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Details

Stereochemistry EPIMERIC
Molecular Formula 2C17H23NO3.H2O.H2O4S
Molecular Weight 694.835
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 6
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ATROPINE SULFATE

SMILES

CN1[C@@]2([H])CC[C@]1([H])C[C@@]([H])(C2)OC(=O)C([H])(CO)c3ccccc3.CN1[C@@]2([H])CC[C@]1([H])C[C@@]([H])(C2)OC(=O)C([H])(CO)c3ccccc3.OS(=O)(=O)O.O

InChI

InChIKey=JPKKQJKQTPNWTR-CHYDPLAESA-N
InChI=1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

HIDE SMILES / InChI

Molecular Formula C17H23NO3
Molecular Weight 289.3701
Charge 0
Count
Stereochemistry EPIMERIC
Additional Stereochemistry No
Defined Stereocenters 2 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula H2O4S
Molecular Weight 98.0796
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/mesh/68001285 | http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206289s000lbl.pdf

Atropine inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves, and on smooth muscles which respond to endogenous acetylcholine but are not so innervated. As with other antimuscarinic agents, the major action of atropine is a competitive or surmountable antagonism which can be overcome by increasing the concentration of acetylcholine at receptor sites of the effector organ (e.g., by using anticholinesterase agents which inhibit the enzymatic destruction of acetylcholine). The receptors antagonized by atropine are the peripheral structures that are stimulated or inhibited by muscarine (i.e., exocrine glands and smooth and cardiac muscle). Responses to postganglionic cholinergic nerve stimulation also may be inhibited by atropine but this occurs less readily than with responses to injected (exogenous) choline esters. Atropine is relatively selective for muscarinic receptors. Its potency at nicotinic receptors is much lower, and actions at non-muscarinic receptors are generally undetectable clinically. Atropine does not distinguish among the M1, M2, and M3 subgroups of muscarinic receptors.

Originator

Curator's Comment:: Atropine was first obtained from the deadly nightshade (Atropa belladonna) by M. Brandes in 1819.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Atropine sulfate

Approved Use

Atropine sulfate is indicated for temporary blockade of severe or life threatening muscarinic effects, e.g., as an antisialagogue, an antivagal agent, an antidote for organophosphorus or muscarinic mushroom poisoning, and to treat bradyasystolic cardiac arrest.

Launch Date

9.9455042E11
Primary
Atropine sulfate

Approved Use

Atropine sulfate is indicated for temporary blockade of severe or life threatening muscarinic effects, e.g., as an antisialagogue, an antivagal agent, an antidote for organophosphorus or muscarinic mushroom poisoning, and to treat bradyasystolic cardiac arrest.

Launch Date

9.9455042E11
Primary
Atropine sulfate

Approved Use

Atropine sulfate is indicated for temporary blockade of severe or life threatening muscarinic effects, e.g., as an antisialagogue, an antivagal agent, an antidote for organophosphorus or muscarinic mushroom poisoning, and to treat bradyasystolic cardiac arrest.

Launch Date

9.9455042E11
Primary
Atropine sulfate

Approved Use

Atropine sulfate is indicated for temporary blockade of severe or life threatening muscarinic effects, e.g., as an antisialagogue, an antivagal agent, an antidote for organophosphorus or muscarinic mushroom poisoning, and to treat bradyasystolic cardiac arrest.

Launch Date

9.9455042E11
Primary
Atropine sulfate

Approved Use

Atropine sulfate is indicated for temporary blockade of severe or life threatening muscarinic effects, e.g., as an antisialagogue, an antivagal agent, an antidote for organophosphorus or muscarinic mushroom poisoning, and to treat bradyasystolic cardiac arrest.

