U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C9H10O3
Molecular Weight 166.1742
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TROPIC ACID

SMILES

c1ccc(cc1)C(CO)C(=O)O

InChI

InChIKey=JACRWUWPXAESPB-UHFFFAOYSA-N
InChI=1S/C9H10O3/c10-6-8(9(11)12)7-4-2-1-3-5-7/h1-5,8,10H,6H2,(H,11,12)

HIDE SMILES / InChI

Molecular Formula C9H10O3
Molecular Weight 166.1742
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Tropic acid (Tropate) is a chiral substance, existing as either a racemic mixture or as a single enantiomer. Tropate is classified as a beta hydroxy acid or a Beta hydroxy acid derivative. Beta hydroxy acids are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom. Tropate is considered to be soluble (in water) and acidic. Tropate can be synthesized from hydratropic acid and propionic acid. Tropate can be synthesized into tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate. Tropic acid is proposed be used topicaly for the treatment of wrinkles.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Antagonist binding in the rat muscarinic receptor A study by docking and X-ray crystallography.
2004 Dec
Two step derivatization for the analyses of organic, amino acids and glycines on filter paper plasma by GC-MS/SIM.
2007 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: May be used topicaly for the treatment of wrinkles: Tropic acid 10 grams is dissolved in 20 ml of ethanol, and the solution thus obtained is mixed with 70 grams of hydrophilic ointment USP. The mixing is continued until a uniform consistency is obtained. The composition thus formulated contains 10% tropic acid as an active ingredient, and has pH 3.7 http://www.google.la/patents/US5561159
ORAL RAT LD50 >5000 mg/kg
Route of Administration: Oral
In Vitro Use Guide
Incubation of 3 umol of dl-tropic acid and 3 umol of NAD1 with 0.5 mg of crude extract protein in glycine-NaOH buffer, pH 9.5, at 30 degrees C for 20 min, followed by diethyl ether extraction and GC-MS analysis, revealed phenylacetic acid to be the major product.
Substance Class Chemical
Created
by admin
on Sat Jun 26 10:40:44 UTC 2021
Edited
by admin
on Sat Jun 26 10:40:44 UTC 2021
Record UNII
9RM4U80765
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TROPIC ACID
MI  
Systematic Name English
NSC-20990
Code English
ATROPINE SULFATE IMPURITY C [EP]
Common Name English
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-
Common Name English
TROPIC ACID [MI]
Common Name English
IPRATROPIUM BROMIDE RELATED COMPOUND C
USP-RS  
Common Name English
2-PHENYLHYDRACRYLIC ACID
Systematic Name English
TROPICAMIDE RELATED COMPOUND C [USP]
Common Name English
2-PHENYL-3-HYDROXYPROPIONIC ACID
Systematic Name English
3-HYDROXY-2-PHENYLPROPIONIC ACID
Systematic Name English
2-PHENYL-3-HYDROXYPROPANOIC ACID
Systematic Name English
TROPICAMIDE IMPURITY C [EP]
Common Name English
(+/-)-2-PHENYL-3-HYDROXYPROPIONIC ACID
Systematic Name English
IPRATROPIUM BROMIDE RELATED COMPOUND C [USP-RS]
Common Name English
TROPICAMIDE RELATED COMPOUND C [USP-RS]
Common Name English
TROPIC ACID, (+/-)-
Common Name English
DL-TROPIC ACID
Common Name English
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, (+/-)-
Common Name English
(+/-)-3-HYDROXY-2-PHENYLPROPIONIC ACID
Systematic Name English
(2RS)-3-HYDROXY-2-PHENYLPROPANOIC ACID
Systematic Name English
(+/-)-TROPIC ACID
Systematic Name English
Code System Code Type Description
USP_CATALOG
1347530
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY USP-RS
PUBCHEM
10726
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY
ECHA (EC/EINECS)
208-465-3
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
ALTERNATIVE
FDA UNII
9RM4U80765
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY
ECHA (EC/EINECS)
209-020-6
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY
WIKIPEDIA
TROPIC ACID
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY
USP_CATALOG
1699038
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY USP-RS
MERCK INDEX
M11228
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY Merck Index
CAS
552-63-6
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
PRIMARY
CAS
529-64-6
Created by admin on Sat Jun 26 10:40:45 UTC 2021 , Edited by admin on Sat Jun 26 10:40:45 UTC 2021
SUPERSEDED
Related Record Type Details
PARENT -> METABOLITE
URINE
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
impurity C at 210 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
PARENT -> IMPURITY
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (TLC)
USP