |
N0000000102
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NDF-RT |
N0000000114
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NDF-RT |
N0000000109
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NCI_THESAURUS |
C29728
Created by
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CFR |
21 CFR 216.24
Created by
admin on Wed Apr 02 09:30:15 GMT 2025 , Edited by admin on Wed Apr 02 09:30:15 GMT 2025
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LIVERTOX |
NBK548248
Created by
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Code System | Code | Type | Description | ||
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36514
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CHEMBL1419
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SIBUTRAMINE
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2586
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WV5EC51866
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5210
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100000084327
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SUB10512MIG
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DB01105
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6124
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C75965
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C058254
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106650-56-0
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PRIMARY | |||
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Sibutramine
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DTXSID1023578
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7209
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m9894
Created by
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PRIMARY | Merck Index |
Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
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SALT/SOLVATE -> PARENT |
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ENANTIOMER -> RACEMATE | |||
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SALT/SOLVATE -> PARENT | |||
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ENANTIOMER -> RACEMATE | |||
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BINDER->LIGAND |
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TRANSPORTER -> INHIBITOR | |||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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METABOLITE ACTIVE -> PARENT | |||
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METABOLITE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |