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Details

Stereochemistry RACEMIC
Molecular Formula C21H25ClN2O3
Molecular Weight 388.8885
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETIRIZINE

SMILES

c1ccc(cc1)C(c2ccc(cc2)Cl)N3CCN(CC3)CCOCC(=O)O

InChI

InChIKey=ZKLPARSLTMPFCP-UHFFFAOYSA-N
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)

HIDE SMILES / InChI

Molecular Formula C21H25ClN2O3
Molecular Weight 388.8885
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment:: description was created based on several sources, including: https://www.drugs.com/pro/cetirizine.html

Cetirizine, a human metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. It is indicated for the relief of nasal and non-nasal symptoms associated with seasonal or perennial allergic rhinitis, hay fever and chronic idiopathic urticaria. Commonly reported adverse reactions of cetirizine include headache, dry mouth and drowsiness or fatigue. Pharmacokinetic interaction studies with Cetirizine in adults were conducted with pseudoephedrine, antipyrine, ketoconazole, erythromycin and azithromycin. No interactions were observed.

CNS Activity

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
ZYRTEC HIVES RELIEF

Approved Use

Tablets should be administered when both the antihistaminic properties of cetirizine hydrochloride and the nasal decongestant properties of pseudoephedrine hydrochloride are desired.

Launch Date

8.183808E11
Palliative
ZYRTEC HIVES RELIEF

Approved Use

Tablets should be administered when both the antihistaminic properties of cetirizine hydrochloride and the nasal decongestant properties of pseudoephedrine hydrochloride are desired.

Launch Date

8.183808E11
Palliative
ZYRTEC HIVES RELIEF

Approved Use

Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: •runny nose •sneezing •itchy, watery eyes •itching of the nose or throat

Launch Date

8.183808E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
311 ng/mL
10 mg 1 times / day multiple, oral
dose: 10 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
CETIRIZINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
978.4 ng/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CETIRIZINE plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: FASTED
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
6375.6 ng × h/mL
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CETIRIZINE plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: FASTED
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
8.3 h
10 mg 1 times / day multiple, oral
dose: 10 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
CETIRIZINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6.9 h
10 mg single, oral
dose: 10 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
CETIRIZINE plasma
Homo sapiens
population: UNHEALTHY
age: CHILD
sex: FEMALE / MALE
food status: FASTED
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
7%
10 mg 1 times / day multiple, oral
dose: 10 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
CETIRIZINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
180 mg single, oral
Overdose
Dose: 180 mg
Route: oral
Route: single
Dose: 180 mg
Sources:
unhealthy, 18 months
n = 1
Health Status: unhealthy
Age Group: 18 months
Sex: M
Population Size: 1
Sources:
270 mg single, oral
Overdose
Dose: 270 mg
Route: oral
Route: single
Dose: 270 mg
Sources:
unhealthy, 18 years
n = 1
Health Status: unhealthy
Age Group: 18 years
Sex: F
Population Size: 1
Sources:
Other AEs: Metabolic acidosis, Hypokalemia...
Other AEs:
Metabolic acidosis (grade 5, 1 patient)
Hypokalemia (grade 5, 1 patient)
Sources:
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
unhealthy, 18 years
n = 1
Health Status: unhealthy
Condition: allergic rhinitis
Age Group: 18 years
Sex: F
Population Size: 1
Sources:
Disc. AE: Delusions, Depression...
AEs leading to
discontinuation/dose reduction:
Delusions (1 patient)
Depression (1 patient)
Sources:
2.5 mg 1 times / day multiple, oral
Dose: 2.5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 2.5 mg, 1 times / day
Sources:
unhealthy, 23 months
n = 1
Health Status: unhealthy
Condition: chronic rhinitis
Age Group: 23 months
Sex: M
Population Size: 1
Sources:
Disc. AE: Insomnia...
AEs leading to
discontinuation/dose reduction:
Insomnia (1 patient)
Sources:
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Other AEs: Dyspepsia, Feeling hot...
Other AEs:
Dyspepsia (1%)
Feeling hot (1%)
Dysgeusia (1%)
Headache (1%)
Paresthesia (1%)
Presyncope (1%)
Hyperhidrosis (1%)
Sources:
60 mg single, oral
Overdose
Dose: 60 mg
Route: oral
Route: single
Dose: 60 mg
Sources:
healthy, 4 years
n = 1
Health Status: healthy
Age Group: 4 years
Sex: M
Population Size: 1
Sources:
Other AEs: Drowsiness, Sedation...
Other AEs:
Drowsiness (severe, 1 patient)
Sedation (1 patient)
Sources:
50 mg 1 times / day multiple, oral
Dose: 50 mg, 1 times / day
Route: oral
Route: multiple
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 46 years
n = 1
Health Status: unhealthy
Condition: chronic idiopathic urticaria
Age Group: 46 years
Sex: M
Population Size: 1
Sources:
5 mg 1 times / day multiple, oral
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
unhealthy, 6 years
n = 1
Health Status: unhealthy
Condition: allergic rhinitis
Age Group: 6 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Dystonic reaction...
AEs leading to
discontinuation/dose reduction:
Dystonic reaction (1 patient)
Sources:
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources: Page: p. 24
unhealthy, > 12 years
n = 2034
Health Status: unhealthy
Age Group: > 12 years
Sex: M+F
Population Size: 2034
Sources: Page: p. 24
Other AEs: Somnolence, Fatigue...
Other AEs:
Somnolence (13.7%)
Fatigue (5.9%)
Dry mouth (5%)
Dizziness (2%)
Pharyngitis (2%)
Sources: Page: p. 24
0.24 % 2 times / day multiple, ophthalmic
Recommended
unhealthy, adult
n = 511
Other AEs: Ocular hyperemia, Visual acuity reduced...
AEs

