U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C20H30NO3.Br.H2O
Molecular Weight 430.376
Optical Activity ( + / - )
Defined Stereocenters 4 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IPRATROPIUM BROMIDE

SMILES

O.[Br-].CC(C)[N@+]1(C)[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)[C@@H](CO)C3=CC=CC=C3

InChI

InChIKey=KEWHKYJURDBRMN-KMYPTGJZSA-M
InChI=1S/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1/t16-,17+,18+,19-,21?;;/m0../s1

HIDE SMILES / InChI
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula BrH
Molecular Weight 80.912
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C20H30NO3
Molecular Weight 332.4571
Charge 1
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 4 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/mesh/68009241

Ipratropium (ipratropium bromide, ATROVENT® HFA) is a muscarinic antagonist structurally related to atropine but often considered safer and more effective for inhalation use. It is indicated for the maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Ipratropium (ipratropium bromide, ATROVENT® HFA) is an anticholinergic (parasympatholytic) agent which, based on animal studies, appears to inhibit vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released at the neuromuscular junctions in the lung. Anticholinergics prevent the increases in intracellular concentration of Ca2+ which is caused by interaction of acetylcholine with the muscarinic receptors on bronchial smooth muscle.

CNS Activity

CNS Penetrant
2554
Curator's Comment: Raeburn, David, Giembycz, Mark A. (2012). Rhinitis: Immunopathology and Pharmacotherapy. Springer. p. 133: "Topical intranasal ipratropium bromide has limited central nervous system penetration".

Originator

Boehringer Ingelheim
131
Sources: Svenska lakartidningen (1962), 59, 3384-5.
Curator's Comment: Ravina, Enrique (2011). The evolution of drug discovery: from traditional medicines to modern drugs (1. Aufl. ed.). Weinheim: Wiley-VCH. p. 144.

Approval Year

1986
103
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
 0.49 nM [Ki]
Antagonist
2778
 1.5 nM [Ki]
Antagonist
2778
 0.51 nM [Ki]
Antagonist
2778
 0.66 nM [Ki]
Antagonist
2778
 1.7 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
ATROVENT HFA

Approved Use

ATROVENT HFA Inhalation Aerosol is indicated as a bronchodilator for maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

Launch Date

1.10142725E12
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
33.5 pg/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day multiple, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: MULTIPLE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
31.7 pg/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day steady-state, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE
food status: UNKNOWN
35.4 pg/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day steady-state, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1.04 pg × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day multiple, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: MULTIPLE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
123 pg × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day steady-state, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE
food status: UNKNOWN
131 pg × h/mL
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day steady-state, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
2 h
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day multiple, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: MULTIPLE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
95.5%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021747s010lbl.pdf
20 μg 4 times / day multiple, respiratory
dose: 20 μg
route of administration: Respiratory
experiment type: MULTIPLE
co-administered: ALBUTEROL
ALBUTEROL
 IPRATROPIUM plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
168 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 168 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 168 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
unhealthy, 18 - 75 years
n = 96
Health Status: unhealthy
Condition: perennial allergic rhinitis
Age Group: 18 - 75 years
Sex: M+F
Population Size: 96
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
Disc. AE: Nasal disorder NOS, Nasal dryness...
AEs leading to
discontinuation/dose reduction:
Nasal disorder NOS (17%)
Nasal dryness (2%)
Epistaxis (2%)
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
168 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 168 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 168 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
unhealthy, 2 - 5 years
n = 43
Health Status: unhealthy
Condition: common colds
Age Group: 2 - 5 years
Sex: M+F
Population Size: 43
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
Disc. AE: Epistaxis...
AEs leading to
discontinuation/dose reduction:
Epistaxis (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
84 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 84 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 84 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
unhealthy, 2 - 5 years
n = 187
Health Status: unhealthy
Condition: allergies
Age Group: 2 - 5 years
Sex: M+F
Population Size: 187
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
Disc. AE: Epistaxis, Upper respiratory tract infection...
AEs leading to
discontinuation/dose reduction:
Epistaxis (1 patient)
Upper respiratory tract infection (1 patient)
Ear infection (1 patient)
Exacerbation of asthma (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
200 ug single, respiratory
Highest studied dose
Dose: 200 ug
Route: respiratory
Route: single
Dose: 200 ug
Sources:
https://pubmed.ncbi.nlm.nih.gov/2150695/
unhealthy, mean 40.7 years
n = 20
Health Status: unhealthy
Condition: stable chronic asthma
Age Group: mean 40.7 years
Sex: M+F
Population Size: 20
Sources:
https://pubmed.ncbi.nlm.nih.gov/2150695/
Disc. AE: Nausea and vomiting...
AEs leading to
discontinuation/dose reduction:
Nausea and vomiting (1 patient)
Sources:
https://pubmed.ncbi.nlm.nih.gov/2150695/
42 ug 1 times / day steady, respiratory
Recommended
Dose: 42 ug, 1 times / day
Route: respiratory
Route: steady
Dose: 42 ug, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751528/
unhealthy, mean 42.6 years
n = 99
Health Status: unhealthy
Condition: rhinorrhea
Age Group: mean 42.6 years
Sex: M+F
Population Size: 99
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751528/
Other AEs: Nasal disorder NOS...
Other AEs:
Nasal disorder NOS (19 patients)
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751528/
AEs