Launch Date

9.9455042E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
860 pg/mL
0.4 μg single, ocular
dose: 0.4 μg
route of administration: Ocular
experiment type: SINGLE
co-administered:
ATROPINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
11.7 ng/mL
1.67 mg single, intramuscular
dose: 1.67 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
ATROPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
9.6 ng/mL
1.67 mg single, intramuscular
dose: 1.67 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
ATROPINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
43245 pg × min/mL
0.4 μg single, ocular
dose: 0.4 μg
route of administration: Ocular
experiment type: SINGLE
co-administered:
ATROPINE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
47.6 ng × h/mL
1.67 mg single, intramuscular
dose: 1.67 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
ATROPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
4.1 h
1.67 mg single, intramuscular
dose: 1.67 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
ATROPINE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
82%
1.67 mg single, intramuscular
dose: 1.67 mg
route of administration: Intramuscular
experiment type: SINGLE
co-administered:
ATROPINE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.1 mg/kg single, intravenous
Dose: 0.1 mg/kg
Route: intravenous
Route: single
Dose: 0.1 mg/kg
Sources:
unhealthy, 10 years
n = 1
Health Status: unhealthy
Age Group: 10 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Kounis syndrome, Chest discomfort...
AEs leading to
discontinuation/dose reduction:
Kounis syndrome (1 patient)
Chest discomfort (1 patient)
Nausea (1 patient)
Vomiting (1 patient)
Sources:
0.5 % 1 times / day multiple, ophthalmic
Highest studied dose
Dose: 0.5 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 1 times / day
Sources:
unhealthy, 10.3 years (range: 2.7–16.8 years)
n = 77
Health Status: unhealthy
Condition: progressive myopia
Age Group: 10.3 years (range: 2.7–16.8 years)
Sex: M+F
Population Size: 77
Sources:
Other AEs: Photophobia, Reading disorder...
Other AEs:
Photophobia (70%)
Reading disorder (25.9%)
Headache (21.7%)
Hot flushes (3.3%)
Conjunctivitis (1.7%)
Blepharitis (1.7%)
Sources:
1 mg single, sublingual
Overdose
Dose: 1 mg
Route: sublingual
Route: single
Dose: 1 mg
Sources:
unhealthy
n = 1
Health Status: unhealthy
Population Size: 1
Sources:
Other AEs: Adverse event...
Other AEs:
Adverse event (severe)
Sources:
AEs

AEs

AESignificanceDosePopulation
Chest discomfort 1 patient
Disc. AE
0.1 mg/kg single, intravenous
Dose: 0.1 mg/kg
Route: intravenous
Route: single
Dose: 0.1 mg/kg
Sources:
unhealthy, 10 years
n = 1
Health Status: unhealthy
Age Group: 10 years
Sex: M
Population Size: 1
Sources:
Kounis syndrome 1 patient
Disc. AE
0.1 mg/kg single, intravenous
Dose: 0.1 mg/kg
Route: intravenous
Route: single
Dose: 0.1 mg/kg
Sources:
unhealthy, 10 years
n = 1
Health Status: unhealthy
Age Group: 10 years
Sex: M
