Details
Stereochemistry | RACEMIC |
Molecular Formula | C17H26ClN.CH4O3S |
Molecular Weight | 375.954 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(O)(=O)=O.CC(C)CC(N(C)C)C1(CCC1)C2=CC=C(Cl)C=C2
InChI
InChIKey=MWKDQYLHASOIBB-UHFFFAOYSA-N
InChI=1S/C17H26ClN.CH4O3S/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;1-5(2,3)4/h6-9,13,16H,5,10-12H2,1-4H3;1H3,(H,2,3,4)
Molecular Formula | CH4O3S |
Molecular Weight | 96.106 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C17H26ClN |
Molecular Weight | 279.848 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionCurator's Comment: description was created based on several sources, including http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm228830.htm
Curator's Comment: description was created based on several sources, including http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm228830.htm
Subitramine is a potent inhibitor of monoamines (serotonin, dopamine, noradrenaline) reuptake that was approved by FDA for the treatmen of obesity. Sibutramine is metabolized to metabolites M1 and M2 which are more active toward the monoamine transporters.The drug was withdrawn from the market because of clinical trial data indicating an increased risk of heart attack and stroke. It was sold under a variety of brand names including Reductil, Meridia and Sibutrex.
CNS Activity
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P31645 Gene ID: 6532.0 Gene Symbol: SLC6A4 Target Organism: Homo sapiens (Human) |
298.0 nM [Ki] | ||
Target ID: Q01959 Gene ID: 6531.0 Gene Symbol: SLC6A3 Target Organism: Homo sapiens (Human) |
943.0 nM [Ki] | ||
Target ID: P23975 Gene ID: 6530.0 Gene Symbol: SLC6A2 Target Organism: Homo sapiens (Human) |
5451.0 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | MERIDIA Approved UseMERIDIA is indicated for the management of obesity, including weight loss and maintenance of weight loss, and should be used in conjunction with a reduced calorie diet. Launch Date1997 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
4 ng/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
7.12 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
4067.7 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
6.4 ng/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
8.09 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
6579.8 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
4368.5 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
SIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
25.5 ng × h/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
133.03 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
100736.1 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
92.1 ng × h/mL |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
205.86 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
194500.9 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
23296.9 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
SIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
22.31 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
25.5 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
17.2 h |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
23.07 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15823773/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
23.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
|
3.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29403750/ |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
SIBUTRAMINE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: FASTED |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
6% |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
6% |
15 mg single, oral dose: 15 mg route of administration: Oral experiment type: SINGLE co-administered: |
DIDESMETHYLSIBUTRAMINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
20 mg 1 times / day multiple, oral (max) Recommended Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: Page: 14 |
unhealthy, adult n = 2068 Health Status: unhealthy Condition: obesity Age Group: adult Sex: unknown Population Size: 2068 Sources: Page: 14 |
Disc. AE: Hypertension, Tachycardia... AEs leading to discontinuation/dose reduction: Hypertension (0.4%) Sources: Page: 14Tachycardia (0.4%) |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Disc. AE: Palpitations... Other AEs: Palpitations... AEs leading to discontinuation/dose reduction: Palpitations (1 patient) Other AEs:Palpitations (2 patients) Sources: |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Other AEs: Palpitations, Paresthesia... Other AEs: Palpitations (1 patient) Sources: Paresthesia (1 patient) Anxiety (1 patient) Insomnia (1 patient) Fatigue (1 patient) |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<1.4%) Other AEs:Tachycardia (<3%) Dry mouth (32.2%) Sources: Anorexia (32.2%) Insomnia (10.3%) Increased appetite (11.6%) Nausea (8.2%) Dyspepsia (5.5%) Nervousness (12.3%) Asthenia (8.9%) Dizziness (12.3%) Constipation (12.3%) Rash (4.1%) Palpitation (4.1%) Vasodilation (4.8%) Dyspnea (1.4%) Taste perversion (4.1%) Hypertension (1.4%) Sweating (4.1%) Tachycardia (6.8%) Ecchymosis (1.4%) Paresthesia (3.4%) |
10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<2%) Other AEs:Tachycardia (<3%) Dry mouth (16.7%) Sources: Anorexia (18.7%) Insomnia (9.4%) Increased appetite (16.7%) Nausea (3.4%) Dyspepsia (4.4%) Nervousness (6.4%) Asthenia (7.9%) Dizziness (7.9%) Constipation (10.8%) Rash (4.9%) Palpitation (4.9%) Vasodilation (2%) Dyspnea (1.5%) Taste perversion (2%) Hypertension (4.9%) Sweating (1%) Tachycardia (4.4%) Ecchymosis (0.5%) Paresthesia (3.9%) |