AEs

AESignificanceDosePopulation
Nasal disorder NOS 17%
Disc. AE
168 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 168 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 168 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
unhealthy, 18 - 75 years
n = 96
Health Status: unhealthy
Condition: perennial allergic rhinitis
Age Group: 18 - 75 years
Sex: M+F
Population Size: 96
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
Epistaxis 2%
Disc. AE
168 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 168 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 168 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
unhealthy, 18 - 75 years
n = 96
Health Status: unhealthy
Condition: perennial allergic rhinitis
Age Group: 18 - 75 years
Sex: M+F
Population Size: 96
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
Nasal dryness 2%
Disc. AE
168 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 168 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 168 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
unhealthy, 18 - 75 years
n = 96
Health Status: unhealthy
Condition: perennial allergic rhinitis
Age Group: 18 - 75 years
Sex: M+F
Population Size: 96
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751529/
Epistaxis 1 patient
Disc. AE
168 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 168 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 168 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
unhealthy, 2 - 5 years
n = 43
Health Status: unhealthy
Condition: common colds
Age Group: 2 - 5 years
Sex: M+F
Population Size: 43
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
Ear infection 1 patient
Disc. AE
84 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 84 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 84 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
unhealthy, 2 - 5 years
n = 187
Health Status: unhealthy
Condition: allergies
Age Group: 2 - 5 years
Sex: M+F
Population Size: 187
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
Epistaxis 1 patient
Disc. AE
84 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 84 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 84 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
unhealthy, 2 - 5 years
n = 187
Health Status: unhealthy
Condition: allergies
Age Group: 2 - 5 years
Sex: M+F
Population Size: 187
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
Exacerbation of asthma 1 patient
Disc. AE
84 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 84 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 84 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
unhealthy, 2 - 5 years
n = 187
Health Status: unhealthy
Condition: allergies
Age Group: 2 - 5 years
Sex: M+F
Population Size: 187
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
Upper respiratory tract infection 1 patient
Disc. AE
84 ug 3 times / day steady, respiratory
Highest studied dose
Dose: 84 ug, 3 times / day
Route: respiratory
Route: steady
Dose: 84 ug, 3 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
unhealthy, 2 - 5 years
n = 187
Health Status: unhealthy
Condition: allergies
Age Group: 2 - 5 years
Sex: M+F
Population Size: 187
Sources:
https://pubmed.ncbi.nlm.nih.gov/15702820/
Nausea and vomiting 1 patient
Disc. AE
200 ug single, respiratory
Highest studied dose
Dose: 200 ug
Route: respiratory
Route: single
Dose: 200 ug
Sources:
https://pubmed.ncbi.nlm.nih.gov/2150695/
unhealthy, mean 40.7 years
n = 20
Health Status: unhealthy
Condition: stable chronic asthma
Age Group: mean 40.7 years
Sex: M+F
Population Size: 20
Sources:
https://pubmed.ncbi.nlm.nih.gov/2150695/
Nasal disorder NOS 19 patients
42 ug 1 times / day steady, respiratory
Recommended
Dose: 42 ug, 1 times / day
Route: respiratory
Route: steady
Dose: 42 ug, 1 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751528/
unhealthy, mean 42.6 years
n = 99
Health Status: unhealthy
Condition: rhinorrhea
Age Group: mean 42.6 years
Sex: M+F
Population Size: 99
Sources:
https://pubmed.ncbi.nlm.nih.gov/7751528/
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer
OCT1
512