Population Size: 1
Sources:
Nausea 1 patient
Disc. AE
0.1 mg/kg single, intravenous
Dose: 0.1 mg/kg
Route: intravenous
Route: single
Dose: 0.1 mg/kg
Sources:
unhealthy, 10 years
n = 1
Health Status: unhealthy
Age Group: 10 years
Sex: M
Population Size: 1
Sources:
Vomiting 1 patient
Disc. AE
0.1 mg/kg single, intravenous
Dose: 0.1 mg/kg
Route: intravenous
Route: single
Dose: 0.1 mg/kg
Sources:
unhealthy, 10 years
n = 1
Health Status: unhealthy
Age Group: 10 years
Sex: M
Population Size: 1
Sources:
Blepharitis 1.7%
0.5 % 1 times / day multiple, ophthalmic
Highest studied dose
Dose: 0.5 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 1 times / day
Sources:
unhealthy, 10.3 years (range: 2.7–16.8 years)
n = 77
Health Status: unhealthy
Condition: progressive myopia
Age Group: 10.3 years (range: 2.7–16.8 years)
Sex: M+F
Population Size: 77
Sources:
Conjunctivitis 1.7%
0.5 % 1 times / day multiple, ophthalmic
Highest studied dose
Dose: 0.5 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 1 times / day
Sources:
unhealthy, 10.3 years (range: 2.7–16.8 years)
n = 77
Health Status: unhealthy
Condition: progressive myopia
Age Group: 10.3 years (range: 2.7–16.8 years)
Sex: M+F
Population Size: 77
Sources:
Headache 21.7%
0.5 % 1 times / day multiple, ophthalmic
Highest studied dose
Dose: 0.5 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 1 times / day
Sources:
unhealthy, 10.3 years (range: 2.7–16.8 years)
n = 77
Health Status: unhealthy
Condition: progressive myopia
Age Group: 10.3 years (range: 2.7–16.8 years)
Sex: M+F
Population Size: 77
Sources:
Reading disorder 25.9%
0.5 % 1 times / day multiple, ophthalmic
Highest studied dose
Dose: 0.5 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 1 times / day
Sources:
unhealthy, 10.3 years (range: 2.7–16.8 years)
n = 77
Health Status: unhealthy
Condition: progressive myopia
Age Group: 10.3 years (range: 2.7–16.8 years)
Sex: M+F
Population Size: 77
Sources:
Hot flushes 3.3%
0.5 % 1 times / day multiple, ophthalmic
Highest studied dose
Dose: 0.5 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 1 times / day
Sources:
unhealthy, 10.3 years (range: 2.7–16.8 years)
n = 77
Health Status: unhealthy
Condition: progressive myopia
Age Group: 10.3 years (range: 2.7–16.8 years)
Sex: M+F
Population Size: 77
Sources:
Photophobia 70%
0.5 % 1 times / day multiple, ophthalmic
Highest studied dose
Dose: 0.5 %, 1 times / day
Route: ophthalmic
Route: multiple
Dose: 0.5 %, 1 times / day
Sources:
unhealthy, 10.3 years (range: 2.7–16.8 years)
n = 77
Health Status: unhealthy
Condition: progressive myopia
Age Group: 10.3 years (range: 2.7–16.8 years)
Sex: M+F
Population Size: 77
Sources:
Adverse event severe
1 mg single, sublingual
Overdose
Dose: 1 mg
Route: sublingual
Route: single
Dose: 1 mg
Sources:
unhealthy
n = 1
Health Status: unhealthy
Population Size: 1
Sources:
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
yes [IC50 1.2 uM]
yes [IC50 39 uM]
yes [IC50 466 uM]
PubMed