30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (2%) Other AEs:Tachycardia (3%) Dry mouth (31.8%) Sources: Anorexia (31.8%) Insomnia (24.5%) Increased appetite (21.2%) Nausea (12.6%) Dyspepsia (12.6%) Nervousness (11.3%) Asthenia (10.6%) Dizziness (7.9%) Constipation (7.9%) Rash (7.3%) Palpitation (6%) Vasodilation (5.3%) Dyspnea (4.6%) Taste perversion (4.6%) Hypertension (3.3%) Sweating (2.6%) Tachycardia (2.6%) Ecchymosis (2%) Paresthesia (1.3%) |
5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<1.2%) Other AEs:Tachycardia (<1.8%) Dry mouth (11.8%) Sources: Anorexia (18.9%) Insomnia (8.3%) Increased appetite (16.6%) Nausea (4.1%) Dyspepsia (4.1%) Nervousness (5.3%) Asthenia (7.1%) Dizziness (8.9%) Constipation (13%) Rash (4.1%) Vasodilation (2.4%) Dyspnea (0.6%) Taste perversion (1.2%) Hypertension (1.2%) Sweating (1.2%) Tachycardia (1.8%) Ecchymosis (1.2%) Paresthesia (2.4%) |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dizziness, Dry mouth... AEs leading to discontinuation/dose reduction: Hypertension (<2%) Other AEs:Tachycardia (<3%) Dizziness (8.2%) Sources: Dry mouth (25.5%) Anorexia (21.4%) Insomnia (10.2%) Increased appetite (14.3%) Nausea (5.1%) Dyspepsia (8.2%) Nervousness (7.7%) Asthenia (6.1%) Constipation (11.7%) Rash (7.1%) Palpitation (2.6%) Vasodilation (2%) Dyspnea (1%) Taste perversion (2.6%) Hypertension (5.1%) Sweating (2.6%) Tachycardia (7.7%) Ecchymosis (3.1%) Paresthesia (2%) |
1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Disc. AE: Hypertension, Tachycardia... Other AEs: Dry mouth, Anorexia... AEs leading to discontinuation/dose reduction: Hypertension (<2%) Other AEs:Tachycardia (<0.7%) Dry mouth (6%) Sources: Anorexia (20.1%) Insomnia (12.1%) Increased appetite (11.4%) Nausea (3.4%) Dyspepsia (4%) Nervousness (4.7%) Asthenia (2.7%) Dizziness (4.7%) Constipation (6.7%) Rash (5.4%) Palpitations (2%) Vasodilation (1.3%) Dyspnea (1.3%) Taste perversion (0.7%) Hypertension (2%) Tachycardia (0.7%) Paresthesia (2%) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Hypertension | 0.4% Disc. AE |
20 mg 1 times / day multiple, oral (max) Recommended Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: Page: 14 |
unhealthy, adult n = 2068 Health Status: unhealthy Condition: obesity Age Group: adult Sex: unknown Population Size: 2068 Sources: Page: 14 |
Tachycardia | 0.4% Disc. AE |
20 mg 1 times / day multiple, oral (max) Recommended Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: Page: 14 |
unhealthy, adult n = 2068 Health Status: unhealthy Condition: obesity Age Group: adult Sex: unknown Population Size: 2068 Sources: Page: 14 |
Palpitations | 1 patient Disc. AE |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Palpitations | 2 patients | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Anxiety | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Fatigue | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Insomnia | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Palpitations | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Paresthesia | 1 patient | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 32 years n = 7 Health Status: unhealthy Condition: vasovagal syncope Age Group: mean 32 years Sex: M+F Population Size: 7 Sources: |
Dyspnea | 1.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Ecchymosis | 1.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Hypertension | 1.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Insomnia | 10.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Increased appetite | 11.6% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Constipation | 12.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Dizziness | 12.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Nervousness | 12.3% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Paresthesia | 3.4% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Anorexia | 32.2% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Dry mouth | 32.2% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Palpitation | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Rash | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Sweating | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Taste perversion | 4.1% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Vasodilation | 4.8% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Dyspepsia | 5.5% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Tachycardia | 6.8% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Nausea | 8.2% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Asthenia | 8.9% | 20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Hypertension | <1.4% Disc. AE |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Tachycardia | <3% Disc. AE |
20 mg 1 times / day multiple, oral Studied dose Dose: 20 mg, 1 times / day Route: oral Route: multiple Dose: 20 mg, 1 times / day Sources: |
unhealthy, mean 42.9 years n = 146 Health Status: unhealthy Condition: obesity Age Group: mean 42.9 years Sex: M+F Population Size: 146 Sources: |