AEs

AESignificanceDosePopulation
Hypokalemia grade 5, 1 patient
270 mg single, oral
Overdose
Dose: 270 mg
Route: oral
Route: single
Dose: 270 mg
Sources:
unhealthy, 18 years
n = 1
Health Status: unhealthy
Age Group: 18 years
Sex: F
Population Size: 1
Sources:
Metabolic acidosis grade 5, 1 patient
270 mg single, oral
Overdose
Dose: 270 mg
Route: oral
Route: single
Dose: 270 mg
Sources:
unhealthy, 18 years
n = 1
Health Status: unhealthy
Age Group: 18 years
Sex: F
Population Size: 1
Sources:
Delusions 1 patient
Disc. AE
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
unhealthy, 18 years
n = 1
Health Status: unhealthy
Condition: allergic rhinitis
Age Group: 18 years
Sex: F
Population Size: 1
Sources:
Depression 1 patient
Disc. AE
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
unhealthy, 18 years
n = 1
Health Status: unhealthy
Condition: allergic rhinitis
Age Group: 18 years
Sex: F
Population Size: 1
Sources:
Insomnia 1 patient
Disc. AE
2.5 mg 1 times / day multiple, oral
Dose: 2.5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 2.5 mg, 1 times / day
Sources:
unhealthy, 23 months
n = 1
Health Status: unhealthy
Condition: chronic rhinitis
Age Group: 23 months
Sex: M
Population Size: 1
Sources:
Dysgeusia 1%
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Dyspepsia 1%
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Feeling hot 1%
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Headache 1%
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Hyperhidrosis 1%
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Paresthesia 1%
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Presyncope 1%
10 mg single, intravenous
Recommended
unhealthy, 39 years
n = 127
Sedation 1 patient
60 mg single, oral
Overdose
Dose: 60 mg
Route: oral
Route: single
Dose: 60 mg
Sources:
healthy, 4 years
n = 1
Health Status: healthy
Age Group: 4 years
Sex: M
Population Size: 1
Sources:
Drowsiness severe, 1 patient
60 mg single, oral
Overdose
Dose: 60 mg
Route: oral
Route: single
Dose: 60 mg
Sources:
healthy, 4 years
n = 1
Health Status: healthy
Age Group: 4 years
Sex: M
Population Size: 1
Sources:
Dystonic reaction 1 patient
Disc. AE
5 mg 1 times / day multiple, oral
Dose: 5 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5 mg, 1 times / day
Sources:
unhealthy, 6 years
n = 1
Health Status: unhealthy
Condition: allergic rhinitis
Age Group: 6 years
Sex: M
Population Size: 1
Sources:
Somnolence 13.7%
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources: Page: p. 24
unhealthy, > 12 years
n = 2034
Health Status: unhealthy
Age Group: > 12 years
Sex: M+F
Population Size: 2034
Sources: Page: p. 24
Dizziness 2%
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources: Page: p. 24
unhealthy, > 12 years
n = 2034
Health Status: unhealthy
Age Group: > 12 years
Sex: M+F
Population Size: 2034
Sources: Page: p. 24
Pharyngitis 2%
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources: Page: p. 24
unhealthy, > 12 years
n = 2034
Health Status: unhealthy
Age Group: > 12 years
Sex: M+F
Population Size: 2034
Sources: Page: p. 24
Dry mouth 5%
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources: Page: p. 24
unhealthy, > 12 years
n = 2034
Health Status: unhealthy
Age Group: > 12 years
Sex: M+F
Population Size: 2034
Sources: Page: p. 24
Fatigue 5.9%
10 mg 1 times / day multiple, oral
Recommended
Dose: 10 mg, 1 times / day
Route: oral
Route: multiple
Dose: 10 mg, 1 times / day
Sources: Page: p. 24
unhealthy, > 12 years
n = 2034
Health Status: unhealthy
Age Group: > 12 years
Sex: M+F
Population Size: 2034
Sources: Page: p. 24
Visual acuity reduced 0.6%
0.24 % 2 times / day multiple, ophthalmic
Recommended
unhealthy, adult
n = 511
Ocular hyperemia 2%
0.24 % 2 times / day multiple, ophthalmic
Recommended
unhealthy, adult
n = 511
Conjunctival hyperemia 5.3%
0.24 % 2 times / day multiple, ophthalmic
Recommended
unhealthy, adult
n = 511
PubMed