PubMed

TitleDatePubMed
Endothelin receptors in human and guinea-pig gallbladder muscle.
2001 Apr 20
Localisation and neural control of the release of calcitonin gene-related peptide (CGRP) from the isolated perfused porcine ileum.
2001 Apr 20
On the mechanisms of cholinergic control of the sinoatrial node discharge.
2001 Feb
Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle.
2001 Feb
Antispasmodic activity of the fruits of Helicteres isora Linn.
2001 Feb
Reversal of rocuronium with edrophonium during propofol versus sevoflurane anesthesia.
2001 Feb
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats.
2001 Feb
Muscarinic receptor subtypes and calcium signaling in Fischer rat thyroid cells.
2001 Feb 1
Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest alpha9-like receptors.
2001 Feb 1
Prognostic interaction between viability and residual myocardial ischemia by dobutamine stress echocardiography in patients with acute myocardial infarction and mildly impaired left ventricular function.
2001 Feb 1
Sympathetic control of nasal blood flow in the rat mediated by alpha(1)-adrenoceptors.
2001 Feb 16
Characterisation of the prejunctional inhibitory muscarinic receptor on cholinergic nerves in the rat urinary bladder.
2001 Feb 16
Mechanisms of hydrogen peroxide-induced relaxation in rabbit mesenteric small artery.
2001 Feb 2
Facilitation of transmitter release in the urinary bladders of neonatal and adult rats via alpha1-adrenoceptors.
2001 Feb 23
Binding of nicotinic ligands to and nicotine-induced calcium signaling in Trypanosoma cruzi.
2001 Feb 23
Photochemical N-demethylation of alkaloids.
2001 Feb 26
[Availability of antidotes in French emergency medical aid units].
2001 Feb 3
[Experiences with cycloplegic drops in German-speaking centers of pediatric ophthalmology and stabology--results of a 1999 survey].
2001 Jan
On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice.
2001 Jan
Increase of peak expiratory flow by atropine is dependent on circadian rhythm.
2001 Jan
[Marked bradycardia during anesthetic induction treated with temporary cardiac pacing in a patient with latent sick sinus syndrome].
2001 Jan
Influence of patient posture on oxygen saturation during fibre-optic bronchoscopy.
2001 Jan
A clinico-epidemiological study of organophosphorus poisoning at a rural-based teaching hospital in eastern Nepal.
2001 Jan
Tris(2,2'-bipyridine)ruthenium(II) electrogenerated chemiluminescence of alkaloid type drugs with solid phase extraction sample preparation.
2001 Jan
Muscarinic activation of transient inward current and contraction in canine colon circular smooth muscle cells.
2001 Jan
Hypotensive infarction of the spinal cord in a rhesus macaque (Macaca mulatta).
2001 Jan
Spectral analysis of circadian rhythms in heart rate variability of dogs.
2001 Jan
Effects of VIP and NO on the motor activity of vascularly perfused rat proximal colon.
2001 Jan
Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles.
2001 Jan
Neural mechanisms underlying migrating motor complex formation in mouse isolated colon.
2001 Jan
Evidence for cocaine and methylecgonidine stimulation of M(2) muscarinic receptors in cultured human embryonic lung cells.
2001 Jan
Characterization of a novel mechanism accounting for the adverse cholinergic effects of the anticancer drug irinotecan.
2001 Jan
Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men.
2001 Jan
Role of PAG in the antinociception evoked from the medial or central amygdala in rats.
2001 Jan 1
Activation of sympathoadrenomedullary system increases pulmonary nitric oxide production in the rabbit.
2001 Jan 12
[Atropine. Principles and rules of utilization].
2001 Jan 15
Role of preoptic and anterior hypothalamic cholinergic input on water intake and body temperature.
2001 Jan 19
The effect of nitrate and ammonium concentrations on growth and alkaloid accumulation of Atropa belladonna hairy roots.
2001 Jan 23
Ghrelin acts in the central nervous system to stimulate gastric acid secretion.
2001 Jan 26
Angiotensinergic and noradrenergic mechanisms in the hypothalamic paraventricular nucleus participate in the drinking response induced by activation of the subfornical organ in rats.
2001 Jan 29
Determination of scopolamine in human serum and microdialysis samples by liquid chromatography-tandem mass spectrometry.
2001 Jan 5
Neural-epithelial cell interplay: in vitro evidence that vagal mediators increase PGE2 production by human nasal epithelial cells.
2001 Jan-Feb
Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques.
2001 Mar
From 'captive' agonism to insurmountable antagonism: demonstrating the power of analytical pharmacology.
2001 Mar
Pharmacological characterization of locomotor sensitization induced by chronic phencyclidine administration.
2001 Mar
Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.
2001 Mar
Respective roles of carbamylcholine and cyclic adenosine monophosphate in their synergistic regulation of cell cycle in thyroid primary cultures.
2001 Mar
Initiation of distension-induced descending peristaltic reflex in opossum esophagus: role of muscle contractility.
2001 Mar
Orally administered atropine enhances motor cortex excitability: a transcranial magnetic stimulation study in human subjects.
2001 Mar 16
5-Hydroxytryptamine and atropine inhibit nicotinic receptors in submucosal neurons.
2001 Mar 2
Patents