Ecchymosis | 0.5% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Sweating | 1% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Dyspnea | 1.5% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Constipation | 10.8% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Dry mouth | 16.7% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Increased appetite | 16.7% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Anorexia | 18.7% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Taste perversion | 2% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Vasodilation | 2% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Nausea | 3.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Paresthesia | 3.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Dyspepsia | 4.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Tachycardia | 4.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Hypertension | 4.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Palpitation | 4.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Rash | 4.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Nervousness | 6.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Asthenia | 7.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Dizziness | 7.9% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Insomnia | 9.4% | 10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Hypertension | <2% Disc. AE |
10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Tachycardia | <3% Disc. AE |
10 mg 1 times / day multiple, oral Recommended Dose: 10 mg, 1 times / day Route: oral Route: multiple Dose: 10 mg, 1 times / day Sources: |
unhealthy, mean 43.3 years n = 203 Health Status: unhealthy Condition: obesity Age Group: mean 43.3 years Sex: M+F Population Size: 203 Sources: |
Paresthesia | 1.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Asthenia | 10.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Nervousness | 11.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Dyspepsia | 12.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Nausea | 12.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Ecchymosis | 2% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Hypertension | 2% Disc. AE |
30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Sweating | 2.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Tachycardia | 2.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Increased appetite | 21.2% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Insomnia | 24.5% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Tachycardia | 3% Disc. AE |
30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Hypertension | 3.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Anorexia | 31.8% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Dry mouth | 31.8% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Dyspnea | 4.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Taste perversion | 4.6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Vasodilation | 5.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Palpitation | 6% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Rash | 7.3% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Constipation | 7.9% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Dizziness | 7.9% | 30 mg 1 times / day multiple, oral Highest studied dose Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 151 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 151 Sources: |
Dyspnea | 0.6% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Ecchymosis | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Hypertension | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Sweating | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Taste perversion | 1.2% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Tachycardia | 1.8% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Dry mouth | 11.8% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Constipation | 13% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Increased appetite | 16.6% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Anorexia | 18.9% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Paresthesia | 2.4% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Vasodilation | 2.4% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Dyspepsia | 4.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Nausea | 4.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Rash | 4.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Nervousness | 5.3% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Asthenia | 7.1% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Insomnia | 8.3% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Dizziness | 8.9% | 5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Hypertension | <1.2% Disc. AE |
5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Tachycardia | <1.8% Disc. AE |
5 mg 1 times / day multiple, oral Minumum effective dose Dose: 5 mg, 1 times / day Route: oral Route: multiple Dose: 5 mg, 1 times / day Sources: |
unhealthy, mean 43.4 years n = 169 Health Status: unhealthy Condition: obesity Age Group: mean 43.4 years Sex: M+F Population Size: 169 Sources: |