OCT2
647

OCT3
150

MATE1
306

MATE2
263
OCTN1
47

OCTN2
50

OCT1
327

OCT2
355

OCT3
80

MATE1
135

MATE2
96
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
OCT1
543
 yes [IC50 17.4 uM]
OCT3
150
 yes [IC50 2.5 uM]
OCT2
648
 yes [IC50 3.6 uM]
MATE1
308
 yes [IC50 30.5 uM]
MATE2
263
 yes [IC50 62.8 uM]
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
MATE1
135
 strong
MATE2
96
 strong
OCT1
327
 strong
OCT2
355
 strong
OCT3
80
 strong
OCTN1
47
 yes
OCTN2
50
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
KeyOrganics
KS-5051
Pharmeks
PHAR218016
ZINC
ZINC000013782937
http://zinc15.docking.org/substances/ZINC000013782937
PubMed

PubMed

TitleDatePubMed
An economic overview of chronic obstructive pulmonary disease.
2001
Use of a long-acting inhaled beta2-adrenergic agonist, salmeterol xinafoate, in patients with chronic obstructive pulmonary disease.
2001 Apr
The role of domiciliary nebulizers in managing patients with severe COPD.
2001 Apr
Tiotropium bromide.
2001 Apr
Antimuscarinic treatment for lung diseases from research to clinical practice.
2001 Apr 27
Evidence-based treatments for acute asthma.
2001 Dec
Inhaled anticholinergic therapy: applied pharmacology and interesting developments.
2001 Jan
Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD.
2001 Jun
Clozapine and sialorrhea: update.
2001 May
Efficacy of IV theophylline in children with severe status asthmaticus.
2001 May
Does adding ipratropium to salbutamol (albuterol) help children with asthma?
2001 Nov
Lower arrythmogenic risk of low dose albuterol plus ipratropium.
2001 Oct
The use of ipratropium bromide for the management of acute asthma exacerbation in adults and children: a systematic review.
2001 Oct
Drug therapy of childhood asthma.
2001 Sep
[Effect of anticholinergic therapy on myocardial reserve dynamics in patients with chronic obstructive bronchitis].
2001 Sep-Dec
[Asthma follow-up after treatment of status asthmaticus in ICU Pneumonology Department in Warsaw Medical University].
2002
Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing.
2002
Role of cholinergic reflexes on the bronchoconstrictor reactivity to neurokinin a in allergic dogs.
2002
Histochemical and biochemical studies on the secretory mechanisms of some glands of guinea-pigs treated with histamine.
2002
Tiotropium bromide.
2002
Pressurised metered-dose inhalers versus all other hand-held inhalers devices to deliver bronchodilators for chronic obstructive pulmonary disease.
2002
Pharmacogenetics, pharmacogenomics and airway disease.
2002
Pharmacodynamic steady state of tiotropium in patients with chronic obstructive pulmonary disease.
2002 Apr
Hospitalizations and mortality in the Lung Health Study.
2002 Aug 1
24-hour efficacy of once-daily desloratadine therapy in patients with seasonal allergic rhinitis [ISRCTN32042139].
2002 Aug 5
Clinical review: severe asthma.
2002 Feb
Improved health outcomes in patients with COPD during 1 yr's treatment with tiotropium.
2002 Feb
Other option in bronchiolitis.
2002 Feb
Hospital management of children with acute asthma exacerbations in Kuwait: adherence to international guidelines.
2002 Jul-Sep
The role of anticholinergics in acute asthma treatment: an evidence-based evaluation.
2002 Jun
Understanding and use of inhaler medication by asthmatics in specialty care in Trinidad: a study following development of Caribbean guidelines for asthma management and prevention.
2002 Jun
[Effect of ipratropium bromide on calcium activated potassium channel in tracheal smooth muscle cells from chronically hypoxic rats].
2002 May
What is the optimal treatment strategy for chronic obstructive pulmonary disease exacerbations?
2002 May
Patents