Sample Use Guides

Atropine as an antisialagogue or for antivagal effects: initial single dose of 0.5 mg to 1 mg; as an antidote for organophosporous or muscarinic mushroom poisoning: initial single dose of 2 mg to 3 mg, repeated every 20­-30 minutes; for bradyasystolic cardiac arrest: 1 mg dose, repeated every 3-5 minutes if asystole persists; in patients with coronary artery disease: total dose should not exceed 0.03 mg/kg to 0.04 mg/kg.
Route of Administration: Other
In Vitro Use Guide
Atropine in doses -5.44 to -4.74 log mol/L totally inhibited the contraction induced by acetylcholine and carbachol in segmental pulmonary artery specimens taken from the patients undergoing thoracic surgery.
Substance Class Chemical
Created
by admin
on Fri Jun 25 21:19:10 UTC 2021
Edited
by admin
on Fri Jun 25 21:19:10 UTC 2021
Record UNII
03J5ZE7KA5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ATROPINE SULFATE
EP   MART.   ORANGE BOOK   USP   USP-RS   VANDF   WHO-IP  
Common Name English
ATROPINI SULFAS [WHO-IP LATIN]
Common Name English
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, 8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(+/-)-, SULFATE (2:1) (SALT), MONOHYDRATE
Systematic Name English
ATROPINUM SULPHURICUM
HPUS  
Common Name English
ATROPINE SULFATE [WHO-IP]
Common Name English
ATROPINE SULFATE HYDRATE [JAN]
Common Name English
ATROPINE SULFATE COMPONENT OF LOW-QUEL
Common Name English
ATROPINE SULFATE [ORANGE BOOK]
Common Name English
ATROPINE SULFATE COMPONENT OF LONOX
Common Name English
ATROPINE SULPHATE
Common Name English
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, 8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(+/-)-, SULPHATE (2:1) (SALT), MONOHYDRATE
Official Name English
ATROPINE SULFATE [USP]
Common Name English
LONOX COMPONENT ATROPINE SULFATE
Common Name English
ATROPINE SULFATE MONOHYDRATE
MI   WHO-DD  
Common Name English
ATROPINE SULFATE COMPONENT OF COLONAID
Common Name English
1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL (+/-)-TROPATE (ESTER), SULPHATE (2:1) (SALT) MONOHYDRATE
Systematic Name English
ATROPINE SULFATE COMPONENT OF LOMANATE
Common Name English
ISOPTO ATROPINE
Brand Name English
ATROPINE SULFATE COMPONENT OF LOMOTIL
Common Name English
DI-ATRO COMPONENT ATROPINE SULFATE
Common Name English
LO-TROL COMPONENT ATROPINE SULFATE
Common Name English
ATROPINE SULFATE COMPONENT OF ENLON-PLUS
Common Name English
NSC-755889
Code English
ATROPINE SULFATE COMPONENT OF MOTOFEN
Common Name English
ATROPINE SULFATE HYDRATE
JAN  
Common Name English
MOTOFEN COMPONENT ATROPINE SULFATE
Common Name English
ATROPINE SULFATE COMPONENT OF LO-TROL
Common Name English
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)- (3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, SULFATE (2:1) (SALT), MONOHYDRATE
Systematic Name English
COLONAID COMPONENT ATROPINE SULFATE
Common Name English
ENLON-PLUS COMPONENT ATROPINE SULFATE
Common Name English
ATROPINE SULFATE [USP-RS]
Common Name English
ATROPINE SULFATE [VANDF]
Common Name English
ATROPINE SULFATE COMPONENT OF DI-ATRO
Common Name English
ATROPT
Brand Name English
BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)- (3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, SULPHATE (2:1) (SALT), MONOHYDRATE
Systematic Name English
ATROPINE SULFATE MONOHYDRATE [WHO-DD]
Common Name English
(+/-)-ENDO-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL .ALPHA.-(HYDROXYMETHYL)BENZENEACETATE SULFATE (2:1) (SALT) MONOHYDRATE
Systematic Name English
ATROPISOL
Brand Name English
ATROPINE SULFATE [MART.]
Common Name English
LOMOTIL COMPONENT ATROPINE SULFATE
Common Name English
LOGEN COMPONENT ATROPINE SULFATE
Common Name English
ATROPINE SULFATE MONOHYDRATE [MI]
Common Name English
ATROPINE SULFATE [EP MONOGRAPH]
Common Name English
ATROPINUM SULPHURICUM [HPUS]
Common Name English
LOW-QUEL COMPONENT ATROPINE SULFATE
Common Name English
1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL (+/-)-TROPATE (ESTER), SULFATE (2:1) (SALT) MONOHYDRATE
Systematic Name English
ATROPINE SULFATE COMPONENT OF LOGEN
Common Name English
LOMANATE COMPONENT ATROPINE SULFATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
CFR 21 CFR 310.533
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
Code System Code Type Description
DRUG BANK
DBSALT000281
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
FDA UNII
03J5ZE7KA5
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
EPA CompTox
5908-99-6
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
NCI_THESAURUS
C2744
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
USP_CATALOG
1045009
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY USP-RS
CAS
5908-99-6
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
EVMPD
SUB00625MIG
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
EVMPD
SUB120273
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ATROPINE SULFATE
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY Description: Colourless crystal or a white, crystalline powder; odourless. Solubility: Soluble in less than 1 part of water; freely soluble in ethanol (~750 g/l) TS; practically insoluble in ether R and benzene R. Category: Cholinergic blocking agent (parasympatholytic). Storage: Atropine sulfate should be kept in a tightly closed container, protected from light. Additional information: Atropine sulfate is very poisonous; it effloresces in dry air; it is slowly affected by light. Definition: Atropine sulfate contains not less than 98.5% and not more than 101.0% of (C17H23NO3)2,H2SO4, calculated with reference to the dried substance.
ChEMBL
CHEMBL517712
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY
EVMPD
SUB126811
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
ALTERNATIVE
MERCK INDEX
M2136
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY Merck Index
RXCUI
153971
Created by admin on Fri Jun 25 21:19:11 UTC 2021 , Edited by admin on Fri Jun 25 21:19:11 UTC 2021
PRIMARY RxNorm
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
IMPURITY -> PARENT
Related Record Type Details
ACTIVE MOIETY
http://apps.who.int/phint/pdf/b/Jb.6.1.38.pdf