PubMed

TitleDatePubMed
Measurement of interstitial cetirizine concentrations in human skin: correlation of drug levels with inhibition of histamine-induced skin responses.
1999 Jun
Cetirizine and loratadine: a comparison using the ED50 in skin reactions.
2000 Mar-Apr
The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare.
2001
Cetirizine/pseudoephedrine.
2001
Impact of rhinitis on airway inflammation: biological and therapeutic implications.
2001
Treatment of urticaria. An evidence-based evaluation of antihistamines.
2001
[The effect of second generation histamine antagonists on the heart].
2001
Is it Crohn's disease? A severe systemic granulomatous reaction to sulfasalazine in patient with rheumatoid arthritis.
2001
Clinical prescribing of allergic rhinitis medication in the preschool and young school-age child: what are the options?
2001
Treatment of severe seasonal rhinoconjunctivitis by a combination of azelastine nasal spray and eye drops: a double-blind, double-placebo study.
2001
Design, synthesis and antihistaminic (H1)activity of some condensed 2-(substituted)arylaminoethylpyrimidin-4(3H)-ones.
2001
Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers.
2001 Apr
Newer antihistamines.
2001 Apr 30
[The allergic pregnant woman].
2001 Dec
Comparative onset of action and symptom relief with cetirizine, loratadine, or placebo in an environmental exposure unit in subjects with seasonal allergic rhinitis: confirmation of a test system.
2001 Dec
Sure outcomes of random events: a model for clinical trials.
2001 Feb 28
Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis.
2001 Jan
Urticaria induced by cetirizine.
2001 Jan
Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma.
2001 Jan
Effects of cetirizine and epinastine on the skin response to histamine iontophoresis.
2001 Jan
Stability of cetirizine dihydrochloride in solid state.
2001 Jan-Feb
Double-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children.
2001 Jul
Stability indicating HPTLC method for the simultaneous determination of pseudoephedrine and cetirizine in pharmaceutical formulations.
2001 Jun
Distributions of results of cetirizine dihydrochloride assay in bulk material.
2001 Jun 19
[Co-administration of histamine H1 antagonist and oral anticoagulants].
2001 Jun-Jul
An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers.
2001 Mar
[The course of allergy: principles for early diagnosis, prevention and early therapy of allergic diseases].
2001 May
Controlled comparison of the efficacy and safety of cetirizine 10 mg o.d. and fexofenadine 120 mg o.d. in reducing symptoms of seasonal allergic rhinitis.
2001 May
Efficacy of nimesulide alone and in combination with cetirizine in acute allergic rhinitis.
2001 May
[Efficacy and safety of fexofenadine and cetirizine in the treatment of allergic rhinitis].
2001 Nov-Dec
Multiwavelength spectrophotometric resolution of the micro-equilibria of cetirizine.
2001 Oct
Preclinical comparison of ebastine and other second generation H1-antihistamines.
2001 Oct
Effects of topical corticosteroid and combined mediator blockade on domiciliary and laboratory measurements of nasal function in seasonal allergic rhinitis.
2001 Oct
Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study.
2001 Sep
Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment.
2001 Sep-Oct
Photosensitivity disorders: cause, effect and management.
2002
Displacement of histamine from liver cells and cell components by ligands for cytochromes P450.
2002
Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells.
2002
Comparison of five new antihistamines (H1-receptor antagonists) in patients with allergic rhinitis using nasal provocation studies and skin tests.
2002 Apr
Are antihistamines useful in managing asthma?
2002 Feb
Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194).
2002 Feb
Cardiotoxicity of new antihistamines and cisapride.
2002 Feb 28
Cetirizine decreases interleukin-4, interleukin-5, and interferon-gamma gene expressions in nasal-associated lymphoid tissue of sensitized mice.
2002 Jan-Feb
Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy.
2002 Jun
Extractionless and sensitive method for high-throughput quantitation of cetirizine in human plasma samples by liquid chromatography-tandem mass spectrometry.
2002 Jun 25
[Skin prick test results in snoring and sleep apnea patients].
2002 Mar
Gateways to clinical trials.
2002 May
Development and validation of a HPLC method for the determination of cetirizine in pharmaceutical dosage forms.
2002 May
Treating seasonal allergic rhinitis. Trial does not show that there is no difference between butterbur and cetirizine.
2002 May 25
Patents