Dyspnea | 1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Insomnia | 10.2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Constipation | 11.7% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Increased appetite | 14.3% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Paresthesia | 2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Vasodilation | 2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Palpitation | 2.6% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Sweating | 2.6% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Taste perversion | 2.6% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Anorexia | 21.4% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Dry mouth | 25.5% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Ecchymosis | 3.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Hypertension | 5.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Nausea | 5.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Asthenia | 6.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Rash | 7.1% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Nervousness | 7.7% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Tachycardia | 7.7% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Dizziness | 8.2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Dyspepsia | 8.2% | 15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Hypertension | <2% Disc. AE |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Tachycardia | <3% Disc. AE |
15 mg 1 times / day multiple, oral Recommended Dose: 15 mg, 1 times / day Route: oral Route: multiple Dose: 15 mg, 1 times / day Sources: |
unhealthy, mean 44.2 years n = 196 Health Status: unhealthy Condition: obesity Age Group: mean 44.2 years Sex: M+F Population Size: 196 Sources: |
Tachycardia | 0.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Taste perversion | 0.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Dyspnea | 1.3% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Vasodilation | 1.3% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Increased appetite | 11.4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Insomnia | 12.1% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Hypertension | 2% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Palpitations | 2% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Paresthesia | 2% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Asthenia | 2.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Anorexia | 20.1% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Nausea | 3.4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Dyspepsia | 4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Dizziness | 4.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Nervousness | 4.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Rash | 5.4% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Dry mouth | 6% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Constipation | 6.7% | 1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Tachycardia | <0.7% Disc. AE |
1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Hypertension | <2% Disc. AE |
1 mg 1 times / day multiple, oral Minumum effective dose Dose: 1 mg, 1 times / day Route: oral Route: multiple Dose: 1 mg, 1 times / day Sources: |
unhealthy, mean 44.5 years n = 149 Health Status: unhealthy Condition: obesity Age Group: mean 44.5 years Sex: M+F Population Size: 149 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 0.829 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 15.6 uM] | |||
yes [IC50 29 uM] | ||||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/23777987/ Page: 5.0 |
yes [IC50 >50 uM] |
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
no | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
yes | |||
Sources: https://pubmed.ncbi.nlm.nih.gov/18474675/ Page: 5.0 |
yes | |||
Page: 3.0 |
yes | yes (co-administration study) Comment: Ketoconazole: resulted in moderate increases in AUC and Cmax of 58% and 36% for M1 and of 20% and 19% for M2, respectively; Erythromycin: resulted in small increases in the AUC (less than 14%) for M1 and M2. A small reduction in Cmax for M1 (11%) and a slight increase in Cmax for M2 (10%) were observed. Other tested drugs that are substrates and/or inhibitors of CYP 450 isozymes were tested. Cimetidine: resulted insmall increases in combined (M1 and M2) plasma Cmax (3.4%) and AUC (7.3%); Simvastatin: no significant effect on plasma Cmax and AUC of M2 or M1 and M2 combined. The Cmax (16%) and AUC (12%) of M1 were slightly decreased. Simvastatin slightly decreased sibutramine Cmax (14%) and AUC (21%); Omeprazole: slightly increased plasma Cmax and AUC of M1 and M2 combined (approximately 15%). M2 Cmax and AUC were not significantly affected whereas M1 Cmax (30%) and AUC (40%) were modestly increased. Plasma Cmax (57%) and AUC (67%) of unchanged sibutramine were moderately increased; Olanzapine: Olanzapine had no significant effect on plasma Cmax and AUC of M2 and M1 and M2 combined, or the AUC of M1; Lorazepam: Lorazepam had no significant effect on the pharmacokinetics of sibutramine metabolites M1 and M2. Page: 3.0 |
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
PubMed
Title | Date | PubMed |
---|---|---|
The endocannabinoid system as a target for obesity treatment. | 2008 |
|
Sibutramine-induced acute myocardial infarction in a young lady. | 2008 Nov |
|
Elevation of QT dispersion after obesity drug sibutramine. | 2010 Nov |
|
[Long-term effects of weight-reducing drugs in hypertensive patients--a survey of a Cochrane review]. | 2011 Feb 21 |
Substance Class |
Chemical
Created
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admin
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Edited
Sat Dec 16 15:54:56 GMT 2023
by
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on
Sat Dec 16 15:54:56 GMT 2023
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Record UNII |
NTF6Z4MEY2
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Record Status |
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676598-10-0
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ACTIVE MOIETY |