Patents

JP2002541233A
400
JP2006517213A
3
JP2010184937A
3
US6632842
3

Sample Use Guides

In Vivo Use Guide
The usual starting dose of ATROVENT® HFA is two inhalations four times a day. Patients may take additional inhalations as required; however, the total number of inhalations should not exceed 12 in 24 hours.
Route of Administration: Oral
In Vitro Use Guide
Ba 679 BR, atropine, and ipratropium bromide inhibited electrical field stimulation (EFS)-induced contraction with IC50 values of 0.17, 0.74, and 0.58 nM, respectively, in guinea pig trachea. Ba 679 BR had a slower onset and longer duration of action than atropine or ipratropium bromide (the times required to attain 50% of the maximum response were 34.8, 3.8, and 7.6 min, respectively, and the times required for 50% recovery of the response were 540, 31.6, and 81.2 min, respectively).
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:39:50 UTC 2023
Edited
by admin
on Fri Dec 15 17:39:50 UTC 2023
Record UNII
J697UZ2A9J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IPRATROPIUM BROMIDE
EP   MART.   ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
IPRATROPIUM BROMIDE COMPONENT OF DUOVENT
Brand Name English
COMBIVENT COMPONENT IPRATROPIUM BROMIDE
Common Name English
IPRATROPIUM BROMIDE [VANDF]
Common Name English
IPRATROPIUM BROMIDE [USP MONOGRAPH]
Common Name English
IPRATROPIUM BROMIDE [USP-RS]
Common Name English
DUONEB COMPONENT IPRATROPIUM BROMIDE
Common Name English
IPRATROPIUM BROMIDE HYDRATE [JAN]
Common Name English
DUOVENT COMPONENT IPRATROPIUM BROMIDE
Brand Name English
SCH 1000-BR-MONOHYDRATE
Code English
IPRATROPIUM BROMIDE COMPONENT OF COMBIVENT
Common Name English
IPRATROPIUM BROMIDE COMPONENT OF DUONEB
Common Name English
8-AZONIABICYCLO(3.2.1)OCTANE, 3-(3-HYDROXY-1-OXO-2-PHENYLPROPOXY)-8-METHYL-8-(1-METHYLETHYL)-, BROMIDE, MONOHYDRATE(ENDO,SYN)-, (±)-
Common Name English
IPRATROPIUM BROMIDE [ORANGE BOOK]
Common Name English
NSC-759613
Code English
IPRATROPIUM BROMIDE [MART.]
Common Name English
IPRATROPIUM BROMIDE HYDRATE
JAN  
Common Name English
(8R)-3.ALPHA.-HYDROXY-8-ISOPROPYL-1.ALPHA.H,5.ALPHA.H-TROPANIUM BROMIDE (±)-TROPATE MONOHYDRATE
Common Name English
SCH-1000-BR-
Code English
ATROVENT
Brand Name English
Ipratropium bromide monohydrate [WHO-DD]
Common Name English
IPRATROPIUM BROMIDE [USAN]
Common Name English
IPRATROPIUM BROMIDE [EP MONOGRAPH]
Common Name English
Classification Tree Code System Code
WHO-VATC QR01AX03
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-ATC R03AL01
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-ATC R03AL02
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
NCI_THESAURUS C319
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
NCI_THESAURUS C29704
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-VATC QR03AL01
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-VATC QR03BB01
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-ATC R03BB01
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-ATC R01AX03
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 25.1
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
WHO-VATC QR03AL02
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
Code System Code Type Description
EVMPD
SUB22932
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
PRIMARY
FDA UNII
J697UZ2A9J
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
PRIMARY
NCI_THESAURUS
C29128
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
PRIMARY
DRUG BANK
DBSALT000208
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
PRIMARY
RS_ITEM_NUM
1347507
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
PRIMARY
RXCUI
203212
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
ALTERNATIVE
EPA CompTox
DTXSID3045772
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
PRIMARY
CAS
66985-17-9
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
PRIMARY
CHEBI
46659
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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SMS_ID
100000091674
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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NSC
759613
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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ChEMBL
CHEMBL1621597
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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DAILYMED
J697UZ2A9J
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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CHEBI
5957
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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WIKIPEDIA
IPRATROPIUM BROMIDE
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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RXCUI
1309404
Created by admin on Fri Dec 15 17:39:50 UTC 2023 , Edited by admin on Fri Dec 15 17:39:50 UTC 2023
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Related Record Type Details
Structure of IPRATROPIUM BROMIDE ANHYDROUS
ANHYDROUS->SOLVATE
Structure of IPRATROPIUM
PARENT -> SALT/SOLVATE
OCT-2
TRANSPORTER -> INHIBITOR
Related Record Type Details
Structure of N-ISOPROPYLNORTROPINE METHOBROMIDE
IMPURITY -> PARENT
Structure of APO-IPRATROPIUM
IMPURITY -> PARENT
Structure of ATROPIC ACID
IMPURITY -> PARENT
Structure of TROPIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (TLC)
USP
Related Record Type Details
Structure of IPRATROPIUM
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