Sample Use Guides

1 to 2 tablets once daily depending upon severity of symptoms; do not take more than 2 tablets in 24 hours
Route of Administration: Oral
In Vitro Use Guide
Cetirizine (10 micrograms/ml) significantly enhanced IL-1 release by human monocytes stimulated by a weak LPS concentration (1 microgram/ml) but could not modify the maximal increase of IL-1 release induced by 10 micrograms/ml of LPS. It did not exert any effect on resting cells. Cetirizine (0.1-10 micrograms/ml) enhanced PGE2 release by resting human monocytes. Concentrations of 1 and 10 micrograms/ml enhanced PGE2 release by LPS-stimulated monocytes, and by healthy and inflamed rat macrophages.
Substance Class Chemical
Created
by admin
on Fri Jun 25 22:45:46 UTC 2021
Edited
by admin
on Fri Jun 25 22:45:46 UTC 2021
Record UNII
YO7261ME24
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CETIRIZINE
HSDB   INN   MI   VANDF   WHO-DD  
INN  
Official Name English
CETIRIZINE [MI]
Common Name English
(+/-)-(2-(4-(P-CHLORO-A-PHENYLBENZYL)-1-PIPERAZINYL)ETHOXY)ACETIC ACID
Common Name English
CETIRIZINE [HSDB]
Common Name English
AC-170
Code English
CETIRIZINE [INN]
Common Name English
ACETIC ACID, (2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPERAZINYL)ETHOXY)-, (+/-)-
Common Name English
CETIRIZINE [WHO-DD]
Common Name English
CETIRIZINE [VANDF]
Common Name English
CETIDERM
Brand Name English
Classification Tree Code System Code
LIVERTOX 180
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
NCI_THESAURUS C29578
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
NDF-RT N0000175587
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
WHO-VATC QR06AE07
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
NDF-RT N0000000190
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
WHO-ATC R06AE07
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
Code System Code Type Description
ChEMBL
CHEMBL1000
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
WIKIPEDIA
CETIRIZINE
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
LACTMED
Cetirizine
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
EPA CompTox
83881-51-0
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
DRUG BANK
DB00341
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
INN
5520
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
MERCK INDEX
M3291
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY Merck Index
RXCUI
20610
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY RxNorm
PUBCHEM
2678
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
EVMPD
SUB07451MIG
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
DRUG CENTRAL
581
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
CAS
83881-51-0
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
NCI_THESAURUS
C1042
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
MESH
D017332
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
IUPHAR
1222
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
HSDB
7739
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
FDA UNII
YO7261ME24
Created by admin on Fri Jun 25 22:45:47 UTC 2021 , Edited by admin on Fri Jun 25 22:45:47 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
TRANSPORTER -> INHIBITOR
TRANSPORTER -> SUBSTRATE
BINDER->LIGAND
TRANSPORTER -> INHIBITOR
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
PARENT -> METABOLITE ACTIVE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC